DK3218396T3 - Fremgangsmåde til fremstilling af højaffinitets antistoffer - Google Patents
Fremgangsmåde til fremstilling af højaffinitets antistoffer Download PDFInfo
- Publication number
- DK3218396T3 DK3218396T3 DK15802270.7T DK15802270T DK3218396T3 DK 3218396 T3 DK3218396 T3 DK 3218396T3 DK 15802270 T DK15802270 T DK 15802270T DK 3218396 T3 DK3218396 T3 DK 3218396T3
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- production
- high affinity
- affinity antibodies
- antibodies
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462079899P | 2014-11-14 | 2014-11-14 | |
| PCT/US2015/060523 WO2016077666A1 (en) | 2014-11-14 | 2015-11-13 | Method for generating high affinity antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3218396T3 true DK3218396T3 (da) | 2023-03-06 |
Family
ID=54754774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15802270.7T DK3218396T3 (da) | 2014-11-14 | 2015-11-13 | Fremgangsmåde til fremstilling af højaffinitets antistoffer |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10752698B2 (da) |
| EP (2) | EP4134378A1 (da) |
| DK (1) | DK3218396T3 (da) |
| ES (1) | ES2939555T3 (da) |
| MA (1) | MA40929A (da) |
| WO (1) | WO2016077666A1 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4134378A1 (en) | 2014-11-14 | 2023-02-15 | Regeneron Pharmaceuticals, Inc. | Method for generating high affinity antibodies |
| CN111351935A (zh) * | 2018-12-20 | 2020-06-30 | 上海恒润达生生物科技有限公司 | Bcma-car亲和力检测方法 |
| CN116003590A (zh) * | 2020-08-06 | 2023-04-25 | 熙源安健医药（上海）有限公司 | 抗ngf抗体及其抗原结合片段、其制备方法和应用 |
| CN116635413A (zh) * | 2020-12-23 | 2023-08-22 | 再生元制药公司 | 用于获得结合跨膜蛋白的抗体的方法和生产所述抗体的细胞 |
| CA3212049A1 (en) | 2021-04-20 | 2022-10-27 | Susan D. Croll | Human antibodies to artemin and methods of use thereof |
| CA3226042A1 (en) | 2021-07-05 | 2023-01-12 | Regeneron Pharmaceuticals, Inc. | Utilization of antibodies to shape antibody responses to an antigen |
| WO2023069421A1 (en) * | 2021-10-18 | 2023-04-27 | Byomass Inc. | Anti-activin a antibodies, compositions and uses thereof |
| WO2023147107A1 (en) * | 2022-01-31 | 2023-08-03 | Byomass Inc. | Myeloproliferative conditions |
| WO2024015816A1 (en) | 2022-07-12 | 2024-01-18 | Regeneron Pharmaceuticals, Inc. | Antibodies to ciliary neurotrophic factor receptor (cntfr) and methods of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
| KR970029803A (ko) | 1995-11-03 | 1997-06-26 | 김광호 | 반도체 메모리장치의 프리차지 회로 |
| US6281005B1 (en) | 1999-05-14 | 2001-08-28 | Copernicus Therapeutics, Inc. | Automated nucleic acid compaction device |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US20050048578A1 (en) * | 2003-06-26 | 2005-03-03 | Epitomics, Inc. | Methods of screening for monoclonal antibodies with desirable activity |
| US8497138B2 (en) * | 2010-09-30 | 2013-07-30 | Genetix Limited | Method for cell selection |
| JP6013356B2 (ja) * | 2010-12-02 | 2016-10-25 | アイム・セラピューティクス・べー・フェー | 高親和性抗体を製造するための手段および方法 |
| GB201316644D0 (en) | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| EP4134378A1 (en) * | 2014-11-14 | 2023-02-15 | Regeneron Pharmaceuticals, Inc. | Method for generating high affinity antibodies |
-
2015
- 2015-11-13 EP EP22199396.7A patent/EP4134378A1/en active Pending
- 2015-11-13 ES ES15802270T patent/ES2939555T3/es active Active
- 2015-11-13 US US15/526,522 patent/US10752698B2/en active Active
- 2015-11-13 MA MA040929A patent/MA40929A/fr unknown
- 2015-11-13 DK DK15802270.7T patent/DK3218396T3/da active
- 2015-11-13 EP EP15802270.7A patent/EP3218396B1/en active Active
- 2015-11-13 WO PCT/US2015/060523 patent/WO2016077666A1/en active Application Filing
-
2020
- 2020-08-07 US US16/987,639 patent/US11808766B2/en active Active
-
2023
- 2023-10-02 US US18/375,755 patent/US20240036043A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3218396A1 (en) | 2017-09-20 |
| US10752698B2 (en) | 2020-08-25 |
| US11808766B2 (en) | 2023-11-07 |
| US20200369783A1 (en) | 2020-11-26 |
| EP3218396B1 (en) | 2022-12-28 |
| EP4134378A1 (en) | 2023-02-15 |
| MA40929A (fr) | 2017-09-20 |
| ES2939555T3 (es) | 2023-04-24 |
| US20240036043A1 (en) | 2024-02-01 |
| US20170327593A1 (en) | 2017-11-16 |
| WO2016077666A1 (en) | 2016-05-19 |
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