JP2016530299A5 - - Google Patents
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- Publication number
- JP2016530299A5 JP2016530299A5 JP2016540401A JP2016540401A JP2016530299A5 JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5 JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- decane
- amino
- pyrimidin
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874545P | 2013-09-06 | 2013-09-06 | |
| US61/874,545 | 2013-09-06 | ||
| US201361899943P | 2013-11-05 | 2013-11-05 | |
| US61/899,943 | 2013-11-05 | ||
| US201462004385P | 2014-05-29 | 2014-05-29 | |
| US62/004,385 | 2014-05-29 | ||
| PCT/US2014/054202 WO2015035113A1 (en) | 2013-09-06 | 2014-09-05 | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530299A JP2016530299A (ja) | 2016-09-29 |
| JP2016530299A5 true JP2016530299A5 (enExample) | 2017-10-12 |
| JP6470290B2 JP6470290B2 (ja) | 2019-02-13 |
Family
ID=51743540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540401A Expired - Fee Related JP6470290B2 (ja) | 2013-09-06 | 2014-09-05 | トリプトファンヒドロキシラーゼ阻害薬としてのスピロ環式化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (8) | US9199994B2 (enExample) |
| EP (1) | EP3041842B8 (enExample) |
| JP (1) | JP6470290B2 (enExample) |
| KR (1) | KR102336075B1 (enExample) |
| CN (1) | CN105764902B (enExample) |
| AR (1) | AR097571A1 (enExample) |
| AU (1) | AU2014315109B2 (enExample) |
| CA (1) | CA2922933C (enExample) |
| CL (1) | CL2016000509A1 (enExample) |
| CY (1) | CY1122652T1 (enExample) |
| DK (1) | DK3041842T3 (enExample) |
| EA (1) | EA032304B1 (enExample) |
| EC (1) | ECSP16014324A (enExample) |
| ES (1) | ES2780828T3 (enExample) |
| HR (1) | HRP20200098T1 (enExample) |
| HU (1) | HUE047574T2 (enExample) |
| IL (1) | IL244315B (enExample) |
| LT (1) | LT3041842T (enExample) |
| MX (1) | MX371191B (enExample) |
| MY (1) | MY186265A (enExample) |
| PE (1) | PE20160648A1 (enExample) |
| PH (1) | PH12016500416A1 (enExample) |
| PL (1) | PL3041842T3 (enExample) |
| PT (1) | PT3041842T (enExample) |
| RS (1) | RS59871B1 (enExample) |
| SG (2) | SG10201802118QA (enExample) |
| SI (1) | SI3041842T1 (enExample) |
| TW (1) | TWI652267B (enExample) |
| UA (1) | UA119247C2 (enExample) |
| WO (1) | WO2015035113A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| CN107176940B (zh) * | 2016-03-09 | 2019-05-28 | 江苏正大丰海制药有限公司 | 一种替卡法林的制备方法 |
| TW201818964A (zh) * | 2016-09-30 | 2018-06-01 | 瑞士商諾伊曼特醫療公司 | 使用色胺酸羥化酶抑制劑之方法 |
| AR110150A1 (es) | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
| US10472313B1 (en) | 2018-02-18 | 2019-11-12 | Graphene 3D Lab Inc. | Process for synthesizing trifluoroketones |
| EP3880680A1 (en) | 2018-11-14 | 2021-09-22 | Altavant Sciences GmbH | A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin |
| WO2020099926A1 (en) | 2018-11-16 | 2020-05-22 | Altavant Sciences Gmbh | A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension |
| US20200188399A1 (en) * | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating interstitial lung disease |
| US20200188398A1 (en) | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating sarcoidosis-associated pulmonary hypertension |
| JP2022518944A (ja) * | 2019-01-30 | 2022-03-17 | アルタバント・サイエンシズ・ゲーエムベーハー | 肺動脈性肺高血圧症を治療するための投与レジメンおよび方法 |
| JP2022525202A (ja) * | 2019-03-15 | 2022-05-11 | アルタバント・サイエンシズ・ゲーエムベーハー | 肺動脈性肺高血圧症および各種疾患に伴う肺動脈性肺高血圧症の治療法と１日あたりの投薬量 |
| JP2023529764A (ja) * | 2019-12-02 | 2023-07-12 | アルタバント・サイエンシズ・ゲーエムベーハー | 下気道障害の処置 |
| CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
| CA3165432A1 (en) | 2020-01-31 | 2021-08-05 | Stephen A. Wring | Dosages and methods for treating pulmonary arterial hypertension with rodatristat |
| WO2023062595A1 (en) | 2021-10-14 | 2023-04-20 | Altavant Sciences Gmbh | Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl |
| WO2023079486A1 (en) | 2021-11-03 | 2023-05-11 | Altavant Sciences Gmbh | Treatment of pulmonary arterial hypertension with rodatristat and ambrisentan |
