CN103517910B - 作为离子通道调节剂的吗啉-螺环哌啶酰胺 - Google Patents

作为离子通道调节剂的吗啉-螺环哌啶酰胺 Download PDF

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CN103517910B
CN103517910B CN201280018832.5A CN201280018832A CN103517910B CN 103517910 B CN103517910 B CN 103517910B CN 201280018832 A CN201280018832 A CN 201280018832A CN 103517910 B CN103517910 B CN 103517910B
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pain
compound
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alkyl
mmol
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CN103517910A (zh
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S·S·哈德尔达-鲁阿
H·M·宾驰
M·P·丹尼诺
L·T·D·范宁
B·A·弗里曼
P·D·J·格鲁滕休斯
N·希尔格拉夫
P·乔什
E·A·卡莱勒
J·蓬蒂洛
A·希尔利纳
U·J·谢斯
D·J·赫雷
V·阿鲁姆加姆
M·T·米勒
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201280018832.5A 2011-03-14 2012-03-13 作为离子通道调节剂的吗啉-螺环哌啶酰胺 Expired - Fee Related CN103517910B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161452538P 2011-03-14 2011-03-14
US61/452,538 2011-03-14
US201161567809P 2011-12-07 2011-12-07
US61/567,809 2011-12-07
PCT/US2012/028882 WO2012125613A1 (en) 2011-03-14 2012-03-13 Morpholine-spirocyclic piperidine amides as modulators of ion channels

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CN103517910A CN103517910A (zh) 2014-01-15
CN103517910B true CN103517910B (zh) 2016-12-14

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US (2) US8828996B2 (enExample)
EP (1) EP2686325B1 (enExample)
JP (1) JP6088443B2 (enExample)
CN (1) CN103517910B (enExample)
AU (1) AU2012229187B2 (enExample)
CA (1) CA2829803A1 (enExample)
ES (1) ES2618929T3 (enExample)
MX (1) MX347982B (enExample)
WO (1) WO2012125613A1 (enExample)

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SI3697795T1 (sl) 2017-10-17 2024-05-31 Acondicionamiento Tarrasense Soli (r)-9-(2,5-difluorofenetil)-4-etil-2-metil-1-oksa-4,9-diazaspiro(5.5) undekan-3-ona
JP2021512935A (ja) 2018-02-12 2021-05-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 疼痛を処置する方法
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JP2024520643A (ja) 2021-06-04 2024-05-24 バーテックス ファーマシューティカルズ インコーポレイテッド ナトリウムチャネルの調節因子としてのヒドロキシ及び（ハロ）アルコキシ置換テトラヒドロフラン
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EP4511115A1 (en) 2022-04-22 2025-02-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
EP4511114A1 (en) 2022-04-22 2025-02-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
AU2023255558A1 (en) 2022-04-22 2024-10-31 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
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