JP2017528519A5 - - Google Patents
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- Publication number
- JP2017528519A5 JP2017528519A5 JP2017530971A JP2017530971A JP2017528519A5 JP 2017528519 A5 JP2017528519 A5 JP 2017528519A5 JP 2017530971 A JP2017530971 A JP 2017530971A JP 2017530971 A JP2017530971 A JP 2017530971A JP 2017528519 A5 JP2017528519 A5 JP 2017528519A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- methoxy
- benzoxazol
- methyl
- methoxypyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043603P | 2014-08-29 | 2014-08-29 | |
| US62/043,603 | 2014-08-29 | ||
| PCT/US2015/047407 WO2016033445A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020214504A Division JP7126541B2 (ja) | 2014-08-29 | 2020-12-24 | ハンチントンタンパク質のイメージング用プローブ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528519A JP2017528519A (ja) | 2017-09-28 |
| JP2017528519A5 true JP2017528519A5 (enExample) | 2018-10-04 |
| JP6817207B2 JP6817207B2 (ja) | 2021-01-20 |
Family
ID=55400648
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017530971A Active JP6817207B2 (ja) | 2014-08-29 | 2015-08-28 | ハンチントンタンパク質のイメージング用プローブ |
| JP2020214504A Active JP7126541B2 (ja) | 2014-08-29 | 2020-12-24 | ハンチントンタンパク質のイメージング用プローブ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020214504A Active JP7126541B2 (ja) | 2014-08-29 | 2020-12-24 | ハンチントンタンパク質のイメージング用プローブ |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10479802B2 (enExample) |
| EP (2) | EP4006016A3 (enExample) |
| JP (2) | JP6817207B2 (enExample) |
| KR (2) | KR102456946B1 (enExample) |
| CN (2) | CN116655618B (enExample) |
| AU (1) | AU2015308774B2 (enExample) |
| BR (1) | BR112017004141B8 (enExample) |
| CA (1) | CA2959501C (enExample) |
| DK (1) | DK3186233T3 (enExample) |
| EA (1) | EA035646B1 (enExample) |
| ES (1) | ES2898965T3 (enExample) |
| HR (1) | HRP20211778T1 (enExample) |
| HU (1) | HUE056957T2 (enExample) |
| IL (1) | IL250803B (enExample) |
| MX (2) | MX380810B (enExample) |
| PL (1) | PL3186233T3 (enExample) |
| PT (1) | PT3186233T (enExample) |
| SG (1) | SG11201701600QA (enExample) |
| SI (1) | SI3186233T1 (enExample) |
| WO (1) | WO2016033445A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107105667B (zh) | 2014-08-29 | 2021-08-17 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| EA035646B1 (ru) * | 2014-08-29 | 2020-07-21 | Сиэйчдиай Фаундэйшн, Инк. | Зонды для визуализации белка хантингтина |
| CA2959505A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| SI3186241T1 (sl) | 2014-08-29 | 2021-03-31 | Chdi Foundation, Inc. | Sonde za slikanje Huntingtonovega proteina |
| MX382156B (es) | 2015-08-28 | 2025-03-13 | Chdi Foundation Inc | Sondas para formar imagenes de proteina de huntingtina. |
| BR112018068066B1 (pt) | 2016-03-11 | 2023-11-28 | Ac Immune Sa | Compostos bicíclicos e seu uso, composição diagnóstica e farmacêutica, misturas, métodos de coleção de dados para diagnóstico, para determinar uma predisposição a, para monitorar transtorno residual e para prever a capacidade de resposta de um paciente sofrendo de transtorno ou anormalidade associado com agregados de alfa-sinucleína, métodos para determinar a quantidade de agregados de alfa-sinucleína e para preparar um composto, kit teste e kit para preparar uma preparação radio farmacêutica |
| CN107056723A (zh) * | 2017-04-21 | 2017-08-18 | 云南大学 | 一种具有抑制血管内皮生长因子受体信号传导的化合物 |
