SG11201801770VA - Method for producing retinal pigment epithelial cells - Google Patents

Method for producing retinal pigment epithelial cells

Info

Publication number
SG11201801770VA
SG11201801770VA SG11201801770VA SG11201801770VA SG11201801770VA SG 11201801770V A SG11201801770V A SG 11201801770VA SG 11201801770V A SG11201801770V A SG 11201801770VA SG 11201801770V A SG11201801770V A SG 11201801770VA SG 11201801770V A SG11201801770V A SG 11201801770VA
Authority
SG
Singapore
Prior art keywords
epithelial cells
retinal pigment
pigment epithelial
producing retinal
producing
Prior art date
Application number
SG11201801770VA
Inventor
Satoshi Ando
Takao Kuroda
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Healios Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd, Healios Kk filed Critical Sumitomo Dainippon Pharma Co Ltd
Publication of SG11201801770VA publication Critical patent/SG11201801770VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
SG11201801770VA 2015-09-08 2016-09-08 Method for producing retinal pigment epithelial cells SG11201801770VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015176896 2015-09-08
PCT/JP2016/076524 WO2017043605A1 (en) 2015-09-08 2016-09-08 Method for producing retinal pigment epithelial cells

Publications (1)

Publication Number Publication Date
SG11201801770VA true SG11201801770VA (en) 2018-04-27

Family

ID=58240199

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201801770VA SG11201801770VA (en) 2015-09-08 2016-09-08 Method for producing retinal pigment epithelial cells

Country Status (13)

Country Link
US (2) US11649432B2 (en)
EP (2) EP3354721B1 (en)
JP (2) JP6792844B6 (en)
KR (1) KR102675213B1 (en)
CN (1) CN108350421A (en)
AU (1) AU2016320991C1 (en)
CA (1) CA2997528C (en)
ES (1) ES2922475T3 (en)
HK (1) HK1251249A1 (en)
IL (1) IL257794B (en)
MY (1) MY189778A (en)
SG (1) SG11201801770VA (en)
WO (1) WO2017043605A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6012164B2 (en) * 2011-11-25 2016-10-25 住友化学株式会社 Method for cryopreserving tissue derived from pluripotent stem cells
WO2016063986A1 (en) 2014-10-24 2016-04-28 大日本住友製薬株式会社 Production method for retinal tissue
MY191740A (en) 2014-10-24 2022-07-13 Sumitomo Chemical Co Production method for nerve tissue
WO2017044488A1 (en) 2015-09-08 2017-03-16 Cellular Dynamics International, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
WO2017043605A1 (en) * 2015-09-08 2017-03-16 大日本住友製薬株式会社 Method for producing retinal pigment epithelial cells
EP3365433A1 (en) 2015-10-20 2018-08-29 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
EP3447129B1 (en) * 2016-04-22 2022-07-20 Sumitomo Pharma Co., Ltd. Method for producing retinal tissue
US11618883B2 (en) 2017-03-08 2023-04-04 Sumitomo Pharma Co., Ltd. Method for producing retinal pigment epithelial cells
AU2018330694A1 (en) 2017-09-08 2020-03-19 Riken Cell aggregate including retinal tissue and production method therefor
SG11202004831QA (en) * 2017-11-24 2020-06-29 Sumitomo Chemical Co Production method for cell mass including neural cells/tissue and non-neural epithelial tissue, and cell mass from same
CN110042082B (en) * 2019-04-19 2020-11-27 安徽中盛溯源生物科技有限公司 Retinal pigment epithelial cell and preparation method and application thereof
CA3137528A1 (en) 2019-04-26 2020-10-29 Riken Composite including neural retina, retinal pigment epithelial cells, and hydrogel, and method for producing same
JPWO2022054924A1 (en) 2020-09-11 2022-03-17
AU2022266430A1 (en) 2021-04-30 2023-12-14 Riken Cord-like aggregates of retinal pigment epithelial cells, device and production method for producing same, and therapeutic agent comprising said cord-like aggregates
CN115261301A (en) * 2021-04-30 2022-11-01 深圳华大生命科学研究院 In-vitro induction and culture method of retinal pigment epithelial cells
CN113528441B (en) * 2021-08-05 2022-09-13 呈诺再生医学科技(珠海横琴新区)有限公司 Rapid and efficient clinical-grade pigment epithelial cell induction method, kit and application
CA3238664A1 (en) 2021-11-19 2023-05-25 Riken Production method for sheet-like retinal tissue

