JP2007531782A5 - - Google Patents

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Publication number
JP2007531782A5
JP2007531782A5 JP2007506716A JP2007506716A JP2007531782A5 JP 2007531782 A5 JP2007531782 A5 JP 2007531782A5 JP 2007506716 A JP2007506716 A JP 2007506716A JP 2007506716 A JP2007506716 A JP 2007506716A JP 2007531782 A5 JP2007531782 A5 JP 2007531782A5
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JP
Japan
Prior art keywords
substituted
disease
unsubstituted
solvate
pharmaceutically acceptable
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JP2007506716A
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English (en)
Japanese (ja)
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JP2007531782A (ja
JP4995076B2 (ja
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Priority claimed from EP04075997A external-priority patent/EP1586318A1/en
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Publication of JP2007531782A publication Critical patent/JP2007531782A/ja
Publication of JP2007531782A5 publication Critical patent/JP2007531782A5/ja
Application granted granted Critical
Publication of JP4995076B2 publication Critical patent/JP4995076B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2007506716A 2004-04-05 2005-04-04 Gsk−3阻害剤 Expired - Lifetime JP4995076B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04075997.9 2004-04-05
EP04075997A EP1586318A1 (en) 2004-04-05 2004-04-05 Thiadiazolidinones as GSK-3 inhibitors
PCT/EP2005/003613 WO2005097117A1 (en) 2004-04-05 2005-04-04 Thiadiazolidinones as gsk-3 inhibitors

Publications (3)

Publication Number Publication Date
JP2007531782A JP2007531782A (ja) 2007-11-08
JP2007531782A5 true JP2007531782A5 (enExample) 2009-01-29
JP4995076B2 JP4995076B2 (ja) 2012-08-08

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ID=34928129

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007506716A Expired - Lifetime JP4995076B2 (ja) 2004-04-05 2005-04-04 Gsk−3阻害剤

Country Status (29)

