CU20170166A7 - Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1, 1, 1-trifluoro-4-hidroxibutan-2-il carbamato como inhibidores de magl - Google Patents

Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1, 1, 1-trifluoro-4-hidroxibutan-2-il carbamato como inhibidores de magl

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Publication number
CU20170166A7
CU20170166A7 CUP2017000166A CU20170166A CU20170166A7 CU 20170166 A7 CU20170166 A7 CU 20170166A7 CU P2017000166 A CUP2017000166 A CU P2017000166A CU 20170166 A CU20170166 A CU 20170166A CU 20170166 A7 CU20170166 A7 CU 20170166A7
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CU
Cuba
Prior art keywords
trifluoro
carbamate
derivatives
hydroxipropan
hydroxibutan
Prior art date
Application number
CUP2017000166A
Other languages
English (en)
Inventor
Elizabeth Mary Beck
Michael Aaron Brodney
Christopher Ryan Butler
Adam Matthew Gilbert
Christopher John Helal
Douglas Scott Johnson
Laura Ann Mcallister
Justin Ian Montgomery
Steven Victor O´Neil
Robert Verhoest Patrick
Bruce Nelsen Rogers
Damien Webb
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20170166A7 publication Critical patent/CU20170166A7/es

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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

<p>La presente invención proporciona, en parte, compuestos de Ia formula I:</p> <p>ESPACIO PARA FÓRMULA<br /> y sus sales farmacéuticamente aceptables; procesos para su preparación; intermediarios usados en su preparación; y composiciones que contienen tales compuestos o sales y sus usos para tratar enfermedades y trastornos mediados por MAGL que incluye, por ejemplo, dolor, un trastorno inflamatorio, lesión cerebral traumática, depresión, ansiedad, enfermedad de Alzheimer, un trastorno metabólico, ACV o cáncer.</p>
CUP2017000166A 2015-07-31 2016-07-18 Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1, 1, 1-trifluoro-4-hidroxibutan-2-il carbamato como inhibidores de magl CU20170166A7 (es)

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