KR102336075B1 - 트립토판 하이드록실레이스 억제제로서 스파이로사이클릭 화합물 - Google Patents

트립토판 하이드록실레이스 억제제로서 스파이로사이클릭 화합물 Download PDF

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KR102336075B1
KR102336075B1 KR1020167009029A KR20167009029A KR102336075B1 KR 102336075 B1 KR102336075 B1 KR 102336075B1 KR 1020167009029 A KR1020167009029 A KR 1020167009029A KR 20167009029 A KR20167009029 A KR 20167009029A KR 102336075 B1 KR102336075 B1 KR 102336075B1
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alkyl
delete delete
cycloalkyl
aryl
membered heterocycloalkyl
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KR20160055190A (ko
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롬배르트 스테판 데
다니엘 알. 골드버그
케니스 브라멜드
에릭 브라이언 쇼그렌
앤드류 스크라이브너
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카로스 파마슈티칼스 인코포레이티드
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020167009029A 2013-09-06 2014-09-05 트립토판 하이드록실레이스 억제제로서 스파이로사이클릭 화합물 Expired - Fee Related KR102336075B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361874545P 2013-09-06 2013-09-06
US61/874,545 2013-09-06
US201361899943P 2013-11-05 2013-11-05
US61/899,943 2013-11-05
US201462004385P 2014-05-29 2014-05-29
US62/004,385 2014-05-29
PCT/US2014/054202 WO2015035113A1 (en) 2013-09-06 2014-09-05 Spirocyclic compounds as tryptophan hydroxylase inhibitors

Publications (2)

Publication Number Publication Date
KR20160055190A KR20160055190A (ko) 2016-05-17
KR102336075B1 true KR102336075B1 (ko) 2021-12-08

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KR1020167009029A Expired - Fee Related KR102336075B1 (ko) 2013-09-06 2014-09-05 트립토판 하이드록실레이스 억제제로서 스파이로사이클릭 화합물

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US (8) US9199994B2 (enExample)
EP (1) EP3041842B8 (enExample)
JP (1) JP6470290B2 (enExample)
KR (1) KR102336075B1 (enExample)
CN (1) CN105764902B (enExample)
AR (1) AR097571A1 (enExample)
AU (1) AU2014315109B2 (enExample)
CA (1) CA2922933C (enExample)
CL (1) CL2016000509A1 (enExample)
CY (1) CY1122652T1 (enExample)
DK (1) DK3041842T3 (enExample)
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EC (1) ECSP16014324A (enExample)
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CN107176940B (zh) * 2016-03-09 2019-05-28 江苏正大丰海制药有限公司 一种替卡法林的制备方法
TW201818964A (zh) * 2016-09-30 2018-06-01 瑞士商諾伊曼特醫療公司 使用色胺酸羥化酶抑制劑之方法
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KR20210102887A (ko) 2018-11-14 2021-08-20 알타반트 사이언시스 게엠베하 말초 세로토닌과 관련된 질병 또는 장애를 치료하기 위한 트립토판 하이드록실라제 1 (tph1)의 결정질 스피로사이클릭 화합물 억제제
US11413287B2 (en) 2018-11-16 2022-08-16 Altavant Sciences Gmbh Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension
WO2020128608A1 (en) 2018-12-17 2020-06-25 Altavant Sciences Gmbh Compound for use in a method for treating sarcoidosis-associated pulmonary hypertension
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WO2020157577A1 (en) 2019-01-30 2020-08-06 Altavant Sciences Gmbh A dosage regime and method for treating pulmonary arterial hypertension with rodatristat ethyl
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