JP2011500598A5 - - Google Patents

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Publication number
JP2011500598A5
JP2011500598A5 JP2010529091A JP2010529091A JP2011500598A5 JP 2011500598 A5 JP2011500598 A5 JP 2011500598A5 JP 2010529091 A JP2010529091 A JP 2010529091A JP 2010529091 A JP2010529091 A JP 2010529091A JP 2011500598 A5 JP2011500598 A5 JP 2011500598A5
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JP
Japan
Prior art keywords
pain
ring
aliphatic
cor
membered
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JP2010529091A
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English (en)
Japanese (ja)
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JP2011500598A (ja
JP5555169B2 (ja
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Priority claimed from PCT/US2008/079542 external-priority patent/WO2009049180A2/en
Publication of JP2011500598A publication Critical patent/JP2011500598A/ja
Publication of JP2011500598A5 publication Critical patent/JP2011500598A5/ja
Application granted granted Critical
Publication of JP5555169B2 publication Critical patent/JP5555169B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010529091A 2007-10-11 2008-10-10 電位開口型ナトリウムチャネルの阻害剤として有用なヘテロアリールアミド Expired - Fee Related JP5555169B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97925807P 2007-10-11 2007-10-11
US60/979,258 2007-10-11
PCT/US2008/079542 WO2009049180A2 (en) 2007-10-11 2008-10-10 Heteroaryl amides useful as inhibitors of voltage-gated sodium channels

Publications (3)

Publication Number Publication Date
JP2011500598A JP2011500598A (ja) 2011-01-06
JP2011500598A5 true JP2011500598A5 (enExample) 2012-11-15
JP5555169B2 JP5555169B2 (ja) 2014-07-23

Family

ID=40429979

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010529091A Expired - Fee Related JP5555169B2 (ja) 2007-10-11 2008-10-10 電位開口型ナトリウムチャネルの阻害剤として有用なヘテロアリールアミド

Country Status (9)

Country Link
US (1) US8519137B2 (enExample)
EP (1) EP2227453B1 (enExample)
JP (1) JP5555169B2 (enExample)
CN (1) CN101883760A (enExample)
AU (1) AU2008310660A1 (enExample)
CA (1) CA2701946A1 (enExample)
MX (1) MX2010003866A (enExample)
NZ (1) NZ584475A (enExample)
WO (1) WO2009049180A2 (enExample)

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PE20160548A1 (es) 2013-07-19 2016-05-21 Vertex Pharma Sulfonamidas como moduladores de canales de sodio
CA2931550C (en) 2013-12-13 2023-09-26 Vertex Pharmaceuticals Incorporated Prodrugs of pyridone amides useful as modulators of sodium channels
WO2016073633A1 (en) 2014-11-05 2016-05-12 University Of Kansas SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)
ES2871551T3 (es) * 2015-02-12 2021-10-29 Univ Southern California Bloqueadores del receptor de la hormona del crecimiento en la prevención y el tratamiento de enfermedades
EP3625214B1 (en) 2017-05-16 2022-07-06 Vertex Pharmaceuticals Incorporated Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
CA3069720A1 (en) 2017-07-11 2019-01-17 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
CN108863970A (zh) 2017-08-14 2018-11-23 四川省中医药转化医学中心 新化合物及其在治疗炎症或炎症相关疾病方面的应用
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AU2019301628C1 (en) 2018-07-09 2025-02-06 Lieber Institute, Inc. Pyridine carboxamide compounds for inhibiting NaV1.8
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CA3104913A1 (en) * 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
US12344595B2 (en) 2018-11-02 2025-07-01 Merck Sharp & Dohme Llc 2-amino-n-phenyl-nicotinamides as NAV1.8 inhibitors
KR102860523B1 (ko) 2018-11-02 2025-09-16 머크 샤프 앤드 돔 엘엘씨 Nav1.8 억제제로서의 2-아미노-n-헤테로아릴-니코틴아미드
WO2020146682A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
WO2020146612A1 (en) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
WO2020199683A1 (zh) * 2019-04-04 2020-10-08 上海海雁医药科技有限公司 氮杂环取代的磺酰基苯甲酰胺衍生物、其制法与医药上的用途
CN112390745B (zh) * 2019-08-19 2022-10-21 江苏恒瑞医药股份有限公司 吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用
MX2022006865A (es) 2019-12-06 2022-07-11 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio.
JP7323723B2 (ja) 2020-06-17 2023-08-08 メルク・シャープ・アンド・ドーム・エルエルシー Ｎａｖ１．８阻害剤としての２－オキソイミダゾリジン－４－カルボキサミド
EP4167994A4 (en) 2020-06-17 2024-07-24 Merck Sharp & Dohme LLC 2-OXO-OXAZOLIDINE-5-CARBOXAMIDE AS NAV1.8 INHIBITORS
MX2023013146A (es) 2021-05-07 2023-11-28 Merck Sharp & Dohme Llc Cicloalquil 3-oxopiperazin carboxamidas y cicloheteroalquil 3-oxopiperazin carboxamidas como inhibidores de nav1.8.
CN117794920A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂
EP4355733A1 (en) 2021-06-15 2024-04-24 Grünenthal GmbH Substituted pyrazole amides
EP4472966A4 (en) * 2022-02-04 2026-01-14 Latigo Biotherapeutics Inc SODIUM CHANNEL BLOCKING COMPOUNDS, THEIR DERIVATIVES AND METHODS OF USE
CN116655497B (zh) * 2022-02-25 2025-06-03 中国科学院上海药物研究所 脒类衍生化合物及其制备方法和用途
CN116789644B (zh) * 2022-03-17 2025-11-11 中国科学院上海药物研究所 酰胺类化合物及其制备方法和用途
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
EP4385984A1 (en) 2022-12-14 2024-06-19 Grünenthal GmbH Pyridine-n-oxides as inhibitors of nav1.8
EP4385980A1 (en) 2022-12-14 2024-06-19 Grünenthal GmbH Indazoles as inhibitors of nav1.8
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EP4385979A1 (en) 2022-12-14 2024-06-19 Grünenthal GmbH Multicyclic inhibitors of nav1.8
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