MA40480B1 - Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie - Google Patents

Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie

Info

Publication number
MA40480B1
MA40480B1 MA40480A MA40480A MA40480B1 MA 40480 B1 MA40480 B1 MA 40480B1 MA 40480 A MA40480 A MA 40480A MA 40480 A MA40480 A MA 40480A MA 40480 B1 MA40480 B1 MA 40480B1
Authority
MA
Morocco
Prior art keywords
schizophrenia
sustained
crystallization
treatment
release formulations
Prior art date
Application number
MA40480A
Other languages
English (en)
Inventor
Wilfredo Morales Jr
Tarek A Zeidan
Renato A Chiarella
Steven G Wright
Jason M Perry
Original Assignee
Alkermes Pharma Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Pharma Ireland Ltd filed Critical Alkermes Pharma Ireland Ltd
Publication of MA40480B1 publication Critical patent/MA40480B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

La présente invention concerne des procédés de production d'injection retard d'aripiprazole lauroxil recristallisé dans lesquels des particules de l'aripiprazole lauroxil ont une surface d'environ 0,50 à environ 3,3 m²/g; et des cristaux d'aripiprazole lauroxil produits par de tels procédés. La présente invention concerne un procédé de fabrication d'un composé de formule (a) sous forme cristalline dans lequel ra est ch20c(o)r et dans lequel r1 est un fragment aliphatique substitué ou non substitué.
MA40480A 2014-08-25 2015-08-24 Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie MA40480B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462041341P 2014-08-25 2014-08-25
PCT/US2015/046525 WO2016032950A1 (fr) 2014-08-25 2015-08-24 Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie

Publications (1)

Publication Number Publication Date
MA40480B1 true MA40480B1 (fr) 2021-08-31

Family

ID=55347322

Family Applications (2)

Application Number Title Priority Date Filing Date
MA40480A MA40480B1 (fr) 2014-08-25 2015-08-24 Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie
MA055917A MA55917A (fr) 2014-08-25 2015-08-24 Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA055917A MA55917A (fr) 2014-08-25 2015-08-24 Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie

Country Status (20)

Country Link
US (5) US10064859B2 (fr)
EP (2) EP3185867B1 (fr)
JP (2) JP6591546B2 (fr)
CN (2) CN107106556B (fr)
AU (2) AU2015306910B2 (fr)
CA (1) CA2959329C (fr)
CY (1) CY1124058T1 (fr)
DK (1) DK3185867T3 (fr)
ES (2) ES2862098T3 (fr)
HR (1) HRP20210551T1 (fr)
HU (1) HUE054641T2 (fr)
IL (1) IL250661B (fr)
LT (1) LT3185867T (fr)
MA (2) MA40480B1 (fr)
PL (1) PL3185867T3 (fr)
PT (1) PT3185867T (fr)
RS (1) RS61709B1 (fr)
SI (1) SI3185867T1 (fr)
SM (1) SMT202100212T1 (fr)
WO (1) WO2016032950A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014080285A2 (fr) 2012-09-19 2014-05-30 Alkermes Pharma Ireland Limited Compositions pharmaceutiques ayant une plus grande stabilité au stockage
US10016415B2 (en) 2014-08-18 2018-07-10 Alkermes Pharma Ireland Limited Aripiprazole prodrug compositions
JP6591546B2 (ja) * 2014-08-25 2019-10-16 アルカームス ファーマ アイルランド リミテッド 統合失調症治療用の持続放出型製剤におけるアリピプラゾール誘導体の結晶化プロセス
EP3294724A4 (fr) * 2015-05-08 2018-11-21 Davuluri, Ramamohan Rao Procédé amélioré pour la préparation d'aripiprazole doté d'une taille de particule réduite
WO2018104953A1 (fr) * 2016-12-07 2018-06-14 Msn Laboratories Private Limited, R&D Center Procédé amélioré pour la préparation de 7-{4-[4-(2,3-dichlorophényl)-pipérazin-1-yl]butoxy}-2oxo-3,4-dihydro-2h-quinolin-1-yl)méthyl dodécanoate
EP3658540B1 (fr) 2017-07-28 2021-12-01 Interquim, S.A. Procédé de préparation du lauroxil d'aripiprazole
CN110218209B (zh) * 2018-03-02 2022-09-30 上海现代药物制剂工程研究中心有限公司 一种依匹哌唑月桂酸酯的晶型a、其制备方法及应用
WO2019173230A1 (fr) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Stratégie de dosage d'aripiprazole
CN113105389B (zh) * 2021-04-16 2022-04-08 江苏海洋大学 一种阿立哌唑药物共晶及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US20050032811A1 (en) 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
KR100931784B1 (ko) * 2003-10-23 2009-12-14 오츠카 세이야쿠 가부시키가이샤 방출조절성 멸균 아리피프라졸 주사제, 그 제조방법
TWI371274B (en) * 2003-10-23 2012-09-01 Bristol Myers Squibb Co Process for making sterile aripiprazole of desired mean particle size
KR20100099292A (ko) 2007-12-19 2010-09-10 얀센 파마슈티카 엔.브이. 장기 작용성 주사가능 팔리페리돈 에스테르와 관련된 투여 요법
US20110003823A1 (en) 2008-08-01 2011-01-06 Alpha Synergy Development, Inc. Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage
AU2010266018B2 (en) * 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
WO2012077134A1 (fr) * 2010-12-07 2012-06-14 Ind-Swift Laboratories Limted Méthode de préparation de polymorphes d'aripiprazole
CA2824045C (fr) * 2011-01-07 2019-04-09 Neodyne Biosciences, Inc. Dispositifs et procedes de traitement des plaies ou de la peau
MX358344B (es) 2011-03-18 2018-08-15 Alkermes Pharma Ireland Ltd Composiciones farmaceuticas que comprenden un antipsicotico insoluble en agua y esteres de sorbitan.
EP2827868B8 (fr) * 2012-03-19 2019-12-18 Alkermes Pharma Ireland Limited Compositions pharmaceutiques comprenant des esters d'acides gras
WO2014080285A2 (fr) * 2012-09-19 2014-05-30 Alkermes Pharma Ireland Limited Compositions pharmaceutiques ayant une plus grande stabilité au stockage
JP6591546B2 (ja) * 2014-08-25 2019-10-16 アルカームス ファーマ アイルランド リミテッド 統合失調症治療用の持続放出型製剤におけるアリピプラゾール誘導体の結晶化プロセス

