DK3347456T3 - Fremgangsmåde til reproducerbar differentiering af retinale pigmentepitelceller af klinisk kvalitet - Google Patents
Fremgangsmåde til reproducerbar differentiering af retinale pigmentepitelceller af klinisk kvalitet Download PDFInfo
- Publication number
- DK3347456T3 DK3347456T3 DK16766444.0T DK16766444T DK3347456T3 DK 3347456 T3 DK3347456 T3 DK 3347456T3 DK 16766444 T DK16766444 T DK 16766444T DK 3347456 T3 DK3347456 T3 DK 3347456T3
- Authority
- DK
- Denmark
- Prior art keywords
- clinical
- procedure
- epithelial cells
- retinal pigment
- pigment epithelial
- Prior art date
Links
- 230000004069 differentiation Effects 0.000 title 1
- 210000002919 epithelial cell Anatomy 0.000 title 1
- 239000000790 retinal pigment Substances 0.000 title 1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562215579P | 2015-09-08 | 2015-09-08 | |
| PCT/US2016/050543 WO2017044483A1 (en) | 2015-09-08 | 2016-09-07 | Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3347456T3 true DK3347456T3 (da) | 2024-02-19 |
Family
ID=56936541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16766444.0T DK3347456T3 (da) | 2015-09-08 | 2016-09-07 | Fremgangsmåde til reproducerbar differentiering af retinale pigmentepitelceller af klinisk kvalitet |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190169569A1 (da) |
| EP (2) | EP3347456B1 (da) |
| JP (3) | JP6983762B2 (da) |
| KR (1) | KR20180042437A (da) |
| CN (2) | CN108473962B (da) |
| AU (2) | AU2016321170B2 (da) |
| CA (1) | CA2997952A1 (da) |
| DK (1) | DK3347456T3 (da) |
| WO (1) | WO2017044483A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2997763A1 (en) | 2015-09-08 | 2017-03-16 | Cellular Dynamics International, Inc. | Macs-based purification of stem cell-derived retinal pigment epithelium |
| EP3347456B1 (en) * | 2015-09-08 | 2023-12-27 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells |
| JP6976939B2 (ja) | 2015-10-20 | 2021-12-08 | フジフィルム セルラー ダイナミクス，インコーポレイテッド | 遺伝的プログラミングによる多系統造血前駆細胞の作製 |
| US11717298B2 (en) | 2016-11-09 | 2023-08-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tissue clamp and implantation method |
| US11458225B2 (en) | 2016-11-09 | 2022-10-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | 3D vascularized human ocular tissue for cell therapy and drug discovery |
| KR20230126745A (ko) | 2016-12-07 | 2023-08-30 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 망막 색소 상피 이식을 위해 피브린 지지체를 사용하는 방법 및 물질 |
| MX2019014503A (es) * | 2017-06-05 | 2020-01-23 | Mayo Found Medical Education & Res | Metodos y materiales para cultivar, proliferar, y diferenciar celulas madre. |
| PL236298B1 (pl) * | 2017-09-21 | 2020-12-28 | Univ Jagiellonski | Sposób otrzymywania upigmentowanych komórek in vitro poprzez różnicowanie ludzkich indukowanych pluripotencjalnych komórek macierzystych |
| CN108531443A (zh) * | 2018-04-04 | 2018-09-14 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 小分子诱导多能性干细胞分化为视网膜色素上皮细胞的方法 |
| WO2019204817A1 (en) * | 2018-04-20 | 2019-10-24 | FUJIFILM Cellular Dynamics, Inc. | Method for differentiation of ocular cells and use thereof |
| SG11202104401RA (en) * | 2018-11-19 | 2021-05-28 | The United States Of America As Represented By The Secretary | Biodegradable tissue replacement implant and its use |
| US20220233602A1 (en) * | 2019-07-05 | 2022-07-28 | Novo Nordisk A/S | Generation of neural stem cell lines derived from human pluripotent stem cells |
