MA27475A1 - Composes de pyrazolo [3,4-b] pyridine et leur utilisation en tant qu'inhibiteurs de phosphodiesterase - Google Patents

Composes de pyrazolo [3,4-b] pyridine et leur utilisation en tant qu'inhibiteurs de phosphodiesterase

Info

Publication number
MA27475A1
MA27475A1 MA28224A MA28224A MA27475A1 MA 27475 A1 MA27475 A1 MA 27475A1 MA 28224 A MA28224 A MA 28224A MA 28224 A MA28224 A MA 28224A MA 27475 A1 MA27475 A1 MA 27475A1
Authority
MA
Morocco
Prior art keywords
sub
sup
optionally substituted
formula
inhibitors
Prior art date
Application number
MA28224A
Other languages
English (en)
Inventor
David George Allen
Diane Mary Coe
Caroline Mary Cook
Michael Dennis Dowle
Christopher David Edlin
Julie Nicole Hamblin
Martin Redpath Johnson
Paul Spencer Jones
Graham Knowles Richard
Jane Mitchell Charlotte
Judith Redgrave Alison
Ward Peter
Kristian Lindvall Mika
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0221455A external-priority patent/GB0221455D0/en
Priority claimed from GBGB0230045.7A external-priority patent/GB0230045D0/en
Priority claimed from GB0306595A external-priority patent/GB0306595D0/en
Priority claimed from GB0308017A external-priority patent/GB0308017D0/en
Priority claimed from GB0319708A external-priority patent/GB0319708D0/en
Priority claimed from GB0321074A external-priority patent/GB0321074D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of MA27475A1 publication Critical patent/MA27475A1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un composé de la formule (I) ou bien un sel de celui-ci, dans laquelle R1 représente alkyle C1-4, fluoroalkyle C1-3, -CH2CH2OH ou -CH2CH2CO2 alkyle C1-2;R2 représente un atome d'hydrogène (H), méthyle ou fluoroalkyle C1;R3 représente cycloalkyle C3-8 facultativement substitué ou cycloalcényle C1-7 facultativement substitué mono-insaturé ou un groupe hétérocyclique facultativement substitué de sous-formule (aa), (bb) ou (cc); dans lesquelles n1 et n2 représentent indépendamment 1 ou 2, et dans lesquelles Y représente O, S, SO2, ou NR10; ou R3 représente un groupe bicyclique (dd) ou (ee); et dans laquelle X représente NR4R5 ou OR5a. Les composés sont des inhibiteurs de phosphodiestérase (PDE), en particulier des inhibiteurs de PDE4. L'invention concerne également l'utilisation d'un composé de la formule (I), ou d'un sel pharmaceutiquement acceptable de celui-ci, dans la fabrication d'un médicament destiné au traitement et/ou à la prophylaxie d'une maladie inflammatoire et/ou allergique chez un mammifère tel que l'homme, par exemple la bronchopneumopathie chronique obstructive (PBCO), l'asthme ou la rhinite allergique.
MA28224A 2002-09-16 2005-04-15 Composes de pyrazolo [3,4-b] pyridine et leur utilisation en tant qu'inhibiteurs de phosphodiesterase MA27475A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0221455A GB0221455D0 (en) 2002-09-16 2002-09-16 Compounds
GBGB0230045.7A GB0230045D0 (en) 2002-12-23 2002-12-23 Compounds
GB0306595A GB0306595D0 (en) 2003-03-21 2003-03-21 Compounds
GB0308017A GB0308017D0 (en) 2003-04-07 2003-04-07 Compounds
GB0319708A GB0319708D0 (en) 2003-08-21 2003-08-21 Compounds
GB0321074A GB0321074D0 (en) 2003-09-09 2003-09-09 Compounds

Publications (1)

Publication Number Publication Date
MA27475A1 true MA27475A1 (fr) 2005-08-01

Family

ID=31999797

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28224A MA27475A1 (fr) 2002-09-16 2005-04-15 Composes de pyrazolo [3,4-b] pyridine et leur utilisation en tant qu'inhibiteurs de phosphodiesterase

Country Status (23)

