JP2011500600A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011500600A5 JP2011500600A5 JP2010529094A JP2010529094A JP2011500600A5 JP 2011500600 A5 JP2011500600 A5 JP 2011500600A5 JP 2010529094 A JP2010529094 A JP 2010529094A JP 2010529094 A JP2010529094 A JP 2010529094A JP 2011500600 A5 JP2011500600 A5 JP 2011500600A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- benzamide
- cor
- sulfonyl
- aliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC*c(cc1)cc(*c2ccccc2)c1C(*(C)(C)c1cccc(N=O)c1)=O Chemical compound CC*c(cc1)cc(*c2ccccc2)c1C(*(C)(C)c1cccc(N=O)c1)=O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97928907P | 2007-10-11 | 2007-10-11 | |
| US60/979,289 | 2007-10-11 | ||
| PCT/US2008/079546 WO2009049183A1 (en) | 2007-10-11 | 2008-10-10 | Aryl amides useful as inhibitors of voltage-gated sodium channels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500600A JP2011500600A (ja) | 2011-01-06 |
| JP2011500600A5 true JP2011500600A5 (enExample) | 2012-11-15 |
| JP5562859B2 JP5562859B2 (ja) | 2014-07-30 |
Family
ID=40373086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529094A Expired - Fee Related JP5562859B2 (ja) | 2007-10-11 | 2008-10-10 | 電位開口型ナトリウムチャネルの阻害剤として有用なアリールアミド |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8779197B2 (enExample) |
| EP (1) | EP2212290B1 (enExample) |
| JP (1) | JP5562859B2 (enExample) |
| KR (1) | KR20100075631A (enExample) |
| CN (1) | CN101883758A (enExample) |
| AU (1) | AU2008310663A1 (enExample) |
| CA (1) | CA2702101A1 (enExample) |
| IL (1) | IL204978A0 (enExample) |
| MX (1) | MX2010003865A (enExample) |
| NZ (1) | NZ584519A (enExample) |
| RU (1) | RU2010118467A (enExample) |
| WO (1) | WO2009049183A1 (enExample) |
| ZA (1) | ZA201002604B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2857687T3 (es) * | 2013-01-31 | 2021-09-29 | Vertex Pharma | Piridona amidas como moduladores de los canales de sodio |
| AR094668A1 (es) * | 2013-01-31 | 2015-08-19 | Vertex Pharma | Amidas como moduladores de canales de sodio |
| CN105073738B (zh) * | 2013-01-31 | 2018-01-05 | 沃泰克斯药物股份有限公司 | 作为钠通道调节剂的喹啉及喹喔啉酰胺类 |
| PE20160548A1 (es) | 2013-07-19 | 2016-05-21 | Vertex Pharma | Sulfonamidas como moduladores de canales de sodio |
| CA2931550C (en) * | 2013-12-13 | 2023-09-26 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
| WO2017062804A1 (en) * | 2015-10-07 | 2017-04-13 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Crmp2 sumoylation inhibitors and uses thereof |
| EP3625214B1 (en) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| CA3069720A1 (en) * | 2017-07-11 | 2019-01-17 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2019157505A1 (en) | 2018-02-12 | 2019-08-15 | Vertex Pharmaceuticals Incorporated | A method of treating pain |
| SG11202100137TA (en) | 2018-07-09 | 2021-02-25 | Lieber Institute Inc | PYRIDAZINE COMPOUNDS FOR INHIBITING Nav1.8 |
| AU2019301628C1 (en) | 2018-07-09 | 2025-02-06 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
| US12344595B2 (en) | 2018-11-02 | 2025-07-01 | Merck Sharp & Dohme Llc | 2-amino-n-phenyl-nicotinamides as NAV1.8 inhibitors |
