JP2010533499A5 - - Google Patents
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- Publication number
- JP2010533499A5 JP2010533499A5 JP2010517170A JP2010517170A JP2010533499A5 JP 2010533499 A5 JP2010533499 A5 JP 2010533499A5 JP 2010517170 A JP2010517170 A JP 2010517170A JP 2010517170 A JP2010517170 A JP 2010517170A JP 2010533499 A5 JP2010533499 A5 JP 2010533499A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- target molecule
- candidate mixture
- minutes
- deoxyuridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 33
- 238000000034 method Methods 0.000 claims 22
- 150000007523 nucleic acids Chemical class 0.000 claims 22
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 108091023037 Aptamer Proteins 0.000 claims 12
- 125000005518 carboxamido group Chemical group 0.000 claims 6
- 230000004048 modification Effects 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 238000007865 diluting Methods 0.000 claims 3
- 238000010494 dissociation reaction Methods 0.000 claims 3
- 230000005593 dissociations Effects 0.000 claims 3
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 claims 2
- -1 2,3-dihydroxypropyl Chemical group 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 2
- 238000007385 chemical modification Methods 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 2
- 229920000447 polyanionic polymer Polymers 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- KISUPFXQEHWGAR-RRKCRQDMSA-N 4-amino-5-bromo-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical group C1=C(Br)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 KISUPFXQEHWGAR-RRKCRQDMSA-N 0.000 claims 1
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 claims 1
- LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical group BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 claims 1
- 208000035657 Abasia Diseases 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 229950004398 broxuridine Drugs 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229940094991 herring sperm dna Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 102000014187 peptide receptors Human genes 0.000 claims 1
- 108010011903 peptide receptors Proteins 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 150000004713 phosphodiesters Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 150000003230 pyrimidines Chemical class 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95028307P | 2007-07-17 | 2007-07-17 | |
| US95029307P | 2007-07-17 | 2007-07-17 | |
| US95028107P | 2007-07-17 | 2007-07-17 | |
| US60/950,283 | 2007-07-17 | ||
| US60/950,293 | 2007-07-17 | ||
| US60/950,281 | 2007-07-17 | ||
| US3142008P | 2008-02-26 | 2008-02-26 | |
| US61/031,420 | 2008-02-26 | ||
| US5159408P | 2008-05-08 | 2008-05-08 | |
| US61/051,594 | 2008-05-08 | ||
| PCT/US2008/070383 WO2009012418A2 (en) | 2007-07-17 | 2008-07-17 | Method for generating aptamers with improved off-rates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014203867A Division JP5938080B2 (ja) | 2007-07-17 | 2014-10-02 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533499A JP2010533499A (ja) | 2010-10-28 |
| JP2010533499A5 true JP2010533499A5 (enExample) | 2011-07-28 |
| JP5684568B2 JP5684568B2 (ja) | 2015-03-11 |
Family
ID=40260081
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517171A Active JP5404620B2 (ja) | 2007-07-17 | 2008-07-17 | 試験試料の多重化分析 |
| JP2010517170A Active JP5684568B2 (ja) | 2007-07-17 | 2008-07-17 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2013220095A Active JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
| JP2014203867A Active JP5938080B2 (ja) | 2007-07-17 | 2014-10-02 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2016028563A Active JP6491610B2 (ja) | 2007-07-17 | 2016-02-18 | 試験試料の多重化分析 |
| JP2016095782A Active JP6407195B2 (ja) | 2007-07-17 | 2016-05-12 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018165689A Pending JP2019004901A (ja) | 2007-07-17 | 2018-09-05 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018206262A Pending JP2019039929A (ja) | 2007-07-17 | 2018-11-01 | 試験試料の多重化分析 |
| JP2020009000A Withdrawn JP2020078311A (ja) | 2007-07-17 | 2020-01-23 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2021081339A Active JP7303244B2 (ja) | 2007-07-17 | 2021-05-13 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2023102137A Active JP7755619B2 (ja) | 2007-07-17 | 2023-06-22 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517171A Active JP5404620B2 (ja) | 2007-07-17 | 2008-07-17 | 試験試料の多重化分析 |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013220095A Active JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
| JP2014203867A Active JP5938080B2 (ja) | 2007-07-17 | 2014-10-02 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2016028563A Active JP6491610B2 (ja) | 2007-07-17 | 2016-02-18 | 試験試料の多重化分析 |
