DK3328849T3 - 1,1,1-trifluor-3-hydroxypropan-2-yl-carbamat-derivater og 1,1,1-trifluor-4-hydroxybutan-2-yl-carbamat-derivater som magl-inhibitorer - Google Patents
1,1,1-trifluor-3-hydroxypropan-2-yl-carbamat-derivater og 1,1,1-trifluor-4-hydroxybutan-2-yl-carbamat-derivater som magl-inhibitorer Download PDFInfo
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- DK3328849T3 DK3328849T3 DK16741698.1T DK16741698T DK3328849T3 DK 3328849 T3 DK3328849 T3 DK 3328849T3 DK 16741698 T DK16741698 T DK 16741698T DK 3328849 T3 DK3328849 T3 DK 3328849T3
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- DK
- Denmark
- Prior art keywords
- carbamate derivatives
- hydroxybutan
- trifluor
- hydroxypropan
- trifluoro
- Prior art date
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- YILHSQUHCTTZNG-UHFFFAOYSA-N (1,1,1-trifluoro-3-hydroxypropan-2-yl)carbamic acid Chemical class OCC(C(F)(F)F)NC(O)=O YILHSQUHCTTZNG-UHFFFAOYSA-N 0.000 title 1
- IRZMZCTYXRHHLJ-UHFFFAOYSA-N (1,1,1-trifluoro-4-hydroxybutan-2-yl)carbamic acid Chemical class OCCC(C(F)(F)F)NC(O)=O IRZMZCTYXRHHLJ-UHFFFAOYSA-N 0.000 title 1
- 102100029814 Monoglyceride lipase Human genes 0.000 title 1
- 101710116393 Monoglyceride lipase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
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- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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DK3328849T5 DK3328849T5 (da) | 2021-02-15 |
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EP (1) | EP3328849B9 (da) |
JP (1) | JP6832914B2 (da) |
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CN (1) | CN107849017B (da) |
AU (1) | AU2016304408B2 (da) |
BR (1) | BR112018000041A2 (da) |
CA (1) | CA2937210A1 (da) |
CL (1) | CL2018000024A1 (da) |
CO (1) | CO2018000858A2 (da) |
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EA (1) | EA035823B1 (da) |
EC (1) | ECSP18006893A (da) |
ES (1) | ES2823049T3 (da) |
GE (1) | GEP20207105B (da) |
HK (1) | HK1249101A1 (da) |
IL (1) | IL257203B (da) |
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PE (1) | PE20180694A1 (da) |
PH (1) | PH12018500087A1 (da) |
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TN (1) | TN2017000544A1 (da) |
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UA (1) | UA121775C2 (da) |
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EP3455226B1 (en) | 2016-05-12 | 2020-12-30 | Lundbeck La Jolla Research Center, Inc. | Spirocycle compounds and methods of making and using same |
JOP20190107A1 (ar) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
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CR20200088A (es) | 2017-08-29 | 2020-04-08 | Lundbeck La Jolla Research Center Inc | Compuestos espirocíclicos y sus métodos de preparación y uso |
JOP20200023A1 (ar) | 2017-08-29 | 2020-02-02 | Lundbeck La Jolla Research Center Inc | مركبات حلقية لولبية وطرق تصنيعها واستخدامها |
MX2020007318A (es) * | 2017-09-29 | 2020-08-24 | Takeda Pharmaceuticals Co | Compuesto heterociclico. |
JP2021518381A (ja) | 2018-03-23 | 2021-08-02 | エイドス セラピューティクス,インコーポレイティド | Ag10を使用するttrアミロイドーシスの治療方法 |
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