CA2768169C - Aminopyridine derivatives for the treatment of tumors and inflammatory diseases - Google Patents

Aminopyridine derivatives for the treatment of tumors and inflammatory diseases Download PDF

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Publication number
CA2768169C
CA2768169C CA2768169A CA2768169A CA2768169C CA 2768169 C CA2768169 C CA 2768169C CA 2768169 A CA2768169 A CA 2768169A CA 2768169 A CA2768169 A CA 2768169A CA 2768169 C CA2768169 C CA 2768169C
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Canada
Prior art keywords
pyrazol
benzimidazol
hplc
diseases
pyridin
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Expired - Fee Related
Application number
CA2768169A
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English (en)
French (fr)
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CA2768169A1 (en
Inventor
Michel Calderini
Margarita Wucherer-Plietker
Ulrich Graedler
Christina Esdar
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
CA2768169A 2009-07-15 2010-06-17 Aminopyridine derivatives for the treatment of tumors and inflammatory diseases Expired - Fee Related CA2768169C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102009033208A DE102009033208A1 (de) 2009-07-15 2009-07-15 Aminopyridinderivate
DE102009033208.1 2009-07-15
PCT/EP2010/003659 WO2011006567A1 (de) 2009-07-15 2010-06-17 Aminopyridinderivate zur behandlung von tumoren und entzündungskrankheiten

Publications (2)

Publication Number Publication Date
CA2768169A1 CA2768169A1 (en) 2011-01-20
CA2768169C true CA2768169C (en) 2017-06-13

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2768169A Expired - Fee Related CA2768169C (en) 2009-07-15 2010-06-17 Aminopyridine derivatives for the treatment of tumors and inflammatory diseases

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Country Link
US (1) US8648201B2 (enExample)
EP (1) EP2454253B1 (enExample)
JP (1) JP5681182B2 (enExample)
CN (1) CN102471317B (enExample)
AR (1) AR077567A1 (enExample)
AU (1) AU2010272920B2 (enExample)
CA (1) CA2768169C (enExample)
DE (1) DE102009033208A1 (enExample)
ES (1) ES2534095T3 (enExample)
IL (1) IL217467A (enExample)
WO (1) WO2011006567A1 (enExample)

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CN112457308B (zh) * 2019-09-09 2024-01-02 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
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KR20250016079A (ko) * 2022-03-02 2025-02-03 항저우 바이오-신세리티 파마-테크 컴퍼니 리미티드 히스타민 h3 수용체 길항제 및 이의 약학적 용도
WO2025247379A1 (zh) * 2024-05-30 2025-12-04 深圳微芯生物科技股份有限公司 一种苯并咪唑类化合物、其制备方法及应用

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JP5681182B2 (ja) 2015-03-04
CN102471317B (zh) 2014-02-26
EP2454253B1 (de) 2015-01-21
WO2011006567A1 (de) 2011-01-20
DE102009033208A1 (de) 2011-01-20
AU2010272920B2 (en) 2016-05-05
JP2012532899A (ja) 2012-12-20
IL217467A0 (en) 2012-03-01
CN102471317A (zh) 2012-05-23
AR077567A1 (es) 2011-09-07
US20120115861A1 (en) 2012-05-10
IL217467A (en) 2015-09-24
AU2010272920A1 (en) 2012-03-08
US8648201B2 (en) 2014-02-11

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