JP2011500599A5 - - Google Patents

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Publication number
JP2011500599A5
JP2011500599A5 JP2010529092A JP2010529092A JP2011500599A5 JP 2011500599 A5 JP2011500599 A5 JP 2011500599A5 JP 2010529092 A JP2010529092 A JP 2010529092A JP 2010529092 A JP2010529092 A JP 2010529092A JP 2011500599 A5 JP2011500599 A5 JP 2011500599A5
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JP
Japan
Prior art keywords
ring
pain
compound
optionally substituted
aliphatic
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JP2010529092A
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English (en)
Japanese (ja)
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JP5436434B2 (ja
JP2011500599A (ja
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Priority claimed from PCT/US2008/079544 external-priority patent/WO2009049181A1/en
Publication of JP2011500599A publication Critical patent/JP2011500599A/ja
Publication of JP2011500599A5 publication Critical patent/JP2011500599A5/ja
Application granted granted Critical
Publication of JP5436434B2 publication Critical patent/JP5436434B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010529092A 2007-10-11 2008-10-10 電位開口型ナトリウムチャネルの阻害剤として有用なアミド Expired - Fee Related JP5436434B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97929207P 2007-10-11 2007-10-11
US60/979,292 2007-10-11
PCT/US2008/079544 WO2009049181A1 (en) 2007-10-11 2008-10-10 Amides useful as inhibitors of voltage-gated sodium channels

Publications (3)

Publication Number Publication Date
JP2011500599A JP2011500599A (ja) 2011-01-06
JP2011500599A5 true JP2011500599A5 (enExample) 2012-11-22
JP5436434B2 JP5436434B2 (ja) 2014-03-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010529092A Expired - Fee Related JP5436434B2 (ja) 2007-10-11 2008-10-10 電位開口型ナトリウムチャネルの阻害剤として有用なアミド

Country Status (13)

