JP2016530299A5 - - Google Patents
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- Publication number
- JP2016530299A5 JP2016530299A5 JP2016540401A JP2016540401A JP2016530299A5 JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5 JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- decane
- amino
- pyrimidin
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874545P | 2013-09-06 | 2013-09-06 | |
| US61/874,545 | 2013-09-06 | ||
| US201361899943P | 2013-11-05 | 2013-11-05 | |
| US61/899,943 | 2013-11-05 | ||
| US201462004385P | 2014-05-29 | 2014-05-29 | |
| US62/004,385 | 2014-05-29 | ||
| PCT/US2014/054202 WO2015035113A1 (en) | 2013-09-06 | 2014-09-05 | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530299A JP2016530299A (ja) | 2016-09-29 |
| JP2016530299A5 true JP2016530299A5 (enExample) | 2017-10-12 |
| JP6470290B2 JP6470290B2 (ja) | 2019-02-13 |
Family
ID=51743540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540401A Expired - Fee Related JP6470290B2 (ja) | 2013-09-06 | 2014-09-05 | トリプトファンヒドロキシラーゼ阻害薬としてのスピロ環式化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (8) | US9199994B2 (enExample) |
| EP (1) | EP3041842B8 (enExample) |
| JP (1) | JP6470290B2 (enExample) |
| KR (1) | KR102336075B1 (enExample) |
| CN (1) | CN105764902B (enExample) |
| AR (1) | AR097571A1 (enExample) |
| AU (1) | AU2014315109B2 (enExample) |
| CA (1) | CA2922933C (enExample) |
| CL (1) | CL2016000509A1 (enExample) |
| CY (1) | CY1122652T1 (enExample) |
| DK (1) | DK3041842T3 (enExample) |
| EA (1) | EA032304B1 (enExample) |
| EC (1) | ECSP16014324A (enExample) |
| ES (1) | ES2780828T3 (enExample) |
| HR (1) | HRP20200098T1 (enExample) |
| HU (1) | HUE047574T2 (enExample) |
| IL (1) | IL244315B (enExample) |
| LT (1) | LT3041842T (enExample) |
| MX (1) | MX371191B (enExample) |
| MY (1) | MY186265A (enExample) |
| PE (1) | PE20160648A1 (enExample) |
| PH (1) | PH12016500416A1 (enExample) |
| PL (1) | PL3041842T3 (enExample) |
| PT (1) | PT3041842T (enExample) |
| RS (1) | RS59871B1 (enExample) |
| SG (2) | SG10202013041QA (enExample) |
| SI (1) | SI3041842T1 (enExample) |
| TW (1) | TWI652267B (enExample) |
| UA (1) | UA119247C2 (enExample) |
| WO (1) | WO2015035113A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| CN107176940B (zh) * | 2016-03-09 | 2019-05-28 | 江苏正大丰海制药有限公司 | 一种替卡法林的制备方法 |
| TW201818964A (zh) * | 2016-09-30 | 2018-06-01 | 瑞士商諾伊曼特醫療公司 | 使用色胺酸羥化酶抑制劑之方法 |
| AR110150A1 (es) | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
| US10472313B1 (en) | 2018-02-18 | 2019-11-12 | Graphene 3D Lab Inc. | Process for synthesizing trifluoroketones |
| KR20210102887A (ko) | 2018-11-14 | 2021-08-20 | 알타반트 사이언시스 게엠베하 | 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제 |
| US11413287B2 (en) | 2018-11-16 | 2022-08-16 | Altavant Sciences Gmbh | Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension |
| WO2020128608A1 (en) | 2018-12-17 | 2020-06-25 | Altavant Sciences Gmbh | Compound for use in a method for treating sarcoidosis-associated pulmonary hypertension |
| US20200188399A1 (en) * | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating interstitial lung disease |
| WO2020157577A1 (en) | 2019-01-30 | 2020-08-06 | Altavant Sciences Gmbh | A dosage regime and method for treating pulmonary arterial hypertension with rodatristat ethyl |
| AU2020244278A1 (en) | 2019-03-15 | 2021-09-30 | Altavant Sciences Gmbh | A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing |
| AU2020395766A1 (en) * | 2019-12-02 | 2022-06-16 | Onspira Therapeutics, Inc. | Treatment of lower airways disorders |
| CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
| JP2023512025A (ja) * | 2020-01-31 | 2023-03-23 | アルタバント・サイエンシズ・ゲーエムベーハー | 肺動脈性肺高血圧症をロダトリスタットで処置するための投与量および方法 |
| WO2023062595A1 (en) | 2021-10-14 | 2023-04-20 | Altavant Sciences Gmbh | Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl |
| WO2023079486A1 (en) | 2021-11-03 | 2023-05-11 | Altavant Sciences Gmbh | Treatment of pulmonary arterial hypertension with rodatristat and ambrisentan |
| JP2026506896A (ja) * | 2023-02-09 | 2026-02-27 | ジェロン・コーポレーション | テロメラーゼ阻害剤化合物 |
| WO2025008449A1 (en) | 2023-07-05 | 2025-01-09 | Institut National de la Santé et de la Recherche Médicale | Use of tryptophan hydroxylase 1 (tph1) inhibitors for the treatment of atherosclerosis |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR920700613A (ko) | 1989-05-16 | 1992-08-10 | 지구르트 퓌터 | 약제제 |
