JP2010280732A5 - - Google Patents

Download PDF

Info

Publication number
JP2010280732A5
JP2010280732A5 JP2010212875A JP2010212875A JP2010280732A5 JP 2010280732 A5 JP2010280732 A5 JP 2010280732A5 JP 2010212875 A JP2010212875 A JP 2010212875A JP 2010212875 A JP2010212875 A JP 2010212875A JP 2010280732 A5 JP2010280732 A5 JP 2010280732A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2010212875A
Other versions
JP2010280732A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2010280732A publication Critical patent/JP2010280732A/ja
Publication of JP2010280732A5 publication Critical patent/JP2010280732A5/ja
Withdrawn legal-status Critical Current

Links

JP2010212875A 2001-12-21 2010-09-22 Lxrのモジュレーター Withdrawn JP2010280732A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34270701P 2001-12-21 2001-12-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2003559988A Division JP5082033B2 (ja) 2001-12-21 2002-12-20 Lxrのモジュレーター

Publications (2)

Publication Number Publication Date
JP2010280732A JP2010280732A (ja) 2010-12-16
JP2010280732A5 true JP2010280732A5 (ja) 2011-06-16

Family

ID=23342938

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2003559988A Expired - Lifetime JP5082033B2 (ja) 2001-12-21 2002-12-20 Lxrのモジュレーター
JP2010212875A Withdrawn JP2010280732A (ja) 2001-12-21 2010-09-22 Lxrのモジュレーター

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2003559988A Expired - Lifetime JP5082033B2 (ja) 2001-12-21 2002-12-20 Lxrのモジュレーター

Country Status (7)

Country Link
US (1) US7998986B2 (ja)
EP (1) EP1465869B1 (ja)
JP (2) JP5082033B2 (ja)
AU (1) AU2002351412B2 (ja)
CA (1) CA2469435A1 (ja)
ES (1) ES2421511T3 (ja)
WO (1) WO2003059884A1 (ja)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482366B2 (en) * 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
CA2469435A1 (en) * 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
ES2367539T3 (es) 2001-12-21 2011-11-04 X-Ceptor Therapeutics, Inc. Moduladores heterocíclicos de receptores nucleares.
WO2003082198A2 (en) * 2002-03-27 2003-10-09 Smithkline Beecham Corporation Methods of treatment with lxr modulators
WO2004111014A1 (en) * 2003-06-06 2004-12-23 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives as modulators of atp-binding cassette transporters
EP1697413A2 (en) * 2003-08-18 2006-09-06 Wyeth Human lxr alpha variants
NZ547696A (en) 2003-12-23 2009-12-24 Astex Therapeutics Ltd Pyrazole derivatives as protein kinase modulators
WO2005100396A1 (en) * 2004-04-16 2005-10-27 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with retinoid x receptor alpha (rxra)
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
RU2007115900A (ru) 2004-10-27 2008-11-10 Дайити Санкио Компани, Лимитед (Jp) Производные бензола, имеющие 2 или более заместителей
JP2008520744A (ja) 2004-11-19 2008-06-19 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗炎症性ピラゾロピリミジン
AU2005310467B2 (en) * 2004-12-01 2011-06-23 Msd K.K. Substituted pyridone derivative
WO2006077012A2 (en) * 2005-01-18 2006-07-27 Genfit S.A. USE OF LXR LIGANDS FOR THE MODULATION OF DENDRITIC CELLS (DCs)
US8343953B2 (en) 2005-06-22 2013-01-01 Astex Therapeutics Limited Pharmaceutical compounds
EP1933832A2 (en) 2005-06-23 2008-06-25 Astex Therapeutics Limited Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
US7790745B2 (en) * 2005-10-21 2010-09-07 Bristol-Myers Squibb Company Tetrahydroisoquinoline LXR Modulators
US7741317B2 (en) * 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
AU2007347115A1 (en) 2006-04-04 2008-10-23 The Regents Of The University Of California PI3 kinase antagonists
FR2903105A1 (fr) * 2006-07-03 2008-01-04 Sanofi Aventis Sa Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique
FR2903107B1 (fr) 2006-07-03 2008-08-22 Sanofi Aventis Sa Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique
WO2008036238A2 (en) * 2006-09-19 2008-03-27 Wyeth Use of lxr modulators for the prevention and treatment of skin aging