| MY202326A (en) | 2017-09-14 | 2024-04-24 | Daiichi Sankyo Co Ltd | Compound having cyclic structure |
| WO2019201921A1 (de) | 2018-04-20 | 2019-10-24 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
| WO2019234243A1 (en) | 2018-06-08 | 2019-12-12 | Ac Immune Sa | Novel compounds for diagnosis |
| WO2020132384A1 (en) | 2018-12-21 | 2020-06-25 | Celgene Corporation | Thienopyridine inhibitors of ripk2 |
| US11389438B2 (en) | 2019-02-25 | 2022-07-19 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| CN111635400A (zh) | 2019-03-02 | 2020-09-08 | 察略盛医药科技(上海)有限公司 | 吡唑并[1,5-a]吡啶类衍生物、及其制备方法和用途 |
| ES3029867T3 (en) * | 2019-12-18 | 2025-06-25 | Chdi Foundation Inc | Compounds and probes for imaging huntingtin protein |
| TWI885039B (zh) | 2020-01-13 | 2025-06-01 | 美商邊際分析公司 | 經取代吡唑并嘧啶及其用途 |
| KR20230008183A (ko) | 2020-05-07 | 2023-01-13 | 에이씨 이뮨 에스에이 | 진단을 위한 신규한 화합물 |
| MX2023001384A (es) * | 2020-08-06 | 2023-04-26 | Chdi Foundation Inc | Compuestos de heterobiarilo y agentes de imagenologia para imagenologia de proteina huntingtina. |
| US20220339302A1 (en) * | 2021-04-08 | 2022-10-27 | Chdi Foundation, Inc. | Isoindolinone compounds and imaging agents for imaging huntingtin protein |
| MX2023012652A (es) | 2021-04-27 | 2024-01-08 | Chdi Foundation Inc | Compuestos deuterados y agentes de imagen para representar la proteína huntingtina. |
| CA3226162A1 (en) | 2021-07-09 | 2023-01-12 | Plexium, Inc. | Aryl compounds and pharmaceutical compositions that modulate ikzf2 |
| CN118215667A (zh) | 2021-11-10 | 2024-06-18 | Ac免疫有限公司 | 用于诊断的4h-咪唑并[1,5-b]吡唑衍生物 |
| AU2022387830A1 (en) | 2021-11-10 | 2024-05-23 | Ac Immune Sa | Dihydropyrrolo[3,4c]-pyrazole derivatives and their use in diagnosis |
| EP4430044A1 (en) | 2021-11-10 | 2024-09-18 | AC Immune SA | Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis |
| TW202425965A (zh) | 2022-09-30 | 2024-07-01 | 日商科研製藥股份有限公司 | 縮環化合物及含有其之醫藥 |
| CN120344535A (zh) | 2022-12-16 | 2025-07-18 | Ac免疫有限公司 | 用于诊断的新化合物 |
| JP2026500311A (ja) | 2022-12-16 | 2026-01-06 | エーシー・イミューン・エス・アー | 診断のための新規化合物 |
| KR20260027149A (ko) * | 2023-05-18 | 2026-02-27 | 엔베다 테라퓨틱스, 인크. | G 단백질 결합 수용체 길항제 |
| WO2025037013A1 (en) | 2023-08-16 | 2025-02-20 | Ac Immune Sa | Diagnostic compounds that bind to alpha-synuclein |
| WO2025106920A1 (en) * | 2023-11-15 | 2025-05-22 | Yale University | Parp pet imaging agents and methods of using the same |
| CN119264072B (zh) * | 2024-12-06 | 2025-05-02 | 国科大杭州高等研究院 | 对细胞成像的荧光探针及其合成方法和应用 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985755A (en) | 1972-06-02 | 1976-10-12 | E. R. Squibb & Sons, Inc. | Pyridine containing isothiocyanobenzoxazoles |
| US4198416A (en) | 1976-09-30 | 1980-04-15 | Meiji Seika Kaisha, Ltd. | 5-Alkoxy-picolinic esters and anti-hypertensive composition containing 5-alkoxy-picolinic esters |
| DE2909754A1 (de) * | 1979-03-13 | 1980-09-18 | Thomae Gmbh Dr K | Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel |
| FR2524468B1 (fr) | 1982-04-06 | 1985-10-18 | Sandoz Sa | Nouveaux derives condenses du thiophene, leur preparation et leur utilisation comme azurants optiques |
| JP2869561B2 (ja) * | 1989-05-22 | 1999-03-10 | 大塚製薬株式会社 | 血小板粘着抑制剤 |
| US5041453A (en) | 1990-05-30 | 1991-08-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 |
