JP2010508338A5 - - Google Patents
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- Publication number
- JP2010508338A5 JP2010508338A5 JP2009535119A JP2009535119A JP2010508338A5 JP 2010508338 A5 JP2010508338 A5 JP 2010508338A5 JP 2009535119 A JP2009535119 A JP 2009535119A JP 2009535119 A JP2009535119 A JP 2009535119A JP 2010508338 A5 JP2010508338 A5 JP 2010508338A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- acetic acid
- propylsulfanyl
- piperidyl
- cyclohexylcarbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86424706P | 2006-11-03 | 2006-11-03 | |
| US86430306P | 2006-11-03 | 2006-11-03 | |
| US60/864,303 | 2006-11-03 | ||
| US60/864,247 | 2006-11-03 | ||
| PCT/GB2007/004131 WO2008053194A2 (en) | 2006-11-03 | 2007-10-31 | Pyridine carboxamides as 11-beta-hsd1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508338A JP2010508338A (ja) | 2010-03-18 |
| JP2010508338A5 true JP2010508338A5 (enExample) | 2012-08-16 |
| JP5165688B2 JP5165688B2 (ja) | 2013-03-21 |
Family
ID=39304797
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535119A Active JP5165688B2 (ja) | 2006-11-03 | 2007-10-31 | 化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US7964618B2 (enExample) |
| EP (2) | EP2086939B8 (enExample) |
| JP (1) | JP5165688B2 (enExample) |
| KR (1) | KR101465275B1 (enExample) |
| CN (3) | CN101787016B (enExample) |
| AR (1) | AR063458A1 (enExample) |
| AT (1) | ATE475649T1 (enExample) |
| AU (1) | AU2007315955B2 (enExample) |
| BR (1) | BRPI0717970C1 (enExample) |
| CA (1) | CA2668006C (enExample) |
| CL (1) | CL2007003176A1 (enExample) |
| CO (1) | CO6321130A2 (enExample) |
| CY (1) | CY1110813T1 (enExample) |
| DE (1) | DE602007008137D1 (enExample) |
| DK (1) | DK2086939T3 (enExample) |
| ES (2) | ES2347491T3 (enExample) |
| HR (1) | HRP20100522T1 (enExample) |
| IL (1) | IL198231A0 (enExample) |
| MX (1) | MX2009004707A (enExample) |
| NO (1) | NO20091603L (enExample) |
| NZ (1) | NZ576501A (enExample) |
| PE (1) | PE20081487A1 (enExample) |
| PL (1) | PL2086939T3 (enExample) |
| PT (1) | PT2086939E (enExample) |
| RS (1) | RS51451B (enExample) |
| RU (1) | RU2451674C2 (enExample) |
| SI (1) | SI2086939T1 (enExample) |
| TW (1) | TW200827346A (enExample) |
| UY (1) | UY30681A1 (enExample) |
| WO (1) | WO2008053194A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2630665C (en) | 2005-11-21 | 2011-03-15 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-.beta.-hydroxysteroid dehydrogenase type i |
| TW200827346A (en) * | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| TW200836719A (en) * | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| WO2008142986A1 (ja) | 2007-05-18 | 2008-11-27 | Shionogi & Co., Ltd. | Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する含窒素複素環誘導体 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009051112A1 (ja) | 2007-10-15 | 2009-04-23 | Takeda Pharmaceutical Company Limited | アミド化合物およびその用途 |
| WO2009056881A1 (en) * | 2007-10-29 | 2009-05-07 | Astrazeneca Ab | Chemical compounds 313 |
| KR20100126306A (ko) * | 2008-02-04 | 2010-12-01 | 아스트라제네카 아베 | 4-[4-(2-(아다만틸카르바모일)-5-ｔｅｒｔ-부틸-피라졸-1-일]벤조산의 신규한 결정형 |
| JP2011518216A (ja) * | 2008-04-22 | 2011-06-23 | アストラゼネカ アクチボラグ | 置換ピリミジン−５−カルボキサミド |
| EP2243479A3 (en) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Novel amide and amidine derivates and uses thereof |
| EP2440204B1 (en) | 2009-06-12 | 2013-12-18 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