| CA3156678A1 (en) | 2019-10-09 | 2021-04-15 | Bluerock Therapeutics Lp | CELLS WITH SUSTAINED TRANSGENIC EXPRESSION |
| KR102224115B1 (ko) | 2020-01-10 | 2021-03-09 | 경북대학교병원 | 3차원 바이오프린팅 기술을 이용한 망막 세포 배양용 구조체 및 이의 활용 |
| EP4314249A1 (en) | 2021-03-25 | 2024-02-07 | Bluerock Therapeutics LP | Methods for obtaining induced pluripotent stem cells |
| CN115261301A (zh) * | 2021-04-30 | 2022-11-01 | 深圳华大生命科学研究院 | 一种视网膜色素上皮细胞体外诱导及培养方法 |
| WO2022251499A1 (en) * | 2021-05-28 | 2022-12-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to generate macular, central and peripheral retinal pigment epithelial cells |
| CN115873797A (zh) * | 2021-09-29 | 2023-03-31 | 北京干细胞与再生医学研究院 | 一种视网膜色素上皮细胞的扩增培养基及培养方法 |
| WO2023196577A1 (en) * | 2022-04-08 | 2023-10-12 | New York Stem Cell Foundation, Inc. | Methods for production of ipscs |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SG49267A1 (en) | 1989-08-14 | 1998-05-18 | Photogenesis Inc | Surgical instrument and cell isolation and transplantation |
| US6045791A (en) | 1992-03-06 | 2000-04-04 | Photogenesis, Inc. | Retinal pigment epithelium transplantation |
| US6416998B1 (en) | 1992-09-02 | 2002-07-09 | Baylor College Of Medicine | Plasmid encoding a modified steroid hormone |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5763270A (en) | 1995-06-07 | 1998-06-09 | Genemedicine, Inc. | Plasmid for delivery of nucleic acids to cells and methods of use |
| WO1998030679A1 (en) | 1997-01-10 | 1998-07-16 | Life Technologies, Inc. | Embryonic stem cell serum replacement |
| US6458589B1 (en) * | 2000-04-27 | 2002-10-01 | Geron Corporation | Hepatocyte lineage cells derived from pluripotent stem cells |
| WO2001088104A2 (en) | 2000-05-17 | 2001-11-22 | Geron Corporation | Neural progenitor cell populations |
| US20030211603A1 (en) | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| US7989425B2 (en) | 2002-09-27 | 2011-08-02 | Genexine Inc. | Vaccine enhancing the protective immunity to hepatitis c virus using plasmid DNA and recombinant adenovirus |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| EP1781776A2 (en) * | 2004-07-29 | 2007-05-09 | Stem Cell Innovations, Inc. | Differentiation of stem cells |
| US7442548B2 (en) | 2004-09-08 | 2008-10-28 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells in medium containing pipecholic acid and gamma amino butyric acid |
| EP2186823A1 (en) | 2005-11-14 | 2010-05-19 | Merial Limited | Gene therapy for renal failure |
| MX2008007654A (es) | 2005-12-13 | 2008-09-26 | Univ Kyoto | Factor de reprogramacion nuclear. |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| AU2008231020B2 (en) | 2007-03-23 | 2013-09-05 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| CN101981446B (zh) | 2008-02-08 | 2016-03-09 | 医疗探索公司 | 用于使用支持向量机分析流式细胞术数据的方法和系统 |
| ES2587395T3 (es) | 2008-06-04 | 2016-10-24 | Cellular Dynamics International, Inc. | Procedimientos para la producción de células IPS usando un enfoque no vírico |
| EP3450545B1 (en) | 2008-10-24 | 2023-08-23 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
| EP2548950B1 (en) | 2009-06-05 | 2017-10-25 | Cellular Dynamics International, Inc. | Reprogramming T cells and hematopoietic cells |
| CA2770412C (en) | 2009-08-07 | 2018-09-11 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US9359592B2 (en) * | 2009-10-06 | 2016-06-07 | Snu R&Db Foundation | Method for differentiation into retinal cells from stem cells |
