|
CN1925855B
(zh)
|
2003-12-19 |
2010-06-16 |
普莱希科公司 |
开发Ret调节剂的化合物和方法
|
|
CA2560454C
(en)
|
2004-03-30 |
2013-05-21 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful as inhibitors of jak and other protein kinases
|
|
US7498342B2
(en)
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
MX2007014377A
(es)
|
2005-05-17 |
2008-02-06 |
Plexxikon Inc |
Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
|
|
ES2380795T3
(es)
*
|
2005-05-20 |
2012-05-18 |
Vertex Pharmaceuticals, Inc. |
Pirrolopiridinas útiles como inhibidores de proteínas quinasas
|
|
DK2395004T3
(en)
|
2005-06-22 |
2016-03-21 |
Plexxikon Inc |
Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
|
|
CA2615291A1
(en)
|
2005-07-14 |
2007-01-18 |
Astellas Pharma Inc. |
Heterocyclic janus kinase 3 inhibitors
|
|
CN102127078A
(zh)
|
2005-07-14 |
2011-07-20 |
安斯泰来制药株式会社 |
Janus激酶3的杂环类抑制剂
|
|
EP2270014A1
(en)
|
2005-09-22 |
2011-01-05 |
Incyte Corporation |
Azepine inhibitors of janus kinases
|
|
AU2015201850B2
(en)
*
|
2005-12-13 |
2017-03-02 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
|
DK3184526T3
(en)
|
2005-12-13 |
2019-01-14 |
Incyte Holdings Corp |
PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR
|
|
EP1968568A4
(en)
*
|
2005-12-22 |
2011-04-13 |
Glaxosmithkline Llc |
HEMMER OF NUTS ACTIVITY
|
|
EP2537849A3
(en)
|
2006-01-17 |
2013-04-03 |
Vertex Pharmaceuticals, Inc. |
Azaindoles useful as inhibitors of janus kinases
|
|
KR101081293B1
(ko)
*
|
2006-01-18 |
2011-11-08 |
에프. 호프만-라 로슈 아게 |
11 베타-에이치에스디1 억제제로서 티아졸
|
|
EP1979353A2
(en)
*
|
2006-01-19 |
2008-10-15 |
OSI Pharmaceuticals, Inc. |
Fused heterobicyclic kinase inhibitors
|
|
RU2008143361A
(ru)
*
|
2006-04-05 |
2010-05-10 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Деазапурины в качестве ингибиторов янус-киназ
|
|
WO2007136790A2
(en)
*
|
2006-05-18 |
2007-11-29 |
Mannkind Corporation |
Intracellular kinase inhibitors
|
|
US8063050B2
(en)
*
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
DK2049500T3
(da)
*
|
2006-07-06 |
2011-12-12 |
Array Biopharma Inc |
Cyclopenta [d]-pyrimidiner som AKT-proteinkinase-inhibitorer
|
|
SI2054418T1
(sl)
|
2006-07-06 |
2012-02-29 |
Array Biopharma Inc |
Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji
|
|
WO2008006025A1
(en)
|
2006-07-06 |
2008-01-10 |
Array Biopharma Inc. |
Dihydrofuro pyrimidines as akt protein kinase inhibitors
|
|
CN101600714B
(zh)
*
|
2006-11-10 |
2013-08-21 |
百时美施贵宝公司 |
吡咯并吡啶激酶抑制剂
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
US8071779B2
(en)
*
|
2006-12-18 |
2011-12-06 |
Inspire Pharmaceuticals, Inc. |
Cytoskeletal active rho kinase inhibitor compounds, composition and use
|
|
NZ577798A
(en)
|
2006-12-21 |
2012-04-27 |
Vertex Pharma |
5-cyano-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
|
|
PE20081581A1
(es)
|
2006-12-21 |
2008-11-12 |
Plexxikon Inc |
COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
|
|
US7872018B2
(en)
|
2006-12-21 |
2011-01-18 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
WO2008079909A1
(en)
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
US8513270B2
(en)
|
2006-12-22 |
2013-08-20 |
Incyte Corporation |
Substituted heterocycles as Janus kinase inhibitors
