JP2012501312A5 - - Google Patents
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- Publication number
- JP2012501312A5 JP2012501312A5 JP2011524403A JP2011524403A JP2012501312A5 JP 2012501312 A5 JP2012501312 A5 JP 2012501312A5 JP 2011524403 A JP2011524403 A JP 2011524403A JP 2011524403 A JP2011524403 A JP 2011524403A JP 2012501312 A5 JP2012501312 A5 JP 2012501312A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- naphthyridin
- amino
- amine
- aminopiperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 aminocarbonyloxy, aminosulfonyl Chemical group 0.000 claims 50
- 125000000753 cycloalkyl group Chemical group 0.000 claims 29
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 15
- 125000001475 halogen functional group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000004423 acyloxy group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000004104 aryloxy group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 6
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 6
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 6
- 125000003386 piperidinyl group Chemical group 0.000 claims 6
- 125000003441 thioacyl group Chemical group 0.000 claims 6
- 150000003573 thiols Chemical class 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004193 piperazinyl group Chemical group 0.000 claims 5
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- GOZBXWPQUSCSOL-YLJYHZDGSA-N (3r,4r)-1-[6-[6-(2,6-difluorophenyl)pyridin-2-yl]quinolin-4-yl]-4-fluoropiperidin-3-amine Chemical compound C1C[C@@H](F)[C@H](N)CN1C1=CC=NC2=CC=C(C=3N=C(C=CC=3)C=3C(=CC=CC=3F)F)C=C12 GOZBXWPQUSCSOL-YLJYHZDGSA-N 0.000 claims 2
- MVHATFDKNQITLT-IIBYNOLFSA-N (3r,4r)-3-amino-1-[6-[6-(1,3-thiazol-2-yl)pyridin-2-yl]quinolin-4-yl]piperidin-4-ol Chemical compound C1C[C@@H](O)[C@H](N)CN1C1=CC=NC2=CC=C(C=3N=C(C=CC=3)C=3SC=CN=3)C=C12 MVHATFDKNQITLT-IIBYNOLFSA-N 0.000 claims 2
- ATIMFZCPBCTHFM-NTKDMRAZSA-N (3r,4r)-3-amino-1-[6-[6-(2,6-difluorophenyl)pyridin-2-yl]quinolin-4-yl]piperidin-4-ol Chemical compound C1C[C@@H](O)[C@H](N)CN1C1=CC=NC2=CC=C(C=3N=C(C=CC=3)C=3C(=CC=CC=3F)F)C=C12 ATIMFZCPBCTHFM-NTKDMRAZSA-N 0.000 claims 2
- HRJZGPILOHKMOC-INIZCTEOSA-N (3s)-1-[6-[4-(2,6-difluorophenyl)pyrimidin-2-yl]quinolin-4-yl]piperidin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CC=C(C=3N=C(C=CN=3)C=3C(=CC=CC=3F)F)C=C12 HRJZGPILOHKMOC-INIZCTEOSA-N 0.000 claims 2
- HUSFRIKYCASQCP-WBVHZDCISA-N (3s,5r)-5-methyl-1-[6-[6-(1,3-thiazol-2-yl)pyridin-2-yl]quinolin-4-yl]piperidin-3-amine Chemical compound C1[C@H](C)C[C@H](N)CN1C1=CC=NC2=CC=C(C=3N=C(C=CC=3)C=3SC=CN=3)C=C12 HUSFRIKYCASQCP-WBVHZDCISA-N 0.000 claims 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 2
- ZSWOHSKPVUUOAX-UHFFFAOYSA-N 2-[4-(2-amino-6-methylpyridin-4-yl)-1,7-naphthyridin-6-yl]-6-(2,6-difluorophenyl)pyridin-3-amine Chemical compound NC1=NC(C)=CC(C=2C3=CC(=NC=C3N=CC=2)C=2C(=CC=C(N=2)C=2C(=CC=CC=2F)F)N)=C1 ZSWOHSKPVUUOAX-UHFFFAOYSA-N 0.000 claims 2
- OYJREFHZQJZOJS-CQSZACIVSA-N 2-[4-[(3r)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(2,6-difluorophenyl)pyridin-3-amine Chemical compound C1[C@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C(=CC=CC=3F)F)N)C=C12 OYJREFHZQJZOJS-CQSZACIVSA-N 0.000 claims 2
