JP2014531465A5 - - Google Patents
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- Publication number
- JP2014531465A5 JP2014531465A5 JP2014533880A JP2014533880A JP2014531465A5 JP 2014531465 A5 JP2014531465 A5 JP 2014531465A5 JP 2014533880 A JP2014533880 A JP 2014533880A JP 2014533880 A JP2014533880 A JP 2014533880A JP 2014531465 A5 JP2014531465 A5 JP 2014531465A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- indazol
- pyrimidin
- methoxy
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GYPBSIFOIFDXKX-UHFFFAOYSA-N C=COCC1(CN)COC1 Chemical compound C=COCC1(CN)COC1 GYPBSIFOIFDXKX-UHFFFAOYSA-N 0.000 description 1
- 0 C[C@](*)(C=C(C)N(*)C(C)=C(C=NC(c1n[n]c2c1C=CC(C)(*)C=C2)=N)N)C=NC Chemical compound C[C@](*)(C=C(C)N(*)C(C)=C(C=NC(c1n[n]c2c1C=CC(C)(*)C=C2)=N)N)C=NC 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11184061 | 2011-10-06 | ||
| EP11184061.7 | 2011-10-06 | ||
| PCT/EP2012/069562 WO2013050438A1 (en) | 2011-10-06 | 2012-10-04 | Substituted benzylindazoles for use as bub1 kinase inhibitors in the treatment of hyperproliferative diseases. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014531465A JP2014531465A (ja) | 2014-11-27 |
| JP2014531465A5 true JP2014531465A5 (enExample) | 2016-01-14 |
| JP6140170B2 JP6140170B2 (ja) | 2017-05-31 |
Family
ID=46968229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014533880A Expired - Fee Related JP6140170B2 (ja) | 2011-10-06 | 2012-10-04 | 過増殖性疾患の処置におけるｂｕｂ１キナーゼ阻害剤として使用するための置換ベンジルインダゾール類 |
Country Status (38)
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
| ES2638144T3 (es) | 2011-12-21 | 2017-10-18 | Bayer Intellectual Property Gmbh | Bencilpirazoles sustituidos |
| JP2015520143A (ja) * | 2012-05-11 | 2015-07-16 | バイエル ファーマ アクチエンゲゼルシャフト | 癌を治療するためのｂｕｂ１阻害薬としての置換されているシクロアルケノピラゾール類 |
| EP2976334A1 (en) * | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
| US20160046604A1 (en) * | 2013-03-21 | 2016-02-18 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted indazoles |
| US20160046610A1 (en) * | 2013-03-21 | 2016-02-18 | Bayer Pharma Aktiengesellschaft | 3-heteroaryl substituted indazoles |
| CA2916116A1 (en) * | 2013-06-21 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Substituted benzylpyrazoles |
| EP3010901B1 (en) * | 2013-06-21 | 2017-09-13 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
| JP2016526540A (ja) * | 2013-06-21 | 2016-09-05 | バイエル ファーマ アクチエンゲゼルシャフト | 置換ベンジルピラゾール |
| JP2016522231A (ja) * | 2013-06-21 | 2016-07-28 | バイエル ファーマ アクチエンゲゼルシャフト | ジアミノヘテロアリール置換ピラゾール類 |
| HK1223097A1 (zh) * | 2013-06-21 | 2017-07-21 | Bayer Pharma Aktiengesellschaft | 杂芳基取代的吡唑 |
| EP3063138A1 (en) * | 2013-10-30 | 2016-09-07 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
| UY36175A (es) * | 2014-06-17 | 2016-01-29 | Bayer Pharma AG | 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas |
| JP2017535514A (ja) * | 2014-09-19 | 2017-11-30 | バイエル ファーマ アクチエンゲゼルシャフト | Ｂｕｂ１キナーゼ阻害薬としてのベンジル置換インダゾール類 |
| WO2016041925A1 (en) * | 2014-09-19 | 2016-03-24 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles |
| EA032401B1 (ru) | 2014-09-19 | 2019-05-31 | Байер Фарма Акциенгезельшафт | Бензилзамещенные индазолы в качестве ингибиторов bub1 |
| JP2017529353A (ja) * | 2014-09-19 | 2017-10-05 | バイエル ファーマ アクチエンゲゼルシャフト | Ｂｕｂ１キナーゼ阻害薬としてのベンジル置換インダゾール類 |
| GB201419264D0 (en) * | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
| SG11201705908VA (en) | 2015-01-28 | 2017-08-30 | Bayer Pharma AG | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| EP3307734B1 (en) * | 2015-06-09 | 2019-11-27 | AbbVie Inc. | Nuclear receptor modulators (ror) for the treatment of inflammatory and autoimmune diseases |
