DE602005023763D1 - Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine - Google Patents

Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine

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Publication number
DE602005023763D1
DE602005023763D1 DE602005023763T DE602005023763T DE602005023763D1 DE 602005023763 D1 DE602005023763 D1 DE 602005023763D1 DE 602005023763 T DE602005023763 T DE 602005023763T DE 602005023763 T DE602005023763 T DE 602005023763T DE 602005023763 D1 DE602005023763 D1 DE 602005023763D1
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Germany
Prior art keywords
inhibitors
protein kinases
pyrazoloa1
atpyrimidines
compounds
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DE602005023763T
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English (en)
Inventor
Juan-Miguel Jimenez
Ronald Knegtel
Jean-Damien Charrier
Dean Stamos
Pan Li
Jon R Come
Alex Aronov
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of DE602005023763D1 publication Critical patent/DE602005023763D1/de
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P11/06—Antiasthmatics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
DE602005023763T 2004-11-04 2005-11-04 Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine Active DE602005023763D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62544604P 2004-11-04 2004-11-04
PCT/US2005/040344 WO2006052913A1 (en) 2004-11-04 2005-11-04 PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES

Publications (1)

Publication Number Publication Date
DE602005023763D1 true DE602005023763D1 (de) 2010-11-04

Family

ID=35809833

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005023763T Active DE602005023763D1 (de) 2004-11-04 2005-11-04 Als inhibitoren von proteinkinasen geeignete pyrazoloä1,5-aüpyrimidine

Country Status (21)

Country Link
US (1) US7528138B2 (de)
EP (1) EP1812440B1 (de)
JP (2) JP5030229B2 (de)
KR (1) KR20070090172A (de)
CN (1) CN101094853B (de)
AT (1) ATE482213T1 (de)
AU (1) AU2005304784B2 (de)
CA (1) CA2586375A1 (de)
DE (1) DE602005023763D1 (de)
DK (1) DK1812440T3 (de)
ES (1) ES2354824T3 (de)
HK (1) HK1113569A1 (de)
IL (1) IL182893A0 (de)
MX (1) MX337817B (de)
NO (1) NO20072795L (de)
NZ (1) NZ555236A (de)
PT (1) PT1812440E (de)
RU (1) RU2417996C2 (de)
SI (1) SI1812440T1 (de)
WO (1) WO2006052913A1 (de)
ZA (1) ZA200704476B (de)

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