| DK0927183T3 (da) | 1996-08-28 | 2004-11-29 | Procter & Gamble | Spirocykliske metalloprotease-inhibitorer |
| KR100790763B1 (ko) | 2000-03-07 | 2008-01-03 | 사노피-아벤티스 도이칠란트 게엠베하 | 치환된 3-페닐-5-알콕시-1,3,4-옥스디아졸-2-온 및 이를 포함하는 호르몬 민감성 리파아제 억제용 약제 |
| KR20040068240A (ko) | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| DE10247680B4 (de) | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| WO2004111004A1 (en) | 2003-06-12 | 2004-12-23 | Novo Nordisk A/S | Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase |
| RU2337908C2 (ru) | 2003-06-12 | 2008-11-10 | Ново Нордиск А/С | Пиридинилкарбаматы в качестве ингибиторов гормон-чувствительной липазы |
| DE102004005172A1 (de) | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| DE102005002130A1 (de) | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| CN103265495B (zh) | 2005-12-29 | 2016-11-16 | 莱西肯医药有限公司 | 多环氨基酸衍生物及其使用方法 |
| UA99270C2 (en) | 2006-12-12 | 2012-08-10 | Лексикон Фармасьютикалз, Инк. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
| EP2120573A4 (en) * | 2007-02-12 | 2011-05-25 | Merck Sharp & Dohme | piperidine |
| WO2008144223A2 (en) | 2007-05-16 | 2008-11-27 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
| EA201070127A1 (ru) | 2007-07-11 | 2010-08-30 | Лексикон Фармасьютикалз , Инк. | Способы лечения легочной гипертензии, родственных заболеваний и нарушений и композиции для их осуществления |
| AU2008279426A1 (en) | 2007-07-26 | 2009-01-29 | Lexicon Pharmaceuticals, Inc. | Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein |
| EP2200601A1 (en) | 2007-09-24 | 2010-06-30 | Universität Zürich Prorektorat Mnw | Blockers of serotonin and its receptors for the treatment of hepatitis |
| JP2011516486A (ja) | 2008-03-31 | 2011-05-26 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 骨質量疾患の診断、予防、及び治療方法 |
| CN101591332B (zh) | 2008-05-30 | 2014-04-16 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| CN104045626B (zh) | 2008-05-30 | 2017-01-11 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| TW201022267A (en) | 2008-10-23 | 2010-06-16 | Gruenenthal Gmbh | Substituierte pyrimidin-und triazin-derivate |
| US8614222B2 (en) | 2008-11-13 | 2013-12-24 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating low bone mass diseases |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| EP2411380A1 (en) | 2009-03-26 | 2012-02-01 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
| US8476290B2 (en) | 2009-06-16 | 2013-07-02 | Ono Pharmaceutical Co., Ltd. | Compound having spiro-bonded cyclic group and use thereof |
| US8796297B2 (en) * | 2009-06-30 | 2014-08-05 | Abbvie Inc. | 4-substituted-2-amino-pyrimidine derivatives |
| US8815883B2 (en) | 2009-11-02 | 2014-08-26 | The Trustees Of Columbia Unviersity In The City Of New York | Compounds and methods for inhibiting serotonin synthesis |
| US20120316171A1 (en) | 2009-11-05 | 2012-12-13 | Tamas Oravecz | Tryptophan Hydroxylase Inhibitors for the Treatment of Cancer |
| EP2504008A1 (en) | 2009-11-23 | 2012-10-03 | Lexicon Pharmaceuticals, Inc. | Methods and assays for the treatment of irritable bowel syndrome |
| EP2533778A1 (en) | 2010-02-10 | 2012-12-19 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease |
| CA2789711C (en) * | 2010-02-17 | 2014-08-05 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
| MA34373B1 (fr) | 2010-07-14 | 2013-07-03 | Novartis Ag | Composés hétérocycliques agonistes du récepteur ip |
| BR112013008240A2 (pt) * | 2010-10-08 | 2017-12-12 | Abbvie Inc | compostos de furo [3-2-d] pirimidina |
| TW201245183A (en) | 2010-11-05 | 2012-11-16 | Lexicon Pharmaceuticals Inc | Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid |
| US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
| EP3763374A1 (en) | 2011-10-17 | 2021-01-13 | Lexicon Pharmaceuticals, Inc. | Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate |
| WO2013074889A1 (en) | 2011-11-17 | 2013-05-23 | The Trustees Of Columbia University In The City Of New York | Methods of treating and preventing leukemia and other cancers of the blood and bone |
| JP6058698B2 (ja) | 2012-01-13 | 2017-01-11 | ノバルティス アーゲー | Ｉｐ受容体アゴニストの塩 |
| ES2565826T3 (es) | 2012-01-13 | 2016-04-07 | Novartis Ag | Pirroles fusionados como agonistas del receptor IP para el tratamiento de hipertensión arterial pulmonar (PAH) y trastornos relacionados |