- YUORUIOLJWUERY-ZDUSSCGKSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(1,3-thiazol-2-yl)pyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3SC=CN=3)N)C=C12 YUORUIOLJWUERY-ZDUSSCGKSA-N 0.000 claims 2
- DEUGTHPDIWIBNL-AWEZNQCLSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(2,3-difluorophenyl)pyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C(=C(F)C=CC=3)F)N)C=C12 DEUGTHPDIWIBNL-AWEZNQCLSA-N 0.000 claims 2
- UVWWZIDGIDLXSG-HNNXBMFYSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(2,4-difluorophenyl)pyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C(=CC(F)=CC=3)F)N)C=C12 UVWWZIDGIDLXSG-HNNXBMFYSA-N 0.000 claims 2
- OYJREFHZQJZOJS-AWEZNQCLSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(2,6-difluorophenyl)pyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C(=CC=CC=3F)F)N)C=C12 OYJREFHZQJZOJS-AWEZNQCLSA-N 0.000 claims 2
- LPLKMKMFBBFYQP-HNNXBMFYSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(2-fluorophenyl)pyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C(=CC=CC=3)F)N)C=C12 LPLKMKMFBBFYQP-HNNXBMFYSA-N 0.000 claims 2
- WVZUHFMFJOSMPG-KRWDZBQOSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(3-methylsulfonylphenyl)pyridin-3-amine Chemical compound CS(=O)(=O)C1=CC=CC(C=2N=C(C(N)=CC=2)C=2N=CC3=NC=CC(=C3C=2)N2C[C@@H](N)CCC2)=C1 WVZUHFMFJOSMPG-KRWDZBQOSA-N 0.000 claims 2
- HREPMROSVIOQON-KRWDZBQOSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(4-fluorophenyl)pyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C=CC(F)=CC=3)N)C=C12 HREPMROSVIOQON-KRWDZBQOSA-N 0.000 claims 2
- CTIFOGRUVOEDFK-KRWDZBQOSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(4-methylsulfonylphenyl)pyridin-3-amine Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CC=C(N)C(C=2N=CC3=NC=CC(=C3C=2)N2C[C@@H](N)CCC2)=N1 CTIFOGRUVOEDFK-KRWDZBQOSA-N 0.000 claims 2
- FDBXKVKVXBEYCA-HNNXBMFYSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-(6-methoxypyridin-2-yl)pyridin-3-amine Chemical compound COC1=CC=CC(C=2N=C(C(N)=CC=2)C=2N=CC3=NC=CC(=C3C=2)N2C[C@@H](N)CCC2)=N1 FDBXKVKVXBEYCA-HNNXBMFYSA-N 0.000 claims 2
- UPWAQZXGUQYYTH-KRWDZBQOSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-phenylpyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C=CC=CC=3)N)C=C12 UPWAQZXGUQYYTH-KRWDZBQOSA-N 0.000 claims 2
- HVLSMSVGNNNZJZ-AWEZNQCLSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-6-thiophen-2-ylpyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3SC=CC=3)N)C=C12 HVLSMSVGNNNZJZ-AWEZNQCLSA-N 0.000 claims 2
- SETCJYIDTBJZQT-LBPRGKRZSA-N 2-[4-[(3s)-3-aminopiperidin-1-yl]-3-fluoro-1,7-naphthyridin-6-yl]-6-(1,3-thiazol-2-yl)pyridin-3-amine Chemical compound C1[C@@H](N)CCCN1C1=C(F)C=NC2=CN=C(C=3C(=CC=C(N=3)C=3SC=CN=3)N)C=C12 SETCJYIDTBJZQT-LBPRGKRZSA-N 0.000 claims 2
- YKSJVFFKFZUNCD-UHFFFAOYSA-N 3-[5-amino-6-[4-(2-amino-6-methylpyridin-4-yl)-1,7-naphthyridin-6-yl]pyridin-2-yl]-4-fluoro-n-propan-2-ylbenzamide Chemical compound CC(C)NC(=O)C1=CC=C(F)C(C=2N=C(C(N)=CC=2)C=2N=CC3=NC=CC(=C3C=2)C=2C=C(N)N=C(C)C=2)=C1 YKSJVFFKFZUNCD-UHFFFAOYSA-N 0.000 claims 2
- KWEQYIYARKVRPE-GOSISDBHSA-N 3-[5-amino-6-[4-[(3r)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]pyridin-2-yl]-4-fluoro-n-propan-2-ylbenzamide Chemical compound CC(C)NC(=O)C1=CC=C(F)C(C=2N=C(C(N)=CC=2)C=2N=CC3=NC=CC(=C3C=2)N2C[C@H](N)CCC2)=C1 KWEQYIYARKVRPE-GOSISDBHSA-N 0.000 claims 2