Country Link
US (2) US20060089375A1 (fr)
EP (1) EP1539753B1 (fr)
JP (1) JP2006503108A (fr)
KR (1) KR20050052501A (fr)
CN (1) CN100387598C (fr)
AT (1) ATE442367T1 (fr)
AU (1) AU2010201417A1 (fr)
BR (1) BR0314392A (fr)
CA (1) CA2497550A1 (fr)
CY (1) CY1109619T1 (fr)
DE (1) DE60329193D1 (fr)
DK (1) DK1539753T3 (fr)
ES (1) ES2331119T3 (fr)
IL (1) IL166898A (fr)
IS (1) IS7709A (fr)
MA (1) MA27475A1 (fr)
MX (1) MXPA05002887A (fr)
NO (1) NO20050841L (fr)
NZ (1) NZ538515A (fr)
PL (1) PL375993A1 (fr)
PT (1) PT1539753E (fr)
SI (1) SI1539753T1 (fr)
WO (1) WO2004024728A2 (fr)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0230045D0 (en) 2002-12-23 2003-01-29 Glaxo Group Ltd Compounds
CN100387598C (zh) * 2002-09-16 2008-05-14 葛兰素集团有限公司 吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
EP1608652A1 (fr) * 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Composes pyrazolopyrimidines et leur utilisation en medecine
AU2004233827B2 (en) * 2003-04-24 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
CA2557004A1 (fr) * 2003-12-19 2005-06-30 Glaxo Group Limited Composes pyrazolo [3,4-b] pyridine et leur utilisation en tant qu'inhibiteurs de la phosphodiesterase
WO2005090352A1 (fr) * 2004-03-16 2005-09-29 Glaxo Group Limited Compose de pyrazolo[3,4-b]pyridine, et son utilisation en tant qu'inhibiteur de pdea4
GB0405933D0 (en) * 2004-03-16 2004-04-21 Glaxo Group Ltd Compounds
WO2005095328A1 (fr) 2004-04-02 2005-10-13 Glaxo Group Limited Processus chimique et nouvelle forme cristalline
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
US7459451B2 (en) * 2004-07-05 2008-12-02 Astellas Pharma Inc. Pyrazolopyridine derivatives
GB0418045D0 (en) 2004-08-12 2004-09-15 Glaxo Group Ltd Compounds
ATE517908T1 (de) 2005-01-10 2011-08-15 Glaxo Group Ltd Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
EP1940836A1 (fr) * 2005-09-29 2008-07-09 Glaxo Group Limited Compose de pyrazolo[3,4-b]pyridine et utilisation en tant qu'inhibiteur de pde4
AR058109A1 (es) 2005-12-20 2008-01-23 Glaxo Group Ltd Acido 3 - (4 - {[4 -(4 -{[3 - (3, 3 - dimetil - 1 - piperidinil)propil]oxi}fenil) - 1 - piperidinil]carbonil} - 1 - naftalenil)propanoico como antagonistas de los receptotres de histamina h1/h3, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamie
CA2644069A1 (fr) 2006-02-28 2007-09-07 Helicon Therapeutics, Inc. Piperazines therapeutiques utilisees comme inhibiteurs de la pde4
US8927546B2 (en) 2006-02-28 2015-01-06 Dart Neuroscience (Cayman) Ltd. Therapeutic piperazines
US7723330B2 (en) * 2006-03-07 2010-05-25 Array Biopharma Inc. Heterobicyclic pyrazole compounds and methods of use
KR20090003349A (ko) 2006-04-20 2009-01-09 글락소 그룹 리미티드 화합물
GB0611587D0 (en) 2006-06-12 2006-07-19 Glaxo Group Ltd Novel compounds
TW200817006A (en) 2006-06-23 2008-04-16 Smithkline Beecham Corp IL-8 receptor antagonist
DK2046787T3 (da) 2006-08-01 2011-07-18 Glaxo Group Ltd Pyrazolo[3,4-B]pyridin-forbindelser, og deres anvendelse som PDE4-inhibitorer
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
WO2009041591A1 (fr) * 2007-09-28 2009-04-02 Kyowa Hakko Kirin Co., Ltd. Dérivé de pyridine fusionnée
EP2070929A1 (fr) * 2007-12-11 2009-06-17 Bayer Schering Pharma Aktiengesellschaft Composés d'alkynylaryle et sels correspondants, compositions pharmaceutiques contenant ceux-ci, procédés de préparation de ceux-ci et usage de ceux-ci
