JP2016530299A5 - - Google Patents
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- Publication number
- JP2016530299A5 JP2016530299A5 JP2016540401A JP2016540401A JP2016530299A5 JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5 JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016540401 A JP2016540401 A JP 2016540401A JP 2016530299 A5 JP2016530299 A5 JP 2016530299A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- decane
- amino
- pyrimidin
- biphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361874545P | 2013-09-06 | 2013-09-06 | |
| US61/874,545 | 2013-09-06 | ||
| US201361899943P | 2013-11-05 | 2013-11-05 | |
| US61/899,943 | 2013-11-05 | ||
| US201462004385P | 2014-05-29 | 2014-05-29 | |
| US62/004,385 | 2014-05-29 | ||
| PCT/US2014/054202 WO2015035113A1 (en) | 2013-09-06 | 2014-09-05 | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530299A JP2016530299A (ja) | 2016-09-29 |
| JP2016530299A5 true JP2016530299A5 (enExample) | 2017-10-12 |
| JP6470290B2 JP6470290B2 (ja) | 2019-02-13 |
Family
ID=51743540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016540401A Expired - Fee Related JP6470290B2 (ja) | 2013-09-06 | 2014-09-05 | トリプトファンヒドロキシラーゼ阻害薬としてのスピロ環式化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (8) | US9199994B2 (enExample) |
| EP (1) | EP3041842B8 (enExample) |
| JP (1) | JP6470290B2 (enExample) |
| KR (1) | KR102336075B1 (enExample) |
| CN (1) | CN105764902B (enExample) |
| AR (1) | AR097571A1 (enExample) |
| AU (1) | AU2014315109B2 (enExample) |
| CA (1) | CA2922933C (enExample) |
| CL (1) | CL2016000509A1 (enExample) |
| CY (1) | CY1122652T1 (enExample) |
| DK (1) | DK3041842T3 (enExample) |
| EA (1) | EA032304B1 (enExample) |
| EC (1) | ECSP16014324A (enExample) |
| ES (1) | ES2780828T3 (enExample) |
| HR (1) | HRP20200098T1 (enExample) |
| HU (1) | HUE047574T2 (enExample) |
| IL (1) | IL244315B (enExample) |
| LT (1) | LT3041842T (enExample) |
| MX (1) | MX371191B (enExample) |
| MY (1) | MY186265A (enExample) |
| PE (1) | PE20160648A1 (enExample) |
| PH (1) | PH12016500416B1 (enExample) |
| PL (1) | PL3041842T3 (enExample) |
| PT (1) | PT3041842T (enExample) |
| RS (1) | RS59871B1 (enExample) |
| SG (2) | SG10201802118QA (enExample) |
| SI (1) | SI3041842T1 (enExample) |
| TW (1) | TWI652267B (enExample) |
| UA (1) | UA119247C2 (enExample) |
| WO (1) | WO2015035113A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
| CN107176940B (zh) * | 2016-03-09 | 2019-05-28 | 江苏正大丰海制药有限公司 | 一种替卡法林的制备方法 |
| WO2018060949A1 (en) * | 2016-09-30 | 2018-04-05 | Roivant Sciences Gmbh | Tryptophan hydroxylase inhibitors for use in the treatment of liver diseases |
| AR110150A1 (es) * | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
| US10472313B1 (en) | 2018-02-18 | 2019-11-12 | Graphene 3D Lab Inc. | Process for synthesizing trifluoroketones |
| US11203597B2 (en) * | 2018-11-14 | 2021-12-21 | Altavant Sciences Gmbh | Crystalline spirocyclic compound, a dosage form containing, a method for using in treatment of disease, and a method for recrystallizing |
| AU2019382168A1 (en) * | 2018-11-16 | 2021-06-03 | Altavant Sciences Gmbh | A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension |
| US20200188399A1 (en) * | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating interstitial lung disease |
