ZA201108050B - Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity - Google Patents

Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity

Info

Publication number
ZA201108050B
ZA201108050B ZA2011/08050A ZA201108050A ZA201108050B ZA 201108050 B ZA201108050 B ZA 201108050B ZA 2011/08050 A ZA2011/08050 A ZA 2011/08050A ZA 201108050 A ZA201108050 A ZA 201108050A ZA 201108050 B ZA201108050 B ZA 201108050B
Authority
ZA
South Africa
Prior art keywords
steroidal
amide derivatives
pyrazole compounds
glucocorticoid activity
novel amide
Prior art date
Application number
ZA2011/08050A
Other languages
English (en)
Inventor
Frank Burkamp
Svetlana Ivanova
Balint Gabos
Alice Ingrid Annea Lisius
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42826696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA201108050(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA201108050B publication Critical patent/ZA201108050B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
ZA2011/08050A 2009-04-03 2011-11-02 Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity ZA201108050B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16632409P 2009-04-03 2009-04-03
PCT/SE2010/050354 WO2010114471A1 (en) 2009-04-03 2010-03-31 Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity

Publications (1)

Publication Number Publication Date
ZA201108050B true ZA201108050B (en) 2014-04-30

Family

ID=42826696

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2011/08050A ZA201108050B (en) 2009-04-03 2011-11-02 Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity

Country Status (24)

Country Link
US (2) US20100256104A1 (enExample)
EP (1) EP2414375A4 (enExample)
JP (1) JP2012522766A (enExample)
KR (1) KR20120034608A (enExample)
CN (1) CN102459306A (enExample)
AR (1) AR076176A1 (enExample)
AU (1) AU2010231954B2 (enExample)
CA (1) CA2757423A1 (enExample)
CL (1) CL2011002461A1 (enExample)
CO (1) CO6501167A2 (enExample)
CR (1) CR20110518A (enExample)
CU (1) CU20110186A7 (enExample)
DO (1) DOP2011000305A (enExample)
EA (1) EA201190234A1 (enExample)
EC (1) ECSP11011368A (enExample)
IL (1) IL215342A0 (enExample)
MX (1) MX2011010263A (enExample)
NI (1) NI201100177A (enExample)
PE (1) PE20120544A1 (enExample)
SG (1) SG174506A1 (enExample)
TW (1) TW201040196A (enExample)
UY (1) UY32525A (enExample)
WO (1) WO2010114471A1 (enExample)
ZA (1) ZA201108050B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010003698A (es) * 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
US20110160167A1 (en) * 2007-12-20 2011-06-30 Astrazeneca Ab Steroid Derivatives Acting As Glucocorticosteroid Receptor Agonists
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
AP2013007331A0 (en) 2011-06-24 2013-12-31 Amgen Inc TRPM8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
HK1222565A1 (zh) * 2013-09-25 2017-07-07 范安德尔研究所 高效糖皮質激素
US10954265B2 (en) 2016-10-14 2021-03-23 Van Andel Research Institute Structures and mechanism for the design of highly potent glucocorticoids
WO2024159212A1 (en) * 2023-01-27 2024-08-02 University Of South Florida Compositions and methods of treating respiratory syncytial virus
CN117024499A (zh) * 2023-07-17 2023-11-10 陕西汉江药业集团股份有限公司 在2位引入亚甲基羟基的甾体化合物制备方法
AU2024396409A1 (en) * 2023-12-08 2026-07-09 Zhejiang Palo Alto Pharmaceuticals, Inc. High-efficacy glucocorticoid polymorph, preparation method therefor, and use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129218A (en) * 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) * 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) * 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2727367A1 (de) * 1977-06-14 1979-01-04 Schering Ag Neue kortikoide
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
AR033290A1 (es) * 2001-04-30 2003-12-10 Glaxo Group Ltd Derivados antiinflamatorios de androstano
GB0507165D0 (en) * 2005-04-08 2005-05-18 Glaxo Group Ltd Novel crystalline pharmaceutical product
MX2010003698A (es) * 2007-10-04 2010-04-21 Astrazeneca Ab Compuestos de [3,2-c]pirazol esteroides con actividad glucocorticoide.
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias

Also Published As

Publication number Publication date
US20130237507A1 (en) 2013-09-12
NI201100177A (es) 2012-06-14
EP2414375A4 (en) 2012-09-19
CR20110518A (es) 2011-11-07
US20100256104A1 (en) 2010-10-07
KR20120034608A (ko) 2012-04-12
MX2011010263A (es) 2011-10-11
ECSP11011368A (es) 2011-11-30
CA2757423A1 (en) 2010-10-07
DOP2011000305A (es) 2012-05-31
UY32525A (es) 2010-10-29
CO6501167A2 (es) 2012-08-15
WO2010114471A1 (en) 2010-10-07
IL215342A0 (en) 2011-12-29
TW201040196A (en) 2010-11-16
PE20120544A1 (es) 2012-06-03
SG174506A1 (en) 2011-10-28
CN102459306A (zh) 2012-05-16
EA201190234A1 (ru) 2012-04-30
CL2011002461A1 (es) 2012-04-09
EP2414375A1 (en) 2012-02-08
AU2010231954A1 (en) 2011-10-27
CU20110186A7 (es) 2012-02-15
JP2012522766A (ja) 2012-09-27
AU2010231954B2 (en) 2012-11-15
AR076176A1 (es) 2011-05-26

Similar Documents

Publication Publication Date Title
IL215342A0 (en) Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocotricoid activity
ZA201108049B (en) Novel derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity
IL204611A0 (en) Steroidal [3, 2-c] pyrazole compounds, with glucocorticoid activity
IL206664A0 (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
ZA201203615B (en) Derivatives of 1-amino-2-cyclobutylethylboronic acid
IL221132A0 (en) Derivatives of betulin
IL216226A0 (en) Cyclopenta [c] pyrrole-2-carboxylate derivatives, preparation thereof, and therapeutic use thereof
IL236830A0 (en) Diazahomoredene derivatives and methods of using them
SI2260029T1 (sl) Priprava morfolinskih derivatov
SI2225238T1 (sl) Derivati amidov 6,7-dihidro-5H-imidazo(1,2-a)imidazol-3-karboksilne kisline
EP2231687A4 (en) NEW DERIVATIVES OF ACYL-CYANPYRROLIDINES
ZA201203076B (en) Spirolactam derivatives and uses of same
IL218132B (en) Crystal forms of 7,6,5,4-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1h-cyclopenta[a]pyrrolo[4,3-c]carbazole-3, 1[2h]-dione and pharmaceutical preparations containing them
IL214764A0 (en) Process for the preparation of pyrazole derivatives
GB0604899D0 (en) Derivatives of 18-glycyrrhetinic acid
IL207557A0 (en) Process for the preparation of pregnane derivatives
IL215521A0 (en) DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES
IL199684A0 (en) Methods for improved stability of steroid derivatives
IL215512A0 (en) Substituted 1-alkylcinnolin-4(1h)-one derivatives, preparation thereof and therapeutic application of same
HK1164328A (en) Novel amide derivatives of steroidal[3,2-c]pyrazole compounds with glucocorticoid activity
HK1164329A (en) Novel derivatives of steroidaly[3,2-c]pyrazole compounds with glucocorticoid activity
GB0805036D0 (en) New use of cyclopenta[g]quinazoline derivatives
PL383550A1 (pl) Nowe pochodne benzeno- i pirydopirydazynonów
HK1143377A (en) Steroidal [3, 2-c]pyrazole compounds, with glucocorticoid activity
GB0821710D0 (en) Derivatives of dihydroindolone