JP2017538721A5 - - Google Patents
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- JP2017538721A5 JP2017538721A5 JP2017532157A JP2017532157A JP2017538721A5 JP 2017538721 A5 JP2017538721 A5 JP 2017538721A5 JP 2017532157 A JP2017532157 A JP 2017532157A JP 2017532157 A JP2017532157 A JP 2017532157A JP 2017538721 A5 JP2017538721 A5 JP 2017538721A5
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- tautomer
- stereoisomer
- hydrate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003814 drug Substances 0.000 claims 21
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- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical group 0.000 claims 11
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- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 10
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- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
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| US12329755B2 (en) | 2019-08-29 | 2025-06-17 | University Of Tennessee Research Foundation | Bromodomain inhibitors to target therapy-resistant cancer |
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| CN113712963B (zh) * | 2021-10-15 | 2022-09-23 | 中国科学院昆明动物研究所 | Bet抑制剂bms-986158在制备抗艾滋病的药物中的应用 |
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| CA2966298A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| CA2966303A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
| WO2016092375A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Corp. | Substituted heterocycles as bromodomain inhibitors |
| WO2016097870A1 (en) | 2014-12-17 | 2016-06-23 | Zenith Epigenetics Corp. | Substituted bicyclic compounds as bromodomain inhibitors |
| CN107406438B (zh) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
-
2015
- 2015-12-16 CN CN201580066751.6A patent/CN107406438B/zh active Active
- 2015-12-16 EP EP15869419.0A patent/EP3233846A4/en not_active Withdrawn
- 2015-12-16 HK HK18104393.5A patent/HK1245247A1/zh unknown
- 2015-12-16 US US15/534,166 patent/US10231953B2/en not_active Expired - Fee Related
- 2015-12-16 JP JP2017532157A patent/JP2017538721A/ja active Pending
- 2015-12-16 CA CA2966450A patent/CA2966450A1/en not_active Abandoned
- 2015-12-16 WO PCT/IB2015/002490 patent/WO2016097863A1/en not_active Ceased
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