| WO2020128608A1 (en) | 2018-12-17 | 2020-06-25 | Altavant Sciences Gmbh | Compound for use in a method for treating sarcoidosis-associated pulmonary hypertension |
| US11607413B2 (en) | 2019-01-30 | 2023-03-21 | Altavant Sciences Gmbh | Dosage regime and method for treating pulmonary arterial hypertension |
| CN113784717A (zh) * | 2019-03-15 | 2021-12-10 | 阿尔塔万特科学公司 | 一种治疗肺动脉高压和相关性肺动脉高压的方法以及每日给药 |
| EP4069847A4 (en) * | 2019-12-02 | 2023-11-15 | Onspira Therapeutics, Inc. | Treatment of lower airways disorders |
| CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
| CA3165432A1 (en) * | 2020-01-31 | 2021-08-05 | Stephen A. Wring | Dosages and methods for treating pulmonary arterial hypertension with rodatristat |
| WO2023062595A1 (en) | 2021-10-14 | 2023-04-20 | Altavant Sciences Gmbh | Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl |
| WO2023079486A1 (en) | 2021-11-03 | 2023-05-11 | Altavant Sciences Gmbh | Treatment of pulmonary arterial hypertension with rodatristat and ambrisentan |
| CN120769851A (zh) * | 2023-02-09 | 2025-10-10 | 美国杰龙生物医药公司 | 端粒酶抑制剂化合物 |
| WO2025008449A1 (en) | 2023-07-05 | 2025-01-09 | Institut National de la Santé et de la Recherche Médicale | Use of tryptophan hydroxylase 1 (tph1) inhibitors for the treatment of atherosclerosis |
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| CN1050373A (zh) | 1989-05-16 | 1991-04-03 | 梅迪斯化学药物工厂普特两合股份公司 | 制备旋光2-芳基链烷酸，特别是2-芳基丙酸的方法 |
| DK0927183T3 (da) | 1996-08-28 | 2004-11-29 | Procter & Gamble | Spirocykliske metalloprotease-inhibitorer |
| HUP0302772A3 (en) | 2000-03-07 | 2007-03-28 | Sanofi Aventis Deutschland | Substituted 3-phenyl-5-alkoxi-1,3,4-oxdiazol-2-one and use thereof for inhibiting hormone-sensitive lipase |
| KR20040068240A (ko) | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| DE10247680B4 (de) | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| AU2004247319A1 (en) | 2003-06-12 | 2004-12-23 | Novo Nordisk A/S | Pyridinyl carbamates as hormone-sensitive lipase inhibitors |
| EP1636187A1 (en) | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase |
| DE102004005172A1 (de) | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| DE102005002130A1 (de) | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| AU2006337137B2 (en) | 2005-12-29 | 2012-06-14 | Tersera Therapeutics Llc | Multicyclic amino acid derivatives and methods of their use |
| UA99270C2 (en) | 2006-12-12 | 2012-08-10 | Лексикон Фармасьютикалз, Инк. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use |
| CA2676920A1 (en) * | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperidine derivatives |
| TW200908981A (en) | 2007-05-16 | 2009-03-01 | Lilly Co Eli | Triazolyl aminopyrimidine compounds |
| CA2693400A1 (en) | 2007-07-11 | 2009-01-15 | Lexicon Pharmaceuticals, Inc. | Methods and compositions for treating pulmonary hypertension and related diseases and disorders |
| BRPI0813835A2 (pt) | 2007-07-26 | 2017-06-06 | Lexicon Pharmaceuticals Inc | métodos de afetar o trânsito gastrointestinal e esvaziamento gástrico, e compostos úteis a esse respeito |
| US20100255001A1 (en) | 2007-09-24 | 2010-10-07 | Universität Zürich Prorektorat Mnw | Blockers of serotonin and its receptors for the treatment of hepatitis |
| BRPI0908719A2 (pt) | 2008-03-31 | 2015-08-18 | Univ Columbia | Metodos de diagnóstico, prevenção e tratamento de doenças de massa óssea |