UY31637A1 (es) 2008-02-06 2009-08-03 Farmacoforos duales-antagonistas muscarinicos de pde4
UY31636A1 (es) 2008-02-06 2009-08-03 Farmacoforos duales-antagonistas muscarinicos de pde4
CL2009000248A1 (es) * 2008-02-06 2009-09-11 Glaxo Group Ltd Compuestos derivados de pirazolo [3,4-b] piridin-5-il, inhibidores de la fosfodiesterasa de tipo iv (pde4) y antagonista de receptores muscarinicos de acetilcolina (machr); composicion farmaceutica que los comprende; y su uso en la preparacion de medicamentos utiles en el tratamiento de enferemedades respiratorias y alergicas
AU2009325091A1 (en) 2008-05-23 2010-06-17 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein inhibitor
US8163743B2 (en) 2008-06-05 2012-04-24 GlaxoGroupLimited 4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases
WO2010094643A1 (fr) 2009-02-17 2010-08-26 Glaxo Group Limited Dérivés de quinoline et applications associées dans la rhinite et l'urticaire
ES2542551T3 (es) 2009-03-09 2015-08-06 Glaxo Group Limited 4-Oxadiazol-2-il-indazoles como inhibidores de PI3 cinasas
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors
EP2408769A1 (fr) 2009-03-17 2012-01-25 Glaxo Group Limited Dérivés de pyrimidine utilisés comme inhibiteurs de ltk
EA201171144A1 (ru) 2009-03-19 2012-04-30 Мерк Шарп Энд Домэ Корп. ОПОСРЕДОВАННОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНА ГОМОЛОГА 1 BTB И CNC, ОСНОВНОГО ФАКТОРА ТРАНСКРИПЦИИ С ЛЕЙЦИНОВОЙ МОЛНИЕЙ 1 (Bach1) С ИСПОЛЬЗОВАНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
JP2012520685A (ja) 2009-03-19 2012-09-10 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸(siNA)を用いたGATA結合タンパク質3(GATA3)遺伝子発現のRNA干渉媒介性阻害
WO2010107958A1 (fr) 2009-03-19 2010-09-23 Merck Sharp & Dohme Corp. INHIBITION INDUITE PAR ARN INTERFÉRENCE DE L'EXPRESSION DU GÈNE TRANSDUCTEUR DE SIGNAL ET ACTIVITATEUR DE TRANSCRIPTION 6 (STAT6) AU MOYEN D'UN ACIDE NUCLÉIQUE INTERFÉRENT COURT (ANsi)
US20120016011A1 (en) 2009-03-19 2012-01-19 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)
EP2411517A2 (fr) 2009-03-27 2012-02-01 Merck Sharp&Dohme Corp. Inhibition à médiation par l'interférence arn de l'expression du gène de la molécule d'adhésion intercellulaire 1 (icam-1) faisant appel à de courts acides nucléiques interférents (ansi)
US20120022142A1 (en) 2009-03-27 2012-01-26 Merck Sharp & Dohme Corp. RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
US20120004281A1 (en) 2009-03-27 2012-01-05 Merck Sharp & Dohme Corp RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA)
WO2010111464A1 (fr) 2009-03-27 2010-09-30 Merck Sharp & Dohme Corp. Inhibition par interférence arn de l'expression du gène kinase 1 de régulation du signal d'apoptose (ask1) au moyen d'un acide nucléique interférent court (ansi)
JP2012521764A (ja) 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸(siNA)を用いた胸腺間質性リンパ球新生因子(TSLP)遺伝子発現のRNA干渉媒介性阻害
WO2010122088A1 (fr) 2009-04-24 2010-10-28 Glaxo Group Limited Pyrazole et triazole carboxamides en tant qu'inhibiteurs du canal crac
UY32571A (es) 2009-04-24 2010-11-30 Glaxo Group Ltd Compuestos derivados de pirazol amida
SI2899191T1 (sl) 2009-04-30 2017-11-30 Glaxo Group Limited Z oksazolom substituirani indazoli kot PI3-kinazni inhibitorji
