ECSP11011558A - Nuevos compuestos químicos. - Google Patents
Nuevos compuestos químicos.Info
- Publication number
- ECSP11011558A ECSP11011558A EC2011011558A ECSP11011558A ECSP11011558A EC SP11011558 A ECSP11011558 A EC SP11011558A EC 2011011558 A EC2011011558 A EC 2011011558A EC SP11011558 A ECSP11011558 A EC SP11011558A EC SP11011558 A ECSP11011558 A EC SP11011558A
- Authority
- EC
- Ecuador
- Prior art keywords
- chemical compounds
- new chemical
- compounds
- medications
- abnormal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención comprende compuestos de la fórmula general (1)en dondeA, B, R1 a R5, Rx m, n y p tal como se definen en la reivindicación 1, que son apropiados para el tratamiento de enfermedades que están caracterizadas por una proliferación celular excesiva o anormal, preparaciones farmacéuticas que contienen tales compuestos, así como su uso como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09161496 | 2009-05-29 | ||
EP10161628 | 2010-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP11011558A true ECSP11011558A (es) | 2012-01-31 |
Family
ID=42289495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2011011558A ECSP11011558A (es) | 2009-05-29 | 2011-12-27 | Nuevos compuestos químicos. |
Country Status (22)
Country | Link |
---|---|
US (1) | US8410126B2 (es) |
EP (1) | EP2435411B1 (es) |
JP (1) | JP5756799B2 (es) |
KR (1) | KR20120135010A (es) |
CN (1) | CN102448943A (es) |
AP (1) | AP2011005978A0 (es) |
AR (1) | AR076620A1 (es) |
AU (1) | AU2010251943A1 (es) |
BR (1) | BRPI1014994A2 (es) |
CA (1) | CA2763700A1 (es) |
CL (1) | CL2011003022A1 (es) |
CO (1) | CO6470899A2 (es) |
EA (1) | EA201101674A1 (es) |
EC (1) | ECSP11011558A (es) |
IL (1) | IL216084A0 (es) |
MA (1) | MA33302B1 (es) |
MX (1) | MX2011012643A (es) |
PE (1) | PE20120370A1 (es) |
SG (1) | SG176599A1 (es) |
TW (1) | TW201107308A (es) |
UY (1) | UY32673A (es) |
WO (1) | WO2010136559A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070293494A1 (en) * | 2006-06-15 | 2007-12-20 | Djung Jane F | 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
LT2300013T (lt) | 2008-05-21 | 2017-12-27 | Ariad Pharmaceuticals, Inc. | Fosforo dariniai kaip kinazių inhibitoriai |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
CA2827172C (en) | 2011-02-17 | 2019-02-26 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
JP5937111B2 (ja) | 2011-02-17 | 2016-06-22 | カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドCancer Therapeutics Crc Pty Limited | Fak阻害剤 |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
WO2013169401A1 (en) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
WO2018005356A1 (en) | 2016-06-27 | 2018-01-04 | Rigel Pharmaceuticals, Inc. | 2,4-diamino-pyrimidine compounds and method for making and using the compounds |
WO2019190259A1 (ko) * | 2018-03-30 | 2019-10-03 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 설폰아마이드 유도체 |
WO2022208454A1 (en) * | 2021-04-02 | 2022-10-06 | Bridge Biotherapeutics, Inc. | N2-phenylpyrimidine-2,4-diamine compounds, and preparation methods and methods of use thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001260081B2 (en) * | 2000-05-22 | 2005-07-28 | Leo Pharma A/S | Benzophenones as inhibitors of il-1beta and tnf-alpha |
WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
WO2003032997A1 (de) * | 2001-10-17 | 2003-04-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pyrimidinderivate, arzneimittel enthaltend diese verbindungen, deren verwendung und verfahren zu ihrer herstellung |
WO2004002964A1 (ja) * | 2002-06-28 | 2004-01-08 | Yamanouchi Pharmaceutical Co., Ltd. | ジアミノピリミジンカルボキサミド誘導体 |
US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
ES2338545T3 (es) * | 2002-12-20 | 2010-05-10 | Pfizer Products Inc. | Derivados de pirimidina para el tratamiento del crecimiento celular anormal. |
JP4099212B2 (ja) * | 2004-05-14 | 2008-06-11 | ファイザー・プロダクツ・インク | 異常な細胞増殖を処置するためのピリミジン誘導体 |
US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
US8623887B2 (en) | 2006-05-15 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Compounds |
ATE497496T1 (de) * | 2006-10-19 | 2011-02-15 | Rigel Pharmaceuticals Inc | 2,4-pyridimediamon-derivate als hemmer von jak- kinasen zur behandlung von autoimmunerkrankungen |
US8138339B2 (en) * | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
KR101773313B1 (ko) * | 2008-04-16 | 2017-08-31 | 포톨라 파마슈티컬스, 인코포레이티드 | syk 또는 JAK 키나제 억제제로서의 2,6-디아미노-피리미딘-5-일-카르복스아미드 |
-
2010