| EP4662204A2 (en) * | 2023-02-09 | 2025-12-17 | Geron Corporation | Telomerase inhibitor compounds |
| WO2025008449A1 (en) | 2023-07-05 | 2025-01-09 | Institut National de la Santé et de la Recherche Médicale | Use of tryptophan hydroxylase 1 (tph1) inhibitors for the treatment of atherosclerosis |
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| NO902190L (no) | 1989-05-16 | 1990-11-19 | Puetter Medice Chem Pharm | Fremgangsmaate for fremstilling av optisk aktive 2-arylalkanonsyrer, saerlig 2-arylpropionsyrer. |
| SK284041B6 (sk) | 1996-08-28 | 2004-08-03 | The Procter And Gamble Company | Spirocyklická metaloproteázová inhibítorová zlúčenina a jej použitie |
| KR100790763B1 (ko) | 2000-03-07 | 2008-01-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 치환된 3-페닐-5-알콕시-1,3,4-옥스디아졸-2-온 및 이를 포함하는 호르몬 민감성 리파아제 억제용 약제 |
| WO2003051841A2 (en) | 2001-12-14 | 2003-06-26 | Novo Nordisk A/S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
| DE10247680B4 (de) | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| EP1636205A1 (en) | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Pyridinyl carbamates as hormone-sensitive lipase inhibitors |
| JP2006527212A (ja) | 2003-06-12 | 2006-11-30 | ノボ ノルディスク アクティーゼルスカブ | ホルモン感受性リパーゼの阻害剤として使用するための、置換ピペラジンカルバメート |
| DE102004005172A1 (de) | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| DE102005002130A1 (de) | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| CN103265495B (zh) | 2005-12-29 | 2016-11-16 | 莱西肯医药有限公司 | 多环氨基酸衍生物及其使用方法 |
| UA99270C2 (en) | 2006-12-12 | 2012-08-10 | Лексикон Фармасьютикалз, Инк. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
| EP2120573A4 (en) * | 2007-02-12 | 2011-05-25 | Merck Sharp & Dohme | piperidine |
| CN101679395B (zh) | 2007-05-16 | 2012-06-13 | 伊莱利利公司 | 三唑基氨基嘧啶化合物 |
| BRPI0814105A2 (pt) | 2007-07-11 | 2015-02-03 | Lexicon Pharmaceuticals Inc | Métodos e composições para o tratamento de hipertensão pulmonar e doenças e distúrbios relacionados |
| WO2009014972A1 (en) | 2007-07-26 | 2009-01-29 | Lexicon Pharmaceuticals, Inc. | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein |
| EP2200601A1 (en) | 2007-09-24 | 2010-06-30 | Universität Zürich Prorektorat Mnw | Blockers of serotonin and its receptors for the treatment of hepatitis |
| JP2011516486A (ja) | 2008-03-31 | 2011-05-26 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 骨質量疾患の診断、予防、及び治療方法 |
| CN101591332B (zh) | 2008-05-30 | 2014-04-16 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| CN104045626B (zh) | 2008-05-30 | 2017-01-11 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| TW201022267A (en) | 2008-10-23 | 2010-06-16 | Gruenenthal Gmbh | Substituierte pyrimidin-und triazin-derivate |
| WO2010056992A1 (en) | 2008-11-13 | 2010-05-20 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating low bone mass diseases |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| EP2411380A1 (en) | 2009-03-26 | 2012-02-01 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
| TW201103540A (en) | 2009-06-16 | 2011-02-01 | Ono Pharmaceutical Co | Compound having spiro-linked cyclic group and uses thereof |
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| US8815883B2 (en) | 2009-11-02 | 2014-08-26 | The Trustees Of Columbia Unviersity In The City Of New York | Compounds and methods for inhibiting serotonin synthesis |
| AU2010315190A1 (en) | 2009-11-05 | 2012-05-10 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
| CN102711757A (zh) | 2009-11-23 | 2012-10-03 | 莱西肯医药有限公司 | 用于治疗肠易激综合征的方法和分析法 |
| JP2013519673A (ja) | 2010-02-10 | 2013-05-30 | レクシコン ファーマシューティカルズ インコーポレイテッド | 転移性骨疾患の治療のためのトリプトファンヒドロキシラーゼ阻害剤 |
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| RU2013120966A (ru) * | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
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| KR102047788B1 (ko) | 2011-10-17 | 2019-11-22 | 렉시컨 파마슈티컬스 인코퍼레이티드 | (s)-에틸 2-아미노-3-(4-(2-아미노-6-((r)-1-(4-클로로-2-(3-메틸-1h-피라졸-1-일)페닐)-2,2,2-트리플루오로에톡시)피리미딘-4-일)페닐)프로파노에이트의 고체 투여 형태 |