| JP2016095782A Active JP6407195B2 (ja) | 2007-07-17 | 2016-05-12 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018165689A Pending JP2019004901A (ja) | 2007-07-17 | 2018-09-05 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018206262A Pending JP2019039929A (ja) | 2007-07-17 | 2018-11-01 | 試験試料の多重化分析 |
| JP2020009000A Withdrawn JP2020078311A (ja) | 2007-07-17 | 2020-01-23 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2021081339A Active JP7303244B2 (ja) | 2007-07-17 | 2021-05-13 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2023102137A Active JP7755619B2 (ja) | 2007-07-17 | 2023-06-22 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8409795B2 (enExample) |
| EP (10) | EP2172566B2 (enExample) |
| JP (11) | JP5404620B2 (enExample) |
| KR (3) | KR101634608B1 (enExample) |
| CN (6) | CN101802225B (enExample) |
| AU (3) | AU2008276001A1 (enExample) |
| CA (4) | CA2693453C (enExample) |
| DK (4) | DK2172566T4 (enExample) |
| ES (6) | ES2604764T3 (enExample) |
| FI (1) | FI3284832T3 (enExample) |
| HR (1) | HRP20150382T1 (enExample) |
| MX (7) | MX344253B (enExample) |
| NO (1) | NO2933340T3 (enExample) |
| PL (1) | PL2489743T3 (enExample) |
| PT (2) | PT2489743E (enExample) |
| SI (1) | SI2489743T1 (enExample) |
| WO (3) | WO2009012420A1 (enExample) |
Families Citing this family (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5993279A (ja) * | 1982-11-17 | 1984-05-29 | 富士通株式会社 | ロボツトによるカ−ド，レシ−ト分離取出し方法 |
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7964356B2 (en) * | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| DK2172566T4 (da) | 2007-07-17 | 2022-06-13 | Somalogic Inc | Fremgangsmåde til generering af aptamerer med forbedrede off-rates |
| US8404830B2 (en) * | 2007-07-17 | 2013-03-26 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8314052B2 (en) * | 2009-03-23 | 2012-11-20 | Base Pair Biotechnologies, Inc. | Methods for simultaneous generation of functional ligands |
| US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
| CA2756463C (en) | 2009-03-24 | 2019-01-22 | University Of Chicago | Slip chip device and methods |
| US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
| US8569252B2 (en) * | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
| AU2013203588C1 (en) * | 2009-07-09 | 2016-06-30 | Somalogic Operating Co., Inc. | Method for generating aptamers with improved off-rates |
| JP5967687B2 (ja) * | 2009-07-17 | 2016-08-10 | Ｎｅｃソリューションイノベータ株式会社 | スフィンゴシルホスホリルコリンに結合するアプタマー分子 |
| US8841429B2 (en) * | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
| US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
| US9453845B2 (en) | 2010-02-01 | 2016-09-27 | Cell Signaling Technology, Inc. | Mass spectroscopy analysis of mutant polypeptides in biological samples |
| EP2550000A4 (en) | 2010-03-24 | 2014-03-26 | Advirna Inc | RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING |
| AU2013202528B2 (en) * | 2010-04-12 | 2015-07-30 | Somalogic Operating Co., Inc. | 5-position modified pyrimidines and their use |
| AU2011240774B2 (en) * | 2010-04-12 | 2014-04-10 | Otsuka Pharmaceutical Co., Ltd. | Aptamers to beta-NGF and their use in treating beta-NGF mediated diseases and disorders |
| MX2012014268A (es) * | 2010-07-09 | 2013-02-12 | Somalogic Inc | Biomarcadores de cancer de pulmon y usos de los mismos. |
| CN103429753A (zh) | 2010-09-27 | 2013-12-04 | 私募蛋白质体公司 | 间皮瘤生物标记及其用途 |
| US9416360B2 (en) | 2010-11-05 | 2016-08-16 | MiRagen Therapeutics, Inc. | Base modified oligonucleotides |
| KR101307616B1 (ko) * | 2011-02-08 | 2013-09-12 | 경희대학교 산학협력단 | Ｐｎａ 앱타머를 이용하여 금속을 분리하는 방법 |
| WO2013099762A1 (ja) | 2011-12-28 | 2013-07-04 | シスメックス株式会社 | 副腎皮質刺激ホルモンと結合する分子およびその利用 |
| EP2798085B1 (en) | 2011-12-30 | 2018-01-24 | Quest Diagnostics Investments Incorporated | Aptamers and diagnostic methods for detecting the egf receptor |
| US9410156B2 (en) | 2012-03-28 | 2016-08-09 | Somalogic, Inc. | Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions |
| EP2856177B1 (en) * | 2012-05-25 | 2020-11-18 | The University of North Carolina At Chapel Hill | Microfluidic devices, solid supports for reagents and related methods |
| MX356413B (es) * | 2012-06-07 | 2018-05-29 | Somalogic Inc | Ensayos multiplexados basados en aptámeros. |
| CN102719430B (zh) * | 2012-06-13 | 2013-06-12 | 湖南大学 | 一种检测组氨酸标签重组蛋白的核酸适配体分子信标探针及其检测方法 |
| KR101556339B1 (ko) * | 2012-07-02 | 2015-10-13 | 국립대학법인 울산과학기술대학교 산학협력단 | 페리오스틴에 대한 압타머 및 이를 포함하는 항암제 조성물 |
| EP2690441A1 (en) | 2012-07-26 | 2014-01-29 | Rheinische Friedrich-Wilhelms-Universität Bonn | Method of determining a protein in a sample |
| CN102912020B (zh) * | 2012-10-20 | 2014-02-19 | 江南大学 | 一种测定赭曲霉毒素a的适配体传感器的构建方法 |
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