| AR078673A1 (es) * | 2009-10-20 | 2011-11-23 | Astrazeneca Ab | Pirimidinas sustituidas con adamantiliminocarbonilo como inhibidores de 11-b-hsd1 826 |
| EP2504328A1 (en) * | 2009-11-24 | 2012-10-03 | Allergan, Inc. | Novel compounds as receptor modulators with therapeutic utility |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| KR20110123657A (ko) * | 2010-05-07 | 2011-11-15 | 에스케이케미칼주식회사 | 피콜린아마이드 및 피리미딘-4-카복사미드 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| CN103180321A (zh) | 2010-09-23 | 2013-06-26 | Abbvie公司 | 氮杂金刚烷衍生物的一水合物 |
| US8471027B2 (en) * | 2011-04-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Adamantyl compounds |
| WO2013010382A1 (zh) * | 2011-07-21 | 2013-01-24 | 山东亨利医药科技有限责任公司 | 杂环取代的嘧啶类化合物 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN102659657B (zh) * | 2012-04-24 | 2014-08-06 | 徐州医学院 | 一种蛋白酶抑制剂pf429242的合成方法 |
| EA201492285A1 (ru) | 2012-06-20 | 2015-04-30 | Ф. Хоффманн-Ля Рош Аг | Соединения n-алкилтриазола в качестве антагонистов лизофосфатидной кислоты (lpar) |
| EA201492283A1 (ru) | 2012-06-20 | 2015-04-30 | Ф. Хоффманн-Ля Рош Аг | Замещенные соединения пиразола в качестве антагонистов рецепторов лизофосфатидной кислоты (lpar) |
| EP3821892A1 (en) | 2019-11-12 | 2021-05-19 | University of Leeds | (s)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl) acetic acid for use in treating wounds |
| GB202216324D0 (en) * | 2022-11-02 | 2022-12-14 | Cerevance Ltd | Novel compounds |
| GB202408335D0 (en) | 2024-06-11 | 2024-07-24 | Astrazeneca Ab | Therapies for wound treatment |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR66581B (enExample) | 1978-02-21 | 1981-03-27 | Delalande Sa | |
| US4734418A (en) | 1984-12-14 | 1988-03-29 | Mitsui Petrochemical Industries, Ltd. | Quinazoline compounds and antihypertensives |
| HU225917B1 (en) | 1999-09-16 | 2007-12-28 | Tanabe Seiyaku Co | Pyrimidine and pyrazine derivatives, pharmaceutical compositions containing them and their use |
| FR2803592A1 (fr) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
| US7273868B2 (en) | 2000-04-28 | 2007-09-25 | Tanabe Seiyaku Co., Ltd. | Pyrazine derivatives |
| AU2001288623A1 (en) | 2000-09-05 | 2002-03-22 | Tularik, Inc. | Fxr modulators |
| NZ526003A (en) | 2000-10-20 | 2005-09-30 | Biocryst Pharm Inc | Biaryl compounds as serine protease inhibitors |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| JP2005528395A (ja) | 2002-04-05 | 2005-09-22 | ザ ユニバーシティ オブ エディンバラ | 組成物 |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| TW200503994A (en) | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
| SE0300457D0 (sv) * | 2003-02-19 | 2003-02-19 | Astrazeneca Ab | Novel compounds |
| SE0300458D0 (sv) * | 2003-02-19 | 2003-02-19 | Astrazeneca Ab | Novel compounds |
| WO2004076420A1 (ja) | 2003-02-26 | 2004-09-10 | Banyu Pharmaceutical Co., Ltd. | ヘテロアリールカルバモイルベンゼン誘導体 |
| EP1618090A1 (en) | 2003-04-11 | 2006-01-25 | Novo Nordisk A/S | 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
| WO2005016877A2 (en) | 2003-08-07 | 2005-02-24 | Merck & Co., Inc. | Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
| EP1670787B1 (en) | 2003-09-11 | 2012-05-30 | iTherX Pharma, Inc. | Cytokine inhibitors |
| GB0327761D0 (en) | 2003-11-29 | 2003-12-31 | Astrazeneca Ab | Compounds |
