KR20110025855A - 이온 채널의 조절제로서의 헤테로사이클릭 유도체 - Google Patents
이온 채널의 조절제로서의 헤테로사이클릭 유도체 Download PDFInfo
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- KR20110025855A KR20110025855A KR1020117002162A KR20117002162A KR20110025855A KR 20110025855 A KR20110025855 A KR 20110025855A KR 1020117002162 A KR1020117002162 A KR 1020117002162A KR 20117002162 A KR20117002162 A KR 20117002162A KR 20110025855 A KR20110025855 A KR 20110025855A
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Landscapes
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| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| CN101300253B (zh) * | 2005-09-09 | 2012-08-22 | 沃泰克斯药物股份有限公司 | 作为电压门控离子通道调控剂的二环衍生物 |
| AU2006306367A1 (en) * | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| CA2687764A1 (en) * | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| WO2009064747A2 (en) | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
| RU2010123876A (ru) * | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
| US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
| US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| CA2714985C (en) | 2008-01-07 | 2018-05-15 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
| US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
| US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| WO2009133641A1 (ja) * | 2008-04-30 | 2009-11-05 | シャープ株式会社 | 照明装置、及び表示装置 |
| USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| US8956346B2 (en) | 2010-05-14 | 2015-02-17 | Rainbow Medical, Ltd. | Reflectance-facilitated ultrasound treatment and monitoring |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN104136442B (zh) * | 2012-01-16 | 2016-12-21 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吡喃‑螺环哌啶酰胺类 |
| US20170058302A1 (en) * | 2014-04-07 | 2017-03-02 | Praj Industries Limited | Method for efficient enzymatic hydrolysis of lignocellulosic materials |
| EP3484464B1 (en) | 2016-03-22 | 2020-10-28 | Merck Sharp & Dohme Corp. | N1-phenylpropane-1,2-diamine compounds with selective activity in voltage-gated sodium channels |
| USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| HUE071358T2 (hu) | 2016-05-20 | 2025-08-28 | Xenon Pharmaceuticals Inc | Benzolszulfonamid vegyületek és terápiás szerként való alkalmazásuk |
| WO2017202376A1 (zh) * | 2016-05-26 | 2017-11-30 | 南京明德新药研发股份有限公司 | 磺酰胺衍生物 |
| USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| WO2018093694A1 (en) * | 2016-11-17 | 2018-05-24 | Merck Sharp & Dohme Corp. | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| JP7022751B2 (ja) | 2016-12-09 | 2022-02-18 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用 |
| SG11202011862PA (en) | 2018-06-13 | 2020-12-30 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
| CN112638898B (zh) | 2018-08-31 | 2024-04-09 | 泽农医药公司 | 杂芳基取代的磺酰胺化合物及其作为钠通道抑制剂的用途 |
| MX2021001380A (es) | 2018-08-31 | 2021-05-27 | Xenon Pharmaceuticals Inc | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos. |
| CN112759536A (zh) * | 2019-11-05 | 2021-05-07 | 常州锐博生物科技有限公司 | 取代的苯磺酰氯的制备方法 |
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| US2324013A (en) | 1941-07-31 | 1943-07-13 | Sharp & Dohme Inc | Amino-substituents of sulphanil-amide derivatives |
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| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| TW200524888A (en) | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| EP1737852A2 (en) * | 2004-04-13 | 2007-01-03 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
| RU2007145434A (ru) | 2005-05-10 | 2009-06-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бициклические производные в качестве модуляторов ионных каналов |
| US7745629B2 (en) | 2005-05-16 | 2010-06-29 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of ion channels |
| ZA200800191B (en) | 2005-06-09 | 2009-04-29 | Vertex Pharmaceuicals Inc | Indane derivatives as modulators of ion channels |
| CN101300253B (zh) | 2005-09-09 | 2012-08-22 | 沃泰克斯药物股份有限公司 | 作为电压门控离子通道调控剂的二环衍生物 |
| EP1934191B1 (en) * | 2005-10-12 | 2012-03-28 | Vertex Pharmaceuticals, Inc. | Biphenyl derivatives as modulators of voltage gated ion channels |
| AU2006306367A1 (en) | 2005-10-21 | 2007-05-03 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| WO2007075895A2 (en) | 2005-12-21 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives as modulators of ion channels |
| US7994174B2 (en) | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| RU2010123876A (ru) | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
| WO2009064747A2 (en) | 2007-11-13 | 2009-05-22 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivati ves and related compounds as modulators of ion channels for the treatment of pain |
-
2009
- 2009-07-01 EP EP09774406A patent/EP2307412A2/en not_active Withdrawn
- 2009-07-01 AU AU2009266979A patent/AU2009266979A1/en not_active Abandoned
- 2009-07-01 US US12/495,880 patent/US7846954B2/en active Active
- 2009-07-01 JP JP2011516842A patent/JP2011526919A/ja active Pending
- 2009-07-01 WO PCT/US2009/049346 patent/WO2010002956A2/en not_active Ceased
- 2009-07-01 CN CN200980127869XA patent/CN102099356A/zh active Pending
- 2009-07-01 CA CA2729681A patent/CA2729681A1/en not_active Abandoned
- 2009-07-01 RU RU2011103451/04A patent/RU2011103451A/ru not_active Application Discontinuation
- 2009-07-01 KR KR1020117002162A patent/KR20110025855A/ko not_active Withdrawn
- 2009-07-01 MX MX2010014193A patent/MX2010014193A/es not_active Application Discontinuation
-
2010
- 2010-10-28 US US12/913,869 patent/US8143297B2/en active Active
- 2010-12-20 ZA ZA2010/09128A patent/ZA201009128B/en unknown
- 2010-12-30 IL IL210412A patent/IL210412A0/en unknown
-
2012
- 2012-02-22 US US13/402,519 patent/US8343763B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010014193A (es) | 2011-02-22 |
| CN102099356A (zh) | 2011-06-15 |
| ZA201009128B (en) | 2012-03-28 |
| IL210412A0 (en) | 2011-03-31 |
| US7846954B2 (en) | 2010-12-07 |
| CA2729681A1 (en) | 2010-01-07 |
| US20110098328A1 (en) | 2011-04-28 |
| EP2307412A2 (en) | 2011-04-13 |
| WO2010002956A3 (en) | 2010-06-10 |
| US8143297B2 (en) | 2012-03-27 |
| US20120149742A1 (en) | 2012-06-14 |
| US8343763B2 (en) | 2013-01-01 |
| AU2009266979A1 (en) | 2010-01-07 |
| WO2010002956A2 (en) | 2010-01-07 |
| JP2011526919A (ja) | 2011-10-20 |
| US20100004300A1 (en) | 2010-01-07 |
| RU2011103451A (ru) | 2012-08-10 |
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