JP2012529483A5 - - Google Patents
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- JP2012529483A5 JP2012529483A5 JP2012514548A JP2012514548A JP2012529483A5 JP 2012529483 A5 JP2012529483 A5 JP 2012529483A5 JP 2012514548 A JP2012514548 A JP 2012514548A JP 2012514548 A JP2012514548 A JP 2012514548A JP 2012529483 A5 JP2012529483 A5 JP 2012529483A5
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- JP
- Japan
- Prior art keywords
- acid
- composition
- use according
- extract
- strawberryside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 14
- 239000000284 extract Substances 0.000 claims 10
- 235000013824 polyphenols Nutrition 0.000 claims 8
- 206010019280 Heart failures Diseases 0.000 claims 7
- -1 triterpenoid polyphenol Chemical class 0.000 claims 7
- OXVUXGFZHDKYLS-BLIWDXROSA-N Tormentic acid Chemical compound C1[C@@H](O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@](O)(C)[C@H]5C4=CC[C@@H]3[C@]21C OXVUXGFZHDKYLS-BLIWDXROSA-N 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 6
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 claims 5
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 claims 5
- 229940022757 asiaticoside Drugs 0.000 claims 5
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims 4
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims 4
- 229920002079 Ellagic acid Polymers 0.000 claims 4
- JXSVIVRDWWRQRT-UYDOISQJSA-N asiatic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C JXSVIVRDWWRQRT-UYDOISQJSA-N 0.000 claims 4
- 229940011658 asiatic acid Drugs 0.000 claims 4
- LBGFKBYMNRAMFC-PYSQTNCISA-N asiatic acid Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@]2(C)[C@H]1C)C(=O)O LBGFKBYMNRAMFC-PYSQTNCISA-N 0.000 claims 4
- 229960002852 ellagic acid Drugs 0.000 claims 4
- 235000004132 ellagic acid Nutrition 0.000 claims 4
- CLXOLTFMHAXJST-UHFFFAOYSA-N esculentic acid Natural products C12CC=C3C4CC(C)(C(O)=O)CCC4(C(O)=O)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(CO)C CLXOLTFMHAXJST-UHFFFAOYSA-N 0.000 claims 4
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims 4
- VULLSLYDWNGNKZ-UHFFFAOYSA-N 12319Tetrahydroxyurs-12-en-28-oic acid Natural products OC1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(O)(C)C5C4=CCC3C21C VULLSLYDWNGNKZ-UHFFFAOYSA-N 0.000 claims 3
- BZIGXGRVQSNLNL-UHFFFAOYSA-N Gemin A Natural products Oc1ccc(C(=O)OC2C(OC(=O)c3cc(O)c(O)c(Oc4c(O)c(O)c(O)cc4C(=O)OC5OC6COC(=O)c7cc(O)c(O)c(O)c7c8c(O)c(O)c(O)cc8C(=O)OC6C9OC(=O)c%10cc(O)c(O)c(O)c%10c%11c(O)c(O)c(O)cc%11C(=O)OC59)c3)OC%12COC(=O)c%13cc(O)c(O)c(O)c%13c%14c(O)c(O)c(O)cc%14C(=O)OC%12C2OC(=O)c%15cc(O)c(O)c(O)c%15)c(O)c1O BZIGXGRVQSNLNL-UHFFFAOYSA-N 0.000 claims 3
- ODXMIHPUPFEYDB-HISCDKSNSA-N Gemin A Chemical compound OC1=C(O)C(O)=CC(C(=O)O[C@@H]2[C@H]([C@@H]3OC(=O)C4=CC(O)=C(O)C(O)=C4C4=C(O)C(O)=C(O)C=C4C(=O)OC[C@H]3O[C@@H]2OC(=O)C=2C=C(OC=3C(=CC(O)=C(O)C=3O)C(=O)O[C@@H]3[C@@H]4OC(=O)C5=CC(O)=C(O)C(O)=C5C5=C(O)C(O)=C(O)C=C5C(=O)O[C@H]4[C@@H]4OC(=O)C5=CC(O)=C(O)C(O)=C5C5=C(O)C(O)=C(O)C=C5C(=O)OC[C@H]4O3)C(O)=C(O)C=2)OC(=O)C=2C=C(O)C(O)=C(O)C=2)=C1 ODXMIHPUPFEYDB-HISCDKSNSA-N 0.000 claims 3
- OXVUXGFZHDKYLS-UHFFFAOYSA-N Jacarandic acid Natural products C1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)C(O)(C)C5C4=CCC3C21C OXVUXGFZHDKYLS-UHFFFAOYSA-N 0.000 claims 3
- 125000005233 alkylalcohol group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- BUWCHLVSSFQLPN-UHFFFAOYSA-N madecassic acid Natural products CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(=O)O)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O BUWCHLVSSFQLPN-UHFFFAOYSA-N 0.000 claims 3
- PRAUVHZJPXOEIF-AOLYGAPISA-N madecassic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2[C@H](O)C[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C PRAUVHZJPXOEIF-AOLYGAPISA-N 0.000 claims 3
- 229940011656 madecassic acid Drugs 0.000 claims 3
- AXTGOJVKRHFYBT-XAZAIFFQSA-N (1r,2r,3r,6s,7s,8r)-3-(hydroxymethyl)-2,3,5,6,7,8-hexahydro-1h-pyrrolizine-1,2,6,7-tetrol Chemical compound O[C@@H]1[C@@H](O)CN2[C@H](CO)[C@@H](O)[C@H](O)[C@H]21 AXTGOJVKRHFYBT-XAZAIFFQSA-N 0.000 claims 2
- 244000146462 Centella asiatica Species 0.000 claims 2
- 235000004032 Centella asiatica Nutrition 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- SWRFKGRMQVLMKA-UHFFFAOYSA-N casuarictin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC2C3OC(=O)C4=CC(O)=C(O)C(O)=C4C4=C(O)C(O)=C(O)C=C4C(=O)OC3C3OC(=O)C4=CC(O)=C(O)C(O)=C4C4=C(O)C(O)=C(O)C=C4C(=O)OCC3O2)=C1 SWRFKGRMQVLMKA-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003648 triterpenes Chemical class 0.000 claims 2
- WKKBYJLXSKPKSC-JVJIQXRHSA-N 19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside Chemical compound O=C([C@]12CC[C@H]([C@@]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)(C)O)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O WKKBYJLXSKPKSC-JVJIQXRHSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- 229930182603 Euscaphic acid Natural products 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- 244000088415 Raphanus sativus Species 0.000 claims 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 claims 1
- 208000024799 Thyroid disease Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- MLKQAGPAYHTNQQ-FUZXVMJXSA-N [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate Chemical compound O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]12[C@@H]([C@@](O)(C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@]4(C)[C@H](C(C)(C)[C@H](O)[C@H](O)C4)CC3)CC=1)CC2 MLKQAGPAYHTNQQ-FUZXVMJXSA-N 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 206010001584 alcohol abuse Diseases 0.000 claims 1
- 208000025746 alcohol use disease Diseases 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 231100000457 cardiotoxic Toxicity 0.000 claims 1
- 230000001451 cardiotoxic effect Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- AXTGOJVKRHFYBT-UHFFFAOYSA-N causarine Natural products OC1C(O)CN2C(CO)C(O)C(O)C21 AXTGOJVKRHFYBT-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims 1
- 229960005156 digoxin Drugs 0.000 claims 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000469 ethanolic extract Substances 0.000 claims 1
- OXVUXGFZHDKYLS-QUFHAEKXSA-N euscaphic acid Chemical compound C1[C@@H](O)[C@@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@](O)(C)[C@H]5C4=CC[C@@H]3[C@]21C OXVUXGFZHDKYLS-QUFHAEKXSA-N 0.000 claims 1
- 230000009395 genetic defect Effects 0.000 claims 1
- 208000007565 gingivitis Diseases 0.000 claims 1
- 235000003642 hunger Nutrition 0.000 claims 1
- 206010020871 hypertrophic cardiomyopathy Diseases 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000401 methanolic extract Substances 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- WKKBYJLXSKPKSC-UHFFFAOYSA-N niga-ichigoside F2 Natural products C1CC(C2(CCC3C(C)(CO)C(O)C(O)CC3(C)C2CC=2)C)(C)C=2C2C(O)(C)C(C)CCC21C(=O)OC1OC(CO)C(O)C(O)C1O WKKBYJLXSKPKSC-UHFFFAOYSA-N 0.000 claims 1
- 208000008494 pericarditis Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000037351 starvation Effects 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000021510 thyroid gland disease Diseases 0.000 claims 1
- MLKQAGPAYHTNQQ-UHFFFAOYSA-N tormentic acid glucosyl ester Natural products C1CC(C2(CCC3C(C)(C)C(O)C(O)CC3(C)C2CC=2)C)(C)C=2C2C(O)(C)C(C)CCC21C(=O)OC1OC(CO)C(O)C(O)C1O MLKQAGPAYHTNQQ-UHFFFAOYSA-N 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18670909P | 2009-06-12 | 2009-06-12 | |
| US61/186,709 | 2009-06-12 | ||
| US18790509P | 2009-06-17 | 2009-06-17 | |
| US61/187,905 | 2009-06-17 | ||
| PCT/IB2010/001410 WO2010143058A1 (en) | 2009-06-12 | 2010-06-11 | Compositions and methods for the prevention and treatment of heart failure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012529483A JP2012529483A (ja) | 2012-11-22 |
| JP2012529483A5 true JP2012529483A5 (https=) | 2013-07-18 |
| JP5689117B2 JP5689117B2 (ja) | 2015-03-25 |
Family
ID=43308481
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514548A Expired - Fee Related JP5689117B2 (ja) | 2009-06-12 | 2010-06-11 | 心不全を防止及び治療するための組成物及び方法 |
| JP2012514554A Expired - Fee Related JP5892929B2 (ja) | 2009-06-12 | 2010-06-11 | 生存期間及び健康寿命を増加させるための組成物及び方法 |
| JP2012514550A Expired - Fee Related JP5892928B2 (ja) | 2009-06-12 | 2010-06-11 | 赤血球凝固の予防及び治療のための組成物並びに方法 |
| JP2012514552A Expired - Fee Related JP5712207B2 (ja) | 2009-06-12 | 2010-06-11 | 脳疾患及び状態の予防及び治療のための組成物及び方法 |
| JP2012514549A Expired - Fee Related JP6076737B2 (ja) | 2009-06-12 | 2010-06-11 | 高血圧症の防止及び治療のための組成物並びに方法 |
| JP2012514551A Expired - Fee Related JP5827618B2 (ja) | 2009-06-12 | 2010-06-11 | 冠動脈性心疾患の予防及び治療のための組成物及び方法 |
| JP2015111092A Pending JP2015155468A (ja) | 2009-06-12 | 2015-06-01 | 赤血球凝固の予防及び治療のための組成物並びに方法 |
| JP2015124801A Pending JP2015164963A (ja) | 2009-06-12 | 2015-06-22 | 冠動脈性心疾患の予防及び治療のための組成物及び方法 |
| JP2015126506A Expired - Fee Related JP6187831B2 (ja) | 2009-06-12 | 2015-06-24 | 生存期間及び健康寿命を増加させるための組成物及び方法 |
| JP2015126332A Pending JP2015164966A (ja) | 2009-06-12 | 2015-06-24 | 高血圧症の防止及び治療のための組成物並びに方法 |
| JP2017090148A Withdrawn JP2017128608A (ja) | 2009-06-12 | 2017-04-28 | 生存期間及び健康寿命を増加させるための組成物及び方法 |
Family Applications After (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514554A Expired - Fee Related JP5892929B2 (ja) | 2009-06-12 | 2010-06-11 | 生存期間及び健康寿命を増加させるための組成物及び方法 |
| JP2012514550A Expired - Fee Related JP5892928B2 (ja) | 2009-06-12 | 2010-06-11 | 赤血球凝固の予防及び治療のための組成物並びに方法 |
| JP2012514552A Expired - Fee Related JP5712207B2 (ja) | 2009-06-12 | 2010-06-11 | 脳疾患及び状態の予防及び治療のための組成物及び方法 |
| JP2012514549A Expired - Fee Related JP6076737B2 (ja) | 2009-06-12 | 2010-06-11 | 高血圧症の防止及び治療のための組成物並びに方法 |
| JP2012514551A Expired - Fee Related JP5827618B2 (ja) | 2009-06-12 | 2010-06-11 | 冠動脈性心疾患の予防及び治療のための組成物及び方法 |
| JP2015111092A Pending JP2015155468A (ja) | 2009-06-12 | 2015-06-01 | 赤血球凝固の予防及び治療のための組成物並びに方法 |
| JP2015124801A Pending JP2015164963A (ja) | 2009-06-12 | 2015-06-22 | 冠動脈性心疾患の予防及び治療のための組成物及び方法 |
| JP2015126506A Expired - Fee Related JP6187831B2 (ja) | 2009-06-12 | 2015-06-24 | 生存期間及び健康寿命を増加させるための組成物及び方法 |
| JP2015126332A Pending JP2015164966A (ja) | 2009-06-12 | 2015-06-24 | 高血圧症の防止及び治療のための組成物並びに方法 |
| JP2017090148A Withdrawn JP2017128608A (ja) | 2009-06-12 | 2017-04-28 | 生存期間及び健康寿命を増加させるための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US9283255B2 (https=) |
| EP (6) | EP2440209A4 (https=) |
| JP (11) | JP5689117B2 (https=) |
| CN (6) | CN102573865B (https=) |
| AU (11) | AU2010258356B2 (https=) |
| WO (6) | WO2010143059A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12397008B2 (en) * | 2006-04-13 | 2025-08-26 | Lead Billion Limited | Pharmaceutical composition and method for regenerating myofibers in the treatment of muscle injuries |
| AU2010258356B2 (en) | 2009-06-12 | 2017-01-19 | Generex Pharmaceuticals, Inc. | Compositions and methods for prevention and treatment of brain diseases and conditions |
| EP2655390B1 (en) * | 2010-12-23 | 2019-03-27 | Huya Bioscience International LLC | Purified cardiogenin isomer and related methods |
| JP6000521B2 (ja) * | 2011-08-10 | 2016-09-28 | 株式会社ブルボン | 血圧上昇抑制剤 |
| US10047034B2 (en) * | 2012-05-16 | 2018-08-14 | Prairie Berry Europe Gmbh | Polyhydroxylated pentacyclic triterpene acids as HMG-COA reductase inhibitors |
| US20140044813A1 (en) * | 2012-08-09 | 2014-02-13 | Kemin Industries, Inc. | Plant Extracts for Improving Cognitive Health and Function |
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