CY1122652T1 - Σπειροκυκλικες ενωσεις ως αναστολεις υδροξυλασης τρυπτοφανης - Google Patents
Σπειροκυκλικες ενωσεις ως αναστολεις υδροξυλασης τρυπτοφανηςInfo
- Publication number
- CY1122652T1 CY1122652T1 CY20201100036T CY201100036T CY1122652T1 CY 1122652 T1 CY1122652 T1 CY 1122652T1 CY 20201100036 T CY20201100036 T CY 20201100036T CY 201100036 T CY201100036 T CY 201100036T CY 1122652 T1 CY1122652 T1 CY 1122652T1
- Authority
- CY
- Cyprus
- Prior art keywords
- inhibitors
- hydrosylase
- tryptophane
- spirocyclic compounds
- diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dispersion Chemistry (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση κατευθύνεται σε σπειροκυκλικές ενώσεις οι οποίες είναι αναστολείς υδροξυλάσης τρυπτοφάνης (ΤΡΗ), ιδιαιτέρως ισόμορφης 1 (ΤΡΗ1), που είναι χρήσιμες στη θεραπεία ασθενειών ή διαταραχών που συνδυάζονται με περιφερική σεροτονίνη που συμπεριλαμβάνει, για παράδειγμα, γαστρεντερικές, καρδιαγγειακές, πνευμονικές, φλεγμονώδεις, μεταβολικές και χαμηλής οστικής μάζας ασθένειες, καθώς επίσης σύνδρομο σεροτονίνης και καρκίνο.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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US201361874545P | 2013-09-06 | 2013-09-06 | |
US201361899943P | 2013-11-05 | 2013-11-05 | |
US201462004385P | 2014-05-29 | 2014-05-29 | |
PCT/US2014/054202 WO2015035113A1 (en) | 2013-09-06 | 2014-09-05 | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
Publications (1)
Publication Number | Publication Date |
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CY1122652T1 true CY1122652T1 (el) | 2021-05-05 |
Family
ID=51743540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20201100036T CY1122652T1 (el) | 2013-09-06 | 2020-01-15 | Σπειροκυκλικες ενωσεις ως αναστολεις υδροξυλασης τρυπτοφανης |
Country Status (31)
Country | Link |
---|---|
US (8) | US9199994B2 (el) |
EP (1) | EP3041842B8 (el) |
JP (1) | JP6470290B2 (el) |
KR (1) | KR102336075B1 (el) |
CN (1) | CN105764902B (el) |
AR (1) | AR097571A1 (el) |
AU (1) | AU2014315109B2 (el) |
CA (1) | CA2922933C (el) |
CL (1) | CL2016000509A1 (el) |
CY (1) | CY1122652T1 (el) |
DK (1) | DK3041842T3 (el) |
EA (1) | EA032304B1 (el) |
EC (1) | ECSP16014324A (el) |
ES (1) | ES2780828T3 (el) |
HK (1) | HK1225720A1 (el) |
HR (1) | HRP20200098T1 (el) |
HU (1) | HUE047574T2 (el) |
IL (1) | IL244315B (el) |
LT (1) | LT3041842T (el) |
MX (1) | MX371191B (el) |
MY (1) | MY186265A (el) |
PE (1) | PE20160648A1 (el) |
PH (1) | PH12016500416B1 (el) |
PL (1) | PL3041842T3 (el) |
PT (1) | PT3041842T (el) |
RS (1) | RS59871B1 (el) |
SG (2) | SG10202013041QA (el) |
SI (1) | SI3041842T1 (el) |
TW (1) | TWI652267B (el) |
UA (1) | UA119247C2 (el) |
WO (1) | WO2015035113A1 (el) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
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UA119247C2 (uk) * | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
CN107176940B (zh) * | 2016-03-09 | 2019-05-28 | 江苏正大丰海制药有限公司 | 一种替卡法林的制备方法 |
WO2018060949A1 (en) | 2016-09-30 | 2018-04-05 | Roivant Sciences Gmbh | Tryptophan hydroxylase inhibitors for use in the treatment of liver diseases |
AR110150A1 (es) | 2016-11-09 | 2019-02-27 | Roivant Sciences Gmbh | Procesos para la preparación de inhibidores de tph1 |
US10472313B1 (en) | 2018-02-18 | 2019-11-12 | Graphene 3D Lab Inc. | Process for synthesizing trifluoroketones |
MX2021005559A (es) * | 2018-11-14 | 2021-09-10 | Altavant Sciences Gmbh | Compuesto espirocíclico cristalino, forma de dosificación que lo contiene, procedimiento de uso en el tratamiento de una enfermedad y procedimiento de recristalización. |
KR20210105343A (ko) * | 2018-11-16 | 2021-08-26 | 알타반트 사이언시스 게엠베하 | 폐동맥 고혈압 및 관련 폐동맥 고혈압의 치료 방법 |
US20200188398A1 (en) | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating sarcoidosis-associated pulmonary hypertension |
US20200188399A1 (en) | 2018-12-17 | 2020-06-18 | Altavant Sciences Gmbh | Method for treating interstitial lung disease |
AU2020213746A1 (en) | 2019-01-30 | 2021-08-19 | Altavant Sciences Gmbh | A dosage regime and method for treating pulmonary arterial hypertension with rodatristat ethyl |
MX2021011224A (es) * | 2019-03-15 | 2021-12-10 | Altavant Sciences Gmbh | Un método para tratar la hipertensión arterial pulmonar y la hipertensión arterial pulmonar asociada y pauta posológica diaria. |
MX2022006636A (es) * | 2019-12-02 | 2022-11-09 | Altavant Sciences Gmbh | Tratamiento de trastornos de las vías respiratorias bajas. |
CN111007170B (zh) * | 2019-12-13 | 2021-06-29 | 中国农业科学院农产品加工研究所 | 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途 |
US20230074252A1 (en) | 2020-01-31 | 2023-03-09 | Altavant Sciences Gmbh | Dosages and methods for treating pulmonary arterial hypertension with rodatristat |
WO2023062595A1 (en) | 2021-10-14 | 2023-04-20 | Altavant Sciences Gmbh | Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl |
WO2023079486A1 (en) | 2021-11-03 | 2023-05-11 | Altavant Sciences Gmbh | Treatment of pulmonary arterial hypertension with rodatristat and ambrisentan |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR920700613A (ko) | 1989-05-16 | 1992-08-10 | 지구르트 퓌터 | 약제제 |
DE69730033T2 (de) | 1996-08-28 | 2005-07-21 | The Procter & Gamble Company, Cincinnati | Spirocyclisch metalloprotease inhibitoren |
DK1263745T3 (da) | 2000-03-07 | 2004-08-16 | Aventis Pharma Gmbh | Substituerede 3-phenyl-5-alkoxy-1,3,4-oxadiaxol-2-oner og anvendelse deraf til inhibering af hormonfölsom lipase |
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