|
|
EP2123651A4
(en)
|
2007-01-12 |
2011-05-04 |
Astellas Pharma Inc |
CONDENSED PYRIDINE COMPOUND
|
|
AU2008228768A1
(en)
*
|
2007-03-22 |
2008-09-25 |
Vertex Pharmaceuticals Incorporated |
N-heterocyclic compounds useful as inhibitors of Janus Kinases
|
|
CA2687931C
(en)
|
2007-05-31 |
2016-05-24 |
Boehringer Ingelheim International Gmbh |
Ccr2 receptor antagonists and uses thereof
|
|
GB0710528D0
(en)
*
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
EP2740731B1
(en)
|
2007-06-13 |
2016-03-23 |
Incyte Holdings Corporation |
Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
KR20150091196A
(ko)
*
|
2007-07-05 |
2015-08-07 |
어레이 바이오파마 인크. |
Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
|
|
CN101801955B
(zh)
|
2007-07-05 |
2013-05-08 |
阵列生物制药公司 |
作为akt蛋白激酶抑制剂的嘧啶基环戊烷
|
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
EP2170830B1
(en)
|
2007-07-17 |
2014-10-15 |
Plexxikon, Inc. |
2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS
|
|
WO2009089352A1
(en)
|
2008-01-08 |
2009-07-16 |
Array Biopharma Inc. |
Pyrrolopyridines as kinase inhibitors
|
|
CA2711699A1
(en)
*
|
2008-01-09 |
2009-07-16 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
|
JP5608098B2
(ja)
*
|
2008-01-09 |
2014-10-15 |
アレイ バイオファーマ、インコーポレイテッド |
キナーゼ阻害薬としてのピラゾロピリジン
|
|
KR101624752B1
(ko)
*
|
2008-01-09 |
2016-05-26 |
어레이 바이오파마 인크. |
Ａｋｔ 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄
|
|
GB0801416D0
(en)
*
|
2008-01-25 |
2008-03-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
WO2009145814A2
(en)
*
|
2008-03-10 |
2009-12-03 |
Vertex Pharmaceuticals Incorporated |
Pyrimidines and pyridines useful as inhibitors of protein kinases
|
|
ES2602577T3
(es)
|
2008-03-11 |
2017-02-21 |
Incyte Holdings Corporation |
Derivados de azetidina y ciclobutano como inhibidores de JAK
|
|
GB0804592D0
(en)
*
|
2008-03-12 |
2008-04-16 |
Glaxo Group Ltd |
Novel compounds
|
|
AR071717A1
(es)
*
|
2008-05-13 |
2010-07-07 |
Array Biopharma Inc |
Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer.
|
|
US8822513B2
(en)
|
2010-03-01 |
2014-09-02 |
Gtx, Inc. |
Compounds for treatment of cancer
|
|
DK2959900T3
(en)
*
|
2008-06-16 |
2017-06-26 |
Univ Tennessee Res Found |
CONNECTION TO TREATMENT OF CANCER
|
|
US9447049B2
(en)
|
2010-03-01 |
2016-09-20 |
University Of Tennessee Research Foundation |
Compounds for treatment of cancer
|
|
US9029408B2
(en)
|
2008-06-16 |
2015-05-12 |
Gtx, Inc. |
Compounds for treatment of cancer
|
|
CL2009001884A1
(es)
*
|
2008-10-02 |
2010-05-14 |
Incyte Holdings Corp |
Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
|
|
DE102008052943A1
(de)
|
2008-10-23 |
2010-04-29 |
Merck Patent Gmbh |
Azaindolderivate
|
|
CN103724328B
(zh)
|
2008-12-19 |
2015-10-14 |
贝林格尔.英格海姆国际有限公司 |
作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
|
|
KR20170058465A
(ko)
|
2009-04-03 |
2017-05-26 |
에프. 호프만-라 로슈 아게 |
프로판-１-술폰산 ｛３-［５-（４-클로로-페닐）-１Ｈ-피롤로［２，３-ｂ］피리딘-３-카르보닐］-２，４-디플루오로-페닐｝-아미드 조성물 및 그의 용도
|
|
WO2010135621A1
(en)
*
|
2009-05-22 |
2010-11-25 |
Incyte Corporation |
3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
|
|
ES2487542T3
(es)
*
|
2009-05-22 |
2014-08-21 |
Incyte Corporation |
Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus
|
|
GEP20207129B
(en)
|
2009-06-17 |
2020-07-10 |
Vertex Pharma |
Inhibitors of influenza viruses replication
|
|
TW201105674A
(en)
|
2009-07-08 |
2011-02-16 |
Leo Pharma As |
Novel JAK receptor and protein tyrosine kinase inhibitors and pharmaceutical use thereof
|
|
TWI466885B
(zh)
*
|
2009-07-31 |
2015-01-01 |
Japan Tobacco Inc |
含氮螺環化合物及其醫藥用途
|
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
US8569295B2
(en)
*
|
2009-08-06 |
2013-10-29 |
Merck Patent Gmbh |
Bicyclic urea compounds
|
|
SG178273A1
(en)
*
|
2009-08-07 |
2012-03-29 |
Merck Patent Gmbh |
Novel azaheterocyclic compounds
|
|
NZ597983A
(en)
|
2009-08-20 |
2014-05-30 |
Karus Therapeutics Ltd |
Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
|
|
WO2011028685A1
(en)
|
2009-09-01 |
2011-03-10 |
Incyte Corporation |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
RU2538204C2
(ru)
|
2009-09-10 |
2015-01-10 |
Ф.Хоффманн-Ля Рош Аг |
Ингибиторы jak
|
|
CA2777114C
(en)
|
2009-10-09 |
2018-10-23 |
Incyte Corporation |
Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
|
|
AU2010315126B2
(en)
|
2009-11-06 |
2015-06-25 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
PL2513093T3
(pl)
|
2009-12-17 |
2015-03-31 |
Centrexion Therapeutics Corp |
Nowi antagoniści receptora CCR2 i ich zastosowanie
|
|
USRE49251E1
(en)
|
2010-01-04 |
2022-10-18 |
Mapi Pharma Ltd. |
Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
|
|
AU2011217961B2
(en)
*
|
2010-02-18 |
2016-05-05 |
Incyte Holdings Corporation |
Cyclobutane and methylcyclobutane derivatives as Janus kinase inhibitors
|
|
CN102883607B
(zh)
|
2010-03-01 |
2015-07-22 |
Gtx公司 |
用于治疗癌的化合物
|
|
SMT201800137T1
(it)
|
2010-03-10 |
2018-07-17 |
Incyte Holdings Corp |
Derivati di piperidin-4-il azetidina come inibitori di jak1
|
|
JP2013526507A
(ja)
|
2010-05-12 |
2013-06-24 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用
|
|
EP2569295B1
(en)
|
2010-05-12 |
2014-11-19 |
Boehringer Ingelheim International GmbH |
New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
|
|
US8841313B2
(en)
|
2010-05-17 |
2014-09-23 |
Boehringer Ingelheim International Gmbh |
CCR2 antagonists and uses thereof
|
|
PH12012502296B1
(en)
|
2010-05-21 |
2017-10-06 |
Incyte Holdings Corp |
Topical formulation for a jak inhibitor
|
|
JP5636094B2
(ja)
|
2010-05-25 |
2014-12-03 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Ｃｃｒ２受容体アンタゴニスト
|
|
EP2576538B1
(en)
|
2010-06-01 |
2015-10-28 |
Boehringer Ingelheim International GmbH |
New CCR2 antagonists
|
|
EP2397482A1
(en)
*
|
2010-06-15 |
2011-12-21 |
Almirall, S.A. |
Heteroaryl imidazolone derivatives as jak inhibitors
|
|
ES2536415T3
(es)
|
2010-11-19 |
2015-05-25 |
Incyte Corporation |
Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK
|
|
SG190839A1
(en)
|
2010-11-19 |
2013-07-31 |
Incyte Corp |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
CN103492381A
(zh)
|
2010-12-16 |
2014-01-01 |
沃泰克斯药物股份有限公司 |
流感病毒复制的抑制剂
|
|
BR112013017184A2
(pt)
|
2011-01-07 |
2016-09-20 |
Leo Pharma As |
composto, composição farmacêutica, uso de um composto, e, método para evitar, tratar ou melhorar doenças
|
|
WO2012109075A1
(en)
|
2011-02-07 |
2012-08-16 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
ES2547916T3
(es)
|
2011-02-18 |
2015-10-09 |
Novartis Pharma Ag |
Terapia de combinación de inhibidores de mTOR/JAK
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
CN103841976A
(zh)
|
2011-04-01 |
2014-06-04 |
基因泰克公司 |
Akt和mek抑制剂化合物的组合及其使用方法
|
|
WO2012135759A1
(en)
|
2011-04-01 |
2012-10-04 |
Genentech, Inc. |
Combinations of akt inhibitor compounds and abiraterone, and methods of use
|
|
WO2012177606A1
(en)
|
2011-06-20 |
2012-12-27 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
EP2729465A2
(en)
|
2011-07-05 |
2014-05-14 |
Vertex Pharmaceuticals Incorporated |
Processes and intermediates for producing azaindoles
|
|
WO2013010839A1
(en)
|
2011-07-15 |
2013-01-24 |
Boehringer Ingelheim International Gmbh |
Novel and selective ccr2 antagonists
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
JP2014521725A
(ja)
|
2011-08-10 |
2014-08-28 |
ノバルティス・ファルマ・アクチェンゲゼルシャフト |
ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
GB201204125D0
(en)
*
|
2012-03-08 |
2012-04-25 |
Karus Therapeutics Ltd |
Compounds
|
|
WO2013148748A1
(en)
*
|
2012-03-29 |
2013-10-03 |
Francis Xavier Tavares |
Lactam kinase inhibitors
|
|
WO2013173720A1
(en)
|
2012-05-18 |
2013-11-21 |
Incyte Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
WO2014013014A1
(en)
|
2012-07-18 |
2014-01-23 |
Fundació Privada Centre De Regulació Genòmica (Crg) |
Jak inhibitors for activation of epidermal stem cell populations
|
|
EP2917202B1
(en)
|
2012-11-07 |
2018-05-02 |
Karus Therapeutics Limited |
Novel histone deacetylase inhibitors and their use in therapy
|
|
PE20151157A1
(es)
|
2012-11-15 |
2015-08-19 |
Incyte Corp |
Formas de dosificacion de ruxolitinib de liberacion sostenida
|
|
FR3001219A1
(fr)
*
|
2013-01-22 |
2014-07-25 |
Centre Nat Rech Scient |
Inhibiteurs de kinases
|
|
WO2014138212A1
(en)
*
|
2013-03-06 |
2014-09-12 |
Allosteros Therapeutics, Inc. |
CaMKII INHIBITORS AND USES THEREOF
|
|
LT3489239T
(lt)
|
2013-03-06 |
2022-03-10 |
Incyte Holdings Corporation |
Jak inhibitoriaus gamybos būdai ir tarpiniai junginiai
|
|
US20140271460A1
(en)
|
2013-03-15 |
2014-09-18 |
G1 Therapeutics, Inc. |
Highly Active Anti-Neoplastic and Anti-Proliferative Agents
|
|
CN105473140B
(zh)
|
2013-03-15 |
2018-04-10 |
G1治疗公司 |
在化学疗法期间对正常细胞的瞬时保护
|
|
JP6118453B2
(ja)
*
|
2013-04-02 |
2017-04-19 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
ブルトンチロシンキナーゼの阻害剤
|
|
KR101790090B1
(ko)
*
|
2013-05-02 |
2017-10-25 |
후지필름 가부시키가이샤 |
에칭 방법, 이에 이용하는 에칭액 및 에칭액의 키트, 및 반도체 기판 제품의 제조 방법
|
|
CN105358550B
(zh)
|
2013-05-10 |
2018-04-06 |
卡鲁斯治疗有限公司 |
组蛋白脱乙酰基酶抑制剂
|
|
UA120499C2
(uk)
|
2013-08-07 |
2019-12-26 |
Інсайт Корпорейшн |
Лікування захворювань із застосуванням лікарських форм з уповільненим вивільненням для інгібітора jak1
|
|
HRP20191525T1
(hr)
|
2013-11-13 |
2019-11-29 |
Vertex Pharma |
Inhibitori replikacije virusa influence
|
|
EP3421468B1
(en)
|
2013-11-13 |
2020-11-04 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing inhibitors of influenza viruses replication
|
|
TR201820925T4
(tr)
*
|
2014-02-04 |
2019-01-21 |
Taiho Pharmaceutical Co Ltd |
Azaindol türevi.
|
|
GB201402431D0
(en)
|
2014-02-12 |
2014-03-26 |
Karus Therapeutics Ltd |
Compounds
|
|
EP2924026A1
(en)
|
2014-03-28 |
2015-09-30 |
Novartis Tiergesundheit AG |
Aminosulfonylmethylcyclohexanes as JAK inhibitors
|
|
WO2015161285A1
(en)
|
2014-04-17 |
2015-10-22 |
G1 Therapeutics, Inc. |
Tricyclic lactams for use in the protection of hematopoietic stem and progenitor cells against ionizing radiation
|
|
AU2015265696B2
(en)
*
|
2014-05-28 |
2018-01-18 |
Astrazeneca Ab |
Processes for the preparation of AZD5363 and novel intermediate used therein
|
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
|
JP6633618B2
(ja)
*
|
2014-08-21 |
2020-01-22 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
強力なｒｏｃｋ阻害剤としてのタイドバックのベンズアミド誘導体
|
|
CN107074856A
(zh)
|
2014-09-05 |
2017-08-18 |
阿略斯泰罗斯医疗公司 |
CaMKII抑制剂及其用途
|
|
WO2016040848A1
(en)
|
2014-09-12 |
2016-03-17 |
G1 Therapeutics, Inc. |
Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
|
|
EP3191098A4
(en)
|
2014-09-12 |
2018-04-25 |
G1 Therapeutics, Inc. |
Combinations and dosing regimes to treat rb-positive tumors
|
|
GB201419228D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201419264D0
(en)
|
2014-10-29 |
2014-12-10 |
Karus Therapeutics Ltd |
Compounds
|
|
CN105837572B
(zh)
*
|
2015-02-02 |
2019-04-19 |
四川大学 |
N-取代苯基酰胺衍生物及其制备方法和用途
|
|
JP6704416B2
(ja)
|
2015-05-13 |
2020-06-03 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
インフルエンザウイルスの複製の阻害剤を調製する方法
|
|
WO2016183120A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
AU2016287584B2
(en)
|
2015-07-02 |
2020-03-26 |
Centrexion Therapeutics Corporation |
(4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
|
|
GB201514751D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201514760D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds and method of use
|
|
GB201514754D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201514758D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Formulation
|
|
HK1250707B
(zh)
|
2015-12-11 |
2020-07-03 |
四川科伦博泰生物医药股份有限公司 |
氮杂环丁烷衍生物、其制备方法及用途
|
|
CN106928252B
(zh)
*
|
2015-12-31 |
2019-09-27 |
成都先导药物开发股份有限公司 |
一种抑制rock的化合物及其制备方法与应用
|
|
EP3492468B1
(en)
|
2016-07-26 |
2022-02-23 |
Suzhou Longbiotech Pharmaceuticals Co., Ltd. |
Heterocyclic compound as jak inhibitor, and salts and therapeutic use thereof
|
|
US12097292B2
(en)
|
2016-08-28 |
2024-09-24 |
Mapi Pharma Ltd. |
Process for preparing microparticles containing glatiramer acetate
|
|
JP7193448B2
(ja)
|
2016-08-31 |
2022-12-20 |
マピ ファーマ リミテッド |
酢酸グラチラマーを含むデポシステム
|
|
WO2018041989A1
(en)
|
2016-09-02 |
2018-03-08 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for diagnosing and treating refractory celiac disease type 2
|
|
AU2018239798B2
(en)
|
2017-03-23 |
2020-08-27 |
Daegu Gyeongbuk Institute Of Science And Technology |
Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
|
|
CN110382052A
(zh)
|
2017-03-26 |
2019-10-25 |
Mapi医药公司 |
用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
|
|
WO2019000683A1
(zh)
*
|
2017-06-30 |
2019-01-03 |
北京泰德制药股份有限公司 |
Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
|
|
CA3063616A1
(en)
|
2017-06-30 |
2019-12-06 |
Beijing Tide Pharmaceutical Co., Ltd. |
Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof
|
|
CN110573501B
(zh)
|
2017-06-30 |
2023-09-29 |
北京泰德制药股份有限公司 |
Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
|
|
CA3072861A1
(en)
*
|
2017-08-23 |
2019-02-28 |
Sprint Bioscience Ab |
Azaindolylpyridone and diazaindolylpyridone compounds
|
|
CN109535164B
(zh)
*
|
2017-09-21 |
2022-01-18 |
上海华汇拓医药科技有限公司 |
Jak激酶抑制剂及其制备方法和在医药领域的应用
|
|
US10800775B2
(en)
*
|
2017-11-03 |
2020-10-13 |
Aclaris Therapeutics, Inc. |
Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
|
|
SG11202002947TA
(en)
|
2017-11-03 |
2020-04-29 |
Aclaris Therapeutics Inc |
Substituted pyrrolopyrimidine jak inhibitors and methods of making and using the same
|
|
WO2019113487A1
(en)
|
2017-12-08 |
2019-06-13 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
|
IL276302B2
(en)
|
2018-01-30 |
2023-11-01 |
Incyte Corp |
Procedures for preparing [1-(3-fluoro-2-(trifluoromethyl(isonicotinyl}piperidine-4-one)
|
|
CN112771025B
(zh)
*
|
2018-03-23 |
2024-02-27 |
重庆复创医药研究有限公司 |
作为rock抑制剂的氘代化合物
|
|
SMT202400306T1
(it)
|
2018-03-30 |
2024-09-16 |
Incyte Corp |
Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
|
|
BR112021002479A2
(pt)
|
2018-08-10 |
2021-07-27 |
Aclaris Therapeutics, Inc. |
composto, composição farmacêutica, método para inibir a atividade de itk ou jak3 em uma população de células, método para tratar um distúrbio mediado por itk ou jak3 em um indivíduo necessitando do mesmo e uso de um composto
|
|
CA3168211A1
(en)
|
2019-01-18 |
2020-07-23 |
Voronoi Co., Ltd. |
Pyrrolopyridine derivative and use thereof for preventing or treating protein kinase related disease
|
|
EP3947737A2
(en)
|
2019-04-02 |
2022-02-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of predicting and preventing cancer in patients having premalignant lesions
|
|
WO2020212395A1
(en)
|
2019-04-16 |
2020-10-22 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of jak inhibitors for the treatment of painful conditions involving nav1.7 channels
|
|
CN113727975A
(zh)
*
|
2019-05-02 |
2021-11-30 |
阿克拉瑞斯治疗股份有限公司 |
作为jak抑制剂的被取代的吡咯并吡啶
|
|
CA3143636A1
(en)
*
|
2019-07-12 |
2021-01-21 |
Michael Lim |
Compositions and methods for treating cerebral vasospasm
|
|
US20220372135A1
(en)
|
2019-09-27 |
2022-11-24 |
Disc Medicine, Inc. |
Methods for treating myelofibrosis and related conditions
|
|
CR20220280A
(es)
|
2019-11-22 |
2022-09-02 |
Incyte Corp |
Terapia de combinación que comprende un inhibidor de alk2 y un inhibidor de jak2
|
|
IL297437A
(en)
|
2020-05-13 |
2022-12-01 |
Disc Medicine Inc |
Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
|
|
EP3915990A1
(en)
*
|
2020-05-26 |
2021-12-01 |
Centre National de la Recherche Scientifique |
4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-3,6-dihydropyridine-1-(2h)-carboxamide derivatives as limk and/or rock kinases inhibitors for use in the treatment of cancer
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
US10988479B1
(en)
|
2020-06-15 |
2021-04-27 |
G1 Therapeutics, Inc. |
Morphic forms of trilaciclib and methods of manufacture thereof
|
|
KR20220081631A
(ko)
|
2020-12-09 |
2022-06-16 |
보로노이 주식회사 |
염증성 질환의 예방 및/또는 치료를 위한 피롤로-피리딘 유도체 화합물의 신규 용도
|
|
CN113402523B
(zh)
*
|
2021-07-13 |
2022-07-12 |
西安交通大学 |
一种靶向肥大细胞MrgX2小分子荧光探针及制备方法和应用
|
|
CN113735859A
(zh)
*
|
2021-08-12 |
2021-12-03 |
安徽医科大学 |
一种激酶抑制剂
|
|
EP4471004A1
(en)
|
2022-01-28 |
2024-12-04 |
Nippon Soda Co., Ltd. |
Method for producing amide compound
|
|
CN117050075A
(zh)
*
|
2022-05-05 |
2023-11-14 |
中国药科大学 |
一类联芳环类bet抑制剂及合成方法与用途
|
|
US20250283174A1
(en)
|
2022-05-16 |
2025-09-11 |
Institut National de la Santé et de la Recherche Médicale |
Methods for assessing the exhaustion of hematopoietic stem cells induced by chronic inflammation
|