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
CA2277278A1 (en) 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
US6280718B1 (en) 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
CN100557023C (en) 2001-06-08 2009-11-04 株式会社载体研究所 Utilize VSV-G pseudo type simian immunodeficient disease poisonous carrier that gene is imported primate embryonic stem cells
US20060194315A1 (en) 2003-03-31 2006-08-31 Condie Brian G Compositions and methods for the control, differentiaton and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway
SG188122A1 (en) 2004-01-23 2013-03-28 Advanced Cell Tech Inc Improved modalities for the treatment of degenerative diseases of the retina
US8492147B2 (en) 2004-06-18 2013-07-23 Riken Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture
US7541186B2 (en) 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
WO2008048647A1 (en) 2006-10-17 2008-04-24 Cythera, Inc. Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
EP2128244A4 (en) 2007-01-18 2012-05-09 Riken Method for induction/differentiation into photoreceptor cell
US8193235B2 (en) * 2009-06-12 2012-06-05 University Of Kansas Compositions and methods for establishing and maintaining stem cells in an undifferentiated state
EP2588594B1 (en) * 2010-07-01 2022-11-30 Regenerative Research Foundation Methods for culturing undifferentiated cells using sustained release compositions
WO2012087965A2 (en) * 2010-12-22 2012-06-28 Fate Therapauetics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of ipscs
EP3636286A1 (en) 2011-05-18 2020-04-15 The Regents of The University of California Compositions and methods for treating retinal diseases
WO2012173207A1 (en) 2011-06-14 2012-12-20 独立行政法人理化学研究所 Method of inducing differentiation to retina cells
US10519422B2 (en) 2012-02-29 2019-12-31 Riken Method of producing human retinal pigment epithelial cells
JP6339998B2 (en) * 2012-04-24 2018-06-06 ダン エス． カウフマン， How to generate natural killer cells from stem cells
EP2882846B1 (en) 2012-06-05 2018-09-05 The Regents of the University of California Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
JP6426110B2 (en) * 2013-02-01 2018-11-21 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ Methods for generating retinal pigment epithelial (RPE) cells derived from population pluripotent stem cells (IPSCs)
US10307444B2 (en) 2013-03-15 2019-06-04 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US11241460B2 (en) 2013-03-15 2022-02-08 Astellas Institute For Regenerative Medicine Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US20160175362A1 (en) 2014-03-14 2016-06-23 Ocata Therapeutics, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US20160175361A1 (en) 2014-03-14 2016-06-23 Advanced Cell Technology, Inc. Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
US10220117B2 (en) * 2013-10-09 2019-03-05 The Regents Of The University Of California Methods of mammalian retinal stem cell production and applications
JP6518878B2 (en) 2013-10-09 2019-05-29 株式会社ヘリオス Method for producing retinal pigment epithelial cells
CA2930092C (en) * 2013-11-11 2024-03-12 Sumitomo Chemical Company, Limited Method for producing retinal pigment epithelial cells
US20150159134A1 (en) * 2013-12-11 2015-06-11 Pfizer Limited Method for producing retinal pigment epithelial cells
JP2015176896A (en) 2014-03-13 2015-10-05 株式会社東芝 Substrate for solid-state imaging device, solid-state imaging device, method of manufacturing substrate for solid-state imaging device, and method of manufacturing solid-state imaging device
MY191740A (en) 2014-10-24 2022-07-13 Sumitomo Chemical Co Production method for nerve tissue
WO2016063986A1 (en) 2014-10-24 2016-04-28 大日本住友製薬株式会社 Production method for retinal tissue
JP6976047B2 (en) 2015-08-28 2021-12-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 How to prepare epalrestat
WO2017043605A1 (en) * 2015-09-08 2017-03-16 大日本住友製薬株式会社 Method for producing retinal pigment epithelial cells
US11618883B2 (en) 2017-03-08 2023-04-04 Sumitomo Pharma Co., Ltd. Method for producing retinal pigment epithelial cells

Also Published As

Publication number Publication date
EP3354721A1 (en) 2018-08-01
CA2997528C (en) 2024-02-13
JPWO2017043605A1 (en) 2018-07-19
KR20180041764A (en) 2018-04-24
US20180258388A1 (en) 2018-09-13
EP3354721B1 (en) 2022-06-08
ES2922475T3 (en) 2022-09-15
MY189778A (en) 2022-03-04
IL257794A (en) 2018-04-30
CN108350421A (en) 2018-07-31
WO2017043605A1 (en) 2017-03-16
AU2016320991A1 (en) 2018-04-05
EP3354721A4 (en) 2019-03-27
AU2016320991C1 (en) 2023-04-06
EP4092109A1 (en) 2022-11-23
CA2997528A1 (en) 2017-03-16
IL257794B (en) 2022-09-01
AU2016320991B2 (en) 2022-09-15
KR102675213B1 (en) 2024-06-13
US20230287342A1 (en) 2023-09-14
JP6792844B2 (en) 2020-12-02
JP6792844B6 (en) 2021-02-03
US11649432B2 (en) 2023-05-16
HK1251249A1 (en) 2019-01-25
JP2021019633A (en) 2021-02-18
JP7016088B2 (en) 2022-02-04

Similar Documents

Publication Publication Date Title
HK1251249A1 (en) Method for producing retinal pigment epithelial cells
IL251856B (en) Production method for retinal tissue
HK1221734A1 (en) Method for producing retinal pigment epithelial cells
ZA201603051B (en) Method of producing retinal pigment epithelial cell
EP3070162A4 (en) Method for producing retinal pigment epithelial cells
EP3594322A4 (en) Method for producing retinal pigment epithelial cells
HK1215759A1 (en) Electrolyte forming process
EP3333266A4 (en) Method for producing selenoneine
EP3227023B8 (en) Method for producing drops
HK1215758A1 (en) Electrolyte forming process
EP3252153A4 (en) Method for producing cell aggregation
EP3294697A4 (en) PROCESS FOR MAKING HCFO-1233zd
EP3237195A4 (en) Methods for producing pressware
EP3296282A4 (en) Method for producing hydrohalofluoroolefins
IL252173A0 (en) Method for producing methyl-dichloro-phosphane
EP3275886A4 (en) Method for producing dialkylaminosilane
EP3133680A4 (en) Method for producing electrode
EP3127943A4 (en) Process for producing nanoparticles
EP3178925A4 (en) Method for producing retinal ganglion cells
EP3127558A4 (en) Method for producing artificial retina
EP3222777A4 (en) Method for producing yarn
EP3347359A4 (en) Process for making isoidide
EP3315585A4 (en) Ferro-coke production method
EP3242937A4 (en) Methods for producing abienol
EP3339334A4 (en) Process for producing fluoropolymer