EP2089009A2 (en) * 2006-09-19 2009-08-19 Wyeth Use of lxr agonists for the treatment of osteoarthritis
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
ES2388967T3 (es) 2007-05-04 2012-10-22 Bristol-Myers Squibb Company Agonistas [6,6]- y [6,7]-bicíclicos del receptor GPR119 acoplado a la proteína G
EP2152707B1 (en) 2007-05-04 2012-06-20 Bristol-Myers Squibb Company [6,5]-bicyclic gpr119 g protein-coupled receptor agonists
WO2008149965A1 (ja) 2007-06-07 2008-12-11 Astellas Pharma Inc. ピリドン化合物
KR20100051814A (ko) * 2007-07-17 2010-05-18 브리스톨-마이어스 스큅 컴퍼니 Gpr119 g 단백질-커플링된 수용체의 조절 방법 및 선택된 화합물
TW200913993A (en) * 2007-08-30 2009-04-01 Takeda Pharmaceutical Substituted pyrazole derivatives
JP5133416B2 (ja) 2007-09-14 2013-01-30 オルソー−マクニール−ジャンセン ファーマシューティカルズ, インコーポレイテッド. 1’,3’−二置換−4−フェニル−3,4,5,6−テトラヒドロ−2h,1’h−[1,4’]ビピリジニル−2’−オン
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
KR101897881B1 (ko) 2008-01-04 2018-09-12 인텔리카인, 엘엘씨 특정 화학 물질, 조성물 및 방법
WO2009102789A2 (en) * 2008-02-15 2009-08-20 Wyeth Use of rxr agonists for the treatment of osteroarthritis
GEP20125664B (en) 2008-02-26 2012-10-10 Takeda Pharmaceuticals Co Condensed heterocyclic derivatives and application thereof
WO2009114874A2 (en) 2008-03-14 2009-09-17 Intellikine, Inc. Benzothiazole kinase inhibitors and methods of use
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
JPWO2009154190A1 (ja) 2008-06-17 2011-12-01 アステラス製薬株式会社 ピリドン化合物
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
BRPI0915231A2 (pt) 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
TW201006821A (en) 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
US8703778B2 (en) 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
PL3135672T3 (pl) * 2008-10-10 2020-11-16 Vm Discovery, Inc. Kompozycje i sposoby leczenia zaburzeń używania alkoholu, bólu i innych chorób
EP2358720B1 (en) 2008-10-16 2016-03-02 The Regents of The University of California Fused ring heteroaryl kinase inhibitors
US8476282B2 (en) 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2430031B1 (en) 2009-05-12 2013-04-17 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8937060B2 (en) 2009-05-12 2015-01-20 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders
US8927718B2 (en) 2009-08-26 2015-01-06 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
WO2011024872A1 (ja) 2009-08-26 2011-03-03 武田薬品工業株式会社 縮合複素環誘導体およびその用途
US8486965B2 (en) 2009-08-26 2013-07-16 Takeda Pharmaceutical Company Limited Pyrrolo[2,3-b]pyridine derivative and use thereof for treatment of cancer
EP2471793B1 (en) 2009-08-26 2016-10-05 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
EA201270755A1 (ru) 2010-04-08 2013-03-29 Бристол-Майерс Сквибб Компани Аналоги пиримидинилпиперидинилоксипиридинона в качестве модуляторов рецептора gpr119
WO2011140161A1 (en) 2010-05-06 2011-11-10 Bristol-Myers Squibb Company Benzofuranyl analogues as gpr119 modulators
CN103002738A (zh) 2010-05-21 2013-03-27 英特利凯恩有限责任公司 用于激酶调节的化学化合物、组合物和方法
BR112013005425A2 (pt) 2010-09-07 2018-05-02 Snu R&Db Foundation compostos sesterterpenos e suas utilizações
WO2012062750A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
AU2011328195B2 (en) 2010-11-08 2015-04-02 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
CN103298474B (zh) 2010-11-10 2016-06-29 无限药品股份有限公司 杂环化合物及其用途
NZ612909A (en) 2011-01-10 2015-09-25 Infinity Pharmaceuticals Inc Processes for preparing isoquinolinones and solid forms of isoquinolinones
AR085397A1 (es) 2011-02-23 2013-09-25 Intellikine Inc Combinacion de inhibidores de quinasa y sus usos
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
WO2012158784A2 (en) * 2011-05-16 2012-11-22 Theodore Mark Kamenecka Modulators of the nuclear hormone receptor ror
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2014000648A (es) 2011-07-19 2014-09-25 Infinity Pharmaceuticals Inc Compuestos heterociclicos y sus usos.
