AR091208A1 - Derivados de piperidina - Google Patents
Derivados de piperidinaInfo
- Publication number
- AR091208A1 AR091208A1 ARP130101895A AR091208A1 AR 091208 A1 AR091208 A1 AR 091208A1 AR P130101895 A ARP130101895 A AR P130101895A AR 091208 A1 AR091208 A1 AR 091208A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- alkoxycarbonyl
- haloalkyl
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Derivados de piperidina reguladores del receptor de proquineticinas. Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable de este para su uso en el tratamiento de una enfermedad o afección mediada por una proquineticina, caracterizado porque en la fórmula (1) W, X, Y y Z representan, cada uno independientemente, N, NH o CH, siempre que W, X, Y y Z no representen, cada uno simultáneamente, un resto CH; m es 0, 1, 2 ó 3; cada R¹ representa independientemente halógeno, ciano, alcoxi C₁₋₆, alcoxicarbonilo C₁₋₆, haloalquilo C₁₋₆, haloalcoxi C₁₋₆, alquiltio C₁₋₆, alquilcarbonilo C₁₋₆, o alquilo C₁₋₆ opcionalmente sustituido con carboxilo o alcoxicarbonilo C₁₋₆; n es 0, 1, 2, 3 o 4; cada R² representa independientemente halógeno, ciano, carboxilo, hidroxilo, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, alcoxicarbonilo C₁₋₆, alcoxi C₁₋₆alquilo C₁₋₆ o un sistema de anillos heterocíclicos de 5 a 9 miembros; R³ representa un átomo de oxígeno o azufre o un grupo C=O, NR⁵ o CR⁶R⁷; R⁵ representa un átomo de hidrógeno o un grupo alquilo C₁₋₆; R⁶ y R⁷ representan, cada uno independientemente, un átomo de hidrógeno o halógeno o ciano, carboxilo, hidroxilo, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, hidroxialquilo C₁₋₆, alcoxicarbonilo C₁₋₆, alcoxi C₁₋₆alquilo C₁₋₆ o un sistema de anillos heterocíclicos de 5 a 9 miembros; R⁴ representa un sistema de anillos heteroaromáticos o aromáticos de 6 a 10 miembros, el sistema de anillos se encuentra opcionalmente sustituido por al menos un sustituyente seleccionado de halógeno, hidroxilo, ciano, oxo, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, haloalquilo C₁₋₆, hidroxialquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, alquiltio C₁₋₆, alquilsulfinilo C₁₋₆, alquilsulfonilo C₁₋₆, alquilcarbonilo C₁₋₆, alquilcarboniloxi C₁₋₆, alcoxicarbonilo C₁₋₆, amino, -CON(R⁸)₂, alquilamino C₁₋₆, di-(alquilo C₁₋₆)amino, cicloalquilo C₃₋₆, cicloalquiloxi C₃₋₆ o cicloalquilmetilo C₃₋₆; y cada R⁸ representa independientemente un átomo de hidrógeno o un grupo alquilo C₁₋₆.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201209587A GB201209587D0 (en) | 2012-05-30 | 2012-05-30 | Therapeutic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR091208A1 true AR091208A1 (es) | 2015-01-21 |
Family
ID=46546171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130101895 AR091208A1 (es) | 2012-05-30 | 2013-05-30 | Derivados de piperidina |
Country Status (24)
| Country | Link |
|---|---|
| US (6) | US20130324576A1 (es) |
| EP (1) | EP2855449B1 (es) |
| JP (1) | JP6177896B2 (es) |
| CN (1) | CN104520292B (es) |
| AR (1) | AR091208A1 (es) |
| CA (1) | CA2873850C (es) |
| CY (1) | CY1120420T1 (es) |
| DK (1) | DK2855449T3 (es) |
| ES (1) | ES2671629T3 (es) |
| GB (1) | GB201209587D0 (es) |
| HK (1) | HK1208675A1 (es) |
| HR (1) | HRP20180729T1 (es) |
| HU (1) | HUE037673T2 (es) |
| LT (1) | LT2855449T (es) |
| ME (1) | ME03078B (es) |
| NO (1) | NO2855449T3 (es) |
| PL (1) | PL2855449T3 (es) |
| PT (1) | PT2855449T (es) |
| RS (1) | RS57329B1 (es) |
| SI (1) | SI2855449T1 (es) |
| TR (1) | TR201807666T4 (es) |
| TW (1) | TWI612041B (es) |
