UY32525A - Compuestos que tienen actividad agonista del receptor de glucocorticosteroides - Google Patents

Compuestos que tienen actividad agonista del receptor de glucocorticosteroides

Info

Publication number
UY32525A
UY32525A UY0001032525A UY32525A UY32525A UY 32525 A UY32525 A UY 32525A UY 0001032525 A UY0001032525 A UY 0001032525A UY 32525 A UY32525 A UY 32525A UY 32525 A UY32525 A UY 32525A
Authority
UY
Uruguay
Prior art keywords
compounds
agonistic activity
glucocorticosteroid receptor
glucocorticosteroid
receptor
Prior art date
Application number
UY0001032525A
Other languages
English (en)
Spanish (es)
Inventor
Annea Lisius
Gabos Balint
Burkamp Frank
Ivanova Svetlana
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42826696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY32525(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY32525A publication Critical patent/UY32525A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
UY0001032525A 2009-04-03 2010-03-26 Compuestos que tienen actividad agonista del receptor de glucocorticosteroides UY32525A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16632409P 2009-04-03 2009-04-03

Publications (1)

Publication Number Publication Date
UY32525A true UY32525A (es) 2010-10-29

Family

ID=42826696

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032525A UY32525A (es) 2009-04-03 2010-03-26 Compuestos que tienen actividad agonista del receptor de glucocorticosteroides

Country Status (24)

Country Link
US (2) US20100256104A1 (enExample)
EP (1) EP2414375A4 (enExample)
JP (1) JP2012522766A (enExample)
KR (1) KR20120034608A (enExample)
CN (1) CN102459306A (enExample)
AR (1) AR076176A1 (enExample)
AU (1) AU2010231954B2 (enExample)
CA (1) CA2757423A1 (enExample)
CL (1) CL2011002461A1 (enExample)
CO (1) CO6501167A2 (enExample)
CR (1) CR20110518A (enExample)
CU (1) CU20110186A7 (enExample)
DO (1) DOP2011000305A (enExample)
EA (1) EA201190234A1 (enExample)
EC (1) ECSP11011368A (enExample)
IL (1) IL215342A0 (enExample)
MX (1) MX2011010263A (enExample)
NI (1) NI201100177A (enExample)
PE (1) PE20120544A1 (enExample)
SG (1) SG174506A1 (enExample)
TW (1) TW201040196A (enExample)
UY (1) UY32525A (enExample)
WO (1) WO2010114471A1 (enExample)
ZA (1) ZA201108050B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010003698A (es) * 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
US20110160167A1 (en) * 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
HK1222565A1 (zh) * 2013-09-25 2017-07-07 范安德尔研究所 高效糖皮質激素
US10954265B2 (en) 2016-10-14 2021-03-23 Van Andel Research Institute Structures and mechanism for the design of highly potent glucocorticoids
WO2024159212A1 (en) * 2023-01-27 2024-08-02 University Of South Florida Compositions and methods of treating respiratory syncytial virus
CN117024499A (zh) * 2023-07-17 2023-11-10 陕西汉江药业集团股份有限公司 在2位引入亚甲基羟基的甾体化合物制备方法
AU2024396409A1 (en) * 2023-12-08 2026-07-09 Zhejiang Palo Alto Pharmaceuticals, Inc. High-efficacy glucocorticoid polymorph, preparation method therefor, and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129218A (en) * 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) * 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) * 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2727367A1 (de) * 1977-06-14 1979-01-04 Schering Ag Neue kortikoide
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
AR033290A1 (es) * 2001-04-30 2003-12-10 Glaxo Group Ltd Derivados antiinflamatorios de androstano
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
MX2010003698A (es) * 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias

Also Published As

Publication number Publication date
US20130237507A1 (en) 2013-09-12
NI201100177A (es) 2012-06-14
ZA201108050B (en) 2014-04-30
EP2414375A4 (en) 2012-09-19
CR20110518A (es) 2011-11-07
US20100256104A1 (en) 2010-10-07
KR20120034608A (ko) 2012-04-12
MX2011010263A (es) 2011-10-11
ECSP11011368A (es) 2011-11-30
CA2757423A1 (en) 2010-10-07
DOP2011000305A (es) 2012-05-31
CO6501167A2 (es) 2012-08-15
WO2010114471A1 (en) 2010-10-07
IL215342A0 (en) 2011-12-29
TW201040196A (en) 2010-11-16
PE20120544A1 (es) 2012-06-03
SG174506A1 (en) 2011-10-28
CN102459306A (zh) 2012-05-16
EA201190234A1 (ru) 2012-04-30
CL2011002461A1 (es) 2012-04-09
EP2414375A1 (en) 2012-02-08
AU2010231954A1 (en) 2011-10-27
CU20110186A7 (es) 2012-02-15
JP2012522766A (ja) 2012-09-27
AU2010231954B2 (en) 2012-11-15
AR076176A1 (es) 2011-05-26

Similar Documents

Publication Publication Date Title
UY32523A (es) Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32611A (es) Compuestos de 1-cianoetilheterociclilcarboxamida sustituidos 750
NI201000043A (es) Compuestos de [3, 2-c] pirazol esteroides con actividad glucocorticoide.
UY33078A (es) Derivados de imidazoquinolina
ECSP14013215A (es) Compuestos novedosos
MX351507B (es) Composiciones farmaceuticas de co- cristales de tramadol y coxibs.
CR20150326A (es) Inhibidores de autotaxina
CL2012001971A1 (es) Compuestos derivados de 1-piperazinil-3-piridin-carboxilato, como bloqueadores de los canales de sodio dependientes de voltaje; composicion farmaceutica; y su uso para el tratamiento de enfermedades respiratorias o del tracto respiratorio tal como asma, epoc, tos, silicosis, entre otras.
PY1337526A (es) Métodos para tratar o prevenir asma administrando un antagonista de IL-4R.
CR20110518A (es) Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide
MX336497B (es) Compuestos de tetrahidro-pirido-piridina y tetrahidro-pirido-pirim idina y su uso como moduladores de los receptores de c5a.
ECSP15013883A (es) Benzamidas
ECSP11011558A (es) Nuevos compuestos químicos.
UY32734A (es) Compuestos agonistas del receptor esfingosina 1-fosfato
CR20170468A (es) Compuestos novedosos
UY35708A (es) Compuestos novedosos como antagonistas del receptor de ácido lisofosfatidico
UY32520A (es) Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
CL2017002498A1 (es) Piridopirimidinonas y su uso como modulares del receptor nmda
ECSP099827A (es) Herbicidas novedosos
ECSP16074482A (es) Ciclopentanos, tetrahidrofuranos y pirrolidinas sustituidas como antagonistas del receptor de orexina
CL2010001432A1 (es) Compuestos derivados de 2-oxo-alquil-1-piperazin-2-ona, afines por los receptores p75ntr; procedimiento para preparar los compuestos; compuesto intermediario; medicamento y composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos utiles para tratar enfermedades neurodegenerativas.
CR20160215A (es) Espiro-oxazolonas
CR20140092A (es) Oxi-ciclohexil-4h, 6h-5-oxa-2,3, 10b-triaza-benzo [e] azulenos como antagonistas de la v1a
CU20100057A7 (es) Compuestos [3,2-c] pirazol esteroides con actividad glucocorticoide
BR112018075817A2 (pt) composto de fórmula (i), medicamento e composição farmacêutica

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20190130