|
CN109112126B
(zh)
*
|
2010-06-23 |
2024-06-14 |
库尔纳公司 |
通过抑制电压门控钠通道α亚基(SCNA)的天然反义转录物而治疗SCNA相关疾病
|
|
WO2012004743A1
(en)
|
2010-07-09 |
2012-01-12 |
Pfizer Limited |
Benzenesulfonamides useful as sodium channel inhibitors
|
|
CA2804351A1
(en)
|
2010-07-12 |
2012-01-19 |
Pfizer Limited |
Chemical compounds
|
|
EP2593431B1
(en)
|
2010-07-12 |
2014-11-19 |
Pfizer Limited |
N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels
|
|
EP2593428B1
(en)
|
2010-07-12 |
2014-11-19 |
Pfizer Limited |
N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels
|
|
EP2593427B1
(en)
|
2010-07-12 |
2014-12-24 |
Pfizer Limited |
Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
|
|
JP2013532184A
(ja)
*
|
2010-07-12 |
2013-08-15 |
ファイザー・リミテッド |
電位開口型ナトリウムチャネル阻害剤として有用なｎ−スルホニルベンズアミド誘導体
|
|
US9656959B2
(en)
|
2010-12-22 |
2017-05-23 |
Purdue Pharma L.P. |
Substituted pyridines as sodium channel blockers
|
|
EP2567959B1
(en)
|
2011-09-12 |
2014-04-16 |
Sanofi |
6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
|
|
EP2922847A1
(en)
|
2012-11-20 |
2015-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
|
|
BR112015018284B1
(pt)
*
|
2013-01-31 |
2023-03-07 |
Vertex Pharmaceuticals Incorporated |
Amidas como moduladores de canais de sódio, seus usos, e composição farmacêutica
|
|
KR102226587B1
(ko)
|
2013-01-31 |
2021-03-11 |
버텍스 파마슈티칼스 인코포레이티드 |
나트륨 채널의 조절제로서의 퀴놀린 및 퀴나졸린 아미드
|
|
CN105026373B
(zh)
*
|
2013-01-31 |
2018-03-30 |
沃泰克斯药物股份有限公司 |
作为钠通道调节剂的吡啶酮酰胺
|
|
JP6337109B2
(ja)
|
2013-07-19 |
2018-06-06 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
ナトリウムチャネルの調節剤としてのスルホンアミド
|
|
SG11201604477SA
(en)
|
2013-12-13 |
2016-07-28 |
Vertex Pharma |
Prodrugs of pyridone amides useful as modulators of sodium channels
|
|
CA2946378A1
(en)
*
|
2014-04-22 |
2015-10-29 |
Q-State Biosciences, Inc. |
Analysis of compounds for pain and sensory disorders
|
|
US10048275B2
(en)
|
2015-03-13 |
2018-08-14 |
Q-State Biosciences, Inc. |
Cardiotoxicity screening methods
|
|
WO2016187543A1
(en)
|
2015-05-21 |
2016-11-24 |
Q-State Biosciences, Inc. |
Optogenetics microscope
|
|
MX386261B
(es)
*
|
2015-10-07 |
2025-03-18 |
Univ Arizona |
Inhibidores de sumoilacion de crmp2 y usos de los mismos
|
|
PL3481201T3
(pl)
*
|
2016-07-07 |
2021-03-22 |
Corteva Agriscience Llc |
Sposoby wytwarzania 4-alkoksy-3-(acylo lub alkilo)oksypikolinamidów
|
|
KR102714561B1
(ko)
|
2017-05-16 |
2024-10-10 |
버텍스 파마슈티칼스 인코포레이티드 |
나트륨 채널의 조절제로서의 중수소화 피리돈 아미드 및 이의 프로드럭
|
|
AU2018300150A1
(en)
*
|
2017-07-11 |
2020-01-30 |
Vertex Pharmaceuticals Incorporated |
Carboxamides as modulators of sodium channels
|
|
US20190343817A1
(en)
|
2018-02-12 |
2019-11-14 |
Vertex Pharmaceuticals Incorporated |
Method of treating pain
|
|
SG11202100130QA
(en)
|
2018-07-09 |
2021-02-25 |
Lieber Institute Inc |
