JP2014508169A5 - - Google Patents
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- JP2014508169A5 JP2014508169A5 JP2013558104A JP2013558104A JP2014508169A5 JP 2014508169 A5 JP2014508169 A5 JP 2014508169A5 JP 2013558104 A JP2013558104 A JP 2013558104A JP 2013558104 A JP2013558104 A JP 2013558104A JP 2014508169 A5 JP2014508169 A5 JP 2014508169A5
- Authority
- JP
- Japan
- Prior art keywords
- och
- pain
- compound according
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161452538P | 2011-03-14 | 2011-03-14 | |
| US61/452,538 | 2011-03-14 | ||
| US201161567809P | 2011-12-07 | 2011-12-07 | |
| US61/567,809 | 2011-12-07 | ||
| PCT/US2012/028882 WO2012125613A1 (en) | 2011-03-14 | 2012-03-13 | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014508169A JP2014508169A (ja) | 2014-04-03 |
| JP2014508169A5 true JP2014508169A5 (enExample) | 2015-04-30 |
| JP6088443B2 JP6088443B2 (ja) | 2017-03-01 |
Family
ID=45888492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558104A Expired - Fee Related JP6088443B2 (ja) | 2011-03-14 | 2012-03-13 | イオンチャネルのモジュレーターとしてのモルホリン−スピロ環式ピペリジンアミド |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8828996B2 (enExample) |
| EP (1) | EP2686325B1 (enExample) |
| JP (1) | JP6088443B2 (enExample) |
| CN (1) | CN103517910B (enExample) |
| AU (1) | AU2012229187B2 (enExample) |
| CA (1) | CA2829803A1 (enExample) |
| ES (1) | ES2618929T3 (enExample) |
| MX (1) | MX347982B (enExample) |
| WO (1) | WO2012125613A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8598164B2 (en) | 2010-05-06 | 2013-12-03 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| SG192248A1 (en) | 2011-02-02 | 2013-09-30 | Vertex Pharma | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
| MX2013009393A (es) | 2011-02-18 | 2013-08-29 | Vertex Pharma | Piperidinamidas cromano-espirociclicas como moduladores de canales de iones. |
| CN104136442B (zh) * | 2012-01-16 | 2016-12-21 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吡喃‑螺环哌啶酰胺类 |
| US9139529B2 (en) | 2013-01-31 | 2015-09-22 | Vertex Pharmaceuticals Incorporated | Substituted quinoxalines as sodium channel modulators |
| IL269964B1 (en) | 2013-01-31 | 2025-09-01 | Vertex Pharma | Pyridone amide compounds, compositions containing them and uses thereof |
| SG11201600383SA (en) | 2013-07-19 | 2016-02-26 | Vertex Pharma | Sulfonamides as modulators of sodium channels |
| UA120039C2 (uk) | 2013-10-14 | 2019-09-25 | ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. | Селективно заміщені сполуки хіноліну |
| BR112016008378B1 (pt) | 2013-10-14 | 2022-11-08 | Eisai R&D Management Co., Ltd | Compostos de quinolina seletivamente substituídos ou sal dos mesmos, e composição farmacêutica contendo os ditos compostos |
| GEP20207082B (en) | 2013-12-13 | 2020-04-10 | Vertex Pharma | Prodrugs of pyridone amides useful as modulators of sodium channels |
| TW201615643A (zh) * | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物 |
| TWI685497B (zh) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| TW201615642A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物 |
| CR20180047A (es) | 2015-07-31 | 2018-03-07 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4-hidroxibutan-2-il carbamato como inhibidores de magl |
| PT3365345T (pt) * | 2015-10-23 | 2020-05-27 | Esteve Labor Dr | Composto de oxa- azaespiro tendo atividade contra a dor |
| TW201734009A (zh) | 2015-10-23 | 2017-10-01 | 艾斯提夫博士實驗股份有限公司 | 具有抗疼痛活性的經取代的□啉衍生物 |
| SI3365346T1 (sl) * | 2015-10-23 | 2020-04-30 | Esteve Pharmaceuticals, S.A. | Spojine oksa diazaspiro s protibolečinskim delovanjem |
| AR106697A1 (es) | 2015-11-16 | 2018-02-07 | Esteve Labor Dr | Compuestos oxadiazoespíricos para el tratamiento del abuso y la adicción a las drogas |
| PL3429352T3 (pl) * | 2016-03-17 | 2022-08-22 | Fmc Corporation | Sposób konwersji enancjomeru-S do jego postaci racemicznej |
| MX2019008626A (es) | 2017-01-20 | 2019-09-19 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). |
| CA3050853A1 (en) | 2017-01-23 | 2018-07-26 | Pfizer Inc. | Heterocyclic spiro compounds as magl inhibitors |