| MXPA06007077A (es) | 2003-12-19 | 2006-08-23 | Pfizer | Derivados de bencenosulfonilamino-piridin-2-ilo y compuestos relacionados como inhibidores de 11-beta-hidroxi esteroide deshidrogenasa tipo 1 para el tratamiento de diabetes y obesidad. |
| ATE407119T1 (de) | 2004-02-24 | 2008-09-15 | Glaxo Group Ltd | Pyridinderivate und deren verwendung als modulatoren des cb2-rezeptors |
| JP2007531753A (ja) * | 2004-03-31 | 2007-11-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 非イミダゾール系複素環式化合物 |
| JP2007536369A (ja) | 2004-05-06 | 2007-12-13 | ファイザー・インク | プロリン及びモルホリン誘導体の新規化合物 |
| TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| JP4809339B2 (ja) | 2004-06-28 | 2011-11-09 | エフ．ホフマン−ラ ロシュ アーゲー | ピリミジン誘導体 |
| WO2006048750A2 (en) | 2004-11-02 | 2006-05-11 | Pfizer Inc. | Novel compounds of substituted and unsubstituted adamantyl amides |
| EP1809290A2 (en) | 2004-11-03 | 2007-07-25 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as ion channel modulators and methods of use |
| CN103242192B (zh) | 2005-01-05 | 2016-05-04 | Abbvie公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| ATE519744T1 (de) | 2005-04-05 | 2011-08-15 | Hoffmann La Roche | 1h-pyrazol-4-carbonsäure-amide, deren herstellung und verwendung als 11-beta-hydroxysteroid- dehydrogenase-hemmer |
| DK1868999T3 (da) | 2005-04-06 | 2009-08-17 | Hoffmann La Roche | Pyridin-3-carboxamidderivater som omvendte CB1-agonister |
| WO2006106423A2 (en) | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase |
| EP2527337A1 (en) | 2005-04-14 | 2012-11-28 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type I |
| EP1891069A1 (en) | 2005-05-24 | 2008-02-27 | AstraZeneca AB | 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators |
| US8952176B2 (en) | 2005-06-07 | 2015-02-10 | Shionogi & Co., Ltd. | Heterocyclic compound having type I 11 β hydroxysteroid dehydrogenase inhibitory activity |
| AU2006255944B2 (en) | 2005-06-08 | 2010-03-04 | Japan Tobacco Inc. | Heterocyclic compound |
| EP1893609B1 (en) | 2005-06-16 | 2009-11-18 | Pfizer, Inc. | N-(pyridin-2-yl)-sulfonamide derivatives |
| US7642259B2 (en) | 2005-07-09 | 2010-01-05 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| EP1915367A1 (en) | 2005-08-09 | 2008-04-30 | AstraZeneca AB | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
| EP1951707A1 (en) | 2005-11-01 | 2008-08-06 | Janssen Pharmaceutica N.V. | Substituted pyrrolones as allosteric modulators of glucokinase |
| WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
| CA2630665C (en) | 2005-11-21 | 2011-03-15 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-.beta.-hydroxysteroid dehydrogenase type i |
| KR20080091503A (ko) | 2006-01-31 | 2008-10-13 | 인사이트 코포레이션 | 아미도 화합물 및 약제로서의 이의 용도 |
| HRP20151078T1 (hr) | 2006-03-22 | 2015-11-20 | F. Hoffmann - La Roche Ag | Pirazoli kao 11-beta-hsd-1 |
| AU2007236049A1 (en) | 2006-04-07 | 2007-10-18 | High Point Pharmaceuticals, Llc | 11beta-hydroxysteroid dehydrogenase type 1 active compounds |
| RU2008146591A (ru) | 2006-04-27 | 2010-06-10 | Зольвай Фармасьютиклз Гмбх (De) | Применение модуляторов каннабиноидного рецептора свх в качестве модуляторов калиевых каналов |
| US20100022589A1 (en) | 2006-07-27 | 2010-01-28 | Mccoull William | Pyridine-3-carboxamide compounds and their use for inhibiting 11-beta-hydroxysteroid dehydrogenase |
| TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
| TW200836719A (en) | 2007-02-12 | 2008-09-16 | Astrazeneca Ab | Chemical compounds |
