JP2017158585A5 - - Google Patents
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- JP2017158585A5 JP2017158585A5 JP2017103182A JP2017103182A JP2017158585A5 JP 2017158585 A5 JP2017158585 A5 JP 2017158585A5 JP 2017103182 A JP2017103182 A JP 2017103182A JP 2017103182 A JP2017103182 A JP 2017103182A JP 2017158585 A5 JP2017158585 A5 JP 2017158585A5
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- 210000004027 cell Anatomy 0.000 claims 113
- 239000003112 inhibitor Substances 0.000 claims 46
- 102000001267 GSK3 Human genes 0.000 claims 15
- 108060006662 GSK3 Proteins 0.000 claims 15
- 229940124647 MEK inhibitor Drugs 0.000 claims 15
- 108091005735 TGF-beta receptors Proteins 0.000 claims 15
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims 15
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 15
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 15
- 239000011435 rock Substances 0.000 claims 15
- 210000004102 animal cell Anatomy 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000008672 reprogramming Effects 0.000 claims 9
- 208000031448 Genomic Instability Diseases 0.000 claims 5
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 102100022464 5'-nucleotidase Human genes 0.000 claims 3
- 108010005465 AC133 Antigen Proteins 0.000 claims 3
- 102000005908 AC133 Antigen Human genes 0.000 claims 3
- 102100037904 CD9 antigen Human genes 0.000 claims 3
- 102100037241 Endoglin Human genes 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 3
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 3
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 3
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 3
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 3
- 101000599862 Homo sapiens Intercellular adhesion molecule 3 Proteins 0.000 claims 3
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 3
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 3
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 3
- 102100025304 Integrin beta-1 Human genes 0.000 claims 3
- 102100037871 Intercellular adhesion molecule 3 Human genes 0.000 claims 3
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 3
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 3
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 3
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 3
- 102100040120 Prominin-1 Human genes 0.000 claims 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 3
- 230000005283 ground state Effects 0.000 claims 3
- 230000006872 improvement Effects 0.000 claims 3
- 230000035899 viability Effects 0.000 claims 3
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
- 210000001766 X chromosome Anatomy 0.000 claims 2
- 108091007416 X-inactive specific transcript Proteins 0.000 claims 2
- 108091035715 XIST (gene) Proteins 0.000 claims 2
- 230000003833 cell viability Effects 0.000 claims 2
- 230000002759 chromosomal effect Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000007420 reactivation Effects 0.000 claims 2
- 210000001082 somatic cell Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 108010059616 Activins Proteins 0.000 claims 1
- -1 CD31 Proteins 0.000 claims 1
- AQGNHMOJWBZFQQ-UHFFFAOYSA-N CT 99021 Chemical group CC1=CNC(C=2C(=NC(NCCNC=3N=CC(=CC=3)C#N)=NC=2)C=2C(=CC(Cl)=CC=2)Cl)=N1 AQGNHMOJWBZFQQ-UHFFFAOYSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 239000000488 activin Substances 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 230000032823 cell division Effects 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020054166A JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061426369P | 2010-12-22 | 2010-12-22 | |
| US61/426,369 | 2010-12-22 | ||
| US201161496991P | 2011-06-14 | 2011-06-14 | |
| US61/496,991 | 2011-06-14 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546290A Division JP6182456B2 (ja) | 2010-12-22 | 2011-12-19 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020054166A Division JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017158585A JP2017158585A (ja) | 2017-09-14 |
| JP2017158585A5 true JP2017158585A5 (https=) | 2017-10-26 |
| JP6682474B2 JP6682474B2 (ja) | 2020-04-15 |
Family
ID=46314809
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546290A Active JP6182456B2 (ja) | 2010-12-22 | 2011-12-19 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2017103182A Active JP6682474B2 (ja) | 2010-12-22 | 2017-05-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2020054166A Active JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2022066559A Active JP7350127B2 (ja) | 2010-12-22 | 2022-04-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2023113157A Active JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2024219417A Pending JP2025039573A (ja) | 2010-12-22 | 2024-12-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013546290A Active JP6182456B2 (ja) | 2010-12-22 | 2011-12-19 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020054166A Active JP7513412B2 (ja) | 2010-12-22 | 2020-03-25 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2022066559A Active JP7350127B2 (ja) | 2010-12-22 | 2022-04-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2023113157A Active JP7606569B2 (ja) | 2010-12-22 | 2023-07-10 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
| JP2024219417A Pending JP2025039573A (ja) | 2010-12-22 | 2024-12-13 | 単細胞選別のための細胞培養プラットホームおよびｉＰＳＣの再プログラミングの増強 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US9732319B2 (https=) |
| EP (1) | EP2655601A4 (https=) |
| JP (6) | JP6182456B2 (https=) |
| KR (6) | KR102482184B1 (https=) |
| CN (3) | CN103380212B (https=) |
| AU (1) | AU2011349446C1 (https=) |
| CA (1) | CA2822638C (https=) |
| WO (1) | WO2012087965A2 (https=) |
Families Citing this family (86)
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| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| EP2393917B1 (en) | 2009-02-03 | 2016-04-06 | Koninklijke Nederlandse Akademie van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising said stem cells. |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| EP2655601A4 (en) | 2010-12-22 | 2014-09-10 | Fate Therapeutics Inc | CELL CULTURAL PLATFORM FOR INDIVIDUAL CELL SIZING AND IMPROVED RESOLUTION OF IPSCS |
| ES2773863T3 (es) | 2011-12-01 | 2020-07-15 | New York Stem Cell Found Inc | Sistema automatizado para la producción de células madre pluripotentes inducidas o células diferenciadas |
| US10428309B2 (en) * | 2011-12-01 | 2019-10-01 | New York Stem Cell Foundation, Inc. | Systems and methods for producing stem cells and differentiated cells |
| JP6433902B2 (ja) * | 2013-01-04 | 2018-12-05 | 国立大学法人京都大学 | 初期化幹細胞 |
| EP2949746A4 (en) * | 2013-01-23 | 2016-07-27 | Tokyo Electron Ltd | METHOD OF SUB-CULTURE OF PLURIPOTENT STEM CELLS |
| CA2899638A1 (en) * | 2013-01-28 | 2014-07-31 | Rutgers, The State University Of New Jersey | Growth matrices for stem cell propagation in vitro and in tissue regeneration |
| KR20210018540A (ko) * | 2013-02-18 | 2021-02-17 | 유니버시티 헬스 네트워크 | 다능성 줄기세포로부터 간세포 및 담관세포의 생성 방법 |
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| CN104278008B (zh) * | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
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| CN105441384B (zh) * | 2014-09-26 | 2021-01-05 | 北京大学 | 一种制备动物和人类原始多潜能干细胞的方法，试剂盒及用途 |
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