| EP3310775B1 (en) * | 2015-06-17 | 2020-04-01 | Bayer Pharma Aktiengesellschaft | 3-amino-1,5,6,7-tetrahydro-4h-indol-4-ones |
| JP2019504826A (ja) * | 2015-12-16 | 2019-02-21 | バイエル ファーマ アクチエンゲゼルシャフト | ヘテロ−１，５，６，７−テトラヒドロ−４ｈ−インドール−４−オン類 |
| WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
| WO2017157992A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders |
| WO2017157991A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases |
| WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
| WO2018158175A1 (en) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combination of bub1 inhibitors |
| WO2018206547A1 (en) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and atr inhibitors |
| WO2018215282A1 (en) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and pi3k inhibitors |
| KR102328682B1 (ko) | 2018-08-27 | 2021-11-18 | 주식회사 대웅제약 | 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물 |
| KR102048050B1 (ko) * | 2019-08-29 | 2020-01-22 | 대한민국 | Adb-푸비나카의 대사체 합성 방법 |
| CN110684016A (zh) * | 2019-09-27 | 2020-01-14 | 上海应用技术大学 | 一种含氟的azd9291衍生物及其制备方法和应用 |
| AU2021347288A1 (en) | 2020-09-23 | 2023-05-04 | Antares Therapeutics, Inc. | Pyrrolo[3,2-c]pyridin-4-one derivatives useful in the treatment of cancer |
| WO2022072634A1 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Bicyclic compounds for use in the treatment cancer |
| WO2022072645A2 (en) | 2020-09-30 | 2022-04-07 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
| WO2022094271A1 (en) | 2020-10-30 | 2022-05-05 | Scorpion Therapeutics, Inc. | Methods for treating cancer |
| WO2022098992A1 (en) | 2020-11-05 | 2022-05-12 | Scorpion Therapeutics, Inc. | Use of macrocyclic compounds in methods of treating cancer |
| WO2022197913A1 (en) | 2021-03-18 | 2022-09-22 | Scorpion Therapeutics, Inc. | Bicyclic derivatives which can be used to treat cancer |
| WO2023173083A1 (en) | 2022-03-11 | 2023-09-14 | Scorpion Therapeutics, Inc. | Tetrahydroindole derivatives as egfr and/or her2 inhibtors useful for the treatment of cancer |
| US20250214980A1 (en) | 2022-03-14 | 2025-07-03 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2024254266A1 (en) | 2023-06-08 | 2024-12-12 | Scorpion Therapeutics, Inc. | A 1,5-dihydro-4h-pyrrolo[3,2-c] pyridin-4-one for use in the treatment of cancer |
| WO2024254298A1 (en) | 2023-06-08 | 2024-12-12 | Scorpion Therapeutics, Inc. | A 1,5-dihydro-4h-pyrrolo[3,2-c] pyridin-4-one for use in the treatment of cancer |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| US5470862A (en) | 1995-02-03 | 1995-11-28 | Ohmeda Pharmaceutical Products Division Inc. | Substituted pyrazolyl compounds and methods employing such compounds |
| EP0934311B1 (de) | 1996-10-14 | 2009-05-13 | Bayer HealthCare AG | Neue heterocyclylmethyl-substituierte pyrazolderivate und ihre verwendung in der behandlung von herz-kreislauf-erkrankungen |
| DE19834047A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19846514A1 (de) * | 1998-10-09 | 2000-04-20 | Bayer Ag | Neue Heterocyclyl-methyl-substituierte Pyrazole |
| US7569592B2 (en) | 2001-12-18 | 2009-08-04 | Merck & Co., Inc. | Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5 |
| US7166293B2 (en) | 2002-03-29 | 2007-01-23 | Carlsbad Technology, Inc. | Angiogenesis inhibitors |
| CN1694708A (zh) | 2002-09-10 | 2005-11-09 | 西奥斯股份有限公司 | TGFβ的抑制剂 |
| DE10244810A1 (de) * | 2002-09-26 | 2004-04-08 | Bayer Ag | Neue Morpholin-überbrückte Indazolderivate |
| WO2007038613A2 (en) | 2005-09-26 | 2007-04-05 | The Regents Of The University Of California | Selective serine/threonine kinase inhibitors |
| WO2005070900A1 (en) | 2004-01-22 | 2005-08-04 | Altana Pharma Ag | N-4-(6- (heteo) aryl-pyrimidin-4-ylaminophenyl) -bezenesulfonamides as kinase inhibitors |
