PE20180694A1 - Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il-carbamato y derivados de 1,1,1-trifluoro-4-hidroxibutan-2-il-carbamato como inhibidores de magl - Google Patents
Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il-carbamato y derivados de 1,1,1-trifluoro-4-hidroxibutan-2-il-carbamato como inhibidores de maglInfo
- Publication number
- PE20180694A1 PE20180694A1 PE2018000153A PE2018000153A PE20180694A1 PE 20180694 A1 PE20180694 A1 PE 20180694A1 PE 2018000153 A PE2018000153 A PE 2018000153A PE 2018000153 A PE2018000153 A PE 2018000153A PE 20180694 A1 PE20180694 A1 PE 20180694A1
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- PE
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- Prior art keywords
- trifluoro
- carbamate
- derivatives
- alkyl
- independently
- Prior art date
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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Abstract
Esta referido a compuestos de la formula (I), en donde R1 y R2 es, de modo independiente, alquilo C1-6 que esta opcionalmente sustituido con uno o varios sustituyentes seleccionados, cada uno de modo independiente, entre OH, halogeno, alcoxi C1-4, entre otros; R3 y R4 es, de modo independiente, H, halogeno, OH, alquilo C1-6, entre otros; R5 y R6 es, de modo independiente, H, alquilo C1-6 o cicloalquilo C3-7, entre otros; R7 es H, alquilo C1-6, entre otros; r es 0 o 1; y sus sales farmaceuticamente aceptables; tambien se refiere a intermediarios usados en su preparacion y sus procesos. Estos compuestos son inhibidores de monoacilglicerol lipasa (MAGL), siendo util para tratar enfermedades y trastornos mediados por MAGL que incluye, por ejemplo, dolor, un trastorno inflamatorio, lesion cerebral traumatica, depresion, ansiedad, enfermedad de Alzheimer, un trastorno metabolico, ACV o cancer
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US201662335290P | 2016-05-12 | 2016-05-12 |
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PE2018000153A PE20180694A1 (es) | 2015-07-31 | 2016-07-18 | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il-carbamato y derivados de 1,1,1-trifluoro-4-hidroxibutan-2-il-carbamato como inhibidores de magl |
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US (3) | US9845301B2 (es) |
EP (1) | EP3328849B9 (es) |
JP (1) | JP6832914B2 (es) |
KR (1) | KR102096349B1 (es) |
CN (1) | CN107849017B (es) |
AU (1) | AU2016304408B2 (es) |
BR (1) | BR112018000041A2 (es) |
CA (1) | CA2937210A1 (es) |
CL (1) | CL2018000024A1 (es) |
CO (1) | CO2018000858A2 (es) |
CR (1) | CR20180047A (es) |
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DO (1) | DOP2018000031A (es) |
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GE (1) | GEP20207105B (es) |
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PE (1) | PE20180694A1 (es) |
PH (1) | PH12018500087A1 (es) |
SV (1) | SV2017005591A (es) |
TN (1) | TN2017000544A1 (es) |
TW (1) | TWI616436B (es) |
UA (1) | UA121775C2 (es) |
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