WO2003095427A1 - Spiro-ring compound - Google Patents
Spiro-ring compound Download PDFInfo
- Publication number
- WO2003095427A1 WO2003095427A1 PCT/JP2003/005812 JP0305812W WO03095427A1 WO 2003095427 A1 WO2003095427 A1 WO 2003095427A1 JP 0305812 W JP0305812 W JP 0305812W WO 03095427 A1 WO03095427 A1 WO 03095427A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- spiro
- ring compound
- hydrogen
- formulae
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- -1 1-hydroxycyclooctyl Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004508514A JPWO2003095427A1 (en) | 2002-05-10 | 2003-05-09 | Spiro ring compounds |
AU2003235912A AU2003235912A1 (en) | 2002-05-10 | 2003-05-09 | Spiro-ring compound |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002135988 | 2002-05-10 | ||
JP2002-135988 | 2002-05-10 | ||
JP2002-214248 | 2002-07-23 | ||
JP2002214248 | 2002-07-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003095427A1 true WO2003095427A1 (en) | 2003-11-20 |
Family
ID=29422399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/005812 WO2003095427A1 (en) | 2002-05-10 | 2003-05-09 | Spiro-ring compound |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPWO2003095427A1 (en) |
AU (1) | AU2003235912A1 (en) |
WO (1) | WO2003095427A1 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006058303A3 (en) * | 2004-11-29 | 2006-12-21 | Vertex Pharma | Modulators of muscarinic receptors |
US7879834B2 (en) | 2004-08-19 | 2011-02-01 | Vertex Pharmaceuticals Incorporated | Spiroindoline modulators of muscarinic receptors |
WO2011060035A1 (en) | 2009-11-16 | 2011-05-19 | Eli Lilly And Company | Spiropiperidine compounds as orl-1 receptor antagonists |
WO2011060217A1 (en) | 2009-11-16 | 2011-05-19 | Eli Lilly And Company | Spiropiperidine compounds as orl-1 receptor antagonists |
US8263605B2 (en) | 2006-02-22 | 2012-09-11 | Vertex Pharmaceutical Incorporated | Modulators of muscarinic receptors |
US8304423B2 (en) | 2006-02-22 | 2012-11-06 | Vertex Pharmaceutical Incorporated | Modulators of muscarinic receptors |
US8367691B2 (en) | 2004-08-19 | 2013-02-05 | Vertex Pharmaceutical Incorporated | Modulators of muscarinic receptors |
US8598164B2 (en) | 2010-05-06 | 2013-12-03 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
US8828996B2 (en) | 2011-03-14 | 2014-09-09 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
US8916565B2 (en) | 2011-02-02 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
JP2018058874A (en) * | 2010-10-18 | 2018-04-12 | セレニス セラピューティクス ホールディング エスアー | Compounds, compositions and methods useful for cholesterol mobilization |
US10385070B2 (en) | 2011-02-18 | 2019-08-20 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
JP2022036285A (en) * | 2015-12-02 | 2022-03-04 | アストライア セラピューティクス, エルエルシー | Piperidinyl nociceptin receptor compounds |
US11827617B2 (en) | 2015-12-02 | 2023-11-28 | Astraea Therapeutics, Llc | Piperidinyl nociceptin receptor compounds |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55143980A (en) * | 1979-04-27 | 1980-11-10 | Dai Ichi Seiyaku Co Ltd | Anti-allergic preparation |
EP0431943A2 (en) * | 1989-12-08 | 1991-06-12 | Merck & Co. Inc. | Nitrogen-containing spirocycles |
WO2000034280A1 (en) * | 1998-12-09 | 2000-06-15 | Banyu Pharmaceutical Co., Ltd. | 4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds |
-
2003
- 2003-05-09 AU AU2003235912A patent/AU2003235912A1/en not_active Abandoned
- 2003-05-09 WO PCT/JP2003/005812 patent/WO2003095427A1/en active Application Filing
- 2003-05-09 JP JP2004508514A patent/JPWO2003095427A1/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55143980A (en) * | 1979-04-27 | 1980-11-10 | Dai Ichi Seiyaku Co Ltd | Anti-allergic preparation |
EP0431943A2 (en) * | 1989-12-08 | 1991-06-12 | Merck & Co. Inc. | Nitrogen-containing spirocycles |
WO2000034280A1 (en) * | 1998-12-09 | 2000-06-15 | Banyu Pharmaceutical Co., Ltd. | 4-oxoimidazolidine-2-spiro-nitrogenous heterocycle compounds |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7879834B2 (en) | 2004-08-19 | 2011-02-01 | Vertex Pharmaceuticals Incorporated | Spiroindoline modulators of muscarinic receptors |
US8497295B2 (en) | 2004-08-19 | 2013-07-30 | Vertex Pharmaceuticals Incorporated | Spiroindoline modulators of muscarinic receptors |
US8367691B2 (en) | 2004-08-19 | 2013-02-05 | Vertex Pharmaceutical Incorporated | Modulators of muscarinic receptors |
US8258148B2 (en) | 2004-08-19 | 2012-09-04 | Vertex Pharmaceutical Incorporated | Spiroindoline modulators of muscarinic receptors |
JP2008521825A (en) * | 2004-11-29 | 2008-06-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | Muscarinic receptor modulators |
WO2006058303A3 (en) * | 2004-11-29 | 2006-12-21 | Vertex Pharma | Modulators of muscarinic receptors |
US8304423B2 (en) | 2006-02-22 | 2012-11-06 | Vertex Pharmaceutical Incorporated | Modulators of muscarinic receptors |
US8263605B2 (en) | 2006-02-22 | 2012-09-11 | Vertex Pharmaceutical Incorporated | Modulators of muscarinic receptors |
US8232289B2 (en) | 2009-11-16 | 2012-07-31 | Eli Lilly And Company | Spiropiperidine compounds as ORL-1 receptor antagonists |
WO2011060035A1 (en) | 2009-11-16 | 2011-05-19 | Eli Lilly And Company | Spiropiperidine compounds as orl-1 receptor antagonists |
WO2011060217A1 (en) | 2009-11-16 | 2011-05-19 | Eli Lilly And Company | Spiropiperidine compounds as orl-1 receptor antagonists |
US8598164B2 (en) | 2010-05-06 | 2013-12-03 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
JP2018058874A (en) * | 2010-10-18 | 2018-04-12 | セレニス セラピューティクス ホールディング エスアー | Compounds, compositions and methods useful for cholesterol mobilization |
US10220040B2 (en) | 2010-10-18 | 2019-03-05 | Cerenis Therapeutics Holding Sa | Compounds, compositions and methods useful for cholesterol mobilization |
US8916565B2 (en) | 2011-02-02 | 2014-12-23 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels |
US9511067B2 (en) | 2011-02-02 | 2016-12-06 | Vertex Pharmaceuticals Incorporated | Substituted spiro[piperidine-4,1'-pyrrolo[1,2-a]pyrazine]s as modulators of ion channels |
US10385070B2 (en) | 2011-02-18 | 2019-08-20 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
US9181273B2 (en) | 2011-03-14 | 2015-11-10 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
US8828996B2 (en) | 2011-03-14 | 2014-09-09 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
JP2022036285A (en) * | 2015-12-02 | 2022-03-04 | アストライア セラピューティクス, エルエルシー | Piperidinyl nociceptin receptor compounds |
US11827617B2 (en) | 2015-12-02 | 2023-11-28 | Astraea Therapeutics, Llc | Piperidinyl nociceptin receptor compounds |
USRE49825E1 (en) | 2015-12-02 | 2024-02-06 | Astraea Therapeutics, Llc | Piperidinyl nociceptin receptor compounds |
JP7472175B2 (en) | 2015-12-02 | 2024-04-22 | アストライア セラピューティクス, エルエルシー | Piperidinyl Nociceptin Receptor Compounds |
Also Published As
Publication number | Publication date |
---|---|
JPWO2003095427A1 (en) | 2005-09-15 |
AU2003235912A1 (en) | 2003-11-11 |
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