JP2016530299A5 - - Google Patents
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- Publication number
- JP2016530299A5 JP2016530299A5 JP2016540401A JP2016540401A JP2016530299A5 JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5 JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- decane
- amino
- pyrimidin
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874545P | 2013-09-06 | 2013-09-06 | |
| US61/874,545 | 2013-09-06 | ||
| US201361899943P | 2013-11-05 | 2013-11-05 | |
| US61/899,943 | 2013-11-05 | ||
| US201462004385P | 2014-05-29 | 2014-05-29 | |
| US62/004,385 | 2014-05-29 | ||
| PCT/US2014/054202 WO2015035113A1 (en) | 2013-09-06 | 2014-09-05 | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530299A JP2016530299A (ja) | 2016-09-29 |
| JP2016530299A5 true JP2016530299A5 (enExample) | 2017-10-12 |
| JP6470290B2 JP6470290B2 (ja) | 2019-02-13 |
Family
ID=51743540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540401A Expired - Fee Related JP6470290B2 (ja) | 2013-09-06 | 2014-09-05 | トリプトファンヒドロキシラーゼ阻害薬としてのスピロ環式化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (8) | US9199994B2 (enExample) |
| EP (1) | EP3041842B8 (enExample) |
| JP (1) | JP6470290B2 (enExample) |
| KR (1) | KR102336075B1 (enExample) |
| CN (1) | CN105764902B (enExample) |
| AR (1) | AR097571A1 (enExample) |
| AU (1) | AU2014315109B2 (enExample) |
| CA (1) | CA2922933C (enExample) |
| CL (1) | CL2016000509A1 (enExample) |
| CY (1) | CY1122652T1 (enExample) |
| DK (1) | DK3041842T3 (enExample) |
| EA (1) | EA032304B1 (enExample) |
| EC (1) | ECSP16014324A (enExample) |
| ES (1) | ES2780828T3 (enExample) |
| HR (1) | HRP20200098T1 (enExample) |
| HU (1) | HUE047574T2 (enExample) |
| IL (1) | IL244315B (enExample) |
| LT (1) | LT3041842T (enExample) |
| MX (1) | MX371191B (enExample) |
| MY (1) | MY186265A (enExample) |
| PE (1) | PE20160648A1 (enExample) |
| PH (1) | PH12016500416A1 (enExample) |
| PL (1) | PL3041842T3 (enExample) |
| PT (1) | PT3041842T (enExample) |
| RS (1) | RS59871B1 (enExample) |
| SG (2) | SG10201802118QA (enExample) |
| SI (1) | SI3041842T1 (enExample) |
| TW (1) | TWI652267B (enExample) |
| UA (1) | UA119247C2 (enExample) |
| WO (1) | WO2015035113A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| CN107176940B (zh) * | 2016-03-09 | 2019-05-28 | 江苏正大丰海制药有限公司 | 一种替卡法林的制备方法 |
| TW201818964A (zh) * | 2016-09-30 | 2018-06-01 | 瑞士商諾伊曼特醫療公司 | 使用色胺酸羥化酶抑制劑之方法 |
| AR110150A1 (es) | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
| US10472313B1 (en) | 2018-02-18 | 2019-11-12 | Graphene 3D Lab Inc. | Process for synthesizing trifluoroketones |
| KR20210102887A (ko) | 2018-11-14 | 2021-08-20 | 알타반트 사이언시스 게엠베하 | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 |
| AU2019382168A1 (en) | 2018-11-16 | 2021-06-03 | Altavant Sciences Gmbh | A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension |
| WO2020128614A1 (en) | 2018-12-17 | 2020-06-25 | Altavant Sciences Gmbh | Method for treating interstital lung disease |
| US20200188398A1 (en) | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating sarcoidosis-associated pulmonary hypertension |
| CN113557022A (zh) * | 2019-01-30 | 2021-10-26 | 阿尔塔万特科学公司 | 用罗达司他乙酯治疗肺动脉高压的给药方案和方法 |
| CN113784717A (zh) * | 2019-03-15 | 2021-12-10 | 阿尔塔万特科学公司 | 一种治疗肺动脉高压和相关性肺动脉高压的方法以及每日给药 |