| CN110740993B (zh) | 2017-05-16 | 2023-09-01 | 沃泰克斯药物股份有限公司 | 用作钠通道调节剂的氘代吡啶酮酰胺及其前药 |
| AU2018300150A1 (en) | 2017-07-11 | 2020-01-30 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| EP3697795B1 (en) | 2017-10-17 | 2023-11-22 | Acondicionamiento Tarrasense | Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one |
| CA3091012A1 (en) | 2018-02-12 | 2019-08-15 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
| EP3820860B1 (en) | 2018-07-09 | 2025-10-15 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting nav1.8 |
| WO2020014246A1 (en) | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting nav1.8 |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
| WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| CN110452183B (zh) * | 2019-09-04 | 2023-03-14 | 中国科学院上海有机化学研究所 | 一种手性杂环化合物的制备方法 |
| HRP20241695T1 (hr) | 2019-12-06 | 2025-02-14 | Vertex Pharmaceuticals Incorporated | Supstituirani tetrahidrofurani kao modulatori natrijevih kanala |
| CN114901640A (zh) * | 2019-12-24 | 2022-08-12 | 兹杜斯生命科学有限公司 | 适用于治疗血脂异常的新型化合物 |
| CN113278021B (zh) * | 2021-05-29 | 2022-09-23 | 天津全和诚科技有限责任公司 | 1,7-二氮杂螺[3.5]壬烷-7-甲酸叔丁酯及其草酸盐的制备方法 |
| US20240368135A1 (en) | 2021-06-04 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| KR20240031300A (ko) | 2021-06-04 | 2024-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널 조절제로서의 n-(하이드록시알킬 (헤테로)아릴) 테트라하이드로푸란 카르복스아미드 |
| AU2022285758A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| JP2024520649A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | （２ｒ，３ｓ，４ｓ，５ｒ）－４－［［３－（３，４－ジフルオロ－２－メトキシ－フェニル）－４，５－ジメチル－５－（トリフルオロメチル）テトラヒドロフラン－２－カルボニル］アミノ］ピリジン－２－カルボキサミドを含む固体剤形及び投与レジメン |
| EP4347033A1 (en) | 2021-06-04 | 2024-04-10 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| CA3221939A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| CN118382436A (zh) * | 2021-10-13 | 2024-07-23 | 凡况生化公司 | 葡糖脑苷脂酶活性的小分子调节剂及其用途 |
| AR129104A1 (es) | 2022-04-22 | 2024-07-17 | Vertex Pharma | Compuestos heteroarilo para el tratamiento del dolor |
| AU2023255771A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| AU2023255558A1 (en) | 2022-04-22 | 2024-10-31 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CA3256248A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharma | HETEROARYL COMPOUNDS FOR PAIN RELIEF |
| IL321269A (en) | 2022-12-06 | 2025-08-01 | Vertex Pharma | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
| WO2025090516A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing compounds for treating pain and solid forms thereof |
| WO2025090465A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2025090511A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing modulators of sodium channels and solid forms of the same for treating pain |
| WO2025090480A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| US20250186419A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens for treating pain |
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| US8598164B2 (en) | 2010-05-06 | 2013-12-03 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
| SG192248A1 (en) | 2011-02-02 | 2013-09-30 | Vertex Pharma | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
| MX2013009393A (es) | 2011-02-18 | 2013-08-29 | Vertex Pharma | Piperidinamidas cromano-espirociclicas como moduladores de canales de iones. |
-
2012
- 2012-03-13 US US13/418,737 patent/US8828996B2/en active Active
- 2012-03-13 CA CA2829803A patent/CA2829803A1/en not_active Abandoned
- 2012-03-13 EP EP12710841.3A patent/EP2686325B1/en active Active
- 2012-03-13 AU AU2012229187A patent/AU2012229187B2/en not_active Ceased
- 2012-03-13 CN CN201280018832.5A patent/CN103517910B/zh not_active Expired - Fee Related
- 2012-03-13 ES ES12710841.3T patent/ES2618929T3/es active Active
- 2012-03-13 JP JP2013558104A patent/JP6088443B2/ja not_active Expired - Fee Related
- 2012-03-13 MX MX2013010476A patent/MX347982B/es active IP Right Grant
- 2012-03-13 WO PCT/US2012/028882 patent/WO2012125613A1/en not_active Ceased
-
2014
- 2014-08-07 US US14/454,227 patent/US9181273B2/en active Active
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