| JP2600644B2 (ja) * | 1991-08-16 | 1997-04-16 | 藤沢薬品工業株式会社 | チアゾリルベンゾフラン誘導体 |
| GB9203798D0 (en) * | 1992-02-21 | 1992-04-08 | Fujisawa Pharmaceutical Co | Quinolylbenzofuran derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| WO1994022846A1 (en) * | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
| GB9317949D0 (en) | 1993-08-28 | 1993-10-13 | Stevens Malcolm F G | Benzothiazole compounds |
| SG64896A1 (en) * | 1995-02-28 | 1999-05-25 | Lilly Co Eli | Benzothiophene compounds intermediates compositions and methods |
| JPH08325265A (ja) * | 1995-05-29 | 1996-12-10 | Fujisawa Pharmaceut Co Ltd | チアゾリルベンゾフラン誘導体の製造方法、および該製造方法に用いられる化合物 |
| CN1209809A (zh) | 1996-01-22 | 1999-03-03 | 藤泽药品工业株式会社 | 新化合物 |
| JPH11171886A (ja) | 1997-12-08 | 1999-06-29 | Mitsui Chem Inc | アミジンまたはグアニジンを側鎖にもつピロリルベンズイミダゾール誘導体 |
| US6573264B1 (en) | 2000-10-23 | 2003-06-03 | Cv Therapeutics, Inc. | Heteroaryl alkyl piperazine derivatives |
| AU2002349705A1 (en) * | 2001-12-03 | 2003-06-17 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| ATE335477T1 (de) | 2001-12-20 | 2006-09-15 | Wyeth Corp | Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| JP2007504283A (ja) | 2003-05-20 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | β−アミロイド斑に作用物質を結合させる方法 |
| WO2005016384A1 (ja) | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤 |
| TW200616974A (en) | 2004-07-01 | 2006-06-01 | Astrazeneca Ab | Chemical compounds |
| KR20080094699A (ko) | 2006-02-15 | 2008-10-23 | 사노피-아벤티스 | 신규 아미노알콜-치환된 아릴디하이드로이소퀴놀리논, 이의제조 방법 및 이의 약물로서의 용도 |
| AU2007288124B2 (en) * | 2006-08-24 | 2013-04-04 | Australian Nuclear Science & Technology Organisation | Fluorinated ligands for targeting peripheral benzodiazepine receptors |
| JP5190893B2 (ja) * | 2006-12-25 | 2013-04-24 | 国立大学法人東北大学 | ベンゾキサゾール誘導体 |
| US7858803B2 (en) * | 2007-04-27 | 2010-12-28 | The General Hospital Corporation | Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders |
| KR101469275B1 (ko) | 2007-06-01 | 2014-12-08 | 재단법인서울대학교산학협력재단 | 베타아밀로이드 침착의 영상화를 위한 헤테로사이클릭 인덴계열의 유도체 및 그의 방사성 동위원소 표지화합물 |
| EP2215074B1 (en) | 2007-09-27 | 2014-02-19 | The United States of America, as Represented by the Secretary, Department of Health and Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| US20090123373A1 (en) * | 2007-11-05 | 2009-05-14 | Yanming Wang | Amyloid-imaging agents |
| US8153813B2 (en) | 2007-12-20 | 2012-04-10 | Abbott Laboratories | Benzothiazole and benzooxazole derivatives and methods of use |
| WO2009146388A1 (en) | 2008-05-28 | 2009-12-03 | The Trustees Of Columbia University In The City Of New York | Voxel-based methods for assessing subjects using positron emission tomography |
| WO2009155024A1 (en) * | 2008-05-30 | 2009-12-23 | Merck & Co., Inc. | Novel substituted indoles |
| AU2009260519A1 (en) * | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| CA2741668A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
| GB0905664D0 (en) * | 2009-04-02 | 2009-05-13 | Summit Corp Plc | Compounds for treatment of duchenne muscular dystrophy |
| NZ595674A (en) | 2009-04-02 | 2012-12-21 | Ct Nac Investigaciones Oncologicas Cnio | Imidazo[2,1-b][1,3,4]thiadiazole derivatives |
| US20120263646A1 (en) | 2009-10-15 | 2012-10-18 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| JP2011168515A (ja) | 2010-02-17 | 2011-09-01 | Kowa Co | エリスロポエチン産生促進作用を有する2−アリールベンゾオキサゾール化合物 |