| US9005967B2 (en) | 2010-01-22 | 2015-04-14 | Kyoto University | Myc variants improve induced pluripotent stem cell generation efficiency |
| US8278620B2 (en) | 2010-05-03 | 2012-10-02 | Thermo Finnigan Llc | Methods for calibration of usable fragmentation energy in mass spectrometry |
| CN103003416B (zh) | 2010-06-15 | 2016-11-16 | 细胞动力学国际有限公司 | 从小体积的外周血产生诱导性多潜能干细胞 |
| JP5896360B2 (ja) * | 2010-07-21 | 2016-04-13 | 国立大学法人京都大学 | ヒト多能性幹細胞から中間中胚葉細胞への分化誘導方法 |
| EP2702135B1 (en) | 2011-04-29 | 2019-04-17 | University of Southern California | Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate |
| US10519422B2 (en) * | 2012-02-29 | 2019-12-31 | Riken | Method of producing human retinal pigment epithelial cells |
| WO2013151186A1 (ja) * | 2012-04-06 | 2013-10-10 | 国立大学法人京都大学 | エリスロポエチン産生細胞の誘導方法 |
| EP2951290B1 (en) * | 2013-02-01 | 2017-11-29 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs) |
| CN105814192A (zh) * | 2013-10-09 | 2016-07-27 | 加利福尼亚大学董事会 | 哺乳动物视网膜干细胞产生方法和应用 |
| AU2014345110B2 (en) * | 2013-11-11 | 2021-01-14 | Riken | Method for producing retinal pigment epithelial cells |
| US20150159134A1 (en) * | 2013-12-11 | 2015-06-11 | Pfizer Limited | Method for producing retinal pigment epithelial cells |
| AU2014363032A1 (en) * | 2013-12-11 | 2016-06-09 | Pfizer Limited | Method for producing retinal pigment epithelial cells |
| EP3347456B1 (en) * | 2015-09-08 | 2023-12-27 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells |
-
2016
- 2016-09-07 EP EP16766444.0A patent/EP3347456B1/en active Active
- 2016-09-07 EP EP23214033.5A patent/EP4345160A2/en active Pending
- 2016-09-07 US US15/758,314 patent/US20190169569A1/en not_active Abandoned
- 2016-09-07 AU AU2016321170A patent/AU2016321170B2/en active Active
- 2016-09-07 CN CN201680060872.4A patent/CN108473962B/zh active Active
- 2016-09-07 CA CA2997952A patent/CA2997952A1/en active Pending
- 2016-09-07 WO PCT/US2016/050543 patent/WO2017044483A1/en active Application Filing
- 2016-09-07 KR KR1020187009942A patent/KR20180042437A/ko not_active Application Discontinuation
- 2016-09-07 DK DK16766444.0T patent/DK3347456T3/da active
- 2016-09-07 JP JP2018512373A patent/JP6983762B2/ja active Active
- 2016-09-07 CN CN202210484960.4A patent/CN114807035B/zh active Active
-
2020
- 2020-07-16 US US16/931,003 patent/US20210139847A1/en active Pending
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2021
- 2021-08-04 JP JP2021128087A patent/JP2021176335A/ja active Pending
-
2022
- 2022-11-24 AU AU2022275469A patent/AU2022275469A1/en active Pending
-
2023
- 2023-09-08 JP JP2023146145A patent/JP2023162441A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210139847A1 (en) | 2021-05-13 |
| WO2017044483A1 (en) | 2017-03-16 |
| AU2016321170A1 (en) | 2018-04-12 |
| EP3347456B1 (en) | 2023-12-27 |
| CN108473962A (zh) | 2018-08-31 |
| CA2997952A1 (en) | 2017-03-16 |
| EP4345160A2 (en) | 2024-04-03 |
| AU2022275469A1 (en) | 2023-01-05 |
| JP2021176335A (ja) | 2021-11-11 |
| KR20180042437A (ko) | 2018-04-25 |
| JP6983762B2 (ja) | 2021-12-17 |
| CN114807035A (zh) | 2022-07-29 |
| CN108473962B (zh) | 2022-04-26 |
| AU2016321170B2 (en) | 2022-09-01 |
| CN114807035B (zh) | 2024-02-02 |
| JP2018526014A (ja) | 2018-09-13 |
| EP3347456A1 (en) | 2018-07-18 |
| JP2023162441A (ja) | 2023-11-08 |
| US20190169569A1 (en) | 2019-06-06 |
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