JP2011526919A5 - - Google Patents
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- JP2011526919A5 JP2011526919A5 JP2011516842A JP2011516842A JP2011526919A5 JP 2011526919 A5 JP2011526919 A5 JP 2011526919A5 JP 2011516842 A JP2011516842 A JP 2011516842A JP 2011516842 A JP2011516842 A JP 2011516842A JP 2011526919 A5 JP2011526919 A5 JP 2011526919A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- compound according
- acute
- compound
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002193 Pain Diseases 0.000 claims description 68
- 150000001875 compounds Chemical class 0.000 claims description 58
- 230000036407 pain Effects 0.000 claims description 55
- 230000001154 acute effect Effects 0.000 claims description 20
- 208000008035 Back Pain Diseases 0.000 claims description 12
- 230000001684 chronic effect Effects 0.000 claims description 12
- 208000004296 neuralgia Diseases 0.000 claims description 11
- 125000001475 halogen functional group Chemical group 0.000 claims description 8
- 208000005298 acute pain Diseases 0.000 claims description 7
- 206010019233 Headaches Diseases 0.000 claims description 6
- 208000004404 Intractable Pain Diseases 0.000 claims description 6
- 208000019695 Migraine disease Diseases 0.000 claims description 6
- 206010028836 Neck pain Diseases 0.000 claims description 6
- 208000004550 Postoperative Pain Diseases 0.000 claims description 6
- 125000001931 aliphatic group Chemical group 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 206010027599 migraine Diseases 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 201000006417 multiple sclerosis Diseases 0.000 claims description 6
- 208000021722 neuropathic pain Diseases 0.000 claims description 6
- 208000009935 visceral pain Diseases 0.000 claims description 6
- 208000005615 Interstitial Cystitis Diseases 0.000 claims description 5
- 230000001272 neurogenic effect Effects 0.000 claims description 5
- 206010002383 Angina Pectoris Diseases 0.000 claims description 4
- 208000000003 Breakthrough pain Diseases 0.000 claims description 4
- 206010058019 Cancer Pain Diseases 0.000 claims description 4
- 208000006561 Cluster Headache Diseases 0.000 claims description 4
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 4
- 206010065390 Inflammatory pain Diseases 0.000 claims description 4
- 208000007914 Labor Pain Diseases 0.000 claims description 4
- 208000008930 Low Back Pain Diseases 0.000 claims description 4
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims description 4
- 208000008765 Sciatica Diseases 0.000 claims description 4
- 108010052164 Sodium Channels Proteins 0.000 claims description 4
- 102000018674 Sodium Channels Human genes 0.000 claims description 4
- 208000006011 Stroke Diseases 0.000 claims description 4
- 208000018912 cluster headache syndrome Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- 231100000869 headache Toxicity 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 201000008482 osteoarthritis Diseases 0.000 claims description 4
- 208000011580 syndromic disease Diseases 0.000 claims description 4
- 206010044652 trigeminal neuralgia Diseases 0.000 claims description 4
- 208000000094 Chronic Pain Diseases 0.000 claims description 3
- 230000002981 neuropathic effect Effects 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 208000004998 Abdominal Pain Diseases 0.000 claims description 2
- 208000019901 Anxiety disease Diseases 0.000 claims description 2
- 206010003011 Appendicitis Diseases 0.000 claims description 2
- 208000006820 Arthralgia Diseases 0.000 claims description 2
- 206010003591 Ataxia Diseases 0.000 claims description 2
- 208000009137 Behcet syndrome Diseases 0.000 claims description 2
- 208000020925 Bipolar disease Diseases 0.000 claims description 2
- 206010006002 Bone pain Diseases 0.000 claims description 2
- 201000006474 Brain Ischemia Diseases 0.000 claims description 2
- 206010064012 Central pain syndrome Diseases 0.000 claims description 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims description 2
- 206010008479 Chest Pain Diseases 0.000 claims description 2
- 201000009273 Endometriosis Diseases 0.000 claims description 2
