SG11201909331UA - Antigen-specific immune effector cells - Google Patents

Antigen-specific immune effector cells

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Publication number
SG11201909331UA
SG11201909331UA SG11201909331UA SG11201909331UA SG 11201909331U A SG11201909331U A SG 11201909331UA SG 11201909331U A SG11201909331U A SG 11201909331UA SG 11201909331U A SG11201909331U A SG 11201909331UA
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Singapore
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suite
madison
science drive
fujifilm
cells
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Maksym Vodyanyk
Xin Zhang
Andrew Brandl
Deepika Rajesh
Bradley Swanson
Christie Munn
Sarah Burton
Wen Wang
Ethan Mcleod
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Fujifilm Cellular Dynamics Inc
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Publication of SG11201909331UA publication Critical patent/SG11201909331UA/en

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Abstract

TNK cells () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT IiiimuolionommillomomimEmolommornovoimill (10) International Publication Number WO 2018/195175 Al (51) International Patent Classification: C07K 14/725 (2006.01) C12N 5/0783 (2010.01) A61K 38/17 (2006.01) C12N 5/074 (2010.01) A61K 35/17 (2015.01) A61P 35/00 (2006.01) A61K 35/545 (2015.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/028133 (22) International Filing Date: 18 April 2018 (18.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/486,875 18 April 2017 (18.04.2017) US (71) Applicant: FUJIFILM CELLULAR DYNAMICS, INC. [US/US]; 525 Science Drive, Suite 200, Madison, WI 53711 (US). (72) Inventors: VODYANYK, Maksym, A.; C/o Fujifilm Cel- lular Dynamics, Inc., 525 Science Drive, Suite 200, Madi- son, WI 53711 (US). ZHANG, Xin; C/o Fujifilm Cellular Dynamics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). BRANDL, Andrew, J.; C/o Fujifilm Cellular Dynamics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). RAJESH, Deepika; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). SWANSON, Bradley; C/o Fujifilm Cellular Dynamics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). MUNN, Christie; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). BURTON, Sarah; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). WANG, Wen, Bo; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). MCLEOD, Ethan; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). (74) Agent: MANN, Monica; Parker Highlander PLLC, 1120 S. Capital Of Texas Highway, Bldg. One, Suite 200, Austin, TX 78746 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (54) Title: ANTIGEN-SPECIFIC IMMUNE EFFECTOR CELLS iPSCs Lymphoid progenitors Genetic programming Transcription factors orift. eo 1 Th Directed differentiation Cytokines _1 FIG. 1A N 1-1 (57) : Provided herein are methods for the production of antigen-specific effector T cells and NK cells from pluripotent © stem cells which express a chimeric antigen receptor (CAR). Further provided herein are methods for the adoptive cell therapy by C administering the effector T cells and/or NK cells provided herein. [Continued on next page] WO 2018/195175 Al MIDEDIM011111 11111111E101301M1101011111111111111011110111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
SG11201909331U 2017-04-18 2018-04-18 Antigen-specific immune effector cells SG11201909331UA (en)

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US201762486875P 2017-04-18 2017-04-18
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US (1) US20200123501A1 (en)
EP (2) EP3612557B1 (en)
JP (1) JP7181219B2 (en)
KR (1) KR20190141190A (en)
CN (1) CN110891967A (en)
AU (1) AU2018254442B2 (en)
BR (1) BR112019021745A2 (en)
CA (1) CA3058779A1 (en)
DK (1) DK3612557T3 (en)
EA (1) EA201992469A1 (en)
ES (1) ES2912383T3 (en)
IL (1) IL269716A (en)
MX (1) MX2019011897A (en)
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WO (1) WO2018195175A1 (en)

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CN109337870B (en) * 2018-12-24 2020-07-03 广东暨德康民生物科技有限责任公司 Human V gamma 9V delta 2T cell amplification method and culture medium
JP7429713B2 (en) * 2019-03-28 2024-02-08 コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー Method for producing immune cells and their use
CN114945376A (en) * 2019-11-05 2022-08-26 希望之城公司 Generation of chimeric antigen receptor modified T cells from stem cells and therapeutic uses thereof
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