EP2507223A1 (fr) 2009-12-03 2012-10-10 Glaxo Group Limited Dérivés de benzpyrazole comme inhibiteurs des pi3 kinases
JP2013512878A (ja) 2009-12-03 2013-04-18 グラクソ グループ リミテッド 新規化合物
US20120238571A1 (en) 2009-12-03 2012-09-20 Glaxo Group Limited Indazole derivatives as pi 3-kinase
EP2512438B1 (fr) 2009-12-16 2017-01-25 3M Innovative Properties Company Formulations et procédés pour le réglage de l'administration de particules d'une certaine taille dans un aérosol-doseur
WO2011110575A1 (fr) 2010-03-11 2011-09-15 Glaxo Group Limited Dérivés de 2-[2-(benzo- ou pyrido-)thiazolylamino]-6- aminopyridine, utiles dans le traitement de maladies respiratoires, allergiques ou inflammatoires
GB201007203D0 (en) 2010-04-29 2010-06-16 Glaxo Group Ltd Novel compounds
US8367829B2 (en) 2010-05-10 2013-02-05 Gilead Sciences, Inc. Bi-functional pyrazolopyridine compounds
EP2397482A1 (fr) 2010-06-15 2011-12-21 Almirall, S.A. Dérivés d'imidazolone d'hétéroaryle en tant qu'inhibiteurs de JAK
EP2593434A1 (fr) 2010-07-16 2013-05-22 Purdue Pharma LP Composés pyridines comme bloqueurs des canaux sodiques
ES2602972T3 (es) 2010-09-08 2017-02-23 Glaxosmithkline Intellectual Property Development Limited Derivados de indazol para su uso en el tratamiento de infección por virus de la gripe
EP2614058B1 (fr) 2010-09-08 2015-07-08 GlaxoSmithKline Intellectual Property Development Limited Polymorphes et sels de n-[5-[4-(5-{[(2r,6s-2,6-diméthyl-4-morpholinyl]- méthyl}-1,3-oxazol-2-yl)-1h-indazol-6-yl]-2-(méthyloxy)-3-pyridinyl]-méthanesulfonamide
WO2012035055A1 (fr) 2010-09-17 2012-03-22 Glaxo Group Limited Nouveaux composés
ES2532213T3 (es) 2010-10-21 2015-03-25 Glaxo Group Limited Compuestos de pirazol que actúan contra afecciones alérgicas, inmunitarias e inflamatorias
EP2630127A1 (fr) 2010-10-21 2013-08-28 Glaxo Group Limited Composés de pyrazole agissant contre des troubles allergiques, inflammatoires et immunitaires
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
CN102485724B (zh) * 2010-12-06 2015-08-12 中国人民解放军军事医学科学院毒物药物研究所 取代噻吩基吡唑并吡啶类化合物及其医药用途
JP2014507458A (ja) 2011-03-11 2014-03-27 グラクソ グループ リミテッド Sykインヒビターとしてのピリド[3,4−B]ピラジン誘導体
GB201104153D0 (en) 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
US9370535B2 (en) 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
EP2527344A1 (fr) 2011-05-25 2012-11-28 Almirall, S.A. Dérivés de pyridin-2(1h)-one utiles comme médicaments pour le traitement de maladies myeloproliferatives, de rejets de greffe, de maladies a médiation immune et de maladies inflammatoires
US9206127B2 (en) 2012-03-16 2015-12-08 Purdue Pharm, L.P. Substituted pyridines as sodium channel blockers
US9714252B2 (en) 2012-12-20 2017-07-25 Purdue Pharma L.P. Cyclic sulfonamides as sodium channel blockers
JP2016525532A (ja) 2013-07-26 2016-08-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 骨髄異形成症候群の処置
JP2016537327A (ja) 2013-10-17 2016-12-01 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 呼吸器疾患の治療のためのpi3k阻害剤
WO2015055691A1 (fr) 2013-10-17 2015-04-23 Glaxosmithkline Intellectual Property Development Limited Inhibiteur de pi3k pour le traitement d'une maladie respiratoire
ES2871027T3 (es) * 2014-03-27 2021-10-28 Eicosis Llc Inhibidores potentes de la epóxido hidrolasa soluble
