JP2014501108A5 - - Google Patents
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- JP2014501108A5 JP2014501108A5 JP2013546290A JP2013546290A JP2014501108A5 JP 2014501108 A5 JP2014501108 A5 JP 2014501108A5 JP 2013546290 A JP2013546290 A JP 2013546290A JP 2013546290 A JP2013546290 A JP 2013546290A JP 2014501108 A5 JP2014501108 A5 JP 2014501108A5
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- 238000000034 method Methods 0.000 claims description 167
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- 108060006662 GSK3 Proteins 0.000 claims description 51
- 239000003795 chemical substances by application Substances 0.000 claims description 51
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims description 51
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims description 51
- 239000011435 rock Substances 0.000 claims description 51
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- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 4
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- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims description 4
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- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims description 4
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- 239000003102 growth factor Substances 0.000 claims description 4
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 4
- 108010059616 Activins Proteins 0.000 claims description 2
- 102100037362 Fibronectin Human genes 0.000 claims description 2
- 108010067306 Fibronectins Proteins 0.000 claims description 2
- 102100026818 Inhibin beta E chain Human genes 0.000 claims description 2
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims description 2
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims description 2
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims description 2
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 2
- 206010043276 Teratoma Diseases 0.000 claims description 2
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- 108010082117 matrigel Proteins 0.000 claims description 2
- 210000002894 multi-fate stem cell Anatomy 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
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- 230000001413 cellular effect Effects 0.000 claims 1
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- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- YRPYWPSDJUJBQH-SFHVURJKSA-N 5-[[5-[[(2s)-1-carboxy-3-oxo-4-(pyridin-4-ylmethylsulfanyl)butan-2-yl]carbamoyl]thiophen-2-yl]methylsulfamoyl]-2-hydroxybenzoic acid Chemical compound N([C@@H](CC(=O)O)C(=O)CSCC=1C=CN=CC=1)C(=O)C(S1)=CC=C1CNS(=O)(=O)C1=CC=C(O)C(C(O)=O)=C1 YRPYWPSDJUJBQH-SFHVURJKSA-N 0.000 description 1
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- 239000003550 marker Substances 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426369P | 2010-12-22 | 2010-12-22 | |
| US61/426,369 | 2010-12-22 | ||
| US201161496991P | 2011-06-14 | 2011-06-14 | |
| US61/496,991 | 2011-06-14 | ||
| PCT/US2011/065900 WO2012087965A2 (en) | 2010-12-22 | 2011-12-19 | Cell culture platform for single cell sorting and enhanced reprogramming of ipscs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017103182A Division JP6682474B2 (ja) | 2010-12-22 | 2017-05-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501108A JP2014501108A (ja) | 2014-01-20 |
| JP2014501108A5 true JP2014501108A5 (https=) | 2015-02-12 |
| JP6182456B2 JP6182456B2 (ja) | 2017-08-23 |
Family
ID=46314809
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546290A Active JP6182456B2 (ja) | 2010-12-22 | 2011-12-19 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2017103182A Active JP6682474B2 (ja) | 2010-12-22 | 2017-05-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2020054166A Active JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2022066559A Active JP7350127B2 (ja) | 2010-12-22 | 2022-04-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2023113157A Active JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2024219417A Pending JP2025039573A (ja) | 2010-12-22 | 2024-12-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017103182A Active JP6682474B2 (ja) | 2010-12-22 | 2017-05-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2020054166A Active JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2022066559A Active JP7350127B2 (ja) | 2010-12-22 | 2022-04-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2023113157A Active JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2024219417A Pending JP2025039573A (ja) | 2010-12-22 | 2024-12-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US9732319B2 (https=) |
