AU2015308774B2 - Probes for imaging huntingtin protein - Google Patents
Probes for imaging huntingtin protein Download PDFInfo
- Publication number
- AU2015308774B2 AU2015308774B2 AU2015308774A AU2015308774A AU2015308774B2 AU 2015308774 B2 AU2015308774 B2 AU 2015308774B2 AU 2015308774 A AU2015308774 A AU 2015308774A AU 2015308774 A AU2015308774 A AU 2015308774A AU 2015308774 B2 AU2015308774 B2 AU 2015308774B2
- Authority
- AU
- Australia
- Prior art keywords
- pyridin
- methoxy
- benzoxazol
- methoxypyridin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C=CC1=CC=CC*1 Chemical compound C=CC1=CC=CC*1 0.000 description 6
- DKYIOZLWCWMAHF-UHFFFAOYSA-N C(COc1ccc(COc2ccc3[o]c(-c4cccnc4)nc3c2)nc1)N1CC[IH]CC1 Chemical compound C(COc1ccc(COc2ccc3[o]c(-c4cccnc4)nc3c2)nc1)N1CC[IH]CC1 DKYIOZLWCWMAHF-UHFFFAOYSA-N 0.000 description 1
- DNKNTYLNTKWYCP-UHFFFAOYSA-N C(COc1ccccn1)Oc1ccc2[o]c(-c3cccnc3)nc2c1 Chemical compound C(COc1ccccn1)Oc1ccc2[o]c(-c3cccnc3)nc2c1 DNKNTYLNTKWYCP-UHFFFAOYSA-N 0.000 description 1
- RPECSDIJZGTXQJ-UHFFFAOYSA-N C=CCOC(c(nc1)cnc1OCC=C)=O Chemical compound C=CCOC(c(nc1)cnc1OCC=C)=O RPECSDIJZGTXQJ-UHFFFAOYSA-N 0.000 description 1
- SPLNVHSRCHNYRB-UHFFFAOYSA-N C=CCOc1ncc(CO)nc1 Chemical compound C=CCOc1ncc(CO)nc1 SPLNVHSRCHNYRB-UHFFFAOYSA-N 0.000 description 1
- QTHQRNWVCRIQCR-UHFFFAOYSA-N CC(C)(C)OC(Nc1ccc(C(O)=O)nc1)=O Chemical compound CC(C)(C)OC(Nc1ccc(C(O)=O)nc1)=O QTHQRNWVCRIQCR-UHFFFAOYSA-N 0.000 description 1
- PXCUWRPONPYDPR-UHFFFAOYSA-N CC(C1=CCCN=C1)=O Chemical compound CC(C1=CCCN=C1)=O PXCUWRPONPYDPR-UHFFFAOYSA-N 0.000 description 1
- APQFHYBAXKSXRW-UHFFFAOYSA-N CC(CC=C1)(C=C1C#[O])C1=[O]=[O]c(ccc(OCc(nc2)ccc2OC)c2)c2N1 Chemical compound CC(CC=C1)(C=C1C#[O])C1=[O]=[O]c(ccc(OCc(nc2)ccc2OC)c2)c2N1 APQFHYBAXKSXRW-UHFFFAOYSA-N 0.000 description 1
- QQDLTPZBHRJRMJ-UHFFFAOYSA-N CC(c(nc1)ncc1OC)=O Chemical compound CC(c(nc1)ncc1OC)=O QQDLTPZBHRJRMJ-UHFFFAOYSA-N 0.000 description 1
- WEBLUDQPXKCQQD-UHFFFAOYSA-N CC1(NC=C(C(OC)=O)N=C1)Cl Chemical compound CC1(NC=C(C(OC)=O)N=C1)Cl WEBLUDQPXKCQQD-UHFFFAOYSA-N 0.000 description 1
- MJTSPTRANGPNRJ-UHFFFAOYSA-N CCc1cncnc1 Chemical compound CCc1cncnc1 MJTSPTRANGPNRJ-UHFFFAOYSA-N 0.000 description 1
- CJUORLZVGHCDKU-UHFFFAOYSA-N COc(cc1)ccc1C#Cc1cnc2[o]c(-c3cccnc3)nc2c1 Chemical compound COc(cc1)ccc1C#Cc1cnc2[o]c(-c3cccnc3)nc2c1 CJUORLZVGHCDKU-UHFFFAOYSA-N 0.000 description 1
- NVOKSUGGLQMGDD-UHFFFAOYSA-N COc1ccc2[o]c(-c(cccc3Br)c3C#C)cc2c1 Chemical compound COc1ccc2[o]c(-c(cccc3Br)c3C#C)cc2c1 NVOKSUGGLQMGDD-UHFFFAOYSA-N 0.000 description 1
- LMLCXYCFTMFTCU-UHFFFAOYSA-N Cc1ccc(COc(cc2N)ccc2O)nc1 Chemical compound Cc1ccc(COc(cc2N)ccc2O)nc1 LMLCXYCFTMFTCU-UHFFFAOYSA-N 0.000 description 1
- AKSLYQSXZULZHV-UHFFFAOYSA-N Cc1cnc2[o]c(-c3ccccc3)nc2c1 Chemical compound Cc1cnc2[o]c(-c3ccccc3)nc2c1 AKSLYQSXZULZHV-UHFFFAOYSA-N 0.000 description 1
- ZAPMTSHEXFEPSD-UHFFFAOYSA-N ClCCN1CCOCC1 Chemical compound ClCCN1CCOCC1 ZAPMTSHEXFEPSD-UHFFFAOYSA-N 0.000 description 1
- JTDIIDXRVCNTDU-UHFFFAOYSA-N ClCc1cnc[n]c1 Chemical compound ClCc1cnc[n]c1 JTDIIDXRVCNTDU-UHFFFAOYSA-N 0.000 description 1