- GGOVNNBQWDKAJJ-KRWDZBQOSA-N 3-[5-amino-6-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]pyridin-2-yl]-4-fluoro-n,n-dimethylbenzamide Chemical compound CN(C)C(=O)C1=CC=C(F)C(C=2N=C(C(N)=CC=2)C=2N=CC3=NC=CC(=C3C=2)N2C[C@@H](N)CCC2)=C1 GGOVNNBQWDKAJJ-KRWDZBQOSA-N 0.000 claims 2
- FUDKTSYUNRLCTD-FQEVSTJZSA-N 3-[5-amino-6-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]pyridin-2-yl]-4-fluoro-n-phenylbenzamide Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C(=CC=C(C=3)C(=O)NC=3C=CC=CC=3)F)N)C=C12 FUDKTSYUNRLCTD-FQEVSTJZSA-N 0.000 claims 2
- KWEQYIYARKVRPE-SFHVURJKSA-N 3-[5-amino-6-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]pyridin-2-yl]-4-fluoro-n-propan-2-ylbenzamide Chemical compound CC(C)NC(=O)C1=CC=C(F)C(C=2N=C(C(N)=CC=2)C=2N=CC3=NC=CC(=C3C=2)N2C[C@@H](N)CCC2)=C1 KWEQYIYARKVRPE-SFHVURJKSA-N 0.000 claims 2
- HMTIPZSXXLHSMP-FQEVSTJZSA-N 3-[5-amino-6-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]pyridin-2-yl]-n-cyclohexyl-4-fluorobenzamide Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CC=C(N=3)C=3C(=CC=C(C=3)C(=O)NC3CCCCC3)F)N)C=C12 HMTIPZSXXLHSMP-FQEVSTJZSA-N 0.000 claims 2
- BKZKUNVXXLXOJM-KRWDZBQOSA-N 3-[5-amino-6-[4-[(3s)-3-aminopiperidin-1-yl]-3-fluoro-1,7-naphthyridin-6-yl]pyridin-2-yl]-4-fluoro-n-propan-2-ylbenzamide Chemical compound CC(C)NC(=O)C1=CC=C(F)C(C=2N=C(C(N)=CC=2)C=2N=CC3=NC=C(F)C(N4C[C@@H](N)CCC4)=C3C=2)=C1 BKZKUNVXXLXOJM-KRWDZBQOSA-N 0.000 claims 2
- XLQOSTSZIBAZPH-AWEZNQCLSA-N 4-[4-[(3s)-3-aminopiperidin-1-yl]-1,7-naphthyridin-6-yl]-2-(2-fluorophenyl)pyrimidin-5-amine Chemical compound C1[C@@H](N)CCCN1C1=CC=NC2=CN=C(C=3C(=CN=C(N=3)C=3C(=CC=CC=3)F)N)C=C12 XLQOSTSZIBAZPH-AWEZNQCLSA-N 0.000 claims 2
- XNJBFWQURVDFJO-UHFFFAOYSA-N S1C(=NC=C1)C1=CC=CC(=N1)C=1C=C2C(=CC=NC2=CC1)C1CCC(CN1)N Chemical compound S1C(=NC=C1)C1=CC=CC(=N1)C=1C=C2C(=CC=NC2=CC1)C1CCC(CN1)N XNJBFWQURVDFJO-UHFFFAOYSA-N 0.000 claims 2
- QQDJGJUETVITCD-UHFFFAOYSA-N S1C(=NC=C1)C1=CC=CC(=N1)C=1C=C2C(=CC=NC2=CN1)C1CCC(CN1)N Chemical compound S1C(=NC=C1)C1=CC=CC(=N1)C=1C=C2C(=CC=NC2=CN1)C1CCC(CN1)N QQDJGJUETVITCD-UHFFFAOYSA-N 0.000 claims 2
- 125000004442 acylamino group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 claims 2
- PFDKGWBVVPMQGY-IAGOWNOFSA-N (3r,4r)-4-fluoro-1-[6-[6-(1,3-thiazol-2-yl)pyridin-2-yl]quinolin-4-yl]piperidin-3-amine Chemical compound C1C[C@@H](F)[C@H](N)CN1C1=CC=NC2=CC=C(C=3N=C(C=CC=3)C=3SC=CN=3)C=C12 PFDKGWBVVPMQGY-IAGOWNOFSA-N 0.000 claims 1
- KRZJRNZICWNMOA-GXSJLCMTSA-N (3s,4r)-4,8-dihydroxy-3-methoxy-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1=CC=C2[C@@H](O)[C@@H](OC)CC(=O)C2=C1O KRZJRNZICWNMOA-GXSJLCMTSA-N 0.000 claims 1
- OHUYDZVINKITJA-AEFFLSMTSA-N (3s,5r)-1-[6-[6-(2,6-difluorophenyl)pyridin-2-yl]quinolin-4-yl]-5-methylpiperidin-3-amine Chemical compound C1[C@H](C)C[C@H](N)CN1C1=CC=NC2=CC=C(C=3N=C(C=CC=3)C=3C(=CC=CC=3F)F)C=C12 OHUYDZVINKITJA-AEFFLSMTSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- GTGFEYLGSCNMKQ-UHFFFAOYSA-N S1C(=NC=C1)C1=NC(=NC=C1)C1(CC=NC2=CC=CC=C12)C1CCC(CN1)N Chemical compound S1C(=NC=C1)C1=NC(=NC=C1)C1(CC=NC2=CC=CC=C12)C1CCC(CN1)N GTGFEYLGSCNMKQ-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910017464 nitrogen compound Inorganic materials 0.000 claims 1
- 150000002830 nitrogen compounds Chemical class 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- PEUGKEHLRUVPAN-UHFFFAOYSA-N piperidin-3-amine Chemical compound NC1CCCNC1 PEUGKEHLRUVPAN-UHFFFAOYSA-N 0.000 claims 1