| WO2007065010A2 (en) * | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
| DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| KR20100016617A (ko) | 2007-05-18 | 2010-02-12 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 과증식성 장애 및 혈관형성 관련 질환의 치료에 유용한 저산소증 유도성 인자 （ｈｉｆ）의 억제제 |
| JP2010111624A (ja) * | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ｔｔｋ阻害作用を有するインダゾール誘導体 |
| US8354399B2 (en) | 2008-12-18 | 2013-01-15 | Nerviano Medical Sciences S.R.L. | Substituted indazole derivatives active as kinase inhibitors |
| WO2011049987A2 (en) | 2009-10-20 | 2011-04-28 | Eiger Biopharmaceuticals, Inc. | Azaindazoles to treat flaviviridae virus infection |
| PH12012501023A1 (en) | 2009-11-27 | 2014-12-19 | Adverio Pharma Gmbh | Method for producing methyl - {4, 6-diamino -2-[1- (2-fluorobenzyl) -1h- pyrazolo [3,4-b] pyridino -3-yl] pyrimidino -5-yl} methyl carbamate and its purification for use thereof as pharmaceutical substance |
| WO2011115804A1 (en) | 2010-03-17 | 2011-09-22 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| SG184243A1 (en) | 2010-03-30 | 2012-10-30 | Verseon Corp | Multisubstituted aromatic compounds as inhibitors of thrombin |
| JP5860459B2 (ja) | 2010-06-30 | 2016-02-16 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | ｓＧＣ刺激薬 |
| UA111754C2 (uk) | 2011-10-06 | 2016-06-10 | Байєр Фарма Акцієнгезелльшафт | Заміщені бензиліндазоли для застосування як інгібіторів bub1-кінази для лікування гіперпроліферативних захворювань |
| ES2638144T3 (es) | 2011-12-21 | 2017-10-18 | Bayer Intellectual Property Gmbh | Bencilpirazoles sustituidos |
| WO2013101830A1 (en) | 2011-12-27 | 2013-07-04 | Ironwood Pharmaceuticals, Inc. | 2 - benzyl, 3 - (pyrimidin- 2 -yl) substituted pyrazoles useful as sgc stimulators |
| JP2015520143A (ja) | 2012-05-11 | 2015-07-16 | バイエル ファーマ アクチエンゲゼルシャフト | 癌を治療するためのｂｕｂ１阻害薬としての置換されているシクロアルケノピラゾール類 |
| WO2014047111A1 (en) | 2012-09-18 | 2014-03-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| EP2897953B8 (en) | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
| US9738610B2 (en) | 2012-09-24 | 2017-08-22 | Whitehead Institute For Biomedical Research | Indazole derivatives and uses thereof |
| US20160046604A1 (en) | 2013-03-21 | 2016-02-18 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted indazoles |
| US20160046610A1 (en) | 2013-03-21 | 2016-02-18 | Bayer Pharma Aktiengesellschaft | 3-heteroaryl substituted indazoles |
| EP2976334A1 (en) | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
| HK1223097A1 (zh) | 2013-06-21 | 2017-07-21 | Bayer Pharma Aktiengesellschaft | 杂芳基取代的吡唑 |
| EP3010901B1 (en) | 2013-06-21 | 2017-09-13 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
| CA2916116A1 (en) | 2013-06-21 | 2014-12-24 | Bayer Pharma Aktiengesellschaft | Substituted benzylpyrazoles |
| JP2016526540A (ja) | 2013-06-21 | 2016-09-05 | バイエル ファーマ アクチエンゲゼルシャフト | 置換ベンジルピラゾール |
| JP2016522231A (ja) | 2013-06-21 | 2016-07-28 | バイエル ファーマ アクチエンゲゼルシャフト | ジアミノヘテロアリール置換ピラゾール類 |
| EP3063138A1 (en) | 2013-10-30 | 2016-09-07 | Bayer Pharma Aktiengesellschaft | Heteroaryl substituted pyrazoles |
| JP2017529353A (ja) | 2014-09-19 | 2017-10-05 | バイエル ファーマ アクチエンゲゼルシャフト | Ｂｕｂ１キナーゼ阻害薬としてのベンジル置換インダゾール類 |
| EA032401B1 (ru) | 2014-09-19 | 2019-05-31 | Байер Фарма Акциенгезельшафт | Бензилзамещенные индазолы в качестве ингибиторов bub1 |
| WO2016041925A1 (en) | 2014-09-19 | 2016-03-24 | Bayer Pharma Aktiengesellschaft | Benzyl substituted indazoles |
| JP2017535514A (ja) | 2014-09-19 | 2017-11-30 | バイエル ファーマ アクチエンゲゼルシャフト | Ｂｕｂ１キナーゼ阻害薬としてのベンジル置換インダゾール類 |
| WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