| JP2023529764A (ja) * | 2019-12-02 | 2023-07-12 | アルタバント・サイエンシズ・ゲーエムベーハー | 下気道障害の処置 |
| CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
| JP2023512025A (ja) * | 2020-01-31 | 2023-03-23 | アルタバント・サイエンシズ・ゲーエムベーハー | 肺動脈性肺高血圧症をロダトリスタットで処置するための投与量および方法 |
| WO2023062595A1 (en) * | 2021-10-14 | 2023-04-20 | Altavant Sciences Gmbh | Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl |
| WO2023079486A1 (en) | 2021-11-03 | 2023-05-11 | Altavant Sciences Gmbh | Treatment of pulmonary arterial hypertension with rodatristat and ambrisentan |
| JP2026506896A (ja) * | 2023-02-09 | 2026-02-27 | ジェロン・コーポレーション | テロメラーゼ阻害剤化合物 |
| EP4739314A1 (en) | 2023-07-05 | 2026-05-13 | Institut National de la Santé et de la Recherche Médicale | Use of tryptophan hydroxylase 1 (tph1) inhibitors for the treatment of atherosclerosis |
Family Cites Families (55)
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|---|---|---|---|---|
| KR920700613A (ko) | 1989-05-16 | 1992-08-10 | 지구르트 퓌터 | 약제제 |
| TR199900429T2 (xx) | 1996-08-28 | 1999-05-21 | The Procter & Gamble Company | Spirosiklik metaloproteaz inhibit�rleri. |
| WO2001066531A1 (de) | 2000-03-07 | 2001-09-13 | Aventis Pharma Deutschland Gmbh | Substituierte 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one (und) ihre verwendung zur hemmung der hormonsensitiven lipase |
| BR0214967A (pt) | 2001-12-14 | 2005-05-10 | Novo Nordisk As | Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente |
| DE10247680B4 (de) | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| JP2006527212A (ja) | 2003-06-12 | 2006-11-30 | ノボ ノルディスク アクティーゼルスカブ | ホルモン感受性リパーゼの阻害剤として使用するための、置換ピペラジンカルバメート |
| CA2526204A1 (en) | 2003-06-12 | 2004-12-23 | Novo Nordisk A/S | Pyridinyl carbamates as hormone-sensitive lipase inhibitors |
| DE102004005172A1 (de) | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| DE102005002130A1 (de) | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| WO2007089335A2 (en) | 2005-12-29 | 2007-08-09 | Lexicon Pharmaceutical Inc. | Multicyclic amino acid derivatives and methods of their use |
| UA99270C2 (en) | 2006-12-12 | 2012-08-10 | Лексикон Фармасьютикалз, Инк. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
| US8252803B2 (en) * | 2007-02-12 | 2012-08-28 | Merck Sharp & Dohme Corp. | Piperidine derivatives |
| EA016781B1 (ru) | 2007-05-16 | 2012-07-30 | Эли Лилли Энд Компани | Триазолиламинопиримидиновые соединения |
| CN101815534A (zh) | 2007-07-11 | 2010-08-25 | 莱西肯医药有限公司 | 用于治疗肺动脉高压以及相关疾病和病症的方法和组合物 |
| US20090029993A1 (en) | 2007-07-26 | 2009-01-29 | Qingyun Liu | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein |
| US20100255001A1 (en) | 2007-09-24 | 2010-10-07 | Universität Zürich Prorektorat Mnw | Blockers of serotonin and its receptors for the treatment of hepatitis |
| NZ588737A (en) | 2008-03-31 | 2012-05-25 | Univ Columbia | Methods of diagnosing, preventing and treating bone mass diseases |
| CN101591332B (zh) | 2008-05-30 | 2014-04-16 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| CN104045626B (zh) | 2008-05-30 | 2017-01-11 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| TW201022267A (en) | 2008-10-23 | 2010-06-16 | Gruenenthal Gmbh | Substituierte pyrimidin-und triazin-derivate |