- 230000001566 pro-viral effect Effects 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9366908P | 2008-09-02 | 2008-09-02 | |
| US61/093,669 | 2008-09-02 | ||
| PCT/EP2009/061182 WO2010026121A1 (en) | 2008-09-02 | 2009-08-31 | Bicyclic kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012501312A JP2012501312A (ja) | 2012-01-19 |
| JP2012501312A5 true JP2012501312A5 (enExample) | 2012-10-11 |
| JP5564045B2 JP5564045B2 (ja) | 2014-07-30 |
Family
ID=41211220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524403A Expired - Fee Related JP5564045B2 (ja) | 2008-09-02 | 2009-08-31 | 二環式キナーゼ阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8735424B2 (enExample) |
| EP (1) | EP2342190A1 (enExample) |
| JP (1) | JP5564045B2 (enExample) |
| KR (1) | KR20110058866A (enExample) |
| CN (1) | CN102203075B (enExample) |
| AU (1) | AU2009289316A1 (enExample) |
| BR (1) | BRPI0918496A2 (enExample) |
| CA (1) | CA2735779A1 (enExample) |
| EA (1) | EA201100426A1 (enExample) |
| MX (1) | MX2011002367A (enExample) |
| WO (1) | WO2010026121A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2474545T (pt) | 2005-12-13 | 2017-02-14 | Incyte Holdings Corp | Pirrolo[2,3-b]piridinas e pirrolo[2,3-b]pirimidinas substituídas com heteroarilo como inibidores de janus quinase |
| GEP20125533B (en) | 2007-06-13 | 2012-05-25 | Incyte Corp | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentyl propanenitrile |
| WO2010135650A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS |
| HRP20192203T1 (hr) | 2009-05-22 | 2020-03-06 | Incyte Holdings Corporation | 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PE20130038A1 (es) | 2010-03-10 | 2013-01-28 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de jak1 |
| RS54824B1 (sr) | 2010-05-21 | 2016-10-31 | Incyte Holdings Corp | Topikalna formulacija za inhibiciju jak-a |
| KR20140019300A (ko) | 2010-11-19 | 2014-02-14 | 인사이트 코포레이션 | Ｊａｋ 억제제로서 사이클로부틸 치환된 피롤로피리딘 및 피롤로피리미딘 유도체 |
| WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| EA201490042A1 (ru) | 2011-06-20 | 2014-10-30 | Инсайт Корпорейшн | Азетидинил-фенил-, пиридил- или пиразинилкарбоксамидные производные как ингибиторы jak |
| US9416132B2 (en) | 2011-07-21 | 2016-08-16 | Tolero Pharmaceuticals, Inc. | Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
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2009
- 2009-08-31 KR KR1020117007560A patent/KR20110058866A/ko not_active Withdrawn
- 2009-08-31 CA CA2735779A patent/CA2735779A1/en not_active Abandoned
- 2009-08-31 BR BRPI0918496A patent/BRPI0918496A2/pt not_active IP Right Cessation
- 2009-08-31 AU AU2009289316A patent/AU2009289316A1/en not_active Abandoned
- 2009-08-31 EP EP09782373A patent/EP2342190A1/en not_active Withdrawn
- 2009-08-31 CN CN200980143219.4A patent/CN102203075B/zh not_active Expired - Fee Related
- 2009-08-31 MX MX2011002367A patent/MX2011002367A/es not_active Application Discontinuation
- 2009-08-31 US US13/060,971 patent/US8735424B2/en active Active
- 2009-08-31 WO PCT/EP2009/061182 patent/WO2010026121A1/en not_active Ceased
- 2009-08-31 JP JP2011524403A patent/JP5564045B2/ja not_active Expired - Fee Related
- 2009-08-31 EA EA201100426A patent/EA201100426A1/ru unknown
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