Country Link
US (2) US7531561B2 (enExample)
EP (2) EP1586318A1 (enExample)
JP (1) JP4995076B2 (enExample)
KR (1) KR101151647B1 (enExample)
CN (1) CN1946398B (enExample)
AR (2) AR048820A1 (enExample)
AT (1) ATE446090T1 (enExample)
AU (1) AU2005230392B2 (enExample)
BR (1) BRPI0508788A (enExample)
CA (1) CA2559740C (enExample)
CY (1) CY1109724T1 (enExample)
DE (1) DE602005017215D1 (enExample)
DK (1) DK1586319T3 (enExample)
EC (1) ECSP066858A (enExample)
ES (1) ES2335505T3 (enExample)
HR (1) HRP20100032T1 (enExample)
IL (1) IL178125A (enExample)
MA (1) MA28515B1 (enExample)
MX (1) MXPA06011194A (enExample)
NO (1) NO332751B1 (enExample)
NZ (1) NZ549904A (enExample)
PL (1) PL1586319T3 (enExample)
PT (1) PT1586319E (enExample)
RS (1) RS51340B (enExample)
RU (1) RU2379300C2 (enExample)
SI (1) SI1586319T1 (enExample)
TW (1) TWI352084B (enExample)
WO (1) WO2005097117A1 (enExample)
ZA (1) ZA200608221B (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60129222T2 (de) 2000-05-11 2008-03-06 Consejo Superior de Investigaciónes Científicas Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3
EP1586318A1 (en) * 2004-04-05 2005-10-19 Neuropharma S.A.U. Thiadiazolidinones as GSK-3 inhibitors
WO2006045581A1 (en) * 2004-10-21 2006-05-04 Neuropharma, S.A. The use of 1, 2, 4-thiadiazolidine-3, 5-diones as ppar activators
ES2258406B1 (es) * 2005-02-10 2007-12-01 Neuropharma, S.A. Uso de compuestos heterociclicos como agentes neurogenicos.
EP1749523A1 (en) * 2005-07-29 2007-02-07 Neuropharma, S.A. GSK-3 inhibitors
US9180118B2 (en) * 2006-07-18 2015-11-10 University Of Rochester Thiadiazolidinone derivatives
WO2008012031A2 (en) * 2006-07-25 2008-01-31 Universität Bern Blockers of gsk3 for the prevention and treatment of pemphigus vulgaris
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
EP2535336A1 (en) 2006-10-21 2012-12-19 Abbott GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors
KR100829468B1 (ko) * 2007-01-17 2008-05-16 한국화학연구원 신규한 1,2,4-티아다이아졸리딘-3,5-다이온 화합물 및 이의제조방법
KR100837785B1 (ko) * 2007-01-17 2008-06-13 한국화학연구원 1,2,4-티아다이아졸리딘-3,5-다이온 화합물을 포함하는염증관련 질환의 치료 및 예방을 위한 약제학적 조성물
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
EP2177510A1 (en) 2008-10-17 2010-04-21 Universität des Saarlandes Allosteric protein kinase modulators
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
KR20120060207A (ko) 2009-08-26 2012-06-11 사노피 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011151359A1 (en) * 2010-06-02 2011-12-08 Noscira, S.A. Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
MX336726B (es) 2010-09-27 2016-01-27 Abbott Gmbh & Co Kg Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3.
WO2012065065A1 (en) * 2010-11-12 2012-05-18 Follica, Inc. Methods and compositions for modulating hair growth, wound healing and scar revision
AU2011338530B2 (en) 2010-12-06 2017-06-15 Follica, Inc. Methods for treating baldness and promoting hair growth
US9090592B2 (en) 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012149335A2 (en) * 2011-04-28 2012-11-01 Richard Neubig Small molecule inhibitors of rgs proteins
EP2527323A1 (en) 2011-05-24 2012-11-28 Noscira, S.A. Urea carbonyl disulfide derivatives and their therapeutic uses
WO2012170657A1 (en) * 2011-06-07 2012-12-13 Georgetown University Targeting gsk-3beta for the treatment of parkinson's disease
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9371299B2 (en) * 2012-02-24 2016-06-21 Asd Therapeutics Partners, Llc Thiadiazolidinediones as GSK-3 inhibitors
RU2509155C1 (ru) * 2012-10-25 2014-03-10 Федеральное государственное бюджетное учреждение науки Институт биохимии им. А.Н. Баха Российской академии наук Способ детекции белков в амилоидном состоянии и набор для детекции белков в амилоидном состоянии
CN103992312A (zh) * 2013-02-18 2014-08-20 江苏欧威医药有限公司 1,2,4-噻二唑-3,5-二酮衍生物及其药物组合物和应用
CN103992313A (zh) * 2013-02-18 2014-08-20 江苏欧威医药有限公司 1,2,4-噻二唑-3,5-二酮衍生物及其药物组合物和用途
WO2015075051A1 (en) 2013-11-19 2015-05-28 Universitaet Des Saarlandes Allosteric inhibitors of atypical protein kinases c
US20170165230A1 (en) 2014-04-09 2017-06-15 Christopher Rudd Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
JP6663863B2 (ja) 2014-06-12 2020-03-13 シーダーズ−サイナイ メディカル センター がん治療のための組成物及び方法
CN107151235B (zh) * 2016-03-04 2019-12-13 上海市计划生育科学研究所 噻二唑烷二酮基gsk3抑制剂在调节精子运动能力中的用途
WO2017153834A1 (en) * 2016-03-10 2017-09-14 Alma Mater Studiorum - Universitá Di Bologna TREATMENT OF CDKL5 DISORDERS WITH GSK3β INHIBITOR TIDEGLUSIB
GB201617820D0 (en) * 2016-10-21 2016-12-07 King S College London Dental treatment
WO2018226721A1 (en) * 2017-06-06 2018-12-13 The J. David Gladstone Institutes Compositions and methods for reactivating latent immunodeficiency virus using a gsk-3 inhibitor
WO2020033919A1 (en) 2018-08-10 2020-02-13 Diapin Therapeutics, Llc Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113827592B (zh) * 2020-06-24 2024-06-18 中国科学院上海药物研究所 一种噻二唑烷二酮基化合物在治疗致病性感染中的应用
AU2022219157A1 (en) * 2021-02-11 2023-08-10 Venca Research, Inc. Compositions and methods for treating arrhythmogenic cardiomyopathy
WO2022182699A1 (en) 2021-02-24 2022-09-01 Teva Pharmaceuticals International Gmbh Solid state forms of tideglusib and process for preparation thereof
EP4340832A1 (en) 2021-05-21 2024-03-27 Amo Pharma Ltd. Method of treating rna repeat mediated diseases with rna repeat binding compound
EP4094760A1 (en) 2021-05-24 2022-11-30 Consejo Superior De Investigaciones Científicas Thiadiazolidinones for their use in the treatment of limb-girdle muscular dystrophy
CN115197167B (zh) * 2022-07-22 2023-07-28 中国药科大学 1,2,4-噻二唑烷-3,5-二酮化合物及其制备方法和应用
CN117986202B (zh) * 2024-04-03 2024-06-14 中国药科大学 具有ptpn2抑制活性的1,2,4-噻二唑烷-3,5-二酮化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60129222T2 (de) * 2000-05-11 2008-03-06 Consejo Superior de Investigaciónes Científicas Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3
ES2166328B1 (es) * 2000-05-11 2003-09-16 Consejo Superior Investigacion Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos
EP1586318A1 (en) * 2004-04-05 2005-10-19 Neuropharma S.A.U. Thiadiazolidinones as GSK-3 inhibitors

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