IL215342A0 - Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocotricoid activity - Google Patents

Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocotricoid activity

Info

Publication number
IL215342A0
IL215342A0 IL215342A IL21534211A IL215342A0 IL 215342 A0 IL215342 A0 IL 215342A0 IL 215342 A IL215342 A IL 215342A IL 21534211 A IL21534211 A IL 21534211A IL 215342 A0 IL215342 A0 IL 215342A0
Authority
IL
Israel
Prior art keywords
glucocotricoid
steroidal
activity
amide derivatives
pyrazole compounds
Prior art date
Application number
IL215342A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Ivanova Svetlana
Burkamp Frank
Gabos Balint
Lisius Alice Ingrid Annea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42826696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL215342(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Ivanova Svetlana, Burkamp Frank, Gabos Balint, Lisius Alice Ingrid Annea filed Critical Astrazeneca Ab
Publication of IL215342A0 publication Critical patent/IL215342A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL215342A 2009-04-03 2011-09-22 Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocotricoid activity IL215342A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16632409P 2009-04-03 2009-04-03
PCT/SE2010/050354 WO2010114471A1 (en) 2009-04-03 2010-03-31 Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity

Publications (1)

Publication Number Publication Date
IL215342A0 true IL215342A0 (en) 2011-12-29

Family

ID=42826696

Family Applications (1)

Application Number Title Priority Date Filing Date
IL215342A IL215342A0 (en) 2009-04-03 2011-09-22 Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocotricoid activity

Country Status (24)

Country Link
US (2) US20100256104A1 (enExample)
EP (1) EP2414375A4 (enExample)
JP (1) JP2012522766A (enExample)
KR (1) KR20120034608A (enExample)
CN (1) CN102459306A (enExample)
AR (1) AR076176A1 (enExample)
AU (1) AU2010231954B2 (enExample)
CA (1) CA2757423A1 (enExample)
CL (1) CL2011002461A1 (enExample)
CO (1) CO6501167A2 (enExample)
CR (1) CR20110518A (enExample)
CU (1) CU20110186A7 (enExample)
DO (1) DOP2011000305A (enExample)
EA (1) EA201190234A1 (enExample)
EC (1) ECSP11011368A (enExample)
IL (1) IL215342A0 (enExample)
MX (1) MX2011010263A (enExample)
NI (1) NI201100177A (enExample)
PE (1) PE20120544A1 (enExample)
SG (1) SG174506A1 (enExample)
TW (1) TW201040196A (enExample)
UY (1) UY32525A (enExample)
WO (1) WO2010114471A1 (enExample)
ZA (1) ZA201108050B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008306593C1 (en) * 2007-10-04 2012-10-04 Astrazeneca Ab Steroidal [3, 2-C] pyrazole compounds, with glucocorticoid activity
CA2707618A1 (en) * 2007-12-20 2009-07-02 Astrazeneca Ab Steroid derivatives acting as glucocorticosteroid receptor agonists
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
PE20140868A1 (es) 2011-06-24 2014-07-18 Amgen Inc Antagonistas trpm8 y su uso en tratamientos
CA2839703A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
WO2015048316A1 (en) * 2013-09-25 2015-04-02 Van Andel Research Institute Highly potent glucocorticoids
JP7146750B2 (ja) * 2016-10-14 2022-10-04 ヴァン アンデル リサーチ インスティテュート 非常に強力な糖質コルチコイドの構造およびデザインのための機構
WO2024159212A1 (en) * 2023-01-27 2024-08-02 University Of South Florida Compositions and methods of treating respiratory syncytial virus
CN117024499A (zh) * 2023-07-17 2023-11-10 陕西汉江药业集团股份有限公司 在2位引入亚甲基羟基的甾体化合物制备方法
WO2025119398A1 (zh) * 2023-12-08 2025-06-12 浙江柏拉阿图医药科技有限公司 高效力糖皮质激素多晶型及其制备方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129218A (en) * 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) * 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) * 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2727367A1 (de) * 1977-06-14 1979-01-04 Schering Ag Neue kortikoide
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
ES2314052T3 (es) * 2001-04-30 2009-03-16 Glaxo Group Limited Derivados de ester de 17beta-carbotioato de androstano con un grupo ester ciclico en la posicion 17alfa.
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AU2008306593C1 (en) * 2007-10-04 2012-10-04 Astrazeneca Ab Steroidal [3, 2-C] pyrazole compounds, with glucocorticoid activity
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias

Also Published As

Publication number Publication date
SG174506A1 (en) 2011-10-28
KR20120034608A (ko) 2012-04-12
TW201040196A (en) 2010-11-16
CA2757423A1 (en) 2010-10-07
ECSP11011368A (es) 2011-11-30
US20100256104A1 (en) 2010-10-07
MX2011010263A (es) 2011-10-11
CN102459306A (zh) 2012-05-16
WO2010114471A1 (en) 2010-10-07
CO6501167A2 (es) 2012-08-15
AR076176A1 (es) 2011-05-26
EA201190234A1 (ru) 2012-04-30
ZA201108050B (en) 2014-04-30
JP2012522766A (ja) 2012-09-27
CL2011002461A1 (es) 2012-04-09
NI201100177A (es) 2012-06-14
CR20110518A (es) 2011-11-07
US20130237507A1 (en) 2013-09-12
DOP2011000305A (es) 2012-05-31
AU2010231954A1 (en) 2011-10-27
EP2414375A1 (en) 2012-02-08
EP2414375A4 (en) 2012-09-19
CU20110186A7 (es) 2012-02-15
PE20120544A1 (es) 2012-06-03
UY32525A (es) 2010-10-29
AU2010231954B2 (en) 2012-11-15

Similar Documents

Publication Publication Date Title
IL215342A0 (en) Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocotricoid activity
ZA201203615B (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
ZA201108049B (en) Novel derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity
ZA201002223B (en) Steroidal [3,2-c]pyrazole compounds,with glucocorticoid activity
IL206664A0 (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
IL208203A0 (en) Heterocyclic derivatives
SI2260029T1 (sl) Priprava morfolinskih derivatov
IL206576A0 (en) Monosebacate of pyrazole derivative
ZA201107350B (en) Imidazo [2 1 b] [1, 3, 4] thiadiazole derivatives
PL2225238T3 (pl) Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego
EP2242493A4 (en) Gefitinib DERIVATIVES
ZA201005383B (en) Substituted arylamide ozazepinopyrimidone derivatives
PT2462133E (pt) Derivados 5-fluoro-2-oxopirimidina-1(2h)-carboxilato
ZA201201473B (en) Spirocyclic amide derivatives
EP2448934A4 (en) DERIVATIVES OF 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN
IL215153A0 (en) Amide derivative compounds, compositions comprising the same and uses there of
IL218500A0 (en) Apogossypolone derivatives as anticaner agents
IL214764A0 (en) Process for the preparation of pyrazole derivatives
GB0604899D0 (en) Derivatives of 18-glycyrrhetinic acid
GB0921210D0 (en) Novel heterocyclic derivatives
IL215521A0 (en) DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES
PL2603512T3 (pl) Pochodne 6,7-dihydro-3h-oksazolo[3,4-a]pirazyno-5,8-dionu
IL199684A0 (en) Methods for improved stability of steroid derivatives
HK1164328A (en) Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity
GB0806744D0 (en) Novel pyrazole derivatives