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof
CR20160529A (es) 2014-05-12 2017-01-02 Glaxosmithkline Intellectual Property (No 2) Ltd Composiciones farmacéuticas para tratar enfermedades infecciosas
US9867831B2 (en) 2014-10-01 2018-01-16 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome
WO2016181990A1 (fr) 2015-05-12 2016-11-17 大鵬薬品工業株式会社 Cristaux de composé azabicyclique
GB201602527D0 (en) 2016-02-12 2016-03-30 Glaxosmithkline Ip Dev Ltd Chemical compounds
JP2019524792A (ja) 2016-08-08 2019-09-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 化合物
CN107964011A (zh) * 2016-10-19 2018-04-27 中国人民解放军军事医学科学院毒物药物研究所 取代吡唑并吡啶类衍生物及其医药用途
GB201706102D0 (en) 2017-04-18 2017-05-31 Glaxosmithkline Ip Dev Ltd Chemical compounds
GB201712081D0 (en) 2017-07-27 2017-09-13 Glaxosmithkline Ip Dev Ltd Chemical compounds
US11512067B2 (en) 2017-09-14 2022-11-29 Daiichi Sankyo Company, Limited Compound having cyclic structure
US11505559B2 (en) 2017-10-30 2022-11-22 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Office Of Technology Transfer, National Institutes Of Health Substituted quinoline analogs as aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors
US11434247B1 (en) * 2017-11-27 2022-09-06 Dart Neuroscience Llc Substituted furanopyrimidine compounds as PDE1 inhibitors
CN111875594A (zh) * 2020-07-21 2020-11-03 中国药科大学 具有磷酸二酯酶4b抑制活性的吲唑杂环类化合物
CN116507336A (zh) 2020-09-10 2023-07-28 Vanda制药公司 治疗pdeiv介导的疾病或病症的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US598973A (en) * 1898-02-15 Water-heater and smoke-consumer
US598838A (en) * 1898-02-08 William b
US3856799A (en) * 1971-08-05 1974-12-24 Squibb & Sons Inc Intermediates for production of amino derivatives of pyrazolopyridine carboxylic acids and esters
BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3833594A (en) * 1971-08-05 1974-09-03 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxylic acids and esters
US3925388A (en) * 1971-08-05 1975-12-09 Squibb & Sons Inc 4-Piperazino-{8 3,4-b{9 pyridine-5-carboxylic acids and esters
US4012373A (en) * 1972-09-22 1977-03-15 E. R. Squibb & Sons, Inc. Pyrazolo[3',4'-2,3]pyrido[4,5-e]b-benzo-1,5-diazepinones
US3979399A (en) * 1972-11-15 1976-09-07 E. R. Squibb & Sons, Inc. Amino derivatives of pyrazolopyridine carboxamides
US3840546A (en) * 1972-11-15 1974-10-08 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxamides
US3833598A (en) * 1972-12-29 1974-09-03 Squibb & Sons Inc Amino derivatives of pyrazolopyridine-6-carboxylic acids and esters
US4115394A (en) * 1974-05-06 1978-09-19 E. R. Squibb & Sons, Inc. Amino derivatives of 6-phenylpyrazolo[3,4-b]pyridines
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
US6326379B1 (en) * 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
JP2002020386A (ja) * 2000-07-07 2002-01-23 Ono Pharmaceut Co Ltd ピラゾロピリジン誘導体
US20050043319A1 (en) * 2001-08-14 2005-02-24 Exonhit Therapeutics Sa Molecular target of neurotoxicity
GB0230045D0 (en) * 2002-12-23 2003-01-29 Glaxo Group Ltd Compounds
CN100387598C (zh) * 2002-09-16 2008-05-14 葛兰素集团有限公司 吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
CA2557004A1 (fr) * 2003-12-19 2005-06-30 Glaxo Group Limited Composes pyrazolo [3,4-b] pyridine et leur utilisation en tant qu'inhibiteurs de la phosphodiesterase