| KR102860523B1 (ko) | 2018-11-02 | 2025-09-16 | 머크 샤프 앤드 돔 엘엘씨 | Nav1.8 억제제로서의 2-아미노-n-헤테로아릴-니코틴아미드 |
| BR112021012909A2 (pt) * | 2019-01-04 | 2021-09-14 | Jiangsu Hengrui Medicine Co., Ltd. | Derivado de 6-oxo-1,6-di-hidropiridazina, método de preparação do mesmo e uso médico do mesmo |
| WO2020146682A1 (en) * | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020146612A1 (en) * | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| CN112996776B (zh) * | 2019-02-20 | 2024-03-15 | 福建盛迪医药有限公司 | 6-氧代-1,6-二氢哒嗪类前药衍生物、其制备方法及其在医药上的应用 |
| CN112390745B (zh) * | 2019-08-19 | 2022-10-21 | 江苏恒瑞医药股份有限公司 | 吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用 |
| TWI770607B (zh) * | 2019-09-12 | 2022-07-11 | 大陸商上海濟煜醫藥科技有限公司 | 吡啶氮氧化合物及其製備方法和用途 |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| CN114437062B (zh) * | 2020-04-30 | 2024-05-17 | 成都海博为药业有限公司 | 一种可作为钠通道调节剂的化合物及其用途 |
| JP7323723B2 (ja) | 2020-06-17 | 2023-08-08 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｎａｖ１．８阻害剤としての２－オキソイミダゾリジン－４－カルボキサミド |
| EP4167994A4 (en) | 2020-06-17 | 2024-07-24 | Merck Sharp & Dohme LLC | 2-OXO-OXAZOLIDINE-5-CARBOXAMIDE AS NAV1.8 INHIBITORS |
| CN114031518B (zh) * | 2020-12-08 | 2023-08-18 | 成都海博为药业有限公司 | 一种苄胺或苄醇衍生物及其用途 |
| MX2023013146A (es) | 2021-05-07 | 2023-11-28 | Merck Sharp & Dohme Llc | Cicloalquil 3-oxopiperazin carboxamidas y cicloheteroalquil 3-oxopiperazin carboxamidas como inhibidores de nav1.8. |
| CN117794920A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂 |
| EP4355733A1 (en) | 2021-06-15 | 2024-04-24 | Grünenthal GmbH | Substituted pyrazole amides |
| JP2025513455A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| CR20250118A (es) * | 2022-09-09 | 2025-08-27 | Latigo Biotherapeutics Inc | Compuestos bloqueadores del canal de sodio, derivados de los mismos y métodos de su uso |
| EP4385984A1 (en) | 2022-12-14 | 2024-06-19 | Grünenthal GmbH | Pyridine-n-oxides as inhibitors of nav1.8 |
| EP4385980A1 (en) | 2022-12-14 | 2024-06-19 | Grünenthal GmbH | Indazoles as inhibitors of nav1.8 |
| AR131345A1 (es) | 2022-12-14 | 2025-03-12 | Gruenenthal Gmbh | SULFOXIMINAS COMO INHIBIDORES DE NaV1.8 |
| EP4385979A1 (en) | 2022-12-14 | 2024-06-19 | Grünenthal GmbH | Multicyclic inhibitors of nav1.8 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130154C (enExample) * | 1957-05-29 | |||
| DE2966048D1 (en) * | 1978-07-20 | 1983-09-15 | Basf Ag | N-arylsulfonyl pyrroles, their preparation and medicaments containing them |
| PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US6620849B2 (en) * | 2000-07-26 | 2003-09-16 | Icafen, Inc. | Potassium channel inhibitors |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| DE60235114D1 (de) | 2001-11-01 | 2010-03-04 | Icagen Inc | Pyrazolamide zur anwendung in der behandlung von schmerz |
| SE0203752D0 (sv) | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| WO2004106324A1 (en) | 2003-05-27 | 2004-12-09 | E.I. Dupont De Nemours And Company | Azolecarboxamide herbicides |
| TW200524888A (en) * | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| TW200628159A (en) | 2004-11-10 | 2006-08-16 | Synta Pharmaceuticals Corp | IL-12 modulatory compounds |