TW201311663A (zh) 2011-08-29 2013-03-16 Infinity Pharmaceuticals Inc 雜環化合物及其用途
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
RU2015115631A (ru) 2012-09-26 2016-11-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Модулирование ire1
RU2662436C2 (ru) 2012-10-15 2018-07-26 Эпизайм, Инк. Содержащие заместители бензольные соединения
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
JP6442475B2 (ja) 2013-03-15 2018-12-19 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Lxr調節因子
ES2694001T3 (es) 2013-03-15 2018-12-17 Bristol-Myers Squibb Company Moduladores de LXR
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
PT3013813T (pt) 2013-06-27 2019-06-14 Pfizer Compostos heteroaromáticos e a sua utilização como ligandos de d1 de dopamina
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
NZ718430A (en) 2013-10-04 2021-12-24 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
AU2015204572B2 (en) 2014-01-10 2020-07-30 Inspirna, Inc. LXR agonists and uses thereof
PL3431106T3 (pl) 2014-01-21 2021-06-28 Janssen Pharmaceutica Nv Kombinacje zawierające pozytywne modulatory allosteryczne metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie
IL279202B2 (en) 2014-01-21 2023-09-01 Janssen Pharmaceutica Nv Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
AU2015231413B2 (en) 2014-03-19 2020-04-23 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
US10583102B2 (en) 2014-10-06 2020-03-10 The Johns Hopkins University Targeting liver nuclear receptors as a treatment for wilson disease
MX2018003058A (es) 2015-09-14 2018-08-01 Infinity Pharmaceuticals Inc Formas solidas de derivados de isoquinolinona, proceso de fabricacion, composiciones que las contienen y metodos de uso de las mismas.
JP7025022B2 (ja) 2016-01-11 2022-02-24 ザ ロックフェラー ユニバーシティー 骨髄系由来抑制細胞関連障害の治療のための方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP7054681B2 (ja) 2016-06-24 2022-04-14 インフィニティー ファーマシューティカルズ, インコーポレイテッド 組合せ療法
US10604541B2 (en) 2016-07-22 2020-03-31 Bristol-Myers Squibb Company Glucokinase activators and methods of using same
WO2019104062A1 (en) 2017-11-21 2019-05-31 Rgenix, Inc. Polymorphs and uses thereof
WO2020112889A2 (en) 2018-11-26 2020-06-04 Denali Therapeutics Inc. Methods for treating dysregulated lipid metabolism
CA3161274A1 (en) 2019-12-13 2021-06-17 Stephen Wald Metal salts and uses thereof

Family Cites Families (243)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US176064A (en) * 1876-04-11 Improvement in screw-cutting machines
US73277A (en) * 1868-01-14 Improvement in gates
US339105A (en) * 1886-03-30 John l
US624583A (en) * 1899-05-09 Paper box
US147493A (en) * 1874-02-17 Improvement in curtain-cord holders
US160818A (en) * 1875-03-16 Improvement in bucket-ears
US103705A (en) * 1870-05-31 Improvement in scissors-sharpener
US557843A (en) * 1896-04-07 Octave-coupler for organs
US137805A (en) * 1873-04-15 Improvement in broom-corn dusters
US294995A (en) * 1884-03-11 Ments
US236581A (en) * 1881-01-11 haworth
US72073A (en) 1867-12-10 Improved boot and shoe-heels
US51813A (en) * 1866-01-02 Improvement in the manufacture of paper-pulp
US54759A (en) * 1866-05-15 Improvement in pantographic machines
US226727A (en) * 1880-04-20 Car-coupling
US17334A (en) * 1857-05-19 Machinery for dressing sewing-thread
US2556A (en) * 1842-04-16 Stove
US122964A (en) * 1872-01-23 1872-01-23 Improvement in watches
US755934A (en) * 1904-02-17 1904-03-29 George M Potter Detonator.
US1226832A (en) * 1916-08-09 1917-05-22 Fred M Webber Pneumatic pitman-balance for swing-jaw rock and ore crushers.
US1261371A (en) * 1917-05-02 1918-04-02 John Ellingsen Window construction.
US5625041A (en) * 1990-09-12 1997-04-29 Delta Biotechnology Limited Purification of proteins
US2077412A (en) * 1930-06-04 1937-04-20 Eugene J Lorand Process for the preparation of a molded cellulose foam from viscose and product thereof
US2345058A (en) * 1939-11-25 1944-03-28 Aetna Standard Eng Co Method of galvanizing
US2824341A (en) * 1953-11-25 1958-02-25 Harold B Neal Awning
DE1189994B (de) * 1957-11-20 1965-04-01 Hoechst Ag Verfahren zur Herstellung von 1-Aminopyridon-(6)-derivaten
CH477475A (de) * 1966-07-25 1969-08-31 Geigy Ag J R Verfahren zur Herstellung von neuen Derivaten der 6-Amino-penicillansäure
US3576814A (en) * 1970-01-30 1971-04-27 Rohm & Haas N-aryl pyrid-2-ones
US3710795A (en) * 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US4159202A (en) * 1973-12-20 1979-06-26 Hoechst Aktiengesellschaft Photopolymer having 2-pyridone side group
US3954734A (en) 1974-01-21 1976-05-04 Parke, Davis & Company Novel antibacterial amide compounds and process means for producing the same
US4038065A (en) * 1974-10-11 1977-07-26 Rohm And Haas Company 1-alkylpyrid-2-one
US4028084A (en) 1974-10-11 1977-06-07 Rohm And Haas Company Derivatives of 3-carboxy pyrid-2-ones
US3951982A (en) * 1974-11-21 1976-04-20 Parke, Davis & Company Trialkylsilyl esters of 6(substituted amino)phenyl-1,-dihydro-2-oxonicotinic acid, methods for their production and conversion to the corresponding acid chlorides
US4053470A (en) 1974-12-23 1977-10-11 Parke, Davis & Company Substituted-1,2-dihydro-2-oxonicotinyl-cephalosporins
IT1039699B (it) 1975-07-03 1979-12-10 Prephar Composizione spermicida a base di derivati benzisotiazolici
DE2637477A1 (de) * 1976-08-20 1978-02-23 Hoechst Ag Dihydro-oxo-nicotinsaeuren und verfahren zu ihrer herstellung
JPS5350179A (en) * 1976-10-15 1978-05-08 Rikagaku Kenkyusho Novel 2-pyridone compounds and their preparation
US4101661A (en) 1977-06-03 1978-07-18 Warner-Lambert Novel antibacterial amide compounds and process means for producing the same
CA1115278A (en) 1979-01-10 1981-12-29 Benjamin J. Pierce Anti-inflammatory 4-pyridones and their preparation
GB2045236A (en) 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
FR2456713A1 (fr) * 1979-05-17 1980-12-12 Emballage Ste Gle Pour Melanges vitrifiables
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS5726653A (en) 1980-05-09 1982-02-12 Ciba Geigy Ag Substituted phenyl ether
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4309552A (en) * 1980-08-07 1982-01-05 A. H. Robins Company, Inc. Synthesis of 4-nitro-1,2-hydrocarbyl pyrazolidines and process for preparation thereof
EP0176064A1 (en) 1980-11-06 1986-04-02 Hoechst Uk Limited Intermediates for the production of 7-oxo-4-thia-1-aza[3,2,0]heptane and 7-oxo-4-thia-1-aza[3,2,0]hept-2-ene derivatives
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US5354772A (en) 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
GR80674B (en) 1983-10-19 1985-02-18 Lilly Co Eli Process for producing 9-carbamoyl fluorene derivatives
US4585894A (en) * 1983-10-19 1986-04-29 Eli Lilly And Company Process for producing 9-carbamoyl fluorene derivatives
US5583024A (en) 1985-12-02 1996-12-10 The Regents Of The University Of California Recombinant expression of Coleoptera luciferase
DD244341A1 (de) 1985-12-18 1987-04-01 Akad Wissenschaften Ddr Verfahren zur herstellung neuer 1h-pyrid-2-one
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5221623A (en) 1986-07-22 1993-06-22 Boyce Thompson Institute For Plant Research, Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
JPS63112566A (ja) 1986-10-28 1988-05-17 Nissan Chem Ind Ltd ピリミジノン誘導体、その製法および殺虫・殺ダニ・殺菌剤
HU203330B (en) 1987-06-10 1991-07-29 Pfizer Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5070012A (en) 1988-03-30 1991-12-03 The Board Of Trustees Of The Leland Stanford Junior University Monitoring of cells and trans-activating transcription elements