| WO2017157992A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | Annulated pyrazoles as bub1 kinase inhibitors for treating proliferative disorders |
| WO2017157991A1 (en) | 2016-03-18 | 2017-09-21 | Bayer Pharma Aktiengesellschaft | 1-alkyl-pyrazoles and -indazoles as bub1 inhibitors for the treatment of hyperproliferative diseases |
| WO2018122168A1 (en) | 2016-12-29 | 2018-07-05 | Bayer Pharma Aktiengesellschaft | Combinations of bub1 kinase and parp inhibitors |
| WO2018158175A1 (en) | 2017-02-28 | 2018-09-07 | Bayer Pharma Aktiengesellschaft | Combination of bub1 inhibitors |
| WO2018206547A1 (en) | 2017-05-12 | 2018-11-15 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and atr inhibitors |
| WO2018215282A1 (en) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combination of bub1 and pi3k inhibitors |
-
2012
- 2012-04-10 UA UAA201404803A patent/UA111754C2/uk unknown
- 2012-10-04 KR KR1020147011914A patent/KR102007056B1/ko not_active Expired - Fee Related
- 2012-10-04 SI SI201231274T patent/SI2763982T1/en unknown
- 2012-10-04 US US14/350,160 patent/US20140249133A1/en active Granted
- 2012-10-04 ES ES12766997.6T patent/ES2665036T3/es active Active
- 2012-10-04 PH PH1/2014/500758A patent/PH12014500758A1/en unknown
- 2012-10-04 DK DK12766997.6T patent/DK2763982T3/en active
- 2012-10-04 PT PT127669976T patent/PT2763982T/pt unknown
- 2012-10-04 EA EA201400412A patent/EA201400412A1/ru unknown
- 2012-10-04 NO NO12766997A patent/NO2763982T3/no unknown
- 2012-10-04 MX MX2014004122A patent/MX361279B/es active IP Right Grant
- 2012-10-04 LT LTEP12766997.6T patent/LT2763982T/lt unknown
- 2012-10-04 EP EP12766997.6A patent/EP2763982B1/en active Active
- 2012-10-04 JP JP2014533880A patent/JP6140170B2/ja not_active Expired - Fee Related
- 2012-10-04 CN CN201280059851.2A patent/CN103974948B/zh not_active Expired - Fee Related
- 2012-10-04 RS RS20180403A patent/RS57099B1/sr unknown
- 2012-10-04 AP AP2014007533A patent/AP3847A/en active
- 2012-10-04 PE PE2014000471A patent/PE20141203A1/es active IP Right Grant
- 2012-10-04 WO PCT/EP2012/069562 patent/WO2013050438A1/en not_active Ceased
- 2012-10-04 HU HUE12766997A patent/HUE037154T2/hu unknown
- 2012-10-04 BR BR112014008045A patent/BR112014008045A2/pt not_active Application Discontinuation
- 2012-10-04 PL PL12766997T patent/PL2763982T3/pl unknown
- 2012-10-04 HR HRP20180546TT patent/HRP20180546T1/hr unknown
- 2012-10-04 AU AU2012320582A patent/AU2012320582B2/en not_active Ceased
- 2012-10-04 CA CA2851037A patent/CA2851037A1/en not_active Abandoned
- 2012-10-04 SG SG11201400616YA patent/SG11201400616YA/en unknown
- 2012-10-05 AR ARP120103719A patent/AR088449A1/es unknown
- 2012-10-05 TW TW101137035A patent/TWI588141B/zh not_active IP Right Cessation
- 2012-10-05 UY UY0001034374A patent/UY34374A/es not_active Application Discontinuation
-
2014
- 2014-03-19 IL IL231591A patent/IL231591A/en active IP Right Grant
- 2014-04-04 GT GT201400063A patent/GT201400063A/es unknown
- 2014-04-04 EC ECSP14013284 patent/ECSP14013284A/es unknown
- 2014-04-04 CO CO14073129A patent/CO6930363A2/es active IP Right Grant
- 2014-04-04 DO DO2014000062A patent/DOP2014000062A/es unknown
- 2014-04-04 CR CR20140161A patent/CR20140161A/es unknown
- 2014-04-04 CU CUP2014000043A patent/CU20140043A7/es unknown
- 2014-04-04 TN TNP2014000138A patent/TN2014000138A1/en unknown
-
2017
- 2017-02-21 US US15/438,254 patent/US10266548B2/en not_active Expired - Fee Related
-
2018
- 2018-04-10 CY CY20181100391T patent/CY1120318T1/el unknown
-
2019
- 2019-03-21 US US16/360,811 patent/US10604532B2/en not_active Expired - Fee Related
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