| UY (1) | UY34835A (es) |
| WO (1) | WO2013179024A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
| EP3010900B1 (en) * | 2013-06-21 | 2018-01-03 | Takeda Pharmaceutical Company Limited | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors |
| GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
| GB201420095D0 (en) | 2014-11-12 | 2014-12-24 | Takeda Pharmaceutical | New use |
| CN106699635B (zh) * | 2015-11-12 | 2019-10-22 | 北京福元医药股份有限公司 | 一种制备Delamanid中间体的方法 |
| US10865194B2 (en) | 2017-11-03 | 2020-12-15 | Fondazione Istituto Italiano Di Tecnologia | Therapeutically active bicyclic-sulphonamides and pharmaceutical compositions |
| CN111566105A (zh) | 2018-01-08 | 2020-08-21 | 豪夫迈·罗氏有限公司 | 作为MAGL抑制剂的八氢吡啶并[1,2-α]吡嗪类化合物 |
| CR20200416A (es) | 2018-03-22 | 2020-10-26 | Hoffmann La Roche | Nuevos compuestos heterocíclicos |
| EP3837263B1 (en) | 2018-08-13 | 2024-07-03 | F. Hoffmann-La Roche AG | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
| CA3151516A1 (en) | 2019-09-12 | 2021-03-18 | F. Hoffmann-La Roche Ag | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
| CA3190277A1 (en) | 2020-09-03 | 2022-03-10 | Joerg Benz | Heterocyclic compounds |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9701292A (es) | 1994-08-24 | 1997-05-31 | Astra Ab | Compuestos espiro-azabiciclicos utiles en la terapia. |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| AR013184A1 (es) | 1997-07-18 | 2000-12-13 | Astrazeneca Ab | Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis |
| SE9702799D0 (sv) | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
| CA2386517A1 (en) | 1999-10-07 | 2001-04-12 | Takeda Chemical Industries, Ltd. | Amine derivatives |
| SE9903760D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
| SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| CO5300399A1 (es) | 2000-02-25 | 2003-07-31 | Astrazeneca Ab | Heterocicliocs que contienen nitrogeno, proceso para su preparacion y composiciones farmaceuticas que los contienen |
| KR20030026979A (ko) | 2000-07-18 | 2003-04-03 | 야마노우치세이야쿠 가부시키가이샤 | 디시아노피리딘 유도체를 포함하는 의약 |
| SE0002729D0 (sv) | 2000-07-20 | 2000-07-20 | Astrazeneca Ab | Novel compound form |
| KR100915263B1 (ko) | 2001-05-18 | 2009-09-03 | 아스트라제네카 아베 | 4(페닐-피페라지닐-메틸)벤즈아미드 유도체 및 통증, 불안증 또는 위장관 장애 치료를 위한 이들의 용도 |
| JP2004532877A (ja) | 2001-06-01 | 2004-10-28 | アストラゼネカ・アクチエボラーグ | 治療に有効なニコチン性アセチルコリン受容体に対する新規なリガンド |
| EP1676844A1 (en) | 2004-12-28 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | 5-HT7 receptor antagonists |
| DE60328010D1 (de) | 2002-04-18 | 2009-07-30 | Astrazeneca Ab | Heterocyclische verbindungen |
| MXPA04010193A (es) | 2002-04-18 | 2005-02-03 | Astrazeneca Ab | Compuesto de tienilo. |
| WO2003087102A1 (en) | 2002-04-18 | 2003-10-23 | Astrazeneca Ab | Furyl compounds |
| SE0202430D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| SE0202465D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New compounds |
| SE0202598D0 (sv) | 2002-09-02 | 2002-09-02 | Astrazeneca Ab | Alpha-7 Nicotinic receptor agonists and statins in combination |
| US8580782B2 (en) * | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| BR0315166A (pt) * | 2002-10-11 | 2005-08-16 | Astrazeneca Ab | Uso de um composto ou de um sal farmaceuticamente aceitável do mesmo, composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para produzir um efeito inibidor de 11betahsd1 em um animal de sangue quente, tal como o homem, que necessita de tratamento |
| AU2003274551A1 (en) | 2002-11-12 | 2004-06-03 | Pfizer Products Inc. | Quinoline derivatives |
