AR076176A1 - Derivados de amida de pirazol (3,2-c) esteroides con actividad agonista del receptor de glucocorticoesteroides - Google Patents
Derivados de amida de pirazol (3,2-c) esteroides con actividad agonista del receptor de glucocorticoesteroidesInfo
- Publication number
- AR076176A1 AR076176A1 ARP100101088A ARP100101088A AR076176A1 AR 076176 A1 AR076176 A1 AR 076176A1 AR P100101088 A ARP100101088 A AR P100101088A AR P100101088 A ARP100101088 A AR P100101088A AR 076176 A1 AR076176 A1 AR 076176A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydroxyl
- group
- halogen
- Prior art date
Links
- 230000001270 agonistic effect Effects 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
- 125000000623 heterocyclic group Chemical group 0.000 abstract 8
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
- 229920006395 saturated elastomer Polymers 0.000 abstract 6
- -1 cyano, hydroxyl Chemical group 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004043 oxo group Chemical group O=* 0.000 abstract 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 3
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005102 carbonylalkoxy group Chemical group 0.000 abstract 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16632409P | 2009-04-03 | 2009-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR076176A1 true AR076176A1 (es) | 2011-05-26 |
Family
ID=42826696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100101088A AR076176A1 (es) | 2009-04-03 | 2010-03-31 | Derivados de amida de pirazol (3,2-c) esteroides con actividad agonista del receptor de glucocorticoesteroides |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20100256104A1 (enExample) |
| EP (1) | EP2414375A4 (enExample) |
| JP (1) | JP2012522766A (enExample) |
| KR (1) | KR20120034608A (enExample) |
| CN (1) | CN102459306A (enExample) |
| AR (1) | AR076176A1 (enExample) |
| AU (1) | AU2010231954B2 (enExample) |
| CA (1) | CA2757423A1 (enExample) |
| CL (1) | CL2011002461A1 (enExample) |
| CO (1) | CO6501167A2 (enExample) |
| CR (1) | CR20110518A (enExample) |
| CU (1) | CU20110186A7 (enExample) |
| DO (1) | DOP2011000305A (enExample) |
| EA (1) | EA201190234A1 (enExample) |
| EC (1) | ECSP11011368A (enExample) |
| IL (1) | IL215342A0 (enExample) |
| MX (1) | MX2011010263A (enExample) |
| NI (1) | NI201100177A (enExample) |
| PE (1) | PE20120544A1 (enExample) |
| SG (1) | SG174506A1 (enExample) |
| TW (1) | TW201040196A (enExample) |
| UY (1) | UY32525A (enExample) |
| WO (1) | WO2010114471A1 (enExample) |
| ZA (1) | ZA201108050B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010003698A (es) * | 2007-10-04 | 2010-04-21 | Astrazeneca Ab | Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide. |
| US20110160167A1 (en) * | 2007-12-20 | 2011-06-30 | Astrazeneca Ab | Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists |
| UY32520A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| EP2723718A1 (en) | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| AP2013007331A0 (en) | 2011-06-24 | 2013-12-31 | Amgen Inc | TRPM8 antagonists and their use in treatments |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| HK1222565A1 (zh) * | 2013-09-25 | 2017-07-07 | 范安德尔研究所 | 高效糖皮質激素 |
| US10954265B2 (en) | 2016-10-14 | 2021-03-23 | Van Andel Research Institute | Structures and mechanism for the design of highly potent glucocorticoids |
| WO2024159212A1 (en) * | 2023-01-27 | 2024-08-02 | University Of South Florida | Compositions and methods of treating respiratory syncytial virus |
| CN117024499A (zh) * | 2023-07-17 | 2023-11-10 | 陕西汉江药业集团股份有限公司 | 在2位引入亚甲基羟基的甾体化合物制备方法 |
| AU2024396409A1 (en) * | 2023-12-08 | 2026-07-09 | Zhejiang Palo Alto Pharmaceuticals, Inc. | High-efficacy glucocorticoid polymorph, preparation method therefor, and use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3129218A (en) * | 1961-11-01 | 1964-04-14 | Merck & Co Inc | 2-alkoxymethylene steroids of the androstane and pregnane series |
