BRPI0813835A2 - métodos de afetar o trânsito gastrointestinal e esvaziamento gástrico, e compostos úteis a esse respeito - Google Patents

métodos de afetar o trânsito gastrointestinal e esvaziamento gástrico, e compostos úteis a esse respeito

Info

Publication number
BRPI0813835A2
BRPI0813835A2 BRPI0813835A BRPI0813835A BRPI0813835A2 BR PI0813835 A2 BRPI0813835 A2 BR PI0813835A2 BR PI0813835 A BRPI0813835 A BR PI0813835A BR PI0813835 A BRPI0813835 A BR PI0813835A BR PI0813835 A2 BRPI0813835 A2 BR PI0813835A2
Authority
BR
Brazil
Prior art keywords
methods
gastric emptying
useful compounds
gastrointestinal transit
affecting gastrointestinal
Prior art date
Application number
BRPI0813835A
Other languages
English (en)
Inventor
Zambrowicz Brian
Liu Qingyun
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of BRPI0813835A2 publication Critical patent/BRPI0813835A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
BRPI0813835A 2007-07-26 2008-07-17 métodos de afetar o trânsito gastrointestinal e esvaziamento gástrico, e compostos úteis a esse respeito BRPI0813835A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95207107P 2007-07-26 2007-07-26
PCT/US2008/070254 WO2009014972A1 (en) 2007-07-26 2008-07-17 Methods of affecting gastrointestinal transit and gastric emptying, and compounds useful therein

Publications (1)

Publication Number Publication Date
BRPI0813835A2 true BRPI0813835A2 (pt) 2017-06-06

Family

ID=39745649

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0813835A BRPI0813835A2 (pt) 2007-07-26 2008-07-17 métodos de afetar o trânsito gastrointestinal e esvaziamento gástrico, e compostos úteis a esse respeito

Country Status (10)

Country Link
US (2) US20090029993A1 (pt)
EP (1) EP2178536A1 (pt)
JP (1) JP2010534662A (pt)
KR (1) KR20100055436A (pt)
CN (1) CN101801385A (pt)
AU (1) AU2008279426A1 (pt)
BR (1) BRPI0813835A2 (pt)
CA (1) CA2694443A1 (pt)
RU (1) RU2010107066A (pt)
WO (1) WO2009014972A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009013982A (es) * 2007-06-26 2010-04-09 Lexicon Pharmaceuticals Inc Composiciones que comprenden inhibidores de triptofano hidroxilasa.
MX2010001938A (es) * 2007-08-24 2010-03-11 Lexicon Pharmaceuticals Inc Metodos para preparar compuestos basados en 4-fenil-6-(2,2,2-trifl uoro-1-feniletoxi)pirimidina.
TW200932729A (en) * 2007-10-08 2009-08-01 Lexicon Pharmaceuticals Inc Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and methods of their use
US8759364B2 (en) 2008-03-31 2014-06-24 The Trustees Of Columbia University In The City Of New York Methods of treating bone mass diseases
US8815883B2 (en) 2009-11-02 2014-08-26 The Trustees Of Columbia Unviersity In The City Of New York Compounds and methods for inhibiting serotonin synthesis
CN102711757A (zh) * 2009-11-23 2012-10-03 莱西肯医药有限公司 用于治疗肠易激综合征的方法和分析法
CN102753168A (zh) * 2010-02-10 2012-10-24 莱西肯医药有限公司 用于治疗转移性骨病的色氨酸羟化酶抑制剂
TWI513694B (zh) 2010-05-11 2015-12-21 Amgen Inc 抑制間變性淋巴瘤激酶的嘧啶化合物
JP2013530180A (ja) 2010-06-16 2013-07-25 パーデュー、ファーマ、リミテッド、パートナーシップ アリール置換インドールおよびその使用
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US20130303763A1 (en) * 2012-03-30 2013-11-14 Michael D. Gershon Methods and compositions for the treatment of necrotizing enterocolitis
UA119247C2 (uk) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
TW201818964A (zh) 2016-09-30 2018-06-01 瑞士商諾伊曼特醫療公司 使用色胺酸羥化酶抑制劑之方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0620756B1 (pt) * 2005-12-29 2021-06-01 Tersera Therapeutics Llc Derivados de aminoácido multicíclicos, formulação farmacêutica compreendendo os mesmos e seus usos para inibir a atividade de triptofano hidroxilase 1 (tph1)
UA99270C2 (en) * 2006-12-12 2012-08-10 Лексикон Фармасьютикалз, Инк. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use

Also Published As

Publication number Publication date
WO2009014972A1 (en) 2009-01-29
RU2010107066A (ru) 2011-09-10
US20100317664A1 (en) 2010-12-16
JP2010534662A (ja) 2010-11-11
EP2178536A1 (en) 2010-04-28
US20090029993A1 (en) 2009-01-29
KR20100055436A (ko) 2010-05-26
AU2008279426A1 (en) 2009-01-29
CN101801385A (zh) 2010-08-11
CA2694443A1 (en) 2009-01-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]