| CA2612976C (en) * | 2005-06-21 | 2012-04-10 | Mitsui Chemicals, Inc. | Amide derivative and insecticide containing the same |
| PE20110118A1 (es) | 2005-10-04 | 2011-03-08 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| MX2008013194A (es) * | 2006-04-11 | 2008-12-01 | Vertex Pharma | Composiciones utiles como inhibidores de canales de sodio regulados por voltaje. |
-
2008
- 2008-10-10 AU AU2008310663A patent/AU2008310663A1/en not_active Abandoned
- 2008-10-10 WO PCT/US2008/079546 patent/WO2009049183A1/en not_active Ceased
- 2008-10-10 CN CN2008801184861A patent/CN101883758A/zh active Pending
- 2008-10-10 CA CA2702101A patent/CA2702101A1/en not_active Abandoned
- 2008-10-10 US US12/249,270 patent/US8779197B2/en active Active
- 2008-10-10 NZ NZ584519A patent/NZ584519A/en not_active IP Right Cessation
- 2008-10-10 RU RU2010118467/04A patent/RU2010118467A/ru not_active Application Discontinuation
- 2008-10-10 MX MX2010003865A patent/MX2010003865A/es active IP Right Grant
- 2008-10-10 JP JP2010529094A patent/JP5562859B2/ja not_active Expired - Fee Related
- 2008-10-10 KR KR1020107010357A patent/KR20100075631A/ko not_active Withdrawn
- 2008-10-10 EP EP08838261.9A patent/EP2212290B1/en active Active
-
2010
- 2010-04-08 IL IL204978A patent/IL204978A0/en unknown
- 2010-04-14 ZA ZA2010/02604A patent/ZA201002604B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2010118467A (ru) | Ариламиды, пригодные в качестве ингибиторов потенциалзависимых натриевых каналов | |
| JP2011500599A5 (enExample) | ||
| JP5491416B2 (ja) | プロスタグランジンｄ２受容体のｎ，ｎ−２置換アミノアルキルビフェニルアンタゴニスト | |
| US10899780B2 (en) | Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases | |
| JP2022050538A (ja) | プロスタサイクリン（ｐｇｉ２）受容体に関連する障害の処置に有用なｐｇｉ２受容体の調節因子 | |
| RU2008144415A (ru) | Композиции, полезные в качестве ингибиторов потенциалзависимых натриевых каналов | |
| RU2010118481A (ru) | Амиды, применимые в качестве ингибиторов потенциалзависимых натриевых каналов | |
| WO2009108720A2 (en) | Antagonists of prostaglandin d2 receptors | |
| AU2007214336B2 (en) | Indoline-sulfonamides compounds | |
| JP2011512359A (ja) | プロスタグランジンｄ２受容体のアンタゴニストとしての環式ジアリールエーテル化合物 | |
| ES2232114T3 (es) | Derivados de cicloalqueno, procedimiento para su produccion, y uso. | |
| JP2011518130A (ja) | プロスタグランジンｄ２受容体のアミノアルキルフェニルアンタゴニスト | |
| JP2012515166A5 (enExample) | ||
| JP5342451B2 (ja) | Ｐｄｅ４阻害剤として有用な置換アセトフェノン | |
| JP2023515617A5 (enExample) | ||
| Nascimento et al. | Co-crystals of non-steroidal anti-inflammatory drugs (NSAIDs): Insight toward formation, methods, and drug enhancement | |
| CN1474818A (zh) | 含有稠合杂环化合物或其盐的糖尿病预防或治疗药 | |
| JP2016500661A5 (enExample) | ||
| GB2461629A (en) | Phenoxy acetic acids as atagonists of prostaglandin D2 receptors | |
| JP2014500330A5 (enExample) | ||
| RU2014119269A (ru) | Полиморфы arry-380, селективного ингибитора erb2, и фармацевтические составы, содержащие их | |
| CN1361763A (zh) | 作为IL－1β和TNF－α的抑制剂的氨基二苯酮 | |
| CN103951615A (zh) | 烷基胺衍生物 | |
| RU2247719C2 (ru) | Аминобензофеноны как ингибиторы il-1 бета и tnf-альфа, фармацевтическая композиция и способ лечения и/или профилактики воспалительных заболеваний | |
| CN103384522B (zh) | 咖啡酸衍生物和它们在改善神经细胞生存力中的用途 |