| US3072639A (en) * | 1962-03-05 | 1963-01-08 | Merck & Co Inc | 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them |
| US3364203A (en) * | 1965-09-09 | 1968-01-16 | Syntex Corp | 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation |
| US3471477A (en) * | 1967-10-18 | 1969-10-07 | Syntex Corp | 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids |
| DE2727367A1 (de) * | 1977-06-14 | 1979-01-04 | Schering Ag | Neue kortikoide |
| DE2735110A1 (de) * | 1977-08-04 | 1979-02-15 | Hoechst Ag | Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung |
| DE2817988A1 (de) * | 1978-04-25 | 1979-11-08 | Hoechst Ag | Corticoid 17-alkylcarbonate und verfahren zu deren herstellung |
| SE8306370D0 (sv) * | 1983-11-18 | 1983-11-18 | Draco Ab | Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions |
| AR033290A1 (es) * | 2001-04-30 | 2003-12-10 | Glaxo Group Ltd | Derivados antiinflamatorios de androstano |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| MX2010003698A (es) * | 2007-10-04 | 2010-04-21 | Astrazeneca Ab | Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide. |
| UY32520A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32521A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Combinación para emplear en el tratamiento de enfermedades respiratorias |
-
2010
- 2010-03-26 UY UY0001032525A patent/UY32525A/es not_active Application Discontinuation
- 2010-03-30 US US12/749,903 patent/US20100256104A1/en not_active Abandoned
- 2010-03-31 AU AU2010231954A patent/AU2010231954B2/en not_active Ceased
- 2010-03-31 WO PCT/SE2010/050354 patent/WO2010114471A1/en not_active Ceased
- 2010-03-31 EP EP10759125A patent/EP2414375A4/en not_active Withdrawn
- 2010-03-31 PE PE2011001757A patent/PE20120544A1/es not_active Application Discontinuation
- 2010-03-31 JP JP2012503371A patent/JP2012522766A/ja active Pending
- 2010-03-31 CN CN2010800248242A patent/CN102459306A/zh active Pending
- 2010-03-31 SG SG2011068327A patent/SG174506A1/en unknown
- 2010-03-31 KR KR1020117026112A patent/KR20120034608A/ko not_active Withdrawn
- 2010-03-31 AR ARP100101088A patent/AR076176A1/es unknown
- 2010-03-31 CA CA2757423A patent/CA2757423A1/en not_active Abandoned
- 2010-03-31 MX MX2011010263A patent/MX2011010263A/es not_active Application Discontinuation
- 2010-03-31 EA EA201190234A patent/EA201190234A1/ru unknown
- 2010-04-02 TW TW099110330A patent/TW201040196A/zh unknown
-
2011
- 2011-09-22 IL IL215342A patent/IL215342A0/en unknown
- 2011-09-30 CO CO11129266A patent/CO6501167A2/es not_active Application Discontinuation
- 2011-10-03 DO DO2011000305A patent/DOP2011000305A/es unknown
- 2011-10-03 CR CR20110518A patent/CR20110518A/es unknown
- 2011-10-03 NI NI201100177A patent/NI201100177A/es unknown
- 2011-10-03 EC EC2011011368A patent/ECSP11011368A/es unknown
- 2011-10-03 CL CL2011002461A patent/CL2011002461A1/es unknown
- 2011-10-03 CU CU20110186A patent/CU20110186A7/es unknown
- 2011-11-02 ZA ZA2011/08050A patent/ZA201108050B/en unknown
-
2013
- 2013-04-17 US US13/864,644 patent/US20130237507A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20130237507A1 (en) | 2013-09-12 |
| NI201100177A (es) | 2012-06-14 |
| ZA201108050B (en) | 2014-04-30 |
| EP2414375A4 (en) | 2012-09-19 |
| CR20110518A (es) | 2011-11-07 |
| US20100256104A1 (en) | 2010-10-07 |
| KR20120034608A (ko) | 2012-04-12 |
| MX2011010263A (es) | 2011-10-11 |
| ECSP11011368A (es) | 2011-11-30 |
| CA2757423A1 (en) | 2010-10-07 |
| DOP2011000305A (es) | 2012-05-31 |
| UY32525A (es) | 2010-10-29 |
| CO6501167A2 (es) | 2012-08-15 |
| WO2010114471A1 (en) | 2010-10-07 |
| IL215342A0 (en) | 2011-12-29 |
| TW201040196A (en) | 2010-11-16 |
| PE20120544A1 (es) | 2012-06-03 |
| SG174506A1 (en) | 2011-10-28 |
| CN102459306A (zh) | 2012-05-16 |
| EA201190234A1 (ru) | 2012-04-30 |
| CL2011002461A1 (es) | 2012-04-09 |
| EP2414375A1 (en) | 2012-02-08 |
| AU2010231954A1 (en) | 2011-10-27 |
| CU20110186A7 (es) | 2012-02-15 |
| JP2012522766A (ja) | 2012-09-27 |
| AU2010231954B2 (en) | 2012-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |