JP2013533736A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013533736A5 JP2013533736A5 JP2013513355A JP2013513355A JP2013533736A5 JP 2013533736 A5 JP2013533736 A5 JP 2013533736A5 JP 2013513355 A JP2013513355 A JP 2013513355A JP 2013513355 A JP2013513355 A JP 2013513355A JP 2013533736 A5 JP2013533736 A5 JP 2013533736A5
- Authority
- JP
- Japan
- Prior art keywords
- residue
- seq
- amino acid
- polypeptide
- gene encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 149
- 108090000765 processed proteins & peptides Proteins 0.000 claims 149
- 102000004196 processed proteins & peptides Human genes 0.000 claims 149
- 125000003275 alpha amino acid group Chemical group 0.000 claims 130
- 108090000623 proteins and genes Proteins 0.000 claims 126
- 238000006467 substitution reaction Methods 0.000 claims 70
- 235000001014 amino acid Nutrition 0.000 claims 58
- 235000019202 steviosides Nutrition 0.000 claims 45
- 239000004383 Steviol glycoside Substances 0.000 claims 39
- 229930182488 steviol glycoside Natural products 0.000 claims 39
- 235000019411 steviol glycoside Nutrition 0.000 claims 39
- 150000008144 steviol glycosides Chemical class 0.000 claims 39
- 101100101356 Stevia rebaudiana UGT91D2 gene Proteins 0.000 claims 22
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 21
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 21
- 235000004279 alanine Nutrition 0.000 claims 21
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 21
- QSRAJVGDWKFOGU-WBXIDTKBSA-N rebaudioside c Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]1(CC[C@H]2[C@@]3(C)[C@@H]([C@](CCC3)(C)C(=O)O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)CC3)C(=C)C[C@]23C1 QSRAJVGDWKFOGU-WBXIDTKBSA-N 0.000 claims 20
- 241000544066 Stevia Species 0.000 claims 19
- 101100262416 Stevia rebaudiana UGT76G1 gene Proteins 0.000 claims 19
- 235000018417 cysteine Nutrition 0.000 claims 19
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 19
- 238000000034 method Methods 0.000 claims 19
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 19
- QFVOYBUQQBFCRH-UHFFFAOYSA-N Steviol Natural products C1CC2(C3)CC(=C)C3(O)CCC2C2(C)C1C(C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-UHFFFAOYSA-N 0.000 claims 18
- RPYRMTHVSUWHSV-CUZJHZIBSA-N rebaudioside D Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RPYRMTHVSUWHSV-CUZJHZIBSA-N 0.000 claims 18
- 229940032084 steviol Drugs 0.000 claims 18
- 125000000539 amino acid group Chemical group 0.000 claims 17
- 239000004475 Arginine Substances 0.000 claims 14
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 14
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 14
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 14
- 235000013922 glutamic acid Nutrition 0.000 claims 14
- 239000004220 glutamic acid Substances 0.000 claims 14
- 229930182817 methionine Natural products 0.000 claims 14
- ONVABDHFQKWOSV-UHFFFAOYSA-N 16-Phyllocladene Natural products C1CC(C2)C(=C)CC32CCC2C(C)(C)CCCC2(C)C31 ONVABDHFQKWOSV-UHFFFAOYSA-N 0.000 claims 13
- 241000196324 Embryophyta Species 0.000 claims 13
- ONVABDHFQKWOSV-HPUSYDDDSA-N ent-kaur-16-ene Chemical compound C1C[C@H](C2)C(=C)C[C@@]32CC[C@@H]2C(C)(C)CCC[C@@]2(C)[C@@H]31 ONVABDHFQKWOSV-HPUSYDDDSA-N 0.000 claims 13
- QFVOYBUQQBFCRH-VQSWZGCSSA-N steviol Chemical compound C([C@@]1(O)C(=C)C[C@@]2(C1)CC1)C[C@H]2[C@@]2(C)[C@H]1[C@](C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-VQSWZGCSSA-N 0.000 claims 13
- 239000001177 diphosphate Substances 0.000 claims 12
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 12
- 235000011180 diphosphates Nutrition 0.000 claims 12
- 239000001776 FEMA 4720 Substances 0.000 claims 10
- 102000003960 Ligases Human genes 0.000 claims 9
- 108090000364 Ligases Proteins 0.000 claims 9
- 101100427140 Stevia rebaudiana UGT74G1 gene Proteins 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 9
- QSIDJGUAAUSPMG-CULFPKEHSA-N steviolmonoside Chemical compound O([C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QSIDJGUAAUSPMG-CULFPKEHSA-N 0.000 claims 9
- 239000001512 FEMA 4601 Substances 0.000 claims 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 8
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 claims 8
- 239000000356 contaminant Substances 0.000 claims 8
- 108010067758 ent-kaurene oxidase Proteins 0.000 claims 8
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 claims 8
- 239000000284 extract Substances 0.000 claims 8
- 239000008103 glucose Substances 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 235000019203 rebaudioside A Nutrition 0.000 claims 8
- QRGRAFPOLJOGRV-UHFFFAOYSA-N rebaudioside F Natural products CC12CCCC(C)(C1CCC34CC(=C)C(CCC23)(C4)OC5OC(CO)C(O)C(OC6OCC(O)C(O)C6O)C5OC7OC(CO)C(O)C(O)C7O)C(=O)OC8OC(CO)C(O)C(O)C8O QRGRAFPOLJOGRV-UHFFFAOYSA-N 0.000 claims 8
- HYLAUKAHEAUVFE-AVBZULRRSA-N rebaudioside f Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)CO1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HYLAUKAHEAUVFE-AVBZULRRSA-N 0.000 claims 8
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 7
- 102000007317 Farnesyltranstransferase Human genes 0.000 claims 7
- 108010007508 Farnesyltranstransferase Proteins 0.000 claims 7
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 7
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 7
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 7
- RLLCWNUIHGPAJY-RYBZXKSASA-N Rebaudioside E Natural products O=C(O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@@H](O)[C@@H](O)[C@H](CO)O1)[C@]1(C)[C@@H]2[C@@](C)([C@@H]3[C@@]4(CC(=C)[C@@](O[C@@H]5[C@@H](O[C@@H]6[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O6)[C@H](O)[C@@H](O)[C@H](CO)O5)(C4)CC3)CC2)CCC1 RLLCWNUIHGPAJY-RYBZXKSASA-N 0.000 claims 7
- YWPVROCHNBYFTP-UHFFFAOYSA-N Rubusoside Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1O YWPVROCHNBYFTP-UHFFFAOYSA-N 0.000 claims 7
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 7
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 7
- 239000004473 Threonine Substances 0.000 claims 7
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 7
- 235000009582 asparagine Nutrition 0.000 claims 7
- 229960001230 asparagine Drugs 0.000 claims 7
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 7
- RLLCWNUIHGPAJY-SFUUMPFESA-N rebaudioside E Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RLLCWNUIHGPAJY-SFUUMPFESA-N 0.000 claims 7
- YWPVROCHNBYFTP-OSHKXICASA-N rubusoside Chemical compound O([C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YWPVROCHNBYFTP-OSHKXICASA-N 0.000 claims 7
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 7
- 239000004474 valine Substances 0.000 claims 7
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 6
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 6
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims 6
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims 6
- 229940013618 stevioside Drugs 0.000 claims 6
- DRSKVOAJKLUMCL-MMUIXFKXSA-N u2n4xkx7hp Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DRSKVOAJKLUMCL-MMUIXFKXSA-N 0.000 claims 6
- 101100101637 Bellis perennis UGAT gene Proteins 0.000 claims 5
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 5
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 5
- 108010045510 NADPH-Ferrihemoprotein Reductase Proteins 0.000 claims 5
- 101100208826 Panax ginseng UGT29 gene Proteins 0.000 claims 5
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 5
- 101100048059 Stevia rebaudiana UGT85C2 gene Proteins 0.000 claims 5
- 230000001588 bifunctional effect Effects 0.000 claims 5
- 238000000338 in vitro Methods 0.000 claims 5
- 229960000310 isoleucine Drugs 0.000 claims 5
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 101100539097 Arabidopsis thaliana UGT79B3 gene Proteins 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- OQPOFZJZPYRNFF-CULFPKEHSA-N tkd5uc898q Chemical compound O=C([C@]1(C)CCC[C@@]2([C@@H]1CC[C@]13C[C@](O)(C(=C)C1)CC[C@@H]23)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OQPOFZJZPYRNFF-CULFPKEHSA-N 0.000 claims 4
- 241000235070 Saccharomyces Species 0.000 claims 3
- 108010036064 UDP-glucuronate decarboxylase Proteins 0.000 claims 3
- 102000057144 Uridine Diphosphate Glucose Dehydrogenase Human genes 0.000 claims 3
- 108010054269 Uridine Diphosphate Glucose Dehydrogenase Proteins 0.000 claims 3
- SRBFZHDQGSBBOR-IOVATXLUSA-N Xylose Natural products O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 3
- 244000005700 microbiome Species 0.000 claims 3
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 claims 2
- YFAUKWZNPVBCFF-XHIBXCGHSA-N 4-CDP-2-C-methyl-D-erythritol Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@](O)(CO)C)O[C@H]1N1C(=O)N=C(N)C=C1 YFAUKWZNPVBCFF-XHIBXCGHSA-N 0.000 claims 2
- 101710166309 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Proteins 0.000 claims 2
- 101710139854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) Proteins 0.000 claims 2
- 101710088071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), chloroplastic Proteins 0.000 claims 2
- 101710086072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) Proteins 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 101001078008 Escherichia coli (strain K12) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Proteins 0.000 claims 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical group C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 2
- 244000061176 Nicotiana tabacum Species 0.000 claims 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 2
- 244000228451 Stevia rebaudiana Species 0.000 claims 2
- 235000006092 Stevia rebaudiana Nutrition 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 108010060155 deoxyxylulose-5-phosphate synthase Proteins 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000005215 recombination Methods 0.000 claims 2
- 230000006798 recombination Effects 0.000 claims 2
- 101710184086 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Proteins 0.000 claims 1
- 101710201168 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Proteins 0.000 claims 1
- 101710195531 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic Proteins 0.000 claims 1
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims 1
- 102100037768 Acetyl-CoA acetyltransferase, mitochondrial Human genes 0.000 claims 1
- DORPKYRPJIIARM-UHFFFAOYSA-N Decaffeoylacteoside Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(OCCC=2C=C(O)C(O)=CC=2)OC(CO)C1O DORPKYRPJIIARM-UHFFFAOYSA-N 0.000 claims 1
- 102000057412 Diphosphomevalonate decarboxylases Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108700023372 Glycosyltransferases Proteins 0.000 claims 1
- 102000051366 Glycosyltransferases Human genes 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims 1
- 108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 claims 1
- 108700040132 Mevalonate kinases Proteins 0.000 claims 1
- 101000958834 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) Diphosphomevalonate decarboxylase mvd1 Proteins 0.000 claims 1
- 101100371766 Oryza sativa subsp. japonica UGT79 gene Proteins 0.000 claims 1
- 101000958925 Panax ginseng Diphosphomevalonate decarboxylase 1 Proteins 0.000 claims 1
- 102100024279 Phosphomevalonate kinase Human genes 0.000 claims 1
- GIPHUOWOTCAJSR-UHFFFAOYSA-N Rebaudioside A. Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1OC(C1O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O GIPHUOWOTCAJSR-UHFFFAOYSA-N 0.000 claims 1
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 claims 1
- DQQDLYVHOTZLOR-OCIMBMBZSA-N UDP-alpha-D-xylose Chemical compound C([C@@H]1[C@H]([C@H]([C@@H](O1)N1C(NC(=O)C=C1)=O)O)O)OP(O)(=O)OP(O)(=O)O[C@H]1OC[C@@H](O)[C@H](O)[C@H]1O DQQDLYVHOTZLOR-OCIMBMBZSA-N 0.000 claims 1
- DQQDLYVHOTZLOR-UHFFFAOYSA-N UDP-alpha-D-xylose Natural products O1C(N2C(NC(=O)C=C2)=O)C(O)C(O)C1COP(O)(=O)OP(O)(=O)OC1OCC(O)C(O)C1O DQQDLYVHOTZLOR-UHFFFAOYSA-N 0.000 claims 1
- DRDCJEIZVLVWNC-SLBWPEPYSA-N UDP-beta-L-rhamnose Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 DRDCJEIZVLVWNC-SLBWPEPYSA-N 0.000 claims 1
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims 1
- DORPKYRPJIIARM-GYAWPQPFSA-N Verbasoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O[C@H](CO)[C@H]1O DORPKYRPJIIARM-GYAWPQPFSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 210000004671 cell-free system Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- ONVABDHFQKWOSV-YQXATGRUSA-N ent-Kaur-16-ene Natural products C1C[C@@H](C2)C(=C)C[C@@]32CC[C@@H]2C(C)(C)CCC[C@@]2(C)[C@@H]31 ONVABDHFQKWOSV-YQXATGRUSA-N 0.000 claims 1
- UIXMIBNGPQGJJJ-UHFFFAOYSA-N ent-kaurene Natural products CC1CC23CCC4C(CCCC4(C)C)C2CCC1C3 UIXMIBNGPQGJJJ-UHFFFAOYSA-N 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 102000002678 mevalonate kinase Human genes 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 108091000116 phosphomevalonate kinase Proteins 0.000 claims 1
- 229930188195 rebaudioside Natural products 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 102200067340 rs2272938 Human genes 0.000 claims 1
- 125000000969 xylosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)CO1)* 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35055310P | 2010-06-02 | 2010-06-02 | |
| US61/350,553 | 2010-06-02 | ||
| US201161434582P | 2011-01-20 | 2011-01-20 | |
| US61/434,582 | 2011-01-20 | ||
| US201161471622P | 2011-04-04 | 2011-04-04 | |
| US61/471,622 | 2011-04-04 | ||
| PCT/US2011/038967 WO2011153378A1 (en) | 2010-06-02 | 2011-06-02 | Recombinant Production of Steviol Glycosides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016217655A Division JP6110551B1 (ja) | 2010-06-02 | 2016-11-07 | ステビオールグリコシドの組換え生成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533736A JP2013533736A (ja) | 2013-08-29 |
| JP2013533736A5 true JP2013533736A5 (https=) | 2014-07-17 |
| JP6177127B2 JP6177127B2 (ja) | 2017-08-09 |
Family
ID=45067080
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013513355A Active JP6177127B2 (ja) | 2010-06-02 | 2011-06-02 | ステビオールグリコシドの組換え生成 |
| JP2016217655A Active JP6110551B1 (ja) | 2010-06-02 | 2016-11-07 | ステビオールグリコシドの組換え生成 |
| JP2016238040A Active JP6509188B2 (ja) | 2010-06-02 | 2016-12-07 | ステビオールグリコシドの組換え生成 |
| JP2019070335A Active JP6947772B2 (ja) | 2010-06-02 | 2019-04-02 | ステビオールグリコシドの組換え生成 |
| JP2021086878A Pending JP2021151238A (ja) | 2010-06-02 | 2021-05-24 | ステビオールグリコシドの組換え生成 |
| JP2023058127A Pending JP2023093503A (ja) | 2010-06-02 | 2023-03-31 | ステビオールグリコシドの組換え生成 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016217655A Active JP6110551B1 (ja) | 2010-06-02 | 2016-11-07 | ステビオールグリコシドの組換え生成 |
| JP2016238040A Active JP6509188B2 (ja) | 2010-06-02 | 2016-12-07 | ステビオールグリコシドの組換え生成 |
| JP2019070335A Active JP6947772B2 (ja) | 2010-06-02 | 2019-04-02 | ステビオールグリコシドの組換え生成 |
| JP2021086878A Pending JP2021151238A (ja) | 2010-06-02 | 2021-05-24 | ステビオールグリコシドの組換え生成 |
| JP2023058127A Pending JP2023093503A (ja) | 2010-06-02 | 2023-03-31 | ステビオールグリコシドの組換え生成 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US9562251B2 (https=) |
| EP (2) | EP2575432B1 (https=) |
| JP (6) | JP6177127B2 (https=) |
| KR (3) | KR102181638B1 (https=) |
| CN (2) | CN105671108A (https=) |
| AU (1) | AU2011261394C1 (https=) |
| BR (5) | BR122021005283B1 (https=) |
| CA (2) | CA3176307A1 (https=) |
| CL (1) | CL2012003373A1 (https=) |
| MX (3) | MX373909B (https=) |
| MY (3) | MY167872A (https=) |
| NZ (3) | NZ604915A (https=) |
| SG (2) | SG186127A1 (https=) |
| WO (1) | WO2011153378A1 (https=) |
Families Citing this family (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8790730B2 (en) | 2005-10-11 | 2014-07-29 | Purecircle Usa | Process for manufacturing a sweetener and use thereof |
| US9386797B2 (en) | 2011-02-17 | 2016-07-12 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US9107436B2 (en) | 2011-02-17 | 2015-08-18 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US9392799B2 (en) | 2011-02-17 | 2016-07-19 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US8318459B2 (en) | 2011-02-17 | 2012-11-27 | Purecircle Usa | Glucosyl stevia composition |
| US8927241B2 (en) | 2009-11-10 | 2015-01-06 | Massachusetts Institute Of Technology | Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway |
| CN102812129B (zh) | 2009-11-10 | 2015-08-26 | 麻省理工学院 | 用于从类异戊二烯途径生产化学和医药产品的微生物工程 |
| US10888099B2 (en) | 2009-11-12 | 2021-01-12 | Purecircle Sdn Bhd. | Granulation of a Stevia sweetener |
| MX353094B (es) | 2009-11-12 | 2017-12-19 | Purecircle Usa Inc | Granulacion de un edulcorante de stevia. |
| US20150344512A1 (en) | 2011-12-19 | 2015-12-03 | Purecircle Usa Inc. | Methods of purifying steviol glycosides and uses of the same |
| EP2544538B1 (en) | 2010-03-12 | 2022-06-15 | PureCircle USA Inc. | High-purity steviol glycosides |
| US10696706B2 (en) | 2010-03-12 | 2020-06-30 | Purecircle Usa Inc. | Methods of preparing steviol glycosides and uses of the same |
| WO2011146833A1 (en) * | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| EP2575432B1 (en) | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| EP2645847B1 (en) * | 2010-11-30 | 2018-01-17 | Massachusetts Institute of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| US9029426B2 (en) | 2010-12-13 | 2015-05-12 | Purecircle Sdn Bhd | Highly soluble Rebaudioside D |
| US9510611B2 (en) | 2010-12-13 | 2016-12-06 | Purecircle Sdn Bhd | Stevia composition to improve sweetness and flavor profile |
| MX362676B (es) | 2011-02-10 | 2019-01-31 | Purecircle Usa | Composición de estevia. |
| US11690391B2 (en) | 2011-02-17 | 2023-07-04 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US9474296B2 (en) | 2011-02-17 | 2016-10-25 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US9603373B2 (en) | 2011-02-17 | 2017-03-28 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US9894922B2 (en) | 2011-05-18 | 2018-02-20 | Purecircle Sdn Bhd | Glucosyl rebaudioside C |
| PL2713763T3 (pl) | 2011-05-31 | 2019-10-31 | Purecircle Usa Inc | Kompozycja stewiowa |
| ES2579827T3 (es) | 2011-06-03 | 2016-08-17 | Purecircle Usa | Composición de estevia |
| BR122019003378B1 (pt) | 2011-06-20 | 2020-07-28 | Purecircle Usa Inc | composição ingerível doce, produto alimentício ou de bebida, preparado de droga, farmacêutico ou cosmético, edulcorante e produto compreendendo a composição ingerível doce |
| US9771434B2 (en) | 2011-06-23 | 2017-09-26 | Purecircle Sdn Bhd | Products from stevia rebaudiana |
| CA3128532A1 (en) | 2011-08-08 | 2013-02-14 | Evolva Sa | Recombinant production of steviol glycosides |
| US10480019B2 (en) | 2011-08-10 | 2019-11-19 | Purecircle Sdn Bhd | Process for producing high-purity rubusoside |
| US20140171520A1 (en) | 2011-09-07 | 2014-06-19 | Avetik Markosyan | Highly soluble stevia sweetener |
| CN103031283B (zh) * | 2011-10-08 | 2015-07-08 | 成都华高瑞甜科技有限公司 | 甜叶菊酶vi及莱鲍迪苷a转化为莱鲍迪苷d的方法 |
| BR112014012543A2 (pt) | 2011-11-23 | 2017-06-13 | Evolva Sa | métodos e materiais para síntese enzimática de compostos de mogrosídeo |
| EP4124245A1 (en) | 2011-12-19 | 2023-02-01 | The Coca-Cola Company | Beverage comprising rebaudioside x |
| FR2984743B1 (fr) * | 2011-12-23 | 2014-08-22 | Oreal | Utilisation cosmetique du steviol, d'un derive glycoside du steviol, ou un de leurs isomeres pour stimuler, restaurer ou reguler le metabolisme des cellules de la peau et des semi-muqueuses. |
| MX355028B (es) * | 2012-01-23 | 2018-03-28 | Dsm Ip Assets Bv | Produccion de diterpeno. |
| US10000783B2 (en) | 2012-03-16 | 2018-06-19 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
| WO2013146555A1 (ja) * | 2012-03-27 | 2013-10-03 | サントリーホールディングス株式会社 | ステビオール配糖体の製造方法 |
| US20130338348A1 (en) * | 2012-03-30 | 2013-12-19 | J.R. Simplot Company | Steviol and steviol glycoside formation in plants |
| MX395285B (es) * | 2012-05-22 | 2025-03-25 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| US9752174B2 (en) | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| TW201402599A (zh) | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
| CN103710318B (zh) * | 2012-09-29 | 2017-01-18 | 中国科学院上海生命科学研究院 | 利用微生物生产甜菊糖苷类化合物的方法 |
| EP2929043A1 (en) | 2012-12-04 | 2015-10-14 | Evolva SA | Methods and materials for biosynthesis of mogroside compounds |
| EP2928321A1 (en) * | 2012-12-05 | 2015-10-14 | Evolva SA | Steviol glycoside compositions sensory properties |
| MY199452A (en) * | 2013-02-06 | 2023-10-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| BR112015019160A2 (pt) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | Produção de glicosídeos de esteviol em hospedeiros recombinantes |
| KR101404728B1 (ko) * | 2013-02-28 | 2014-06-09 | 씨제이제일제당 (주) | 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법 |
| EP2970354B1 (en) * | 2013-03-15 | 2018-05-30 | The Coca-Cola Company | Steviol glycosides and their compositions |
| CA2912347A1 (en) * | 2013-05-31 | 2014-12-04 | Dsm Ip Assets B.V. | Extracellular diterpene production |
| MX367033B (es) | 2013-05-31 | 2019-08-02 | Dsm Ip Assets Bv | Microorganismos para la produccion de diterpeno. |
| EP3714699B1 (en) | 2013-06-07 | 2024-12-18 | PureCircle USA Inc. | Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier |
| US10952458B2 (en) | 2013-06-07 | 2021-03-23 | Purecircle Usa Inc | Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier |
| KR101559478B1 (ko) | 2013-06-24 | 2015-10-13 | 한국생명공학연구원 | 효소전환법을 이용한 천연 고감미료의 제조방법 |
| EP3021689B1 (en) * | 2013-07-15 | 2021-03-24 | DSM IP Assets B.V. | Diterpene production |
| EP3024941B1 (en) * | 2013-07-23 | 2019-07-03 | DSM IP Assets B.V. | Diterpene production in yarrowia |
| EP3536697A1 (en) | 2013-07-31 | 2019-09-11 | DSM IP Assets B.V. | Recovery of steviol glycosides |
| AU2014298430A1 (en) * | 2013-07-31 | 2016-02-11 | Dsm Ip Assets B.V. | Steviol glycosides |
| WO2015016393A1 (ja) * | 2013-08-02 | 2015-02-05 | サントリーホールディングス株式会社 | ヘキセノール配糖体化酵素の利用方法 |
| CN103397064B (zh) * | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| US20160215306A1 (en) * | 2013-08-30 | 2016-07-28 | Evolva Sa | Method for producing modified resveratrol |
| AU2014342939B2 (en) * | 2013-11-01 | 2018-03-22 | Conagen Inc. | Recombinant production of steviol glycosides |
| EP3099802A1 (en) | 2014-01-31 | 2016-12-07 | The University of Copenhagen | Biosynthesis of forskolin and related compounds |
| US20180020709A1 (en) * | 2014-04-16 | 2018-01-25 | Purecircle Usa Inc. | Rebaudioside m biosynthetic production and recovery methods |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11202461B2 (en) | 2014-09-02 | 2021-12-21 | Purecircle Sdn Bhd | Stevia extracts |
| CN105850727B (zh) | 2015-01-23 | 2018-12-07 | 谱赛科美国公司 | 甜叶菊新品种及高rd、rm含量甜菊糖苷的制备 |
| CN105850709B (zh) * | 2015-01-23 | 2018-08-21 | 谱赛科美国公司 | 甜叶菊新品种817096谱星5号及高rd含量甜菊糖苷的制备 |
| CA2960693A1 (en) | 2014-09-09 | 2016-03-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP4166010A1 (en) * | 2014-09-19 | 2023-04-19 | PureCircle SDN BHD | High-purity steviol glycosides |
| WO2016048994A2 (en) * | 2014-09-23 | 2016-03-31 | President And Fellows Of Harvard College | Systems and methods of cell-free protein synthesis in droplets and other compartments |
| CN113016623A (zh) * | 2014-09-26 | 2021-06-25 | 谱赛科美国股份有限公司 | 用于甜菊的单核苷酸多态性(snp)标志物 |
| CA2963300C (en) | 2014-10-01 | 2024-04-30 | Evolva Sa | Methods and materials for biosynthesis of mogroside compounds |
| BR112017006163B1 (pt) * | 2014-10-03 | 2022-04-05 | Conagen Inc | Produto de consumo oral e método para adoçar o mesmo |
| EP3204506B1 (en) * | 2014-10-08 | 2022-01-12 | DSM IP Assets B.V. | Steviol glycoside production |
| CN107109453A (zh) | 2014-11-05 | 2017-08-29 | 马努斯生物合成股份有限公司 | 甜菊醇糖苷的微生物产生 |
| WO2016075302A1 (en) * | 2014-11-13 | 2016-05-19 | Evolva Sa | Methods and materials for biosynthesis of manoyl oxide |
| CN108522291B (zh) | 2015-01-23 | 2022-01-04 | 谱赛科美国公司 | 利用甜叶菊新品种814011谱星3号制备高rm含量甜菊糖苷的方法 |
| EP3250686A1 (en) * | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| CA2987508A1 (en) | 2015-05-28 | 2016-12-01 | Evolva Sa | Biosynthesis of phenylpropanoids and phenylpropanoid derivatives |
| US10612065B2 (en) | 2015-05-29 | 2020-04-07 | Cargill, Incorporated | Heat treatment to produce glycosides |
| EP3303553B1 (en) | 2015-05-29 | 2022-07-27 | Cargill, Incorporated | Fermentation methods for producing steviol glycosides using high ph |
| EP3303552A4 (en) * | 2015-05-29 | 2019-01-16 | Cargill, Incorporated | FERMENTATION METHOD FOR THE PRODUCTION OF STEVIOL GLYCOSIDES WITH MULTIPHASE SUPPLY |
| CN107820394A (zh) | 2015-07-10 | 2018-03-20 | 帝斯曼知识产权资产管理有限公司 | 甜菊醇糖苷组合物 |
| US11124535B2 (en) | 2015-07-10 | 2021-09-21 | Dsm Ip Assets B.V. | Steviol glycoside composition |
| US10844414B2 (en) | 2015-08-06 | 2020-11-24 | Cargill, Incorporated | Methods for producing steviol glycosides in engineered yeast |
| MX2018001620A (es) | 2015-08-07 | 2018-06-11 | Evolva Sa | Produccion de glucosidos de esteviol en hospedadores recombinantes. |
| WO2017034942A1 (en) | 2015-08-21 | 2017-03-02 | Manus Biosynthesis, Inc. | Increasing productivity of e. coli host cells that functionally express p450 enzymes |
| US9765117B2 (en) | 2015-08-24 | 2017-09-19 | Romek Figa | Peptides for treating cancer |
| CN108138152B (zh) | 2015-10-05 | 2023-01-06 | 帝斯曼知识产权资产管理有限公司 | 贝壳杉烯酸羟化酶 |
| US11647771B2 (en) | 2015-10-26 | 2023-05-16 | Purecircle Usa Inc. | Steviol glycoside compositions |
| WO2017093895A1 (en) | 2015-11-30 | 2017-06-08 | Purecircle Sdn Bhd | Process for producing high purity steviol glycosides |
| EP3387136B1 (en) * | 2015-12-10 | 2022-01-05 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| RU2764635C2 (ru) | 2015-12-15 | 2022-01-19 | ПЬЮРСЁРКЛ ЮЭсЭй ИНК. | Композиция стевиол гликозида |
| WO2017153538A1 (en) | 2016-03-11 | 2017-09-14 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10982249B2 (en) | 2016-04-13 | 2021-04-20 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| WO2017198681A1 (en) * | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3458599A1 (en) | 2016-05-16 | 2019-03-27 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2017214026A1 (en) * | 2016-06-06 | 2017-12-14 | Tate & Lyle Ingredients Americas Llc | Glycosylated steviol glycoside compositions and methods of preparing glycosylated steviol glycoside compositions |
| JP2019517801A (ja) | 2016-06-15 | 2019-06-27 | コデクシス， インコーポレイテッド | 操作されたβ−グルコシダーゼおよびグルコシル化方法 |
| PT3497222T (pt) | 2016-08-12 | 2022-02-09 | Amyris Inc | Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos |
| US11312985B2 (en) | 2016-10-21 | 2022-04-26 | Pepsico, Inc. | Enzymatic method for preparing Rebaudioside C |
| CN116574775A (zh) | 2016-10-21 | 2023-08-11 | 百事可乐公司 | 一种酶法制备瑞鲍迪甙j的方法 |
| BR112019008048A2 (pt) | 2016-10-21 | 2019-07-02 | Pepsico Inc | método para preparar rebaudiosídeo n com o uso de método enzimático |
| WO2018083338A1 (en) | 2016-11-07 | 2018-05-11 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP6970689B2 (ja) * | 2016-12-27 | 2021-11-24 | サントリーホールディングス株式会社 | 新規ステビオール配糖体およびその製造方法、ならびにそれを含む甘味料組成物 |
| EP3564369A4 (en) | 2016-12-27 | 2020-07-29 | Suntory Holdings Limited | STEVIOL GLYCOSIDE HEXOSE TRANSFERASE AND CODING GENE FOR THIS |
| CN108341781B (zh) * | 2017-01-25 | 2021-09-03 | 中国科学院分子植物科学卓越创新中心 | 植物次生代谢产物生物合成途径中相关酶类的解析方法 |
| BR112019015454A2 (pt) | 2017-01-26 | 2020-03-24 | Manus Bio, Inc. | Manipulação metabólica para produção microbiana de produtos terpenoides |
| KR102905512B1 (ko) * | 2017-02-03 | 2025-12-29 | 테이트 앤드 라일 솔루션스 유에스에이 엘엘씨 | 조작된 글리코실트랜스퍼라제 및 스테비올 글리코시드 글루코실화 방법 |
| IL296347B2 (en) * | 2017-02-21 | 2024-03-01 | Univ Duke | Compositions and methods for robust dynamic metabolic control |
| ES2942429T3 (es) * | 2017-03-31 | 2023-06-01 | Suntory Holdings Ltd | Nuevo glucósido de esteviol y método de producción del mismo, y composición edulcorante que lo contiene |
| CN110494564B (zh) * | 2017-04-12 | 2024-03-15 | 三得利控股株式会社 | 来自甜菊的鼠李糖合成酶及基因 |
| PE20200291A1 (es) * | 2017-05-15 | 2020-02-05 | Purecircle Usa Inc | Glicosidos de esteviol de alta pureza |
| WO2018211032A1 (en) | 2017-05-17 | 2018-11-22 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3638804A1 (en) | 2017-06-15 | 2020-04-22 | Evolva SA | Production of mogroside compounds in recombinant hosts |
| CA3071029A1 (en) * | 2017-08-11 | 2019-02-14 | Amyris, Inc. | Pisum sativum kaurene oxidase for high efficiency production of rebaudiosides |
| WO2019055325A2 (en) * | 2017-09-12 | 2019-03-21 | Biocapital Holdings, Llc | BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES |
| BR112020009838A2 (pt) * | 2017-12-05 | 2020-11-17 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| MY204735A (en) * | 2018-07-16 | 2024-09-11 | Manus Bio Inc | Production of steviol glycosides through whole cell biotransformation |
| IL280302B2 (en) | 2018-07-30 | 2025-09-01 | Codexis Inc | Engineered glycosyltransferases and methods for glycosylation of steviol glycoside |
| EP3877519B1 (en) | 2018-11-09 | 2026-03-11 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| MX2021005569A (es) | 2018-11-20 | 2021-07-06 | Purecircle Usa Inc | Cultivar de stevia aneuploide 'ap-1'. |
| WO2020264179A1 (en) * | 2019-06-25 | 2020-12-30 | Manus Bio, Inc. | Uridine diphosphate-dependent glycosyltransferase enzyme |
| JP7197019B2 (ja) | 2019-08-08 | 2022-12-27 | 東亞合成株式会社 | 水易解体性接着剤組成物 |
| CN110592040A (zh) * | 2019-09-18 | 2019-12-20 | 江苏施宇甜生物科技有限公司 | 一种用于生产upd糖基转移酶的重组枯草芽孢杆菌的工艺 |
| CN111424065B (zh) * | 2020-03-24 | 2022-08-16 | 金禾益康(北京)生物科技有限公司 | 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法 |
| WO2023006179A1 (en) | 2020-07-27 | 2023-02-02 | Dsm Ip Assets B.V. | Method to produce retinyl acetate |
| CN112147253B (zh) * | 2020-09-25 | 2022-04-01 | 安徽瑞思威尔科技有限公司 | 一种灵芝酒中42种有效成分的UPC2-PDA-Q-Tof/MS检测方法 |
| US20250290081A1 (en) | 2020-10-22 | 2025-09-18 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| WO2022139522A1 (ko) * | 2020-12-23 | 2022-06-30 | 주식회사 삼양사 | 당전이 효소 및 이를 이용한 스테비올 배당체의 제조방법 |
| CN112877355A (zh) * | 2021-01-22 | 2021-06-01 | 杜云龙 | 一种利用烟草表达三七皂苷的方法 |
| WO2022245988A2 (en) * | 2021-05-18 | 2022-11-24 | Biokai, Inc. | Production of carotenoids |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| WO2023006851A1 (en) | 2021-07-27 | 2023-02-02 | Dsm Ip Assets B.V. | Fermentative production of retinyl acetate in the presence of ethanol |
| CN115975827A (zh) * | 2021-10-15 | 2023-04-18 | 中国科学院分子植物科学卓越创新中心 | 用于甜茶素生产的宿主细胞及方法 |
| US20250051818A1 (en) * | 2021-12-24 | 2025-02-13 | Samyang Corporation | Production of rebaudioside |
| CN114703217B (zh) * | 2022-03-26 | 2025-09-02 | 江苏省中国科学院植物研究所 | 一种甜菊自交系种子转基因体系的建立方法 |
| CN114752575B (zh) * | 2022-04-07 | 2023-06-13 | 内蒙古工业大学 | 一种nad+依赖性脱氢酶基因及其在提高辅酶q10产量中的应用 |
| CN119487193A (zh) | 2022-07-07 | 2025-02-18 | 三得利控股株式会社 | 甜菊醇糖苷生物合成变异酶与其利用 |
| CN116162607B (zh) * | 2023-01-04 | 2025-07-01 | 中国科学院大连化学物理研究所 | 一种甜菊糖苷糖基转移酶基因及其编码产物与应用 |
| CN116004563B (zh) * | 2023-01-17 | 2023-11-17 | 华中农业大学 | 一种茶树类黄酮糖基转移酶及其应用 |
| CN116724112B (zh) * | 2023-03-24 | 2024-02-02 | 森瑞斯生物科技(深圳)有限公司 | HMG-CoA还原酶突变体及其在生产萜类化合物中的应用 |
| WO2024228615A1 (en) * | 2023-05-03 | 2024-11-07 | Purecircle Sdn. Bhd. | High-purity steviol glycosides |
Family Cites Families (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58149697A (ja) | 1982-02-27 | 1983-09-06 | Dainippon Ink & Chem Inc | β−１，３グリコシルステビオシドの製造方法 |
| JPS59101408A (ja) * | 1982-12-02 | 1984-06-12 | Junichi Iwamura | 植物生長調整剤 |
| US5198360A (en) | 1990-01-19 | 1993-03-30 | Eli Lilly And Company | Dna sequence conferring a plaque inhibition phenotype |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| JPH03277275A (ja) | 1990-03-28 | 1991-12-09 | Dainippon Ink & Chem Inc | 新規酵素及びその酵素を用いた配糖体の製造方法 |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| US5712112A (en) | 1992-11-04 | 1998-01-27 | National Science Council Of R.O.C. | Gene expression system comprising the promoter region of the alpha-amylase genes |
| WO1995002683A1 (en) | 1993-07-15 | 1995-01-26 | Neose Pharmaceuticals | Method of synthesizing saccharide compositions |
| US7186891B1 (en) | 1996-04-12 | 2007-03-06 | University Of Kentucky, Research Foundation | Plant cells and plants expressing chimeric isoprenoid synthases |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| WO1999018224A1 (en) | 1997-10-06 | 1999-04-15 | The Centre National De Recherche Scientifique | Plant fatty acid hydroxylase genes |
| US6255557B1 (en) | 1998-03-31 | 2001-07-03 | Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada | Stevia rebaudiana with altered steviol glycoside composition |
| EP2175025A1 (en) | 1998-04-14 | 2010-04-14 | Kyowa Hakko Bio Co., Ltd. | Process for producing isoprenoid compounds by using microorganisms |
| TWI250210B (en) | 1998-05-06 | 2006-03-01 | Dsm Ip Assets Bv | An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate |
| EP0955363A3 (en) | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | Dna sequences encoding enzymes involved in production of isoprenoids |
| JP4579415B2 (ja) | 1998-07-06 | 2010-11-10 | ディーシーブイ・インコーポレイテッド・ドゥーイング・ビジネス・アズ・バイオ−テクニカル・リソーシィズ | ビタミン製造方法 |
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| AR021636A1 (es) | 1998-12-17 | 2002-07-31 | Rubicon Forests Holdings Ltd | Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides |
| AU2594300A (en) | 1998-12-23 | 2000-07-12 | Samuel Roberts Noble Foundation, Inc., The | Plant transformation process |
| MXPA01010488A (es) | 1999-04-15 | 2003-07-21 | Calgene Llc | Secuencias de acidos nucleicos para proteinas que intervienen en sintesis isoprenoide. |
| NZ513993A (en) | 1999-04-21 | 2001-09-28 | Samuel Roberts Noble Found Inc | Plant transformation process |
| ATE373715T1 (de) | 1999-08-04 | 2007-10-15 | Adelbert Bacher | Isoprenoid biosynthese |
| AU6780700A (en) | 1999-08-18 | 2001-03-13 | Paradigm Genetics, Inc. | Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration |
| WO2001083769A2 (en) | 2000-05-03 | 2001-11-08 | The Salk Institute For Biological Studies | Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis |
| DE10027821A1 (de) | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
| WO2002010398A2 (en) | 2000-07-31 | 2002-02-07 | Hahn Frederick M | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| US7109033B2 (en) | 2000-08-24 | 2006-09-19 | The Scripps Research Institute | Stress-regulated genes of plants, transgenic plants containing same, and methods of use |
| US6660507B2 (en) | 2000-09-01 | 2003-12-09 | E. I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| US6818424B2 (en) | 2000-09-01 | 2004-11-16 | E. I. Du Pont De Nemours And Company | Production of cyclic terpenoids |
| US6689601B2 (en) | 2000-09-01 | 2004-02-10 | E. I. Du Pont De Nemours And Company | High growth methanotropic bacterial strain |
| AU2001291114A1 (en) | 2000-09-19 | 2002-04-02 | Microbia, Inc. | Modulation of secondary metabolite production by zinc binuclear cluster proteins |
| AU9635901A (en) | 2000-09-29 | 2002-04-08 | Cargill Inc | Isoprenoid production |
| CN1345963A (zh) * | 2000-09-29 | 2002-04-24 | 上海博德基因开发有限公司 | 一种新的多肽——udp糖基转移酶(ugt)及钴胺素结合蛋白9.57和编码这种多肽的多核苷酸 |
| US6949362B2 (en) | 2000-12-12 | 2005-09-27 | E. I. Du Pont De Nemours And Company | Rhodococcus cloning and expression vectors |
| DE60239386D1 (de) | 2001-01-25 | 2011-04-21 | Evolva Ltd | Zellbibliothek |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| DE10201458A1 (de) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| US7034140B2 (en) | 2001-04-24 | 2006-04-25 | E.I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| AU2002316966B2 (en) | 2001-06-06 | 2007-05-17 | Dsm Ip Assets B.V. | Improved isoprenoid production |
| EP1402042A2 (en) | 2001-06-22 | 2004-03-31 | Syngenta Participations AG | Abiotic stress responsive polynucleotides and polypeptides |
| NZ513755A (en) | 2001-08-24 | 2001-09-28 | Ann Rachel Holmes | Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs |
| US20040072311A1 (en) | 2001-08-28 | 2004-04-15 | Dicosimo Deana J. | Production of cyclic terpenoids |
| US20040010815A1 (en) | 2001-09-26 | 2004-01-15 | Lange B. Markus | Identification and characterization of plant genes |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| JP2005185101A (ja) | 2002-05-30 | 2005-07-14 | National Institute Of Agrobiological Sciences | 植物の全長ｃＤＮＡおよびその利用 |
| DE60329505D1 (de) | 2002-08-20 | 2009-11-12 | Suntory Holdings Ltd | Neue glycosyltransferase-gene |
| ES2305501T3 (es) | 2002-09-27 | 2008-11-01 | Dsm Ip Assets B.V. | Gen escualeno sintasa (sqs). |
| US7098000B2 (en) | 2003-06-04 | 2006-08-29 | E. I. Du Pont De Nemoure And Company | Method for production of C30-aldehyde carotenoids |
| US7422884B2 (en) | 2003-06-12 | 2008-09-09 | Dsm Ip Assetts B.V. | Feedback-resistant mevalonate kinases |
| US7569389B2 (en) | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| ATE537269T1 (de) | 2004-05-21 | 2011-12-15 | Univ California | Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen |
| AU2005321630A1 (en) | 2004-07-02 | 2006-07-06 | Metanomics Gmbh | Process for the production of fine chemicals |
| US20060014264A1 (en) | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
| JPWO2006016395A1 (ja) | 2004-08-09 | 2008-05-01 | 国立大学法人東北大学 | Ｕｄｐ−グルクロニル基転移酵素およびその遺伝子 |
| JP5074185B2 (ja) | 2004-08-19 | 2012-11-14 | ディーエスエム アイピー アセッツ ビー．ブイ． | イソプレノイドの生成 |
| US7923552B2 (en) | 2004-10-18 | 2011-04-12 | SGF Holdings, LLC | High yield method of producing pure rebaudioside A |
| US8338155B2 (en) | 2004-12-14 | 2012-12-25 | Dsm Ip Assets B.V. | Modified mevalonate kinase with reduced feedback inhibition |
| CA2598792A1 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| WO2006096392A2 (en) | 2005-03-04 | 2006-09-14 | Diversa Corporation | Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them |
| JP4284562B2 (ja) * | 2005-03-04 | 2009-06-24 | 独立行政法人産業技術総合研究所 | Ｕｄｐ−キシロースの製造方法 |
| US7989677B2 (en) | 2005-08-17 | 2011-08-02 | Nestec S. A. | Nucleic acids and proteins associated with sucrose accumulation in coffee |
| CA2624230A1 (en) | 2005-08-22 | 2007-03-01 | Co2 Boost Llc | A device and process to generate co2 used for indoor crop production and underwater gardening |
| US8293307B2 (en) * | 2005-10-11 | 2012-10-23 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
| US20070116833A1 (en) * | 2005-11-23 | 2007-05-24 | The Coca-Cola Company | High-Potency Sweetener Composition with Calcium and Compositions Sweetened Therewith |
| AU2006318781B2 (en) | 2005-11-23 | 2012-11-01 | The Coca-Cola Company | Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses |
| KR100784261B1 (ko) | 2006-01-02 | 2007-12-11 | 한국과학기술원 | 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법 |
| US7927851B2 (en) * | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| EP2090662A3 (en) | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
| US8114645B2 (en) | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| EP2035827B1 (en) | 2006-06-19 | 2012-10-17 | Givaudan S.A. | Nucleic acid, polypeptide and its use |
| WO2008008256A2 (en) | 2006-07-07 | 2008-01-17 | The Regents Of The University Of California | Methods for enhancing production of isoprenoid compounds by host cells |
| EP2066778B1 (en) | 2006-09-26 | 2016-01-27 | The Regents of The University of California | Production of isoprenoids and isoprenoid precursors |
| US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
| US7629156B2 (en) | 2006-09-28 | 2009-12-08 | E.I. Du Pont De Nemours And Company | Ethanol production in fermentation of mixed sugars containing xylose |
| CN101200480B (zh) | 2006-12-15 | 2011-03-30 | 成都华高药业有限公司 | 莱鲍迪甙a的提取方法 |
| JP4915917B2 (ja) | 2006-12-22 | 2012-04-11 | 独立行政法人農業・食品産業技術総合研究機構 | ラクト−ｎ−ビオースｉ及びガラクト−ｎ−ビオースの製造方法 |
| ES2381892T3 (es) | 2007-01-22 | 2012-06-01 | Cargill, Incorporated | Procedimiento para producir composiciones de rebaudiósido A purificado que utiliza la cristalización disolvente/antidisolvente |
| US20130071521A1 (en) * | 2007-03-14 | 2013-03-21 | Pepsico, Inc. | Rebaudioside d sweeteners and food products sweetened with rebaudioside d |
| JP2008237110A (ja) | 2007-03-27 | 2008-10-09 | Institute Of Physical & Chemical Research | ステビオール合成酵素遺伝子及びステビオールの製造方法 |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| US20080292775A1 (en) | 2007-05-22 | 2008-11-27 | The Coca-Cola Company | Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses |
| WO2009005704A1 (en) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| JP2009034080A (ja) | 2007-08-03 | 2009-02-19 | Sanei Gen Ffi Inc | 新規糖転移酵素、及びそれを利用した配糖体の製造 |
| US7964232B2 (en) | 2007-09-17 | 2011-06-21 | Pepsico, Inc. | Steviol glycoside isomers |
| DE112008002456T5 (de) | 2007-09-21 | 2011-01-13 | Basf Plant Science Gmbh | Pflanzen mit erhöhtem Ertrag |
| MY155722A (en) | 2007-12-03 | 2015-11-30 | Dsm Ip Assets Bv | Novel nutraceutical compositions containing stevia extract or stevia extract constituents and uses thereof |
| WO2009086049A2 (en) | 2007-12-27 | 2009-07-09 | Mc Neil Nutritionals, Llc | Synergistic sweetening compositions |
| BRPI0907786B1 (pt) * | 2008-02-20 | 2021-06-01 | Ceres, Inc. | Método de produção de uma planta e método de aumentar o nível de tolerância a baixo teor de nitrogênio em uma planta |
| TWI475963B (zh) | 2008-02-25 | 2015-03-11 | 可口可樂公司 | 甜菊糖苷ａ衍生性產物以及製造彼的方法 |
| CA2728285A1 (en) | 2008-03-03 | 2009-09-11 | Joule Unlimited, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| WO2009140394A1 (en) | 2008-05-13 | 2009-11-19 | Cargill, Incorporated | Separation of rebaudioside a from stevia glycosides using chromatography |
| CN101314776B (zh) | 2008-07-11 | 2010-11-03 | 南京农业大学 | 二磷酸尿核甘葡萄糖基转移酶基因及其所编码的蛋白质 |
| WO2010021001A2 (en) | 2008-08-19 | 2010-02-25 | Kaushik Ramakrishnan S | Process for preparing sweetener from stevia rebaudiana |
| ES2592377T3 (es) | 2008-10-03 | 2016-11-29 | Morita Kagaku Kogyo Co., Ltd. | Nuevos glucósidos de esteviol |
| CN101720910B (zh) | 2008-10-23 | 2012-07-25 | 大闽食品（漳州）有限公司 | 一种甜菊糖甙的制备方法 |
| US8614085B2 (en) | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| US20100297722A1 (en) | 2009-05-20 | 2010-11-25 | Board Of Trustees Of Southern Illinois University | Transgenic moss producing terpenoids |
| DK2440661T3 (en) | 2009-06-08 | 2018-03-12 | Jennewein Biotechnologie Gmbh | HMO synthesis |
| KR20120027363A (ko) | 2009-06-16 | 2012-03-21 | 이피씨 (베이징) 내추럴 프로덕츠 컴퍼니, 리미티드 | 뒷맛을 감소시키거나 제거하기 위한 레바우디오사이드 ｄ를 포함하는 조성물 및 그의 제조 방법 |
| CN102573521B (zh) | 2009-09-04 | 2014-04-09 | 红点生物公司 | 包括莱鲍迪苷a或d的甜度增强剂 |
| AU2010298437B2 (en) | 2009-09-22 | 2014-06-19 | Redpoint Bio Corporation | Novel polymorphs of rebaudioside C and methods for making and using the same |
| US8299224B2 (en) | 2009-10-15 | 2012-10-30 | Purecircle Sdn Bhd | High-purity Rebaudioside D |
| CA3015571C (en) | 2009-10-15 | 2021-07-06 | Purecircle Sdn Bhd | High-purity rebaudioside d and applications |
| US8703224B2 (en) | 2009-11-04 | 2014-04-22 | Pepsico, Inc. | Method to improve water solubility of Rebaudioside D |
| CN102812129B (zh) | 2009-11-10 | 2015-08-26 | 麻省理工学院 | 用于从类异戊二烯途径生产化学和医药产品的微生物工程 |
| WO2011062748A1 (en) | 2009-11-23 | 2011-05-26 | E.I. Du Pont De Nemours And Company | Sucrose transporter genes for increasing plant seed lipids |
| HUE041436T2 (hu) | 2009-12-10 | 2019-05-28 | Univ Minnesota | Tal-effektor-közvetített DNS-módosítás |
| WO2011090709A1 (en) | 2009-12-28 | 2011-07-28 | The Coca-Cola Company | Sweetness enhancers, compositions thereof, and methods for use |
| KR101244315B1 (ko) | 2010-10-19 | 2013-03-14 | 이화여자대학교 산학협력단 | 에탄올―저항성 효모 유전자 및 이의 용도 |
| WO2011140329A1 (en) | 2010-05-06 | 2011-11-10 | Ceres, Inc. | Transgenic plants having increased biomass |
| WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| US9249420B2 (en) | 2010-05-31 | 2016-02-02 | Vib Vzw | Isobutanol production using yeasts with modified transporter expression |
| EP2575432B1 (en) | 2010-06-02 | 2019-08-14 | Evolva, Inc. | Recombinant production of steviol glycosides |
| US20120021111A1 (en) | 2010-07-23 | 2012-01-26 | Aexelon Therapeutics, Inc. | Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture |
| US20120083593A1 (en) | 2010-10-01 | 2012-04-05 | Shanghai Yongyou Bioscience Inc. | Separation and Purification of Stevioside and Rebaudioside A |
| EP2645847B1 (en) * | 2010-11-30 | 2018-01-17 | Massachusetts Institute of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| KR20130014227A (ko) | 2011-07-29 | 2013-02-07 | 한국생명공학연구원 | 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법 |
| CA3128532A1 (en) | 2011-08-08 | 2013-02-14 | Evolva Sa | Recombinant production of steviol glycosides |
| IN2014CN01129A (https=) | 2011-08-08 | 2015-04-10 | Evolva Sa | |
| BR112014012543A2 (pt) | 2011-11-23 | 2017-06-13 | Evolva Sa | métodos e materiais para síntese enzimática de compostos de mogrosídeo |
| CN103159808B (zh) | 2011-12-09 | 2017-03-29 | 上海泓博智源医药股份有限公司 | 一种制备天然甜味剂的工艺方法 |
| EP4124245A1 (en) | 2011-12-19 | 2023-02-01 | The Coca-Cola Company | Beverage comprising rebaudioside x |
| MX355028B (es) | 2012-01-23 | 2018-03-28 | Dsm Ip Assets Bv | Produccion de diterpeno. |
| CN102559528B (zh) | 2012-02-09 | 2013-08-21 | 南京工业大学 | 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用 |
| US10000783B2 (en) | 2012-03-16 | 2018-06-19 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
| MX395285B (es) | 2012-05-22 | 2025-03-25 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| CN103710318B (zh) | 2012-09-29 | 2017-01-18 | 中国科学院上海生命科学研究院 | 利用微生物生产甜菊糖苷类化合物的方法 |
| EP2928321A1 (en) | 2012-12-05 | 2015-10-14 | Evolva SA | Steviol glycoside compositions sensory properties |
| MY199452A (en) | 2013-02-06 | 2023-10-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| BR112015019160A2 (pt) | 2013-02-11 | 2017-08-22 | Dalgaard Mikkelsen Michael | Produção de glicosídeos de esteviol em hospedeiros recombinantes |
| EP2953809B1 (en) | 2013-02-11 | 2016-12-28 | Dana Belgium N.V. | Hydrostatic and direct drive transmission |
| MX367033B (es) | 2013-05-31 | 2019-08-02 | Dsm Ip Assets Bv | Microorganismos para la produccion de diterpeno. |
| CA2912347A1 (en) | 2013-05-31 | 2014-12-04 | Dsm Ip Assets B.V. | Extracellular diterpene production |
| KR101559478B1 (ko) | 2013-06-24 | 2015-10-13 | 한국생명공학연구원 | 효소전환법을 이용한 천연 고감미료의 제조방법 |
| EP3021689B1 (en) | 2013-07-15 | 2021-03-24 | DSM IP Assets B.V. | Diterpene production |
| EP3024941B1 (en) | 2013-07-23 | 2019-07-03 | DSM IP Assets B.V. | Diterpene production in yarrowia |
| AU2014298430A1 (en) | 2013-07-31 | 2016-02-11 | Dsm Ip Assets B.V. | Steviol glycosides |
| EP3536697A1 (en) | 2013-07-31 | 2019-09-11 | DSM IP Assets B.V. | Recovery of steviol glycosides |
| WO2015016393A1 (ja) | 2013-08-02 | 2015-02-05 | サントリーホールディングス株式会社 | ヘキセノール配糖体化酵素の利用方法 |
| CN103397064B (zh) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| US20160215306A1 (en) | 2013-08-30 | 2016-07-28 | Evolva Sa | Method for producing modified resveratrol |
| WO2015051454A1 (en) | 2013-10-07 | 2015-04-16 | Vineland Research And Innovation Centre | Compositions and methods for producing steviol and steviol glycosides |
| SG10201807693YA (en) | 2014-03-07 | 2018-10-30 | Evolva Sa | Methods for recombinant production of saffron compounds |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CA2960693A1 (en) | 2014-09-09 | 2016-03-17 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3250686A1 (en) | 2015-01-30 | 2017-12-06 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| CN104845990A (zh) | 2015-06-11 | 2015-08-19 | 山东大学 | 拟南芥糖基转移酶基因ugt73c7在提高植物抗病性中的应用 |
| MX2018001620A (es) | 2015-08-07 | 2018-06-11 | Evolva Sa | Produccion de glucosidos de esteviol en hospedadores recombinantes. |
-
2011
- 2011-06-02 EP EP11790428.4A patent/EP2575432B1/en active Active
- 2011-06-02 NZ NZ604915A patent/NZ604915A/en unknown
- 2011-06-02 BR BR122021005283-2A patent/BR122021005283B1/pt active IP Right Grant
- 2011-06-02 NZ NZ708078A patent/NZ708078A/en unknown
- 2011-06-02 BR BR112012030836A patent/BR112012030836B8/pt active IP Right Grant
- 2011-06-02 MY MYPI2012005201A patent/MY167872A/en unknown
- 2011-06-02 EP EP19185998.2A patent/EP3593633A1/en active Pending
- 2011-06-02 KR KR1020197010945A patent/KR102181638B1/ko active Active
- 2011-06-02 US US13/701,406 patent/US9562251B2/en active Active
- 2011-06-02 CA CA3176307A patent/CA3176307A1/en active Pending
- 2011-06-02 SG SG2012088548A patent/SG186127A1/en unknown
- 2011-06-02 MY MYPI2018000365A patent/MY185668A/en unknown
- 2011-06-02 MX MX2017005290A patent/MX373909B/es unknown
- 2011-06-02 BR BR122021005297-2A patent/BR122021005297B1/pt active IP Right Grant
- 2011-06-02 KR KR1020177033599A patent/KR101971818B1/ko active Active
- 2011-06-02 CN CN201610087593.9A patent/CN105671108A/zh active Pending
- 2011-06-02 MX MX2012014016A patent/MX349121B/es active IP Right Grant
- 2011-06-02 CA CA2802627A patent/CA2802627C/en active Active
- 2011-06-02 BR BR122021005304-9A patent/BR122021005304B1/pt active IP Right Grant
- 2011-06-02 KR KR1020137000003A patent/KR101802547B1/ko active Active
- 2011-06-02 SG SG10201709458QA patent/SG10201709458QA/en unknown
- 2011-06-02 AU AU2011261394A patent/AU2011261394C1/en active Active
- 2011-06-02 JP JP2013513355A patent/JP6177127B2/ja active Active
- 2011-06-02 BR BR122021005287-5A patent/BR122021005287B1/pt active IP Right Grant
- 2011-06-02 MY MYPI2014003063A patent/MY180803A/en unknown
- 2011-06-02 WO PCT/US2011/038967 patent/WO2011153378A1/en not_active Ceased
- 2011-06-02 CN CN201180038475.4A patent/CN103179850B/zh active Active
- 2011-06-02 NZ NZ700097A patent/NZ700097A/en unknown
-
2012
- 2012-11-30 CL CL2012003373A patent/CL2012003373A1/es unknown
- 2012-11-30 MX MX2020007169A patent/MX2020007169A/es unknown
-
2016
- 2016-11-07 JP JP2016217655A patent/JP6110551B1/ja active Active
- 2016-12-07 JP JP2016238040A patent/JP6509188B2/ja active Active
- 2016-12-16 US US15/382,354 patent/US10392644B2/en active Active
-
2019
- 2019-04-02 JP JP2019070335A patent/JP6947772B2/ja active Active
- 2019-07-02 US US16/460,320 patent/US20200140912A1/en not_active Abandoned
-
2021
- 2021-05-24 JP JP2021086878A patent/JP2021151238A/ja active Pending
- 2021-07-12 US US17/373,612 patent/US20220073960A1/en not_active Abandoned
-
2023
- 2023-03-31 JP JP2023058127A patent/JP2023093503A/ja active Pending
- 2023-09-20 US US18/470,785 patent/US20240110215A1/en not_active Abandoned
-
2024
- 2024-06-27 US US18/756,786 patent/US12428628B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013533736A5 (https=) | ||
| CN103710318B (zh) | 利用微生物生产甜菊糖苷类化合物的方法 | |
| JP7061145B2 (ja) | レバウディオサイドｄおよびレバウディオサイドｍの改良された産生方法 | |
| JP2014524247A5 (https=) | ||
| CN107949632B (zh) | 用于使用高pH生产甜菊醇糖苷的发酵方法和由此获得的组合物 | |
| CN103179850B (zh) | 甜菊糖苷的重组生产 | |
| CA2843606C (en) | Recombinant production of steviol glycosides | |
| US10000783B2 (en) | Steviol glucosyltransferases and genes encoding the same | |
| US20220081699A1 (en) | Heat treatment to produce glycosides | |
| EP2645847B1 (en) | Microbial production of natural sweeteners, diterpenoid steviol glycosides | |
| KR101983115B1 (ko) | 사프란 화합물의 재조합 생성을 위한 방법 및 물질 | |
| US20190203244A1 (en) | Preparation of rebaudioside m in a single reaction vessel | |
| CN108064135A (zh) | 二萜的生产 | |
| CN105247064A (zh) | 细胞外的二萜生产 | |
| CA2994288A1 (en) | Fermentation methods for producing steviol glycosides | |
| CN107567492A (zh) | Udp‑糖基转移酶 | |
| EP3114210A2 (en) | Methods for recombinant production of saffron compounds | |
| CN107614677A (zh) | 用于使用多阶段进料生产甜菊醇糖苷的发酵方法 | |
| CN109796516B (zh) | 一组天然与非天然的原人参三醇型人参皂苷的合成方法 | |
| CN107922465A (zh) | 甜菊醇糖苷转运 | |
| CN107922913A (zh) | 甜菊醇糖苷转运 | |
| CN108138152B (zh) | 贝壳杉烯酸羟化酶 | |
| JP2022524214A (ja) | Ｕｄｐ－ラムノースの生合成生産 | |
| HK40054956B (zh) | Udp-鼠李糖的生物合成生产 | |
| RU2019104496A (ru) | Udp-зависимая гликозилтрансфераза для высокоэффективного продуцирования ребаудиозидов |