Country Link
US (2) US8389734B2 (enExample)
EP (1) EP2212292B1 (enExample)
JP (1) JP5436434B2 (enExample)
KR (1) KR20100066583A (enExample)
CN (1) CN101855210A (enExample)
AU (1) AU2008310661A1 (enExample)
CA (1) CA2701766A1 (enExample)
IL (1) IL204977A0 (enExample)
MX (1) MX2010003864A (enExample)
NZ (1) NZ584474A (enExample)
RU (1) RU2010118481A (enExample)
WO (1) WO2009049181A1 (enExample)
ZA (1) ZA201002471B (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101914309B1 (ko) * 2010-06-23 2018-11-02 큐알엔에이, 인크. 전압 작동 나트륨 통로, 알파 소단위(scna)에 대한 자연 안티센스 전사체의 저해에 의한 전압 작동 나트륨 통로, 알파 소단위(scna) 관련된 질환의 치료
CA2804593C (en) 2010-07-09 2015-11-24 Pfizer Limited Biphenyloxybenzensulphonamide derivatives useful as sodium channel inhibitors
WO2012007883A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
JP2013531030A (ja) 2010-07-12 2013-08-01 ファイザー・リミテッド 電位開口型ナトリウムチャネルの阻害剤としてのｎ−スルホニルベンズアミド
CA2804716A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
ES2526541T3 (es) 2010-07-12 2015-01-13 Pfizer Limited N-sulfonilbenzamidas como inhibidores de canales de sodio dependientes de voltaje
CA2801032A1 (en) 2010-07-12 2012-01-19 Pfizer Limited N-sulfonylbenzamide derivatives useful as voltage gated sodium channel inhibitors
JP2014500303A (ja) * 2010-12-22 2014-01-09 パーデュー、ファーマ、リミテッド、パートナーシップ ナトリウムチャネル遮断剤としての置換ピリジン
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP2016501203A (ja) 2012-11-20 2016-01-18 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インドールアミン２，３−ジオキシゲナーゼの阻害剤として有用な化合物
ES2857687T3 (es) * 2013-01-31 2021-09-29 Vertex Pharma Piridona amidas como moduladores de los canales de sodio
AR094668A1 (es) * 2013-01-31 2015-08-19 Vertex Pharma Amidas como moduladores de canales de sodio
CN105073738B (zh) 2013-01-31 2018-01-05 沃泰克斯药物股份有限公司 作为钠通道调节剂的喹啉及喹喔啉酰胺类
PE20160548A1 (es) 2013-07-19 2016-05-21 Vertex Pharma Sulfonamidas como moduladores de canales de sodio
CA2931550C (en) * 2013-12-13 2023-09-26 Vertex Pharmaceuticals Incorporated Prodrugs of pyridone amides useful as modulators of sodium channels
CA2946385A1 (en) * 2014-04-22 2015-10-29 Q-State Biosciences, Inc. Diagnostic methods for neuronal disorders
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
WO2016187543A1 (en) 2015-05-21 2016-11-24 Q-State Biosciences, Inc. Optogenetics microscope
WO2017062804A1 (en) * 2015-10-07 2017-04-13 The Arizona Board Of Regents On Behalf Of The University Of Arizona Crmp2 sumoylation inhibitors and uses thereof
KR102384531B1 (ko) * 2016-07-07 2022-04-08 코르테바 애그리사이언스 엘엘씨 4-알콕시-3-(아실 또는 알킬)옥시피콜린아미드의 제조 방법
EP3625214B1 (en) 2017-05-16 2022-07-06 Vertex Pharmaceuticals Incorporated Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
CA3069720A1 (en) * 2017-07-11 2019-01-17 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
WO2019157505A1 (en) 2018-02-12 2019-08-15 Vertex Pharmaceuticals Incorporated A method of treating pain
AU2019301628C1 (en) 2018-07-09 2025-02-06 Lieber Institute, Inc. Pyridine carboxamide compounds for inhibiting NaV1.8
SG11202100137TA (en) 2018-07-09 2021-02-25 Lieber Institute Inc PYRIDAZINE COMPOUNDS FOR INHIBITING Nav1.8
CN110885328B (zh) * 2018-09-10 2022-08-12 成都康弘药业集团股份有限公司 作为钠通道阻滞剂的磺酰胺类化合物及其用途
KR102860523B1 (ko) 2018-11-02 2025-09-16 머크 샤프 앤드 돔 엘엘씨 Nav1.8 억제제로서의 2-아미노-n-헤테로아릴-니코틴아미드
US12344595B2 (en) 2018-11-02 2025-07-01 Merck Sharp & Dohme Llc 2-amino-n-phenyl-nicotinamides as NAV1.8 inhibitors
WO2020146682A1 (en) * 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
WO2020146612A1 (en) * 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Esters and carbamates as modulators of sodium channels
CN112390745B (zh) * 2019-08-19 2022-10-21 江苏恒瑞医药股份有限公司 吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用
TWI770607B (zh) * 2019-09-12 2022-07-11 大陸商上海濟煜醫藥科技有限公司 吡啶氮氧化合物及其製備方法和用途
MX2022006865A (es) 2019-12-06 2022-07-11 Vertex Pharma Tetrahidrofuranos sustituidos como moduladores de canales de sodio.
CN113045487B (zh) * 2019-12-27 2025-01-17 明慧医药（上海）有限公司 一种选择性钠通道调节剂及其制备和应用
EP4167994A4 (en) 2020-06-17 2024-07-24 Merck Sharp & Dohme LLC 2-OXO-OXAZOLIDINE-5-CARBOXAMIDE AS NAV1.8 INHIBITORS
JP7323723B2 (ja) 2020-06-17 2023-08-08 メルク・シャープ・アンド・ドーム・エルエルシー Ｎａｖ１．８阻害剤としての２－オキソイミダゾリジン－４－カルボキサミド
MX2023013146A (es) 2021-05-07 2023-11-28 Merck Sharp & Dohme Llc Cicloalquil 3-oxopiperazin carboxamidas y cicloheteroalquil 3-oxopiperazin carboxamidas como inhibidores de nav1.8.
CN117794920A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂
EP4355733A1 (en) 2021-06-15 2024-04-24 Grünenthal GmbH Substituted pyrazole amides
JP2025513455A (ja) 2022-04-22 2025-04-24 バーテックス ファーマシューティカルズ インコーポレイテッド 疼痛の治療のためのヘテロアリール化合物
EP4570788A1 (en) 2022-08-12 2025-06-18 Guangzhou Fermion Technology Co., Ltd. Compound as voltage-gated sodium channel inhibitor
EP4385980A1 (en) 2022-12-14 2024-06-19 Grünenthal GmbH Indazoles as inhibitors of nav1.8
EP4385984A1 (en) 2022-12-14 2024-06-19 Grünenthal GmbH Pyridine-n-oxides as inhibitors of nav1.8
AR131345A1 (es) 2022-12-14 2025-03-12 Gruenenthal Gmbh SULFOXIMINAS COMO INHIBIDORES DE NaV1.8
EP4385979A1 (en) 2022-12-14 2024-06-19 Grünenthal GmbH Multicyclic inhibitors of nav1.8
KR20250173577A (ko) * 2023-04-19 2025-12-10 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 Nav1.8억제제 및 이의 제조 방법 및 용도

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL130154C (enExample) * 1957-05-29
DE2966048D1 (en) 1978-07-20 1983-09-15 Basf Ag N-arylsulfonyl pyrroles, their preparation and medicaments containing them
US4228449A (en) * 1978-12-26 1980-10-14 Hughes Aircraft Company Semiconductor diode array liquid crystal device
US6620849B2 (en) * 2000-07-26 2003-09-16 Icafen, Inc. Potassium channel inhibitors
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
DE60235114D1 (de) 2001-11-01 2010-03-04 Icagen Inc Pyrazolamide zur anwendung in der behandlung von schmerz
SE0203752D0 (sv) 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
WO2004106324A1 (en) 2003-05-27 2004-12-09 E.I. Dupont De Nemours And Company Azolecarboxamide herbicides
EP1632477B1 (en) * 2003-06-12 2017-03-01 Astellas Pharma Inc. Benzamide derivative or salt thereof
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
TW200524888A (en) * 2003-08-08 2005-08-01 Vertex Pharma Compositions useful as inhibitors of voltage-gated ion channels
TW200628159A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp IL-12 modulatory compounds
PE20110118A1 (es) 2005-10-04 2011-03-08 Aventis Pharma Inc Compuestos de pirimidina amida como inhibidores de pgds
MX2008013194A (es) * 2006-04-11 2008-12-01 Vertex Pharma Composiciones utiles como inhibidores de canales de sodio regulados por voltaje.
US8383734B2 (en) * 2006-07-17 2013-02-26 Syracuse University Multi-solution bone cements and methods of making the same

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