| US20140378463A1 (en) | 2012-01-13 | 2014-12-25 | Novartis Ag | IP receptor agonist heterocyclic compounds |
| WO2013105061A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | Fused dihydropyrido [2,3 -b] pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| WO2013105065A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | Fused piperidines as ip receptor agonists for the treatment of pah and related disorders |
| US20150005311A1 (en) | 2012-01-13 | 2015-01-01 | Novartis Ag | IP receptor agonist heterocyclic compounds |
| EP2634190A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| US20130303763A1 (en) | 2012-03-30 | 2013-11-14 | Michael D. Gershon | Methods and compositions for the treatment of necrotizing enterocolitis |
| WO2014082034A1 (en) | 2012-11-26 | 2014-05-30 | Lexicon Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome |
| WO2014124523A1 (en) | 2013-02-15 | 2014-08-21 | Mcmaster University | A method of treating obesity |
| WO2014195847A2 (en) | 2013-06-03 | 2014-12-11 | Actelion Pharmaceuticals Ltd | Novel use of stable isotope labeled l-tryptophan |
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| CN105745211B (zh) | 2013-11-19 | 2017-09-26 | 埃科特莱茵药品有限公司 | 作为色氨酸羟化酶的抑制剂的三环咪唑化合物 |
| AR098436A1 (es) | 2013-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Compuestos tricíclicos de piperidina |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| EP3061761A1 (en) | 2015-02-24 | 2016-08-31 | Max-Delbrück-Centrum für Molekulare Medizin | Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same |
| CA2980100A1 (en) | 2015-05-04 | 2016-11-10 | Actelion Pharmaceuticals Ltd | Tricyclic piperidine compounds |
-
2014
- 2014-05-09 UA UAA201603580A patent/UA119247C2/uk unknown
- 2014-09-05 EP EP14786383.1A patent/EP3041842B8/en active Active
- 2014-09-05 HU HUE14786383A patent/HUE047574T2/hu unknown
- 2014-09-05 RS RS20200059A patent/RS59871B1/sr unknown
- 2014-09-05 LT LTEP14786383.1T patent/LT3041842T/lt unknown
- 2014-09-05 PE PE2016000340A patent/PE20160648A1/es unknown
- 2014-09-05 SG SG10202013041QA patent/SG10202013041QA/en unknown
- 2014-09-05 ES ES14786383T patent/ES2780828T3/es active Active
- 2014-09-05 MY MYPI2016000415A patent/MY186265A/en unknown
- 2014-09-05 KR KR1020167009029A patent/KR102336075B1/ko not_active Expired - Fee Related
- 2014-09-05 DK DK14786383.1T patent/DK3041842T3/da active
- 2014-09-05 SG SG10201802118QA patent/SG10201802118QA/en unknown
- 2014-09-05 AR ARP140103327A patent/AR097571A1/es active IP Right Grant
- 2014-09-05 EA EA201690534A patent/EA032304B1/ru not_active IP Right Cessation
- 2014-09-05 CN CN201480060427.9A patent/CN105764902B/zh not_active Expired - Fee Related
- 2014-09-05 CA CA2922933A patent/CA2922933C/en active Active
- 2014-09-05 PL PL14786383T patent/PL3041842T3/pl unknown
- 2014-09-05 AU AU2014315109A patent/AU2014315109B2/en not_active Ceased
- 2014-09-05 PT PT147863831T patent/PT3041842T/pt unknown
- 2014-09-05 US US14/477,948 patent/US9199994B2/en active Active
- 2014-09-05 HR HRP20200098TT patent/HRP20200098T1/hr unknown
- 2014-09-05 SI SI201431461T patent/SI3041842T1/sl unknown
- 2014-09-05 MX MX2016002936A patent/MX371191B/es active IP Right Grant
- 2014-09-05 WO PCT/US2014/054202 patent/WO2015035113A1/en not_active Ceased
- 2014-09-05 TW TW103130893A patent/TWI652267B/zh not_active IP Right Cessation
- 2014-09-05 JP JP2016540401A patent/JP6470290B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-01 US US14/841,868 patent/US9512122B2/en not_active Expired - Fee Related
-
2016
- 2016-02-28 IL IL244315A patent/IL244315B/en active IP Right Grant
- 2016-03-03 PH PH12016500416A patent/PH12016500416A1/en unknown
- 2016-03-04 CL CL2016000509A patent/CL2016000509A1/es unknown
- 2016-04-06 EC ECIEPI201614324A patent/ECSP16014324A/es unknown
- 2016-09-28 US US15/278,130 patent/US9750740B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/645,054 patent/US10045988B2/en active Active
-
2018
- 2018-05-14 US US15/978,361 patent/US10350208B2/en active Active
-
2019
- 2019-05-30 US US16/426,698 patent/US10660893B2/en active Active
-
2020
- 2020-01-15 CY CY20201100036T patent/CY1122652T1/el unknown
- 2020-04-16 US US16/850,542 patent/US10946018B2/en not_active Expired - Fee Related
-
2021
- 2021-03-15 US US17/201,750 patent/US11759462B2/en active Active
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