Pyridine carboxamide compounds for inhibiting nav1.8
|
|
AU2019302534B2
(en)
|
2018-07-09 |
2024-10-03 |
Lieber Institute, Inc. |
Pyridazine compounds for inhibiting NaV1.8
|
|
CN110885328B
(zh)
*
|
2018-09-10 |
2022-08-12 |
成都康弘药业集团股份有限公司 |
作为钠通道阻滞剂的磺酰胺类化合物及其用途
|
|
WO2020092187A1
(en)
*
|
2018-11-02 |
2020-05-07 |
Merck Sharp & Dohme Corp. |
2-amino-n-phenyl-nicotinamides as nav1.8 inhibitors
|
|
GEAP202315648A
(en)
|
2018-11-02 |
2023-07-25 |
Merck Sharp & Dohme Llc |
2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors
|
|
WO2020146612A1
(en)
*
|
2019-01-10 |
2020-07-16 |
Vertex Pharmaceuticals Incorporated |
Esters and carbamates as modulators of sodium channels
|
|
WO2020146682A1
(en)
*
|
2019-01-10 |
2020-07-16 |
Vertex Pharmaceuticals Incorporated |
Carboxamides as modulators of sodium channels
|
|
CN112390745B
(zh)
*
|
2019-08-19 |
2022-10-21 |
江苏恒瑞医药股份有限公司 |
吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用
|
|
KR20220101606A
(ko)
*
|
2019-09-12 |
2022-07-19 |
상하이 제민케어 파마슈티칼스 컴퍼니 리미티드 |
피리딘 산질화물 및 이의 제조 방법과 용도
|
|
PH12022551379A1
(en)
|
2019-12-06 |
2023-05-03 |
Vertex Pharma |
Substituted tetrahydrofurans as modulators of sodium channels
|
|
CN113045487B
(zh)
*
|
2019-12-27 |
2025-01-17 |
明慧医药（上海）有限公司 |
一种选择性钠通道调节剂及其制备和应用
|
|
KR20230026404A
(ko)
|
2020-06-17 |
2023-02-24 |
머크 샤프 앤드 돔 엘엘씨 |
Nav1.8 억제제로서의 2-옥소-옥사졸리딘-5-카르복스아미드
|
|
US11802122B2
(en)
|
2020-06-17 |
2023-10-31 |
Merck Sharp & Dohme Llc |
2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors
|
|
EP4334293A1
(en)
|
2021-05-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Cycloalkyl 3-oxopiperazine carboxamides and cycloheteroalkyl 3-oxopiperazine carboxamides as nav1.8 inhibitors
|
|
WO2022256842A1
(en)
|
2021-06-04 |
2022-12-08 |
Vertex Pharmaceuticals Incorporated |
Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
|
|
SI4347031T1
(sl)
|
2021-06-04 |
2026-01-30 |
Vertex Pharmaceuticals Incorporated |
N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
|
|
US11999699B2
(en)
|
2021-06-15 |
2024-06-04 |
Grünenthal GmbH |
Substituted pyrazole amides
|
|
JP2025513455A
(ja)
|
2022-04-22 |
2025-04-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
疼痛の治療のためのヘテロアリール化合物
|
|
CN117586180A
(zh)
*
|
2022-08-12 |
2024-02-23 |
广州费米子科技有限责任公司 |
用作电压-门控钠通道抑制剂的化合物
|
|
EP4385980A1
(en)
|
2022-12-14 |
2024-06-19 |
Grünenthal GmbH |
Indazoles as inhibitors of nav1.8
|
|
AR131345A1
(es)
|
2022-12-14 |
2025-03-12 |
Gruenenthal Gmbh |
SULFOXIMINAS COMO INHIBIDORES DE NaV1.8
|
|
EP4385979A1
(en)
|
2022-12-14 |
2024-06-19 |
Grünenthal GmbH |
Multicyclic inhibitors of nav1.8
|
|
EP4385984A1
(en)
|
2022-12-14 |
2024-06-19 |
Grünenthal GmbH |
Pyridine-n-oxides as inhibitors of nav1.8
|
|
WO2024217344A1
(zh)
*
|
2023-04-19 |
2024-10-24 |
中国科学院上海药物研究所 |
Nav1.8抑制剂及其制备方法和用途
|