| CN101591332B (zh) | 2008-05-30 | 2014-04-16 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| CN104045626B (zh) | 2008-05-30 | 2017-01-11 | 莱西肯医药有限公司 | 基于4-苯基-6-(2,2,2-三氟-1-苯基乙氧基)嘧啶的化合物及其应用方法 |
| TW201022267A (en) | 2008-10-23 | 2010-06-16 | Gruenenthal Gmbh | Substituierte pyrimidin-und triazin-derivate |
| US8614222B2 (en) | 2008-11-13 | 2013-12-24 | The Trustees Of Columbia University In The City Of New York | Methods of preventing and treating low bone mass diseases |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| EP2411380A1 (en) | 2009-03-26 | 2012-02-01 | Ranbaxy Laboratories Limited | Process for the preparation of desloratadine |
| TW201103540A (en) | 2009-06-16 | 2011-02-01 | Ono Pharmaceutical Co | Compound having spiro-linked cyclic group and uses thereof |
| US8796297B2 (en) * | 2009-06-30 | 2014-08-05 | Abbvie Inc. | 4-substituted-2-amino-pyrimidine derivatives |
| US8815883B2 (en) | 2009-11-02 | 2014-08-26 | The Trustees Of Columbia Unviersity In The City Of New York | Compounds and methods for inhibiting serotonin synthesis |
| EP2496231A1 (en) | 2009-11-05 | 2012-09-12 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
| WO2011063181A1 (en) | 2009-11-23 | 2011-05-26 | Lexicon Pharmaceuticals, Inc. | Methods and assays for the treatment of irritable bowel syndrome |
| US20130137635A1 (en) | 2010-02-10 | 2013-05-30 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of metastatic bone disease |
| WO2011103196A1 (en) * | 2010-02-17 | 2011-08-25 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
| SG186989A1 (en) | 2010-07-14 | 2013-02-28 | Novartis Ag | Ip receptor agonist heterocyclic compounds |
| MX2013003913A (es) * | 2010-10-08 | 2013-09-26 | Abbvie Inc | Compuestos de furo [3, 2-d] pirimidina. |
| TW201245183A (en) | 2010-11-05 | 2012-11-16 | Lexicon Pharmaceuticals Inc | Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| SG11201401583YA (en) | 2011-10-17 | 2014-09-26 | Lexicon Pharmaceuticals Inc | Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate |
| WO2013074889A1 (en) | 2011-11-17 | 2013-05-23 | The Trustees Of Columbia University In The City Of New York | Methods of treating and preventing leukemia and other cancers of the blood and bone |
| EP2802583A1 (en) | 2012-01-13 | 2014-11-19 | Novartis AG | Fused piperidines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
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| US20140378463A1 (en) | 2012-01-13 | 2014-12-25 | Novartis Ag | IP receptor agonist heterocyclic compounds |
| JP6073923B2 (ja) | 2012-01-13 | 2017-02-01 | ノバルティス アーゲー | 肺動脈高血圧症（ｐａｈ）および関連障害の治療のためのｉｐ受容体アゴニストとしての縮合ピロール |
| WO2013105061A1 (en) | 2012-01-13 | 2013-07-18 | Novartis Ag | Fused dihydropyrido [2,3 -b] pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders |
| EP2802584B1 (en) | 2012-01-13 | 2015-11-18 | Novartis AG | Salts of an ip receptor agonist |
| EP2634190A1 (en) * | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
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| WO2014082034A1 (en) | 2012-11-26 | 2014-05-30 | Lexicon Pharmaceuticals, Inc. | Methods for treating irritable bowel syndrome |
| WO2014124523A1 (en) | 2013-02-15 | 2014-08-21 | Mcmaster University | A method of treating obesity |
| WO2014195847A2 (en) | 2013-06-03 | 2014-12-11 | Actelion Pharmaceuticals Ltd | Novel use of stable isotope labeled l-tryptophan |
| UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| CN105745211B (zh) | 2013-11-19 | 2017-09-26 | 埃科特莱茵药品有限公司 | 作为色氨酸羟化酶的抑制剂的三环咪唑化合物 |
| AR098436A1 (es) | 2013-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Compuestos tricíclicos de piperidina |
| WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
| EP3061761A1 (en) | 2015-02-24 | 2016-08-31 | Max-Delbrück-Centrum für Molekulare Medizin | Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same |
| EP3292127A1 (en) | 2015-05-04 | 2018-03-14 | Actelion Pharmaceuticals Ltd | Tricyclic piperidine compounds |
-
2014
- 2014-05-09 UA UAA201603580A patent/UA119247C2/uk unknown
- 2014-09-05 SG SG10201802118QA patent/SG10201802118QA/en unknown
- 2014-09-05 KR KR1020167009029A patent/KR102336075B1/ko not_active Expired - Fee Related
- 2014-09-05 PE PE2016000340A patent/PE20160648A1/es unknown
- 2014-09-05 LT LTEP14786383.1T patent/LT3041842T/lt unknown
- 2014-09-05 DK DK14786383.1T patent/DK3041842T3/da active
- 2014-09-05 SI SI201431461T patent/SI3041842T1/sl unknown
- 2014-09-05 SG SG10202013041QA patent/SG10202013041QA/en unknown
- 2014-09-05 AU AU2014315109A patent/AU2014315109B2/en not_active Ceased
- 2014-09-05 US US14/477,948 patent/US9199994B2/en active Active
- 2014-09-05 MX MX2016002936A patent/MX371191B/es active IP Right Grant
- 2014-09-05 TW TW103130893A patent/TWI652267B/zh not_active IP Right Cessation
- 2014-09-05 WO PCT/US2014/054202 patent/WO2015035113A1/en not_active Ceased
- 2014-09-05 EP EP14786383.1A patent/EP3041842B8/en active Active
- 2014-09-05 ES ES14786383T patent/ES2780828T3/es active Active
- 2014-09-05 HU HUE14786383A patent/HUE047574T2/hu unknown
- 2014-09-05 PL PL14786383T patent/PL3041842T3/pl unknown
- 2014-09-05 PT PT147863831T patent/PT3041842T/pt unknown
- 2014-09-05 CN CN201480060427.9A patent/CN105764902B/zh not_active Expired - Fee Related
- 2014-09-05 MY MYPI2016000415A patent/MY186265A/en unknown
- 2014-09-05 JP JP2016540401A patent/JP6470290B2/ja not_active Expired - Fee Related
- 2014-09-05 HR HRP20200098TT patent/HRP20200098T1/hr unknown
- 2014-09-05 RS RS20200059A patent/RS59871B1/sr unknown
- 2014-09-05 CA CA2922933A patent/CA2922933C/en active Active
- 2014-09-05 EA EA201690534A patent/EA032304B1/ru not_active IP Right Cessation
- 2014-09-05 AR ARP140103327A patent/AR097571A1/es active IP Right Grant
-
2015
- 2015-09-01 US US14/841,868 patent/US9512122B2/en not_active Expired - Fee Related
-
2016
- 2016-02-28 IL IL244315A patent/IL244315B/en active IP Right Grant
- 2016-03-03 PH PH12016500416A patent/PH12016500416B1/en unknown
- 2016-03-04 CL CL2016000509A patent/CL2016000509A1/es unknown
- 2016-04-06 EC ECIEPI201614324A patent/ECSP16014324A/es unknown
- 2016-09-28 US US15/278,130 patent/US9750740B2/en not_active Expired - Fee Related
-
2017
- 2017-07-10 US US15/645,054 patent/US10045988B2/en active Active
-
2018
- 2018-05-14 US US15/978,361 patent/US10350208B2/en active Active
-
2019
- 2019-05-30 US US16/426,698 patent/US10660893B2/en active Active
-
2020
- 2020-01-15 CY CY20201100036T patent/CY1122652T1/el unknown
- 2020-04-16 US US16/850,542 patent/US10946018B2/en not_active Expired - Fee Related
-
2021
- 2021-03-15 US US17/201,750 patent/US11759462B2/en active Active
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