| WO2004074283A1 (en) * | 2003-02-21 | 2004-09-02 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
| EP2426120A1 (en) | 2003-08-18 | 2012-03-07 | Fujifilm Finechemicals Co., Ltd. | Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them |
| BRPI0417697A (pt) | 2003-12-15 | 2007-04-03 | Schering Corp | inibidores de protease de aspartila heterocìclicos |
| MXPA06011807A (es) | 2004-04-13 | 2007-02-21 | Icagen Inc | Piridinas policiclicas como moduladores del canal del ion de potasio. |
| AR058407A1 (es) | 2005-12-29 | 2008-01-30 | Janssen Pharmaceutica Nv | Antagonistas del receptor de proquineticina 2 |
| CA2635842C (en) | 2005-12-29 | 2015-02-17 | Janssen Pharmaceutica N.V. | Prokineticin 1 receptor antagonists |
| US7964728B2 (en) | 2006-07-06 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Azaindole derivatives with a combination of partial nicotinic acetyl-choline receptor agonism and dopamine reuptake inhibition |
| US7897776B2 (en) * | 2007-04-23 | 2011-03-01 | Salutria Pharmaceuticals Llc | Sulfonamide containing compounds for treatment of inflammatory disorders |
| WO2010077976A2 (en) | 2008-12-17 | 2010-07-08 | The Regents Of The University Of California | Prokineticin receptor antagonists and uses thereof |
| US8436019B2 (en) * | 2009-03-31 | 2013-05-07 | Vanderbilt University | Sulfonyl-piperidin-4-yl methylamine amide analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders |
| GB201209587D0 (en) * | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
-
2012
- 2012-05-30 GB GB201209587A patent/GB201209587D0/en not_active Ceased
-
2013
- 2013-05-20 TW TW102117795A patent/TWI612041B/zh active
- 2013-05-29 PT PT137282380T patent/PT2855449T/pt unknown
- 2013-05-29 HU HUE13728238A patent/HUE037673T2/hu unknown
- 2013-05-29 ES ES13728238.0T patent/ES2671629T3/es active Active
- 2013-05-29 JP JP2015514586A patent/JP6177896B2/ja active Active
- 2013-05-29 US US13/904,198 patent/US20130324576A1/en not_active Abandoned
- 2013-05-29 PL PL13728238T patent/PL2855449T3/pl unknown
- 2013-05-29 TR TR2018/07666T patent/TR201807666T4/tr unknown
- 2013-05-29 WO PCT/GB2013/051415 patent/WO2013179024A1/en active Application Filing
- 2013-05-29 RS RS20180673A patent/RS57329B1/sr unknown
- 2013-05-29 ME MEP-2018-154A patent/ME03078B/me unknown
- 2013-05-29 US US14/402,751 patent/US9475795B2/en active Active
- 2013-05-29 CA CA2873850A patent/CA2873850C/en active Active
- 2013-05-29 DK DK13728238.0T patent/DK2855449T3/en active
- 2013-05-29 CN CN201380037673.8A patent/CN104520292B/zh active Active
- 2013-05-29 LT LTEP13728238.0T patent/LT2855449T/lt unknown
- 2013-05-29 NO NO13728238A patent/NO2855449T3/no unknown
- 2013-05-29 SI SI201331026T patent/SI2855449T1/en unknown
- 2013-05-29 EP EP13728238.0A patent/EP2855449B1/en active Active
- 2013-05-30 AR ARP130101895 patent/AR091208A1/es active IP Right Grant
- 2013-05-30 UY UY34835A patent/UY34835A/es not_active Application Discontinuation
-
2015
- 2015-09-23 HK HK15109353.5A patent/HK1208675A1/xx unknown
-
2016
- 2016-09-12 US US15/262,436 patent/US10167273B2/en active Active
-
2018
- 2018-05-10 HR HRP20180729TT patent/HRP20180729T1/hr unknown
- 2018-05-31 CY CY20181100581T patent/CY1120420T1/el unknown
- 2018-11-19 US US16/194,762 patent/US10544126B2/en active Active
-
2019
- 2019-12-09 US US16/707,079 patent/US11512066B2/en active Active
-
2022
- 2022-10-10 US US17/962,781 patent/US12054474B2/en active Active
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