| WO2010056992A1 (en) | 2008-11-13 | 2010-05-20 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating low bone mass diseases |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| WO2010109442A1 (en) | 2009-03-26 | 2010-09-30 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
| TW201103540A (en) | 2009-06-16 | 2011-02-01 | Ono Pharmaceutical Co | Compound having spiro-linked cyclic group and uses thereof |
| US8796297B2 (en) * | 2009-06-30 | 2014-08-05 | Abbvie Inc. | 4-substituted-2-amino-pyrimidine derivatives |
| US8815883B2 (en) | 2009-11-02 | 2014-08-26 | The Trustees Of Columbia Unviersity In The City Of New York | Compounds and methods for inhibiting serotonin synthesis |
| CA2779681A1 (en) | 2009-11-05 | 2011-05-12 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
| CN102711757A (zh) | 2009-11-23 | 2012-10-03 | 莱西肯医药有限公司 | 用于治疗肠易激综合征的方法和分析法 |
| CN102753168A (zh) | 2010-02-10 | 2012-10-24 | 莱西肯医药有限公司 | 用于治疗转移性骨病的色氨酸羟化酶抑制剂 |
| AU2011218167B2 (en) * | 2010-02-17 | 2014-07-10 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
| BR112013000946B1 (pt) | 2010-07-14 | 2020-09-08 | Novartis Ag | Compostos heterocíclicos agonistas de receptor de ip, seus usos, composição e combinação farmacêuticas |
| RU2013120966A (ru) | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
| TW201245183A (en) | 2010-11-05 | 2012-11-16 | Lexicon Pharmaceuticals Inc | Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| WO2013059146A1 (en) | 2011-10-17 | 2013-04-25 | Lexicon Pharmaceuticals, Inc. | Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate |
| WO2013074889A1 (en) | 2011-11-17 | 2013-05-23 | The Trustees Of Columbia University In The City Of New York | Methods of treating and preventing leukemia and other cancers of the blood and bone |
| EP2802583A1 (en) | 2012-01-13 | 2014-11-19 | Novartis AG | Fused piperidines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| US9115129B2 (en) | 2012-01-13 | 2015-08-25 | Novartis Ag | Substituted pyrido[2,3-B]pyrazines as IP receptor agonists |
| WO2013105058A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | 7,8- dihydropyrido [3, 4 - b] pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| EP2802582A1 (en) | 2012-01-13 | 2014-11-19 | Novartis AG | Fused dihydropyrido [2,3 -b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| AR089698A1 (es) | 2012-01-13 | 2014-09-10 | Novartis Ag | Compuestos heterociclicos antagonistas del receptor ip |
| US9174985B2 (en) | 2012-01-13 | 2015-11-03 | Novartis Ag | Salts of 7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanoic acid as IP receptor agonists |
| EP2634190A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| US20130303763A1 (en) | 2012-03-30 | 2013-11-14 | Michael D. Gershon | Methods and compositions for the treatment of necrotizing enterocolitis |
| WO2014082034A1 (en) | 2012-11-26 | 2014-05-30 | Lexicon Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome |
| WO2014124523A1 (en) | 2013-02-15 | 2014-08-21 | Mcmaster University | A method of treating obesity |
| WO2014195847A2 (en) | 2013-06-03 | 2014-12-11 | Actelion Pharmaceuticals Ltd | Novel use of stable isotope labeled l-tryptophan |
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| AR098436A1 (es) | 2013-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Compuestos tricíclicos de piperidina |
| WO2015075025A1 (en) | 2013-11-19 | 2015-05-28 | Actelion Pharmaceuticals Ltd | Tricyclic imidazole compounds as inhibitors of tryptophan hydroxylase |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| EP3061761A1 (en) | 2015-02-24 | 2016-08-31 | Max-Delbrück-Centrum für Molekulare Medizin | Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same |
| EP3292127A1 (en) | 2015-05-04 | 2018-03-14 | Actelion Pharmaceuticals Ltd | Tricyclic piperidine compounds |
-
2014
- 2014-05-09 UA UAA201603580A patent/UA119247C2/uk unknown
- 2014-09-05 RS RS20200059A patent/RS59871B1/sr unknown
- 2014-09-05 PL PL14786383T patent/PL3041842T3/pl unknown
- 2014-09-05 DK DK14786383.1T patent/DK3041842T3/da active
- 2014-09-05 PE PE2016000340A patent/PE20160648A1/es unknown
- 2014-09-05 TW TW103130893A patent/TWI652267B/zh not_active IP Right Cessation
- 2014-09-05 CA CA2922933A patent/CA2922933C/en active Active
- 2014-09-05 AU AU2014315109A patent/AU2014315109B2/en not_active Ceased
- 2014-09-05 SG SG10201802118QA patent/SG10201802118QA/en unknown
- 2014-09-05 HR HRP20200098TT patent/HRP20200098T1/hr unknown
- 2014-09-05 US US14/477,948 patent/US9199994B2/en active Active
- 2014-09-05 SG SG10202013041QA patent/SG10202013041QA/en unknown
- 2014-09-05 JP JP2016540401A patent/JP6470290B2/ja not_active Expired - Fee Related
- 2014-09-05 LT LTEP14786383.1T patent/LT3041842T/lt unknown
- 2014-09-05 CN CN201480060427.9A patent/CN105764902B/zh not_active Expired - Fee Related
- 2014-09-05 SI SI201431461T patent/SI3041842T1/sl unknown
- 2014-09-05 KR KR1020167009029A patent/KR102336075B1/ko not_active Expired - Fee Related
- 2014-09-05 EA EA201690534A patent/EA032304B1/ru not_active IP Right Cessation
- 2014-09-05 EP EP14786383.1A patent/EP3041842B8/en active Active
- 2014-09-05 AR ARP140103327A patent/AR097571A1/es active IP Right Grant
- 2014-09-05 WO PCT/US2014/054202 patent/WO2015035113A1/en not_active Ceased
- 2014-09-05 MY MYPI2016000415A patent/MY186265A/en unknown
- 2014-09-05 PT PT147863831T patent/PT3041842T/pt unknown
- 2014-09-05 HU HUE14786383A patent/HUE047574T2/hu unknown
- 2014-09-05 ES ES14786383T patent/ES2780828T3/es active Active
- 2014-09-05 MX MX2016002936A patent/MX371191B/es active IP Right Grant
-
2015
- 2015-09-01 US US14/841,868 patent/US9512122B2/en not_active Expired - Fee Related
-
2016
- 2016-02-28 IL IL244315A patent/IL244315B/en active IP Right Grant
- 2016-03-03 PH PH12016500416A patent/PH12016500416A1/en unknown
- 2016-03-04 CL CL2016000509A patent/CL2016000509A1/es unknown
- 2016-04-06 EC ECIEPI201614324A patent/ECSP16014324A/es unknown
- 2016-09-28 US US15/278,130 patent/US9750740B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/645,054 patent/US10045988B2/en active Active
-
2018
- 2018-05-14 US US15/978,361 patent/US10350208B2/en active Active
-
2019
- 2019-05-30 US US16/426,698 patent/US10660893B2/en active Active
-
2020
- 2020-01-15 CY CY20201100036T patent/CY1122652T1/el unknown
- 2020-04-16 US US16/850,542 patent/US10946018B2/en not_active Expired - Fee Related
-
2021
- 2021-03-15 US US17/201,750 patent/US11759462B2/en active Active
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