- 2010-05-21 US US12/784,813 patent/US8410126B2/en active Active
- 2010-05-28 WO PCT/EP2010/057408 patent/WO2010136559A1/en active Application Filing
- 2010-05-28 CA CA2763700A patent/CA2763700A1/en not_active Abandoned
- 2010-05-28 TW TW099117275A patent/TW201107308A/zh unknown
- 2010-05-28 EA EA201101674A patent/EA201101674A1/ru unknown
- 2010-05-28 SG SG2011086790A patent/SG176599A1/en unknown
- 2010-05-28 UY UY0001032673A patent/UY32673A/es not_active Application Discontinuation
- 2010-05-28 MA MA34394A patent/MA33302B1/fr unknown
- 2010-05-28 JP JP2012512388A patent/JP5756799B2/ja active Active
- 2010-05-28 BR BRPI1014994A patent/BRPI1014994A2/pt not_active Application Discontinuation
- 2010-05-28 PE PE2011002012A patent/PE20120370A1/es not_active Application Discontinuation
- 2010-05-28 AP AP2011005978A patent/AP2011005978A0/xx unknown
- 2010-05-28 EP EP10724385.9A patent/EP2435411B1/en active Active
- 2010-05-28 AU AU2010251943A patent/AU2010251943A1/en not_active Abandoned
- 2010-05-28 KR KR1020117031173A patent/KR20120135010A/ko not_active Application Discontinuation
- 2010-05-28 AR ARP100101883A patent/AR076620A1/es unknown
- 2010-05-28 MX MX2011012643A patent/MX2011012643A/es not_active Application Discontinuation
- 2010-05-28 CN CN2010800234907A patent/CN102448943A/zh active Pending
-
2011
- 2011-11-01 IL IL216084A patent/IL216084A0/en unknown
- 2011-11-29 CL CL2011003022A patent/CL2011003022A1/es unknown
- 2011-12-15 CO CO11173252A patent/CO6470899A2/es not_active Application Discontinuation
- 2011-12-27 EC EC2011011558A patent/ECSP11011558A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20120135010A (ko) | 2012-12-12 |
AR076620A1 (es) | 2011-06-22 |
SG176599A1 (en) | 2012-01-30 |
MX2011012643A (es) | 2011-12-14 |
CN102448943A (zh) | 2012-05-09 |
EA201101674A1 (ru) | 2012-06-29 |
JP2012528121A (ja) | 2012-11-12 |
EP2435411B1 (en) | 2014-10-29 |
AU2010251943A1 (en) | 2011-12-01 |
EP2435411A1 (en) | 2012-04-04 |
MA33302B1 (fr) | 2012-05-02 |
US20110130401A1 (en) | 2011-06-02 |
AP2011005978A0 (en) | 2011-12-31 |
US8410126B2 (en) | 2013-04-02 |
CO6470899A2 (es) | 2012-06-29 |
JP5756799B2 (ja) | 2015-07-29 |
BRPI1014994A2 (pt) | 2016-05-03 |
TW201107308A (en) | 2011-03-01 |
CL2011003022A1 (es) | 2012-07-13 |
UY32673A (es) | 2010-12-31 |
WO2010136559A1 (en) | 2010-12-02 |
CA2763700A1 (en) | 2010-12-02 |
IL216084A0 (en) | 2012-01-31 |
PE20120370A1 (es) | 2012-05-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ECSP11011558A (es) | Nuevos compuestos químicos. | |
ECSP13012448A (es) | Nuevas aminopirazoloquinazolinas. | |
UY32494A (es) | Nuevas 2,4-diaminopirimidinas, sales farmacéuticas de las mismas, composiciones conteniéndolas y aplicaciones | |
UY33817A (es) | ?nuevas oxindolpirimidinas bencílicas?. | |
UY32259A (es) | Nuevos compuestos de hidroxiareno, preparados farmaceuticos que los contienen y aplicaciones | |
UY33199A (es) | 5-alquinil-pirimidinas. | |
CR20150326A (es) | Inhibidores de autotaxina | |
ECSP12011830A (es) | Nuevos compuestos. | |
CO6470845A2 (es) | Derivados de pirimidina novedosos y su uso en el tratamiento del cancer y enfermedades adicionales | |
UY32240A (es) | Nuevas 2,4-diaminopirimidinas, sus sales farmacéuticamente aceptables, composiciones conteniéndolas y aplicaciones. | |
CR20140161A (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
MX2011005934A (es) | Compuestos organicos. | |
ECSP12012318A (es) | Inhibidores de pirazolil quinazolina cinasa | |
UY32611A (es) | Compuestos de 1-cianoetilheterociclilcarboxamida sustituidos 750 | |
CL2012001971A1 (es) | Compuestos derivados de 1-piperazinil-3-piridin-carboxilato, como bloqueadores de los canales de sodio dependientes de voltaje; composicion farmaceutica; y su uso para el tratamiento de enfermedades respiratorias o del tracto respiratorio tal como asma, epoc, tos, silicosis, entre otras. | |
ECSP099823A (es) | Nuevos compuestos químicos | |
PE20150966A1 (es) | Compuestos heteroaromaticos y su uso como ligandos d1 de dopamina | |
UY32009A (es) | 5-alquinil-pirimidinas | |
BR112012029647A2 (pt) | novos derivados de pirimidinas | |
UY33349A (es) | Nuevos compuestos de quinoxalina, quinolina y quinazolina, composiciones farmacéuticas que los contienen y uso de los mismos | |
ECSP11010816A (es) | Nuevos Compuestos | |
CR20150171A (es) | Benzamidas | |
CO6290768A2 (es) | Tiazolil-dihidro-indazoles | |
CO6460762A2 (es) | 5-alquinil-piridinas | |
ECSP12012110A (es) | 5-alquinil-pirimidinas |