- 208000024720 Fabry Disease Diseases 0.000 claims description 2
- 206010016059 Facial pain Diseases 0.000 claims description 2
- 208000001640 Fibromyalgia Diseases 0.000 claims description 2
- 206010019909 Hernia Diseases 0.000 claims description 2
- 208000007514 Herpes zoster Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 206010020853 Hypertonic bladder Diseases 0.000 claims description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- 206010021639 Incontinence Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- 208000035945 Labour pain Diseases 0.000 claims description 2
- 206010024229 Leprosy Diseases 0.000 claims description 2
- 206010026749 Mania Diseases 0.000 claims description 2
- 208000016285 Movement disease Diseases 0.000 claims description 2
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims description 2
- 208000030858 Myofascial Pain Syndromes Diseases 0.000 claims description 2
- 206010061533 Myotonia Diseases 0.000 claims description 2
- 208000005890 Neuroma Diseases 0.000 claims description 2
- 208000001294 Nociceptive Pain Diseases 0.000 claims description 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 2
- 206010033557 Palpitations Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims description 2
- 208000000450 Pelvic Pain Diseases 0.000 claims description 2
- 208000010886 Peripheral nerve injury Diseases 0.000 claims description 2
- 208000004983 Phantom Limb Diseases 0.000 claims description 2
- 206010056238 Phantom pain Diseases 0.000 claims description 2
- 206010037596 Pyelonephritis Diseases 0.000 claims description 2
- 206010037779 Radiculopathy Diseases 0.000 claims description 2
- 206010038419 Renal colic Diseases 0.000 claims description 2
- 206010040037 Sensory neuropathy hereditary Diseases 0.000 claims description 2
- 208000000491 Tendinopathy Diseases 0.000 claims description 2
- 206010043255 Tendonitis Diseases 0.000 claims description 2
- 206010043269 Tension headache Diseases 0.000 claims description 2
- 208000008548 Tension-Type Headache Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 2
- 206010046543 Urinary incontinence Diseases 0.000 claims description 2
- 208000025609 Urogenital disease Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 210000001015 abdomen Anatomy 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 201000003229 acute pancreatitis Diseases 0.000 claims description 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 2
- 230000036506 anxiety Effects 0.000 claims description 2
- 206010003119 arrhythmia Diseases 0.000 claims description 2
- 230000006793 arrhythmia Effects 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 208000034757 axonal type 2FF Charcot-Marie-Tooth disease Diseases 0.000 claims description 2
- 206010008118 cerebral infarction Diseases 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 201000000182 femoral cancer Diseases 0.000 claims description 2
- 208000037584 hereditary sensory and autonomic neuropathy Diseases 0.000 claims description 2
- 201000006847 hereditary sensory neuropathy Diseases 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000003243 intestinal obstruction Diseases 0.000 claims description 2
- 230000003211 malignant effect Effects 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 208000015706 neuroendocrine disease Diseases 0.000 claims description 2
- 201000001119 neuropathy Diseases 0.000 claims description 2
- 230000007823 neuropathy Effects 0.000 claims description 2
- 208000020629 overactive bladder Diseases 0.000 claims description 2
- 208000027753 pain disease Diseases 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 208000001297 phlebitis Diseases 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 208000007056 sickle cell anemia Diseases 0.000 claims description 2
- 201000009890 sinusitis Diseases 0.000 claims description 2
- 208000020431 spinal cord injury Diseases 0.000 claims description 2
- 208000005198 spinal stenosis Diseases 0.000 claims description 2
- 230000007863 steatosis Effects 0.000 claims description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 2