Also Published As

Publication number Publication date
NO20050841L (no) 2005-06-15
CY1109619T1 (el) 2014-08-13
JP2006503108A (ja) 2006-01-26
PL375993A1 (en) 2005-12-12
BR0314392A (pt) 2005-07-12
WO2004024728A3 (fr) 2004-10-21
EP1539753B1 (fr) 2009-09-09
NZ538515A (en) 2007-04-27
PT1539753E (pt) 2009-12-10
CN100387598C (zh) 2008-05-14
DK1539753T3 (da) 2010-01-04
EP1539753A2 (fr) 2005-06-15
MXPA05002887A (es) 2005-05-27
KR20050052501A (ko) 2005-06-02
ATE442367T1 (de) 2009-09-15
SI1539753T1 (sl) 2009-12-31
DE60329193D1 (de) 2009-10-22
WO2004024728A2 (fr) 2004-03-25
ES2331119T3 (es) 2009-12-22
CN1694882A (zh) 2005-11-09
US20060089375A1 (en) 2006-04-27
IL166898A (en) 2010-06-30
US20080175914A1 (en) 2008-07-24
AU2010201417A1 (en) 2010-04-29
AU2003285300A1 (en) 2004-04-30
CA2497550A1 (fr) 2004-03-25
IS7709A (is) 2005-02-24

Similar Documents

Publication Publication Date Title
MA27475A1 (fr) Composes de pyrazolo [3,4-b] pyridine et leur utilisation en tant qu'inhibiteurs de phosphodiesterase
TW200500364A (en) Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors
KR100313641B1 (ko) 6-페닐피리딜-2-아민유도체
NO20063340L (no) Pyrazol-[3,4-B]-pyridinforbindelser, og deres anvendelse som fosfodiesteraseinhibitorer
JP2013530179A (ja) 呼吸器合胞体ウイルス(rsv)感染の処置に使用するためのウレイド−ピラゾール誘導体
WO2007040438A3 (fr) Derives d'imidazo(4,5-b) pyridine utilises comme inhibiteurs de la glycogene synthase kinase 3 pour le traitement de la demence et de troubles neurodegeneratifs
GEP20104973B (en) Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors
WO2007039781A3 (fr) Nouveaux composes
WO2006011024A3 (fr) Nouveaux composes tricycliques utilises dans le traitement de troubles inflammatoires et allergiques, procede de preparation associe, et compositions pharmaceutiques les contenant
KR20180128390A (ko) 인돌리논 화합물과 섬유성 질환의 치료에서 이의 용도
KR20180004817A (ko) 삼환형 화합물 및 포스포다이에스터라제 억제제로서 이의 용도
ID27509A (id) Turunan piridin tersubstitusi-2,3 proses pembuatannya, komposisi farmasi yang mengandung senyawa tersebut, dan senyawa-antaranya
RU2009109100A (ru) НОВЫЕ 5,7-ДИЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ [1,3]ТИАЗОЛО[4,5-d]ПИРИМИДИН-2(3Н)-ОНА И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
WO2016138199A1 (fr) Composés benzothiophène et benzothiazole
RU2012131280A (ru) [4-(5-аминометил-2-фторфенил)пиперидин-1-ил]-(1н-пирролопиридинил)метаноны и их синтез
MX2012008147A (es) Derivados de pirrazolopiridina.
CA2837248A1 (fr) Nouveaux derives de phtalazinone -pyrrolopyrimidinecarboxamide
CN106065018B (zh) 取代的吲哚化合物及其使用方法和用途
MY135776A (en) PYRAZOLO [3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
WO2007030780A3 (fr) Agents antitumoraux
EP2470531A1 (fr) Méthylpyrrolopyrimidine-carboxamides
JPWO2020016129A5 (fr)
RU2021103602A (ru) Производные тирозинамида в качестве ингибиторов rho-киназы
CA3126689A1 (fr) Compose heteroaryle a noyau fusionne utilise en tant qu'inhibiteur d'alk4/5
RU2007114284A (ru) Производное имидазола