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| ES2561353T3 (es) | 2012-01-13 | 2016-02-25 | Novartis Ag | Sales de un agonista del receptor IP |
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| US20130303763A1 (en) | 2012-03-30 | 2013-11-14 | Michael D. Gershon | Methods and compositions for the treatment of necrotizing enterocolitis |
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| JP2016509017A (ja) | 2013-02-15 | 2016-03-24 | マクマスター ユニバーシティー | 肥満の治療方法 |
| WO2014195847A2 (en) | 2013-06-03 | 2014-12-11 | Actelion Pharmaceuticals Ltd | Novel use of stable isotope labeled l-tryptophan |
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US10189839B2 (en) | 2013-11-19 | 2019-01-29 | Actelion Pharmaceuticals Ltd | Tricyclic imidazole compounds as inhibitors of tryptophan hydroxylase |
| AR098436A1 (es) | 2013-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Compuestos tricíclicos de piperidina |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| EP3061761A1 (en) | 2015-02-24 | 2016-08-31 | Max-Delbrück-Centrum für Molekulare Medizin | Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same |
| WO2016177690A1 (en) | 2015-05-04 | 2016-11-10 | Actelion Pharmaceuticals Ltd | Tricyclic piperidine compounds |
-
2014
- 2014-05-09 UA UAA201603580A patent/UA119247C2/uk unknown
- 2014-09-05 PT PT147863831T patent/PT3041842T/pt unknown
- 2014-09-05 SG SG10201802118QA patent/SG10201802118QA/en unknown
- 2014-09-05 EA EA201690534A patent/EA032304B1/ru not_active IP Right Cessation
- 2014-09-05 WO PCT/US2014/054202 patent/WO2015035113A1/en not_active Ceased
- 2014-09-05 PL PL14786383T patent/PL3041842T3/pl unknown
- 2014-09-05 SG SG10202013041QA patent/SG10202013041QA/en unknown
- 2014-09-05 AR ARP140103327A patent/AR097571A1/es active IP Right Grant
- 2014-09-05 MY MYPI2016000415A patent/MY186265A/en unknown
- 2014-09-05 MX MX2016002936A patent/MX371191B/es active IP Right Grant
- 2014-09-05 RS RS20200059A patent/RS59871B1/sr unknown
- 2014-09-05 PE PE2016000340A patent/PE20160648A1/es unknown
- 2014-09-05 KR KR1020167009029A patent/KR102336075B1/ko not_active Expired - Fee Related
- 2014-09-05 CN CN201480060427.9A patent/CN105764902B/zh not_active Expired - Fee Related
- 2014-09-05 EP EP14786383.1A patent/EP3041842B8/en active Active
- 2014-09-05 HU HUE14786383A patent/HUE047574T2/hu unknown
- 2014-09-05 AU AU2014315109A patent/AU2014315109B2/en not_active Ceased
- 2014-09-05 CA CA2922933A patent/CA2922933C/en active Active
- 2014-09-05 LT LTEP14786383.1T patent/LT3041842T/lt unknown
- 2014-09-05 TW TW103130893A patent/TWI652267B/zh not_active IP Right Cessation
- 2014-09-05 ES ES14786383T patent/ES2780828T3/es active Active
- 2014-09-05 HR HRP20200098TT patent/HRP20200098T1/hr unknown
- 2014-09-05 DK DK14786383.1T patent/DK3041842T3/da active
- 2014-09-05 JP JP2016540401A patent/JP6470290B2/ja not_active Expired - Fee Related
- 2014-09-05 SI SI201431461T patent/SI3041842T1/sl unknown
- 2014-09-05 US US14/477,948 patent/US9199994B2/en active Active
-
2015
- 2015-09-01 US US14/841,868 patent/US9512122B2/en not_active Expired - Fee Related
-
2016
- 2016-02-28 IL IL244315A patent/IL244315B/en active IP Right Grant
- 2016-03-03 PH PH12016500416A patent/PH12016500416A1/en unknown
- 2016-03-04 CL CL2016000509A patent/CL2016000509A1/es unknown
- 2016-04-06 EC ECIEPI201614324A patent/ECSP16014324A/es unknown
- 2016-09-28 US US15/278,130 patent/US9750740B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/645,054 patent/US10045988B2/en active Active
-
2018
- 2018-05-14 US US15/978,361 patent/US10350208B2/en active Active
-
2019
- 2019-05-30 US US16/426,698 patent/US10660893B2/en active Active
-
2020
- 2020-01-15 CY CY20201100036T patent/CY1122652T1/el unknown
- 2020-04-16 US US16/850,542 patent/US10946018B2/en not_active Expired - Fee Related
-
2021
- 2021-03-15 US US17/201,750 patent/US11759462B2/en active Active
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