- 230000002123 temporal effect Effects 0.000 claims description 2
- 201000004415 tendinitis Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 208000004371 toothache Diseases 0.000 claims description 2
- 230000008733 trauma Effects 0.000 claims description 2
- 230000009529 traumatic brain injury Effects 0.000 claims description 2
- 208000026533 urinary bladder disease Diseases 0.000 claims description 2
- 206010059604 Radicular pain Diseases 0.000 claims 1
- 230000005176 gastrointestinal motility Effects 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- XXXYTJWRFBDEIQ-ZETCQYMHSA-N Clc1cc(Cl)cc([C@@H]2CNCC2)c1 Chemical compound Clc1cc(Cl)cc([C@@H]2CNCC2)c1 XXXYTJWRFBDEIQ-ZETCQYMHSA-N 0.000 description 2
- IGGITLBQEJIWMP-UHFFFAOYSA-N O=C(CCC1)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O Chemical compound O=C(CCC1)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O IGGITLBQEJIWMP-UHFFFAOYSA-N 0.000 description 2
- DIPBZRFENUVMIY-LFABVHOISA-N O=C([C@H](CC1)N(CC2)CC2c(cc2)ccc2F)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O Chemical compound O=C([C@H](CC1)N(CC2)CC2c(cc2)ccc2F)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O DIPBZRFENUVMIY-LFABVHOISA-N 0.000 description 2
- GECZPYDHACICBN-LFABVHOISA-N O=C([C@H](CC1)N(CC2)CC2c2cccc(Cl)c2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O Chemical compound O=C([C@H](CC1)N(CC2)CC2c2cccc(Cl)c2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O GECZPYDHACICBN-LFABVHOISA-N 0.000 description 2
- DVPLZFXUNFBMJJ-ZYZRXSCRSA-N O=C([C@H](CC1)N(CC2)CC2c2ccccc2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O Chemical compound O=C([C@H](CC1)N(CC2)CC2c2ccccc2)N1c(cc1)ccc1S(Nc1ncc[s]1)(=O)=O DVPLZFXUNFBMJJ-ZYZRXSCRSA-N 0.000 description 2
- 0 [*+]Nc1ncc[s]1 Chemical compound [*+]Nc1ncc[s]1 0.000 description 2
- 208000020401 Depressive disease Diseases 0.000 description 1
- 102000004605 NAV1.1 Voltage-Gated Sodium Channel Human genes 0.000 description 1
- 108010003129 NAV1.1 Voltage-Gated Sodium Channel Proteins 0.000 description 1
- 102000000706 NAV1.3 Voltage-Gated Sodium Channel Human genes 0.000 description 1
- 108010002565 NAV1.3 Voltage-Gated Sodium Channel Proteins 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7722008P | 2008-07-01 | 2008-07-01 | |
| US61/077,220 | 2008-07-01 | ||
| PCT/US2009/049346 WO2010002956A2 (en) | 2008-07-01 | 2009-07-01 | Heterocyclic derivatives as modulators of ion channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526919A JP2011526919A (ja) | 2011-10-20 |
| JP2011526919A5 true JP2011526919A5 (enExample) | 2012-08-09 |
Family
ID=41464851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516842A Pending JP2011526919A (ja) | 2008-07-01 | 2009-07-01 | イオンチャネルの阻害剤としての複素環式誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7846954B2 (enExample) |
| EP (1) | EP2307412A2 (enExample) |
| JP (1) | JP2011526919A (enExample) |
| KR (1) | KR20110025855A (enExample) |
| CN (1) | CN102099356A (enExample) |
| AU (1) | AU2009266979A1 (enExample) |
| CA (1) | CA2729681A1 (enExample) |
| IL (1) | IL210412A0 (enExample) |
| MX (1) | MX2010014193A (enExample) |
| RU (1) | RU2011103451A (enExample) |
| WO (1) | WO2010002956A2 (enExample) |
| ZA (1) | ZA201009128B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| CN101300253B (zh) * | 2005-09-09 | 2012-08-22 | 沃泰克斯药物股份有限公司 | 作为电压门控离子通道调控剂的二环衍生物 |
| AU2006306367A1 (en) * | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| CA2687764A1 (en) * | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| WO2009064747A2 (en) | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
| RU2010123876A (ru) * | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
| US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
| US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| CA2714985C (en) | 2008-01-07 | 2018-05-15 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
| US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
| US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| WO2009133641A1 (ja) * | 2008-04-30 | 2009-11-05 | シャープ株式会社 | 照明装置、及び表示装置 |
| USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| US8956346B2 (en) | 2010-05-14 | 2015-02-17 | Rainbow Medical, Ltd. | Reflectance-facilitated ultrasound treatment and monitoring |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN104136442B (zh) * | 2012-01-16 | 2016-12-21 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吡喃‑螺环哌啶酰胺类 |
| US20170058302A1 (en) * | 2014-04-07 | 2017-03-02 | Praj Industries Limited | Method for efficient enzymatic hydrolysis of lignocellulosic materials |
| EP3484464B1 (en) | 2016-03-22 | 2020-10-28 | Merck Sharp & Dohme Corp. | N1-phenylpropane-1,2-diamine compounds with selective activity in voltage-gated sodium channels |
| USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| HUE071358T2 (hu) | 2016-05-20 | 2025-08-28 | Xenon Pharmaceuticals Inc | Benzolszulfonamid vegyületek és terápiás szerként való alkalmazásuk |
| WO2017202376A1 (zh) * | 2016-05-26 | 2017-11-30 | 南京明德新药研发股份有限公司 | 磺酰胺衍生物 |
| USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| WO2018093694A1 (en) * | 2016-11-17 | 2018-05-24 | Merck Sharp & Dohme Corp. | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| JP7022751B2 (ja) | 2016-12-09 | 2022-02-18 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用 |
| SG11202011862PA (en) | 2018-06-13 | 2020-12-30 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
| CN112638898B (zh) | 2018-08-31 | 2024-04-09 | 泽农医药公司 | 杂芳基取代的磺酰胺化合物及其作为钠通道抑制剂的用途 |
| MX2021001380A (es) | 2018-08-31 | 2021-05-27 | Xenon Pharmaceuticals Inc | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos. |
| CN112759536A (zh) * | 2019-11-05 | 2021-05-07 | 常州锐博生物科技有限公司 | 取代的苯磺酰氯的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2324013A (en) | 1941-07-31 | 1943-07-13 | Sharp & Dohme Inc | Amino-substituents of sulphanil-amide derivatives |
| NL130753C (enExample) | 1965-10-19 | |||
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| TW200524888A (en) | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| EP1737852A2 (en) * | 2004-04-13 | 2007-01-03 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
| RU2007145434A (ru) | 2005-05-10 | 2009-06-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бициклические производные в качестве модуляторов ионных каналов |
| US7745629B2 (en) | 2005-05-16 | 2010-06-29 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
| ZA200800191B (en) | 2005-06-09 | 2009-04-29 | Vertex Pharmaceuicals Inc | Indane derivatives as modulators of ion channels |
| CN101300253B (zh) | 2005-09-09 | 2012-08-22 | 沃泰克斯药物股份有限公司 | 作为电压门控离子通道调控剂的二环衍生物 |
| EP1934191B1 (en) * | 2005-10-12 | 2012-03-28 | Vertex Pharmaceuticals, Inc. | Biphenyl derivatives as modulators of voltage gated ion channels |
| AU2006306367A1 (en) | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| WO2007075895A2 (en) | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| US7994174B2 (en) | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| RU2010123876A (ru) | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
| WO2009064747A2 (en) | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
-
2009
- 2009-07-01 EP EP09774406A patent/EP2307412A2/en not_active Withdrawn
- 2009-07-01 AU AU2009266979A patent/AU2009266979A1/en not_active Abandoned
- 2009-07-01 US US12/495,880 patent/US7846954B2/en active Active
- 2009-07-01 JP JP2011516842A patent/JP2011526919A/ja active Pending
- 2009-07-01 WO PCT/US2009/049346 patent/WO2010002956A2/en not_active Ceased
- 2009-07-01 CN CN200980127869XA patent/CN102099356A/zh active Pending
- 2009-07-01 CA CA2729681A patent/CA2729681A1/en not_active Abandoned
- 2009-07-01 RU RU2011103451/04A patent/RU2011103451A/ru not_active Application Discontinuation
- 2009-07-01 KR KR1020117002162A patent/KR20110025855A/ko not_active Withdrawn
- 2009-07-01 MX MX2010014193A patent/MX2010014193A/es not_active Application Discontinuation
-
2010
- 2010-10-28 US US12/913,869 patent/US8143297B2/en active Active
- 2010-12-20 ZA ZA2010/09128A patent/ZA201009128B/en unknown
- 2010-12-30 IL IL210412A patent/IL210412A0/en unknown
-
2012
- 2012-02-22 US US13/402,519 patent/US8343763B2/en active Active
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