US5194438A (en) * 1988-07-15 1993-03-16 Basf Aktiengesellschaft α-arylacrylates substituted by a trifluoromethylpyrimidinyloxy radical, fungicidal compositions and methods
DE3823991A1 (de) 1988-07-15 1990-02-15 Basf Ag Heterocyclisch substituierte (alpha)-aryl-acrylsaeureester und fungizide, die diese verbindungen enthalten
DE3922392A1 (de) 1989-07-07 1991-01-17 Merck Patent Gmbh Chromanderivate
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5683888A (en) 1989-07-22 1997-11-04 University Of Wales College Of Medicine Modified bioluminescent proteins and their use
DE3934176A1 (de) 1989-10-13 1991-04-18 Basf Ag Cyclische amide
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
EP0487745A4 (en) 1990-06-19 1993-01-20 Meiji Seika Kabushiki Kaisha Pyridine derivative with angiotensin ii antagonism
US5380721A (en) * 1990-09-10 1995-01-10 Sterling Winthrop Inc. Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
US5283179A (en) 1990-09-10 1994-02-01 Promega Corporation Luciferase assay method
AU8940491A (en) 1990-10-31 1992-05-26 Smithkline Beecham Corporation Substituted indolizino(1,2-b)quinolinones
WO1993020818A1 (en) 1990-10-31 1993-10-28 Smithkline Beecham Corporation SUBSTITUTED INDOLIZINO[1,2-b]QUINOLINONES
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
US5177080A (en) * 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
DE4129340A1 (de) 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5332750A (en) 1991-09-04 1994-07-26 Merck Patent Gesellschaft Mit Beschrankter Haftung 1,2-dihydro-2-oxopyridines
AU2579692A (en) * 1991-09-17 1993-04-27 Salk Institute For Biological Studies, The Receptor of the thyroid/steroid hormone receptor superfamily
DE4221583A1 (de) * 1991-11-12 1993-05-13 Bayer Ag Substituierte biphenylpyridone
US5278289A (en) 1991-11-12 1994-01-11 Johnson Alan J Antihemophilic factor stabilization
US5504070A (en) * 1991-12-05 1996-04-02 Berlex Laboratories, Inc. Inhibitors of the conversion of big endothelin to endothelin
DE69228047T2 (de) 1991-12-10 1999-05-27 Bristol Myers Squibb Co Führer für Schienbeinosteotomie
DE4141187A1 (de) * 1991-12-13 1993-06-17 Bayer Ag Verfahren zur herstellung von substituierten pyrazolinen
AU668694B2 (en) 1991-12-19 1996-05-16 Sanofi-Synthelabo Saccharin derivative proteolytic enzyme inhibitors
US5378720A (en) 1991-12-19 1995-01-03 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
ES2113399T3 (es) 1991-12-26 1998-05-01 Mitsubishi Chem Corp Derivados de beta-oxo-beta-bencenopropano-tio-amida.
AU3611093A (en) 1992-02-21 1993-09-13 Smithkline Beecham Corporation Substituted furo(3',4':6,7)indolizino(1,2-b)quinolinones
DE4206045A1 (de) 1992-02-27 1993-09-02 Bayer Ag Sulfonylbenzyl substituierte pyridone
CA2135173A1 (en) 1992-05-20 1993-11-25 Bruce E. Witzel Ester derivatives of 4-aza-steroids
AU668180B2 (en) 1992-05-20 1996-04-26 Merck & Co., Inc. 17-ethers and thioethers of 4-aza-steroids
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
GB9213694D0 (en) 1992-06-27 1992-08-12 Keynes Roger J Improvements in or relating to neuroregeneration
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
DE4319040A1 (de) 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
DE4319041A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Trisubstituierte Biphenyle
DE4309552A1 (de) 1993-03-24 1994-09-29 Bayer Ag Substituierte Stickstoff-Heterocyclen
US5814645A (en) 1993-03-24 1998-09-29 Bayer Aktiengesellschaft Arylor hetaryl substituted nitrogen heterocycles and their use as pesticides
DE4313747A1 (de) 1993-04-27 1994-11-03 Bayer Ag Verfahren zur Herstellung von substituierten Biphenyltetrazolen
DE4316077A1 (de) 1993-05-13 1994-11-17 Bayer Ag Substituierte Mono- und Bihydridylmethylpyridone
AP9400651A0 (en) 1993-07-15 1995-12-30 Pfizer Azacyclic-heterocyclic compounds as angiotensin II receptor antagonists.
WO1995003803A1 (en) 1993-08-03 1995-02-09 Smithkline Beecham Corporation SUBSTITUTED FURO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLINONES
US5514716A (en) * 1994-02-25 1996-05-07 Sterling Winthrop, Inc. Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
DE4407488A1 (de) * 1994-03-07 1995-09-14 Bayer Ag Verwendung von Biphenyl- und Pyridylmethylpyridonen
RU2139279C1 (ru) 1994-04-08 1999-10-10 Сумитомо Кемикал Компани, Лимитед Производные простого эфира, средство для борьбы с насекомыми и соединение фенола
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
DE4414648A1 (de) 1994-04-27 1995-11-02 Merck Patent Gmbh Verfahren zur Umsetzung von substituierten Pyrid-2-onen mit Arylalkylhalogeniden
US5598269A (en) * 1994-05-12 1997-01-28 Children's Hospital Medical Center Laser guided alignment apparatus for medical procedures
AU3085895A (en) 1994-07-26 1996-02-22 Sankyo Company Limited N-phenylated amide and urea derivatives
JP3466765B2 (ja) 1994-07-27 2003-11-17 キッコーマン株式会社 ビオチン化ホタルルシフェラーゼ、ビオチン化ホタルルシフェラーゼ遺伝子、新規な組み換え体dna、ビオチン化ホタルルシフェラーゼの製造法及び生物発光分析法
US5698571A (en) 1994-10-05 1997-12-16 Eli Lilly And Company 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine
US5744482A (en) 1994-10-05 1998-04-28 Eli Lilly And Company Serotonin agonist in combination with a tachykinin receptor antagonist in the treatment or prevention of migraine
WO1996012181A1 (en) 1994-10-12 1996-04-25 Research & Diagnostics Systems, Inc. Reticulocyte assay control
US5659042A (en) 1994-10-25 1997-08-19 Allergan Method for preparing esters of halonicotinic acids
US5607967A (en) * 1994-10-27 1997-03-04 Merck & Co., Inc. Treatment of alzheimer's disease with 5-(tetradecyloxy)-2-furan carboxylic acid
US5955108A (en) 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
EP0800517A1 (en) 1994-12-29 1997-10-15 Allergan Acetylenes disubstituted with a 5 or 8 substituted tetrahydronaphthyl or dihydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5648514A (en) 1994-12-29 1997-07-15 Allergan Substituted acetylenes having retinoid-like biological activity
US5599967A (en) * 1994-12-29 1997-02-04 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity
US5618943A (en) * 1994-12-29 1997-04-08 Allergan Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5543534A (en) 1994-12-29 1996-08-06 Allergan Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity
US5618931A (en) * 1994-12-29 1997-04-08 Allergan Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US5514825A (en) * 1994-12-29 1996-05-07 Allergan, Inc. Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity
US6005086A (en) 1995-01-13 1999-12-21 The Salk Institute For Biological Studies Farnesoid activated receptor polypeptides, and nucleic acid encoding the same
US5789426A (en) 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
US5869428A (en) 1995-03-13 1999-02-09 Ishihara Sangyo Kaisha Ltd. Pyridonesulfonylurea compounds, process for their production and herbicides containing them
US5741657A (en) * 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for β-lactamase and methods of use
DE19518739A1 (de) 1995-05-22 1996-11-28 Basf Ag N-Aminopyridonderivate
JPH08325248A (ja) 1995-05-26 1996-12-10 Chugoku Kayaku Kk テトラゾール類の新規な合成試薬及びそれを用いたテトラゾール類の製造方法
US5612363A (en) * 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
RU2166330C2 (ru) 1995-06-07 2001-05-10 Джи. Ди. Сирл Энд Ко. Комбинация, содержащая антагонист рецептора ангиотензина ii и эпоксистероидный антагонист рецептора альдостерона
AU5982296A (en) 1995-06-07 1996-12-30 G.D. Searle & Co. Method to treat cardiofibrosis with a combination of an angi otensin ii antagonist and spironolactone
DK0831911T3 (da) 1995-06-07 2002-07-22 Searle & Co Kombinationsterapi til behandling af kongestivt hjertesvigt med spironolacton og angiotensin II-antagonist
AU5966196A (en) 1995-06-08 1997-01-09 Eli Lilly And Company Methods of treating cold and allergic rhinitis
US5849587A (en) 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
WO1996041631A1 (en) 1995-06-09 1996-12-27 Eli Lilly And Company Methods of treating cold and allergic rhinitis
DE19527568A1 (de) 1995-07-28 1997-01-30 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US5776699A (en) 1995-09-01 1998-07-07 Allergan, Inc. Method of identifying negative hormone and/or antagonist activities
US6008204A (en) 1995-09-01 1999-12-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5958954A (en) 1995-09-01 1999-09-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5952345A (en) 1995-09-01 1999-09-14 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
CN1195995A (zh) * 1995-09-21 1998-10-14 安达里斯有限公司 用于药物传递的胞转载体和增强剂
CA2232505A1 (en) 1995-09-22 1997-03-27 Andrew I. Chitty Apparatus and process for multiple chemical reactions
US5888830A (en) 1995-09-22 1999-03-30 Berlex Laboratories, Inc. Apparatus and process for multiple chemical reactions
JP2002500618A (ja) 1995-10-31 2002-01-08 イーライ・リリー・アンド・カンパニー 抗血栓性ジアミン
US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
AU4837996A (en) 1996-02-29 1997-09-16 Delta Biotechnology Limited High purity albumin production process
US5877207A (en) 1996-03-11 1999-03-02 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5869497A (en) * 1996-03-15 1999-02-09 Eli Lilly And Company Method of treating or ameliorating the symptoms of common cold or allergic rhinitis
EA199800858A1 (ru) 1996-03-15 1999-02-25 Эли Лилли Энд Компани Способ лечения насморка или аллергического ринита
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
US5773594A (en) 1996-06-21 1998-06-30 Allergan Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
AU724541B2 (en) 1996-06-21 2000-09-21 Allergan, Inc. Substituted tetrahydronaphthalene and dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US6555690B2 (en) * 1996-06-21 2003-04-29 Allergan, Inc. Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5723666A (en) * 1996-06-21 1998-03-03 Allergan Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5808124A (en) 1996-06-21 1998-09-15 Allergan O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5747542A (en) 1996-06-21 1998-05-05 Allergan Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity
US5763635A (en) 1996-06-21 1998-06-09 Allergan Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
US5741896A (en) * 1996-06-21 1998-04-21 Allergan O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5618503A (en) * 1996-06-28 1997-04-08 Chemical Research & Licensing Company Antimony pentafluoride
DE19627421A1 (de) 1996-07-08 1998-01-15 Bayer Ag Verwendung von substituierten Biphenylen
US5693641A (en) 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
US5962473A (en) 1996-08-16 1999-10-05 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
US5753635A (en) 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
WO1998011895A1 (en) 1996-09-18 1998-03-26 Eli Lilly And Company A method for the prevention of migraine
US5955604A (en) 1996-10-15 1999-09-21 The Regents Of The University Of California Substrates for β-lactamase and uses thereof
PT933996E (pt) * 1996-10-17 2002-02-28 Basf Ag Processo para o combate de fungos patogenicos em plantas de cultura
ZA979961B (en) 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP1082958A3 (en) 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
US5728846A (en) 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