- LXIBANSYVFWOAR-UHFFFAOYSA-N N#Cc(c(Br)ccc1)c1I Chemical compound N#Cc(c(Br)ccc1)c1I LXIBANSYVFWOAR-UHFFFAOYSA-N 0.000 description 1
- HGZJJKZPPMFIBU-UHFFFAOYSA-N N#Cc1cc(C=O)ccc1 Chemical compound N#Cc1cc(C=O)ccc1 HGZJJKZPPMFIBU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- Theoretical Computer Science (AREA)
- Pulmonology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043603P | 2014-08-29 | 2014-08-29 | |
| US62/043,603 | 2014-08-29 | ||
| PCT/US2015/047407 WO2016033445A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2015308774A1 AU2015308774A1 (en) | 2017-03-16 |
| AU2015308774A8 AU2015308774A8 (en) | 2017-03-23 |
| AU2015308774B2 true AU2015308774B2 (en) | 2020-03-19 |
Family
ID=55400648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015308774A Active AU2015308774B2 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US10479802B2 (enExample) |
| EP (2) | EP4006016A3 (enExample) |
| JP (2) | JP6817207B2 (enExample) |
| KR (2) | KR102456946B1 (enExample) |
| CN (2) | CN116655618B (enExample) |
| AU (1) | AU2015308774B2 (enExample) |
| BR (1) | BR112017004141B8 (enExample) |
| CA (1) | CA2959501C (enExample) |
| DK (1) | DK3186233T3 (enExample) |
| EA (1) | EA035646B1 (enExample) |
| ES (1) | ES2898965T3 (enExample) |
| HR (1) | HRP20211778T1 (enExample) |
| HU (1) | HUE056957T2 (enExample) |
| IL (1) | IL250803B (enExample) |
| MX (2) | MX380810B (enExample) |
| PL (1) | PL3186233T3 (enExample) |
| PT (1) | PT3186233T (enExample) |
| SG (1) | SG11201701600QA (enExample) |
| SI (1) | SI3186233T1 (enExample) |
| WO (1) | WO2016033445A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX386798B (es) | 2014-08-29 | 2025-03-19 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
| ES2818107T3 (es) | 2014-08-29 | 2021-04-09 | Chdi Foundation Inc | Sondas para obtener imágenes de la proteína huntingtina |
| US10479802B2 (en) | 2014-08-29 | 2019-11-19 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| DK3186241T3 (da) | 2014-08-29 | 2021-01-11 | Chdi Foundation Inc | Prober til billeddannelse af huntington-protein |
| PT3340796T (pt) | 2015-08-28 | 2021-07-28 | Chdi Foundation Inc | Sondas para imagens da proteína huntingtina |
| CN116199700A (zh) | 2016-03-11 | 2023-06-02 | Ac免疫有限公司 | 用于诊断和治疗的双环化合物 |
| CN107056723A (zh) * | 2017-04-21 | 2017-08-18 | 云南大学 | 一种具有抑制血管内皮生长因子受体信号传导的化合物 |
| US11512067B2 (en) | 2017-09-14 | 2022-11-29 | Daiichi Sankyo Company, Limited | Compound having cyclic structure |
| US20210169080A1 (en) | 2018-04-20 | 2021-06-10 | Bayer Aktiengesellschaft | Heterocycle derivatives as pesticides |
| US20210252175A1 (en) | 2018-06-08 | 2021-08-19 | Ac Immune Sa | Novel compounds for diagnosis |
| AR117472A1 (es) | 2018-12-21 | 2021-08-11 | Celgene Corp | Inhibidores de tienopiridina de ripk2 |
| EP3931186A1 (en) | 2019-02-25 | 2022-01-05 | CHDI Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| CN111635400A (zh) | 2019-03-02 | 2020-09-08 | 察略盛医药科技(上海)有限公司 | 吡唑并[1,5-a]吡啶类衍生物、及其制备方法和用途 |
| ES3029867T3 (en) * | 2019-12-18 | 2025-06-25 | Chdi Foundation Inc | Compounds and probes for imaging huntingtin protein |