| WO2012007510A1 (en) * | 2010-07-14 | 2012-01-19 | Bayer Pharma Aktiengesellschaft | Compounds for binding and imaging amyloid plaques and their use |
| ES2536319T3 (es) | 2010-11-30 | 2015-05-22 | Takeda Pharmaceutical Company Limited | Compuestos bicíclicos como inhibidores de acetil-CoA carboxilasa (ACC) |
| CN102391260B (zh) | 2011-09-29 | 2014-12-10 | 上海交通大学 | 3-甲酮-6-取代-苯并呋喃类化合物及其制备方法和用途 |
| SG11201406759YA (en) | 2012-04-26 | 2014-11-27 | Bristol Myers Squibb Co | Imidazothiadiazole derivatives as protease activated receptor 4 (par4) inhibitors for treating platelet aggregation |
| US9370588B2 (en) | 2013-01-04 | 2016-06-21 | University Of Massachusetts | Luciferin amides |
| GB201306248D0 (en) * | 2013-04-05 | 2013-05-22 | Ucl Business Plc | Compounds and their uses |
| AU2014291142B2 (en) | 2013-07-17 | 2018-10-11 | Otsuka Pharmaceutical Co., Ltd. | Cyanotriazole compounds |
| CN107105667B (zh) | 2014-08-29 | 2021-08-17 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| CA2959505A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| SI3186241T1 (sl) | 2014-08-29 | 2021-03-31 | Chdi Foundation, Inc. | Sonde za slikanje Huntingtonovega proteina |
| EA035646B1 (ru) | 2014-08-29 | 2020-07-21 | Сиэйчдиай Фаундэйшн, Инк. | Зонды для визуализации белка хантингтина |
| MX382156B (es) | 2015-08-28 | 2025-03-13 | Chdi Foundation Inc | Sondas para formar imagenes de proteina de huntingtina. |
-
2015
- 2015-08-28 EA EA201790407A patent/EA035646B1/ru unknown
- 2015-08-28 HU HUE15836321A patent/HUE056957T2/hu unknown
- 2015-08-28 JP JP2017530971A patent/JP6817207B2/ja active Active
- 2015-08-28 MX MX2017002703A patent/MX380810B/es unknown
- 2015-08-28 HR HRP20211778TT patent/HRP20211778T1/hr unknown
- 2015-08-28 ES ES15836321T patent/ES2898965T3/es active Active
- 2015-08-28 SG SG11201701600QA patent/SG11201701600QA/en unknown
- 2015-08-28 US US15/507,208 patent/US10479802B2/en active Active
- 2015-08-28 WO PCT/US2015/047407 patent/WO2016033445A1/en not_active Ceased
- 2015-08-28 PT PT158363218T patent/PT3186233T/pt unknown
- 2015-08-28 BR BR112017004141A patent/BR112017004141B8/pt active IP Right Grant
- 2015-08-28 CN CN202310475134.8A patent/CN116655618B/zh active Active
- 2015-08-28 AU AU2015308774A patent/AU2015308774B2/en active Active
- 2015-08-28 CA CA2959501A patent/CA2959501C/en active Active
- 2015-08-28 CN CN201580058282.3A patent/CN107108534B/zh active Active
- 2015-08-28 PL PL15836321T patent/PL3186233T3/pl unknown
- 2015-08-28 KR KR1020177008383A patent/KR102456946B1/ko active Active
- 2015-08-28 DK DK15836321.8T patent/DK3186233T3/da active
- 2015-08-28 KR KR1020227035965A patent/KR102586736B1/ko active Active
- 2015-08-28 SI SI201531751T patent/SI3186233T1/sl unknown
- 2015-08-28 EP EP21192872.6A patent/EP4006016A3/en not_active Withdrawn
- 2015-08-28 EP EP15836321.8A patent/EP3186233B8/en active Active
-
2017
- 2017-02-27 IL IL250803A patent/IL250803B/en active IP Right Grant
- 2017-02-28 MX MX2021003311A patent/MX2021003311A/es unknown
-
2019
- 2019-08-02 US US16/530,594 patent/US11059836B2/en active Active
-
2020
- 2020-12-24 JP JP2020214504A patent/JP7126541B2/ja active Active
-
2022
- 2022-08-05 US US17/881,895 patent/US12258355B2/en active Active
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