| EP (1) | EP2655601A4 (https=) |
| JP (6) | JP6182456B2 (https=) |
| KR (6) | KR20140063501A (https=) |
| CN (3) | CN103380212B (https=) |
| AU (1) | AU2011349446C1 (https=) |
| CA (1) | CA2822638C (https=) |
| WO (1) | WO2012087965A2 (https=) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| ES2579909T3 (es) | 2009-02-03 | 2016-08-17 | Koninklijke Nederlandse Akademie Van Wetenschappen | Medio de cultivo para células madre epiteliales y organoides que comprenden dichas células madre |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| WO2012087965A2 (en) | 2010-12-22 | 2012-06-28 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of ipscs |
| US10428309B2 (en) * | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| WO2013082509A1 (en) | 2011-12-01 | 2013-06-06 | The New York Stem Cell Foundation | Automated system for producing induced pluripotent stem cells or differentiated cells |
| WO2014106947A1 (en) * | 2013-01-04 | 2014-07-10 | Kyoto University | Reprogrammed stem cell |
| WO2014115799A1 (ja) * | 2013-01-23 | 2014-07-31 | 東京エレクトロン株式会社 | 多能性幹細胞の継代培養方法 |
| EP2948541B1 (en) * | 2013-01-28 | 2019-09-18 | Rutgers, The State University of New Jersey | Growth matrices for stem cell propagation in vitro and in tissue regeneration |
| CN113913366B (zh) * | 2013-02-18 | 2025-01-10 | 大学健康网络 | 由多能干细胞生成肝细胞和胆管细胞的方法 |
| EP3008174A4 (en) * | 2013-06-11 | 2017-03-08 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US20160115447A1 (en) * | 2013-06-11 | 2016-04-28 | President And Fellows Of Harvard College | Compositions and methods for improving induced neuron generation |
| CN103333920A (zh) * | 2013-06-18 | 2013-10-02 | 西北农林科技大学 | 一种建立猪iPS细胞系的培养基及其培养方法 |
| CN104278008B (zh) * | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
| WO2015011031A1 (en) | 2013-07-23 | 2015-01-29 | F. Hoffmann-La Roche Ag | Small molecule based conversion of somatic cells into neural crest cells |
| KR101655383B1 (ko) * | 2013-07-27 | 2016-09-08 | 고려대학교 산학협력단 | 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물 |
| WO2015064715A1 (ja) * | 2013-10-30 | 2015-05-07 | 東亞合成株式会社 | ゲノム不安定なｉＰＳ細胞の除去方法および該方法に用いられる合成ペプチド |
| KR101697110B1 (ko) * | 2013-11-01 | 2017-01-18 | 건국대학교 글로컬산학협력단 | 세포융합을 통한 줄기세포의 역분화능 측정 방법 |
| CN103667349B (zh) * | 2013-11-15 | 2017-02-15 | 安徽农业大学 | 一种高效获取猪诱导性多能干细胞的方法 |
| SG11201606934SA (en) * | 2014-03-04 | 2016-09-29 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| AU2015261380B2 (en) | 2014-05-16 | 2021-04-15 | Koninklijke Nederlandse Akademie Van Wetenschappen | Improved culture method for organoids |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| EP3183336B2 (en) * | 2014-08-22 | 2025-07-09 | Cambridge Enterprise Limited | Resetting pluripotent stem cells |
| CN105441384B (zh) * | 2014-09-26 | 2021-01-05 | 北京大学 | 一种制备动物和人类原始多潜能干细胞的方法，试剂盒及用途 |
| WO2016057649A1 (en) * | 2014-10-07 | 2016-04-14 | NuTech Medical, Inc. | Mesenchymal stem cell diagnostic testing |
| GB201421094D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| GB201421092D0 (en) | 2014-11-27 | 2015-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium |
| CN107614678B (zh) * | 2014-12-18 | 2021-04-30 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| US10738280B2 (en) | 2015-03-18 | 2020-08-11 | Ono Pharmaceutical Co., Ltd. | Method for producing naïve pluripotent stem cells |
| CN104707173B (zh) * | 2015-04-01 | 2017-03-29 | 中国人民解放军总医院 | 一种三维细胞培养平台、其制备方法及其使用方法 |
| SG11201708579WA (en) * | 2015-04-21 | 2017-11-29 | Gen Automation Lab Tech Inc | High resolution systems, kits, apparatus, and methods for high throughput microbiology applications |
| US10712356B2 (en) | 2015-04-21 | 2020-07-14 | General Automation Lab Technologies Inc. | Apparatus and method for picking biological sample |
| CN105624104B (zh) * | 2015-06-01 | 2018-10-12 | 中国医学科学院血液病医院（血液学研究所） | 一种提高人间充质干细胞功能的细胞处理方法 |
| EP3331988B1 (en) | 2015-08-07 | 2023-09-20 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Chemical reprogramming to generate neuronal cells |
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| CN114807035B (zh) | 2015-09-08 | 2024-02-02 | (由卫生与公众服务部部长代表的)美利坚合众国 | 临床级别视网膜色素上皮细胞的可再现的分化方法 |
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