| MX2022008627A (es) | 2020-01-13 | 2022-11-08 | Verge Analytics Inc | Pirazolo-pirimidinas sustituidas y usos de las mismas. |
| IL297965A (en) | 2020-05-07 | 2023-01-01 | Ac Immune Sa | New compounds for diagnosis |
| CA3190418A1 (en) * | 2020-08-06 | 2022-02-10 | Chdi Foundation, Inc. | Heterobiaryl compounds and imaging agents for imaging huntingtin protein |
| IL307507A (en) * | 2021-04-08 | 2023-12-01 | Chdi Foundation Inc | Isoindolinone compounds and imaging agents for imaging HUNTINGTIN protein |
| MX2023012652A (es) | 2021-04-27 | 2024-01-08 | Chdi Foundation Inc | Compuestos deuterados y agentes de imagen para representar la proteína huntingtina. |
| TW202317546A (zh) | 2021-07-09 | 2023-05-01 | 美商普萊克斯姆公司 | 調節ikzf2之芳基化合物及醫藥組合物 |
| KR20240116741A (ko) | 2021-11-10 | 2024-07-30 | 에이씨 이뮨 에스에이 | 디하이드로피롤로[3,4c]-피라졸 유도체 및 진단에서의 그의 용도 |
| US20250042905A1 (en) | 2021-11-10 | 2025-02-06 | Ac Immune Sa | Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis |
| MX2024005426A (es) | 2021-11-10 | 2024-05-21 | Ac Immune Sa | Derivados de 4h-imidazo[1,5-b]pirazol para diagnostico. |
| TW202425965A (zh) | 2022-09-30 | 2024-07-01 | 日商科研製藥股份有限公司 | 縮環化合物及含有其之醫藥 |
| CN120344535A (zh) | 2022-12-16 | 2025-07-18 | Ac免疫有限公司 | 用于诊断的新化合物 |
| EP4634190A1 (en) | 2022-12-16 | 2025-10-22 | AC Immune SA | Novel compounds for diagnosis |
| WO2024239000A2 (en) * | 2023-05-18 | 2024-11-21 | Enveda Therapeutics, Inc. | G-protein coupled receptor antagonist |
| WO2025037013A1 (en) | 2023-08-16 | 2025-02-20 | Ac Immune Sa | Diagnostic compounds that bind to alpha-synuclein |
| WO2025106920A1 (en) * | 2023-11-15 | 2025-05-22 | Yale University | Parp pet imaging agents and methods of using the same |
| CN119264072B (zh) * | 2024-12-06 | 2025-05-02 | 国科大杭州高等研究院 | 对细胞成像的荧光探针及其合成方法和应用 |
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| WO2010051196A1 (en) * | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| US20110085985A1 (en) * | 2008-05-30 | 2011-04-14 | Barrow James C | Novel substituted azabenzoxazoles |
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| DE2909754A1 (de) * | 1979-03-13 | 1980-09-18 | Thomae Gmbh Dr K | Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel |
| FR2524468B1 (fr) | 1982-04-06 | 1985-10-18 | Sandoz Sa | Nouveaux derives condenses du thiophene, leur preparation et leur utilisation comme azurants optiques |
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| GB9203798D0 (en) | 1992-02-21 | 1992-04-08 | Fujisawa Pharmaceutical Co | Quinolylbenzofuran derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| WO1994022846A1 (en) * | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
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| JPH08325265A (ja) * | 1995-05-29 | 1996-12-10 | Fujisawa Pharmaceut Co Ltd | チアゾリルベンゾフラン誘導体の製造方法、および該製造方法に用いられる化合物 |
| US5994378A (en) | 1996-01-22 | 1999-11-30 | Fujisawa Pharmaceutical Co., Ltd. | Thiazolylbenzofuran derivatives and pharmaceutical compositions containing them |
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