PE20120544A1 - Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide - Google Patents

Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide

Info

Publication number
PE20120544A1
PE20120544A1 PE2011001757A PE2011001757A PE20120544A1 PE 20120544 A1 PE20120544 A1 PE 20120544A1 PE 2011001757 A PE2011001757 A PE 2011001757A PE 2011001757 A PE2011001757 A PE 2011001757A PE 20120544 A1 PE20120544 A1 PE 20120544A1
Authority
PE
Peru
Prior art keywords
methyl
pirazole
carbonyl
halogen
alkyl
Prior art date
Application number
PE2011001757A
Other languages
English (en)
Spanish (es)
Inventor
Frank Burkamp
Balint Gabos
Svetlana Ivanova
Alice Ingrid Annea Lisius
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42826696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120544(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20120544A1 publication Critical patent/PE20120544A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PE2011001757A 2009-04-03 2010-03-31 Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide PE20120544A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16632409P 2009-04-03 2009-04-03

Publications (1)

Publication Number Publication Date
PE20120544A1 true PE20120544A1 (es) 2012-06-03

Family

ID=42826696

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001757A PE20120544A1 (es) 2009-04-03 2010-03-31 Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide

Country Status (24)

Country Link
US (2) US20100256104A1 (enExample)
EP (1) EP2414375A4 (enExample)
JP (1) JP2012522766A (enExample)
KR (1) KR20120034608A (enExample)
CN (1) CN102459306A (enExample)
AR (1) AR076176A1 (enExample)
AU (1) AU2010231954B2 (enExample)
CA (1) CA2757423A1 (enExample)
CL (1) CL2011002461A1 (enExample)
CO (1) CO6501167A2 (enExample)
CR (1) CR20110518A (enExample)
CU (1) CU20110186A7 (enExample)
DO (1) DOP2011000305A (enExample)
EA (1) EA201190234A1 (enExample)
EC (1) ECSP11011368A (enExample)
IL (1) IL215342A0 (enExample)
MX (1) MX2011010263A (enExample)
NI (1) NI201100177A (enExample)
PE (1) PE20120544A1 (enExample)
SG (1) SG174506A1 (enExample)
TW (1) TW201040196A (enExample)
UY (1) UY32525A (enExample)
WO (1) WO2010114471A1 (enExample)
ZA (1) ZA201108050B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008306593C1 (en) * 2007-10-04 2012-10-04 Astrazeneca Ab Steroidal [3, 2-C] pyrazole compounds, with glucocorticoid activity
CA2707618A1 (en) * 2007-12-20 2009-07-02 Astrazeneca Ab Steroid derivatives acting as glucocorticosteroid receptor agonists
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
PE20140868A1 (es) 2011-06-24 2014-07-18 Amgen Inc Antagonistas trpm8 y su uso en tratamientos
CA2839703A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
WO2015048316A1 (en) * 2013-09-25 2015-04-02 Van Andel Research Institute Highly potent glucocorticoids
JP7146750B2 (ja) * 2016-10-14 2022-10-04 ヴァン アンデル リサーチ インスティテュート 非常に強力な糖質コルチコイドの構造およびデザインのための機構
WO2024159212A1 (en) * 2023-01-27 2024-08-02 University Of South Florida Compositions and methods of treating respiratory syncytial virus
CN117024499A (zh) * 2023-07-17 2023-11-10 陕西汉江药业集团股份有限公司 在2位引入亚甲基羟基的甾体化合物制备方法
WO2025119398A1 (zh) * 2023-12-08 2025-06-12 浙江柏拉阿图医药科技有限公司 高效力糖皮质激素多晶型及其制备方法和用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129218A (en) * 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) * 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) * 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2727367A1 (de) * 1977-06-14 1979-01-04 Schering Ag Neue kortikoide
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
ES2314052T3 (es) * 2001-04-30 2009-03-16 Glaxo Group Limited Derivados de ester de 17beta-carbotioato de androstano con un grupo ester ciclico en la posicion 17alfa.
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
AU2008306593C1 (en) * 2007-10-04 2012-10-04 Astrazeneca Ab Steroidal [3, 2-C] pyrazole compounds, with glucocorticoid activity
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias

Also Published As

Publication number Publication date
SG174506A1 (en) 2011-10-28
KR20120034608A (ko) 2012-04-12
IL215342A0 (en) 2011-12-29
TW201040196A (en) 2010-11-16
CA2757423A1 (en) 2010-10-07
ECSP11011368A (es) 2011-11-30
US20100256104A1 (en) 2010-10-07
MX2011010263A (es) 2011-10-11
CN102459306A (zh) 2012-05-16
WO2010114471A1 (en) 2010-10-07
CO6501167A2 (es) 2012-08-15
AR076176A1 (es) 2011-05-26
EA201190234A1 (ru) 2012-04-30
ZA201108050B (en) 2014-04-30
JP2012522766A (ja) 2012-09-27
CL2011002461A1 (es) 2012-04-09
NI201100177A (es) 2012-06-14
CR20110518A (es) 2011-11-07
US20130237507A1 (en) 2013-09-12
DOP2011000305A (es) 2012-05-31
AU2010231954A1 (en) 2011-10-27
EP2414375A1 (en) 2012-02-08
EP2414375A4 (en) 2012-09-19
CU20110186A7 (es) 2012-02-15
UY32525A (es) 2010-10-29
AU2010231954B2 (en) 2012-11-15

Similar Documents

Publication Publication Date Title
PE20120544A1 (es) Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide
PE20090776A1 (es) DERIVADOS DE TETRADECAHIDROCICLOPENTA[5,6]NAFTO[1,2-f]INDAZOL COMO AGONISTAS DEL RECEPTOR DE GLUCOCORTICOSTEROIDES
PE20081612A1 (es) Analogos de las pterinas
AR083813A1 (es) Derivados de pirazol aminopirimidina como moduladores de lrrk2
ES2721018T3 (es) N-Acil-(3-sustituido)-(8-metil)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor NK-3, composición farmacéutica, métodos para su uso en trastornos mediados por el receptor de NK-3
AR078171A1 (es) Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas
AR049706A1 (es) Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
AR075022A1 (es) Derivados oxadiazole como agonistas de los receptores de esfingosina-1-fosfato (s1p1)
PE20130404A1 (es) Compuestos heterociclicos agonistas del receptor ip
PH12015501878A1 (en) Tetrahydroimidazo[1,5-d][1,4]oxazepine derivative
PE20121614A1 (es) Derivados de 6-amino,4-carbonil-pirimidina sustituida como antagonistas del receptor ccr2
AR040351A1 (es) Derivados de quinuclidina-amida, composicion farmaceutica, procedimiento de preparacion del compuesto y su uso para fabricar medicamentos
MX2009011498A (es) Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
MX2013007295A (es) Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.
AR068045A1 (es) Derivados de catecolamina y prodrogas de los mismos
AR046200A1 (es) Derivados de pirazina y su uso farmaceutico. procesos de preparacion y composiciones farmaceuticas
BR112015015275A8 (pt) composto heterocíclico substituído por halogênio, antagonista do receptor de lpa, composição farmacêutica e uso
AR078278A1 (es) Antagonistas de la tiazol y oxazol hepcidina, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de anemias y enfermedades asociadas a deficiencias de hierro.
MX381182B (es) Compuesto heterociclico biciclico o triciclico novedoso.
CO6230982A2 (es) Compuestos triciclicos que contienen actividad antagonista de factor de liberacion de corticotropina y composiciones farmaceuticas que los contienen
AR079271A1 (es) 3,6-diazabiciclo(3.1.1)heptanos como ligandos de receptores nicotinicos neuronales de acetilcolina
PE20120894A1 (es) Derivados de isoxazolidina
AR066712A1 (es) Pirazol-pirrolidinas como inhibidores de gamma secretasa, una composicion farmaceutica que las comprende y su uso en eltratamiento de enfermedades mediadas por la inhibicion de la sintesis del peptido beta-amiloide.
CL2012000967A1 (es) Compuestos derivados de amida de los acidos indazol-4-carboxilico y 1-h-pirazolo[3,4-c]piridina-4-carboxilico, agonistas del receptor ccr1; composicion farmaceutica; utiles en el tratamiento de inflamaciones cronicas, alergias, soriasis, artritis reumatoidea, esclerosis multiple, diabetes tipo 1, entre otras.
AR059896A1 (es) Derivados estereoisomericos de tetrahidronaftaleno, metodo de preparacion, medicamentos que los contienen, y uso como agentes antiinflamatorios.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal