JP2014525427A5 - - Google Patents
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- Publication number
- JP2014525427A5 JP2014525427A5 JP2014527682A JP2014527682A JP2014525427A5 JP 2014525427 A5 JP2014525427 A5 JP 2014525427A5 JP 2014527682 A JP2014527682 A JP 2014527682A JP 2014527682 A JP2014527682 A JP 2014527682A JP 2014525427 A5 JP2014525427 A5 JP 2014525427A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- group
- heterocyclyl
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11179491 | 2011-08-31 | ||
| EP11179491.3 | 2011-08-31 | ||
| PCT/EP2012/067018 WO2013030367A1 (en) | 2011-08-31 | 2012-08-31 | Biphenylcarboxamides as rock kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014525427A JP2014525427A (ja) | 2014-09-29 |
| JP2014525427A5 true JP2014525427A5 (enExample) | 2015-10-15 |
Family
ID=46796597
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527682A Withdrawn JP2014525427A (ja) | 2011-08-31 | 2012-08-31 | Ｒｏｃｋキナーゼ阻害剤としてのビフェニルカルボキサミド |
| JP2014527680A Pending JP2014525425A (ja) | 2011-08-31 | 2012-08-31 | 新規のｒｏｃｋキナーゼ阻害剤 |
| JP2014527681A Withdrawn JP2014525426A (ja) | 2011-08-31 | 2012-08-31 | 新規のソフトｒｏｃｋ阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527680A Pending JP2014525425A (ja) | 2011-08-31 | 2012-08-31 | 新規のｒｏｃｋキナーゼ阻害剤 |
| JP2014527681A Withdrawn JP2014525426A (ja) | 2011-08-31 | 2012-08-31 | 新規のソフトｒｏｃｋ阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9079858B2 (enExample) |
| EP (3) | EP2751079A1 (enExample) |
| JP (3) | JP2014525427A (enExample) |
| KR (2) | KR20140079386A (enExample) |
| CN (3) | CN103874684A (enExample) |
| AU (3) | AU2012300834A1 (enExample) |
| BR (3) | BR112014004435A2 (enExample) |
| CA (3) | CA2846752A1 (enExample) |
| EA (3) | EA201490516A1 (enExample) |
| ES (1) | ES2560830T3 (enExample) |
| IL (2) | IL231123A0 (enExample) |
| MX (3) | MX2014002394A (enExample) |
| PT (1) | PT2751080E (enExample) |
| SG (2) | SG11201400117QA (enExample) |
| WO (3) | WO2013030365A1 (enExample) |
| ZA (3) | ZA201401417B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10842669B2 (en) * | 2008-11-13 | 2020-11-24 | Gholam A. Peyman | Ophthalmic drug delivery method |
| EP2751079A1 (en) | 2011-08-31 | 2014-07-09 | Amakem NV | Biphenylcarboxamides as rock kinase inhibitors |
| RS63503B1 (sr) | 2012-10-05 | 2022-09-30 | Kadmon Corporation Llc | Inhibitori rho kinaze |
| HUE033962T2 (en) * | 2013-01-29 | 2018-01-29 | Redx Pharma Plc | Pyridine derivatives as soft rock (RHO kinase) inhibitors |
| WO2014171464A1 (ja) * | 2013-04-15 | 2014-10-23 | 株式会社レナサイエンス | Ｐａｉ－１阻害剤の新規用途 |
| JP6200596B2 (ja) * | 2013-12-17 | 2017-09-20 | イーライ リリー アンド カンパニー | ジメチル安息香酸化合物 |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| CA3110661A1 (en) | 2018-08-29 | 2020-03-05 | University Of Massachusetts | Inhibition of protein kinases to treat friedreich ataxia |
| CN113801111B (zh) * | 2020-06-12 | 2025-10-17 | 上海翰森生物医药科技有限公司 | 联苯类衍生物抑制剂及其制备方法和应用 |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| CA3238227A1 (en) | 2021-11-11 | 2023-05-19 | The Doshisha | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
| WO2024052704A1 (en) * | 2022-09-08 | 2024-03-14 | Redx Pharma Plc | Solid forms of a rock inhibitor |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026112260A1 (en) | 2024-11-21 | 2026-05-28 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026122764A2 (en) | 2024-12-06 | 2026-06-11 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026128688A2 (en) | 2024-12-13 | 2026-06-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026161839A1 (en) | 2025-01-27 | 2026-07-30 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005723A1 (fr) | 1988-11-24 | 1990-05-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane et leur utilisation en medecine |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| ES2166786T3 (es) | 1993-10-01 | 2002-05-01 | Astrazeneca Ab | Procedimiento i. |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| GB0124928D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| US7405295B2 (en) * | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
| US7683097B2 (en) * | 2004-05-27 | 2010-03-23 | Propharmacon Inc. | Topoisomerase inhibitors |
| US20100190788A1 (en) * | 2005-07-11 | 2010-07-29 | Olivier Defert | Amide derivatives as kinase inhitors |
| CN101248046A (zh) * | 2005-07-11 | 2008-08-20 | 德福根有限公司 | 作为激酶抑制剂的酰胺衍生物 |
| JP2009505948A (ja) | 2005-07-11 | 2009-02-12 | デブジェン エヌブイ | キナーゼ阻害剤としてのアミド誘導体 |
| US20070042321A1 (en) * | 2005-08-22 | 2007-02-22 | Florman Michael J | Grinder guard |
| PL1940786T3 (pl) * | 2005-09-16 | 2010-12-31 | Arrow Therapeutics Ltd | Pochodne bifenylowe i ich zastosowanie w leczeniu zapalenia wątroby typu C |
| WO2007042321A2 (en) * | 2005-10-13 | 2007-04-19 | Devgen N.V. | Kinase inhibitors |
| CN101687819B (zh) * | 2007-08-17 | 2013-03-20 | 卫材R&D管理有限公司 | 外用剂 |
| NZ602191A (en) | 2010-03-02 | 2014-07-25 | Amakem Nv | Heterocyclic amides as rock inhibitors |
| GB201018996D0 (en) * | 2010-11-10 | 2010-12-22 | Amakem Nv | Novel ROCK inhibitors |
| KR20140020972A (ko) * | 2011-03-28 | 2014-02-19 | 에프. 호프만-라 로슈 아게 | 티아졸로피리미딘 화합물 |
| GB201114854D0 (en) * | 2011-08-29 | 2011-10-12 | Amakem Nv | Novel rock inhibitors |
| EP2751079A1 (en) * | 2011-08-31 | 2014-07-09 | Amakem NV | Biphenylcarboxamides as rock kinase inhibitors |
| AU2012307535A1 (en) * | 2011-09-13 | 2014-04-03 | Novartis Ag | Combinations comprising a S1P receptor modulator |
-
2012
- 2012-08-31 EP EP12756692.5A patent/EP2751079A1/en not_active Withdrawn
- 2012-08-31 WO PCT/EP2012/067016 patent/WO2013030365A1/en not_active Ceased
- 2012-08-31 CA CA2846752A patent/CA2846752A1/en not_active Abandoned
- 2012-08-31 SG SG11201400117QA patent/SG11201400117QA/en unknown
- 2012-08-31 SG SG11201400058PA patent/SG11201400058PA/en unknown
- 2012-08-31 BR BR112014004435A patent/BR112014004435A2/pt not_active IP Right Cessation
- 2012-08-31 PT PT127596666T patent/PT2751080E/pt unknown
- 2012-08-31 WO PCT/EP2012/067018 patent/WO2013030367A1/en not_active Ceased
- 2012-08-31 AU AU2012300834A patent/AU2012300834A1/en not_active Abandoned
- 2012-08-31 MX MX2014002394A patent/MX2014002394A/es unknown
- 2012-08-31 EP EP12759666.6A patent/EP2751080B1/en not_active Not-in-force
- 2012-08-31 BR BR112014004447A patent/BR112014004447A2/pt not_active IP Right Cessation
- 2012-08-31 CA CA2846695A patent/CA2846695A1/en not_active Abandoned
- 2012-08-31 MX MX2014002393A patent/MX2014002393A/es unknown
- 2012-08-31 BR BR112014004545A patent/BR112014004545A2/pt not_active IP Right Cessation
- 2012-08-31 KR KR1020147008449A patent/KR20140079386A/ko not_active Withdrawn
- 2012-08-31 WO PCT/EP2012/067017 patent/WO2013030366A1/en not_active Ceased
- 2012-08-31 AU AU2012300832A patent/AU2012300832A1/en not_active Abandoned
- 2012-08-31 EA EA201490516A patent/EA201490516A1/ru unknown
- 2012-08-31 KR KR1020147008450A patent/KR20140072879A/ko not_active Withdrawn
- 2012-08-31 EA EA201490515A patent/EA201490515A1/ru unknown
- 2012-08-31 ES ES12759666.6T patent/ES2560830T3/es active Active
- 2012-08-31 JP JP2014527682A patent/JP2014525427A/ja not_active Withdrawn
- 2012-08-31 CN CN201280048515.8A patent/CN103874684A/zh active Pending
- 2012-08-31 US US14/241,092 patent/US9079858B2/en not_active Expired - Fee Related
- 2012-08-31 EA EA201490495A patent/EA024232B1/ru not_active IP Right Cessation
- 2012-08-31 US US14/241,093 patent/US9067889B2/en not_active Expired - Fee Related
- 2012-08-31 MX MX2014002395A patent/MX2014002395A/es unknown
- 2012-08-31 JP JP2014527680A patent/JP2014525425A/ja active Pending
- 2012-08-31 CN CN201280048511.XA patent/CN103874682A/zh active Pending
- 2012-08-31 CA CA2846694A patent/CA2846694A1/en not_active Abandoned
- 2012-08-31 US US14/241,096 patent/US9174939B2/en not_active Expired - Fee Related
- 2012-08-31 EP EP12753983.1A patent/EP2751078A1/en not_active Withdrawn
- 2012-08-31 JP JP2014527681A patent/JP2014525426A/ja not_active Withdrawn
- 2012-08-31 AU AU2012300833A patent/AU2012300833B2/en not_active Expired - Fee Related
- 2012-08-31 CN CN201280048514.3A patent/CN103874683A/zh active Pending
-
2014
- 2014-02-24 IL IL231123A patent/IL231123A0/en unknown
- 2014-02-24 IL IL231122A patent/IL231122A0/en unknown
- 2014-02-25 ZA ZA2014/01417A patent/ZA201401417B/en unknown
- 2014-02-25 ZA ZA2014/01416A patent/ZA201401416B/en unknown
- 2014-02-25 ZA ZA2014/01418A patent/ZA201401418B/en unknown
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