| WO2008142986A1 (ja) | 2007-05-18 | 2008-11-27 | Shionogi & Co., Ltd. | Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する含窒素複素環誘導体 |
| KR101158191B1 (ko) | 2007-07-17 | 2012-06-19 | 에프. 호프만-라 로슈 아게 | 11ｂ-하이드록시스테로이드 탈수소효소의 억제제 |
| EA201000701A1 (ru) | 2007-11-06 | 2010-12-30 | Астразенека Аб | 4-[4-(2-адамантилкарбамоил)-5-трет-бутилпиразол-1-ил]бензойная кислота-465 |
| KR20100126306A (ko) | 2008-02-04 | 2010-12-01 | 아스트라제네카 아베 | 4-[4-(2-(아다만틸카르바모일)-5-ｔｅｒｔ-부틸-피라졸-1-일]벤조산의 신규한 결정형 |
| JP2011518216A (ja) | 2008-04-22 | 2011-06-23 | アストラゼネカ アクチボラグ | 置換ピリミジン−５−カルボキサミド |
| EP2391607A1 (en) | 2009-01-30 | 2011-12-07 | AstraZeneca AB | Novel process for preparing carboxy-containing pyrazoleamido compounds 597 |
| AR078673A1 (es) * | 2009-10-20 | 2011-11-23 | Astrazeneca Ab | Pirimidinas sustituidas con adamantiliminocarbonilo como inhibidores de 11-b-hsd1 826 |
-
2007
- 2007-10-29 TW TW096140633A patent/TW200827346A/zh unknown
- 2007-10-30 US US11/928,744 patent/US7964618B2/en active Active
- 2007-10-31 BR BRPI0717970A patent/BRPI0717970C1/pt active IP Right Grant
- 2007-10-31 KR KR1020097010339A patent/KR101465275B1/ko active Active
- 2007-10-31 DE DE602007008137T patent/DE602007008137D1/de active Active
- 2007-10-31 DK DK07824375.5T patent/DK2086939T3/da active
- 2007-10-31 PL PL07824375T patent/PL2086939T3/pl unknown
- 2007-10-31 PT PT07824375T patent/PT2086939E/pt unknown
- 2007-10-31 RS RSP-2010/0422A patent/RS51451B/sr unknown
- 2007-10-31 SI SI200730335T patent/SI2086939T1/sl unknown
- 2007-10-31 RU RU2009115830/04A patent/RU2451674C2/ru active
- 2007-10-31 CN CN2010101438299A patent/CN101787016B/zh active Active
- 2007-10-31 AT AT07824375T patent/ATE475649T1/de active
- 2007-10-31 UY UY30681A patent/UY30681A1/es not_active Application Discontinuation
- 2007-10-31 AU AU2007315955A patent/AU2007315955B2/en active Active
- 2007-10-31 NZ NZ576501A patent/NZ576501A/en not_active IP Right Cessation
- 2007-10-31 WO PCT/GB2007/004131 patent/WO2008053194A2/en not_active Ceased
- 2007-10-31 EP EP07824375A patent/EP2086939B8/en active Active
- 2007-10-31 MX MX2009004707A patent/MX2009004707A/es active IP Right Grant
- 2007-10-31 CN CN2012100119350A patent/CN102603711A/zh active Pending
- 2007-10-31 CN CN2007800491675A patent/CN101573336B/zh not_active Expired - Fee Related
- 2007-10-31 ES ES07824375T patent/ES2347491T3/es active Active
- 2007-10-31 ES ES10163730T patent/ES2423206T3/es active Active
- 2007-10-31 JP JP2009535119A patent/JP5165688B2/ja active Active
- 2007-10-31 CA CA2668006A patent/CA2668006C/en active Active
- 2007-10-31 HR HR20100522T patent/HRP20100522T1/hr unknown
- 2007-10-31 EP EP10163730.4A patent/EP2233480B1/en active Active
- 2007-11-02 CL CL200703176A patent/CL2007003176A1/es unknown
- 2007-11-02 AR ARP070104887A patent/AR063458A1/es not_active Application Discontinuation
- 2007-11-05 PE PE2007001517A patent/PE20081487A1/es not_active Application Discontinuation
-
2009
- 2009-04-20 IL IL198231A patent/IL198231A0/en unknown
- 2009-04-22 NO NO20091603A patent/NO20091603L/no not_active Application Discontinuation
- 2009-04-29 CO CO09043382A patent/CO6321130A2/es not_active Application Discontinuation
- 2009-08-14 US US12/541,565 patent/US8673938B2/en active Active
- 2009-08-14 US US12/541,574 patent/US20090312372A1/en not_active Abandoned
-
2010
- 2010-10-04 CY CY20101100879T patent/CY1110813T1/el unknown
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