Also Published As

Publication number Publication date
HRP20210551T1 (hr) 2021-08-20
PT3185867T (pt) 2021-04-12
US20190015408A1 (en) 2019-01-17
US11883394B2 (en) 2024-01-30
NZ729479A (en) 2021-03-26
AU2015306910A1 (en) 2017-03-16
US20210205302A1 (en) 2021-07-08
US10973816B2 (en) 2021-04-13
US10064859B2 (en) 2018-09-04
EP3185867B1 (fr) 2021-01-13
US10478434B2 (en) 2019-11-19
RS61709B1 (sr) 2021-05-31
JP2017526747A (ja) 2017-09-14
CA2959329C (fr) 2023-06-27
EP3185867A1 (fr) 2017-07-05
CN107106556A (zh) 2017-08-29
AU2015306910A8 (en) 2020-11-19
SI3185867T1 (sl) 2021-08-31
CA2959329A1 (fr) 2016-03-03
DK3185867T3 (da) 2021-03-15
CY1124058T1 (el) 2022-05-27
LT3185867T (lt) 2021-06-10
ES2994850T3 (en) 2025-02-03
PL3185867T3 (pl) 2021-11-22
WO2016032950A1 (fr) 2016-03-03
EP3185867A4 (fr) 2018-01-24
US20240245676A1 (en) 2024-07-25
IL250661B (en) 2020-04-30
CN111454207B (zh) 2024-10-18
HUE054641T2 (hu) 2021-09-28
AU2015306910B2 (en) 2020-11-19
MA55917A (fr) 2022-03-16
EP3865476A1 (fr) 2021-08-18
US20200108063A1 (en) 2020-04-09
EP3865476B1 (fr) 2024-08-14
CN107106556B (zh) 2020-06-05
ES2862098T3 (es) 2021-10-07
AU2020264303A1 (en) 2020-11-26
SMT202100212T1 (it) 2021-07-12
AU2020264303B2 (en) 2022-10-13
US20160051546A1 (en) 2016-02-25
JP2019210296A (ja) 2019-12-12
CN111454207A (zh) 2020-07-28
IL250661A0 (en) 2017-04-30
JP6591546B2 (ja) 2019-10-16

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