JP2001509165A (ja) * 1997-01-24 2001-07-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア バリヤ機能の回復、表皮の分化の促進及び増殖の抑制のためのFXR、PPARα及びLXRαの活性剤の使用
US5855654A (en) * 1997-01-30 1999-01-05 Rohm And Haas Company Pyridazinones as marine antifouling agents
US5760276A (en) 1997-03-06 1998-06-02 Allergan Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity
US6350774B1 (en) * 1997-04-30 2002-02-26 Eli Lilly And Company Antithrombotic agents
DE69828522T2 (de) 1997-04-30 2005-12-15 Eli Lilly And Co., Indianapolis Antithrombotische mittel
JP3771672B2 (ja) 1997-05-27 2006-04-26 曙ブレーキ工業株式会社 ブレーキペダル操作検出装置
DE19729061A1 (de) 1997-07-08 1999-01-14 Agfa Gevaert Ag Farbfotografisches Aufzeichnungsmaterial
US6380201B1 (en) * 1997-08-05 2002-04-30 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
GB9723078D0 (en) 1997-10-31 1998-01-07 Cerebrus Ltd Chemical compounds
US6156784A (en) 1997-12-18 2000-12-05 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as phosphotyrosine mimics
WO1999031066A1 (en) 1997-12-18 1999-06-24 Boehringer Ingelheim Pharmaceuticals, Inc. Pyridones as src family sh2 domain inhibitors
WO1999040062A1 (en) 1998-02-05 1999-08-12 Novo Nordisk A/S Hydrazone derivatives
EP1076655A1 (en) 1998-04-08 2001-02-21 Novartis AG N-pyridonyl herbicides
CZ20003978A3 (cs) 1998-04-27 2001-09-12 Centre National De La Recherche Scientifique Deriváty 3-(amino- nebo aminoalkyl) pyridinonu a jejich použití
DE19826671A1 (de) 1998-06-16 1999-12-23 Hoechst Schering Agrevo Gmbh 1,3-Oxazolin- und 1,3-Thiazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
WO2000017334A2 (en) 1998-09-23 2000-03-30 Ludmila Solomin Analysis of ligand activated nuclear receptors i(in vivo)
EP1137940A4 (en) 1998-10-23 2004-06-02 Glaxo Group Ltd METHOD FOR IDENTIFYING LIGANDS OF NUCLEAR RECEPTORS
GB2345058A (en) 1998-12-01 2000-06-28 Cerebrus Pharm Ltd Hydroxypyridone compounds useful in the treatment of oxidative damage to the central nervous system
EP1006108A1 (en) 1998-12-01 2000-06-07 Cerebrus Pharmaceuticals Limited 3-Hydroxy-2(1H)-pyridinone or 3-hydroxy-4(1H)-pyridinone derivatives useful as reactive oxygen species (ROS) scavengers
EP1006112A1 (en) 1998-12-01 2000-06-07 Cerebrus Pharmaceuticals Limited 3-Hydroxy-2(1H)-pyridinone or 3-hydroxy-4(1H)-pyridinone derivatives useful as reactive oxygen species (ROS) scavengers
US6294503B1 (en) 1998-12-03 2001-09-25 Ishihara Sangyo Kaisha, Ltd. Fused heterocycle compounds, process for their preparation, and herbicidal compositions containing them
ES2326850T3 (es) 1998-12-23 2009-10-20 Glaxo Group Limited Ensayos para ligandos de receptores nucleares.
US6465258B1 (en) 1999-01-07 2002-10-15 Tularik, Inc. FXR receptor-mediated modulation cholesterol metabolism
US6071955A (en) 1999-02-25 2000-06-06 The Regents Of The University Of California FXR, PPARA and LXRA activators to treat acne/acneiform conditions
US6316503B1 (en) 1999-03-15 2001-11-13 Tularik Inc. LXR modulators
DE60029029T2 (de) 1999-03-26 2007-06-14 City Of Hope, Duarte Screenen nach FXR-Rezeptormodulatoren
AU4641400A (en) 1999-06-02 2000-12-18 Ishihara Sangyo Kaisha Ltd. Fused tricyclic compounds, process for their preparation, and herbicidal compositions containing them
JP2003508031A (ja) 1999-06-18 2003-03-04 スィーヴィー セラピューティクス インコーポレイテッド Atp結合カセット輸送体蛋白質abc1を用いるコレステロール流出を増加させhdlを上昇させるための組成物および方法
AU6074700A (en) 1999-07-08 2001-01-30 Tularik Inc. Compositions and methods for raising hdl cholesterol levels
CA2382562A1 (en) 1999-09-01 2001-03-08 University Of British Columbia Compositions and methods for modulating hdl cholesterol and triglyceride levels
US6479035B1 (en) 1999-09-11 2002-11-12 Smithkline Beecham Corporation Pharmaceutical formulation of fluticasone propionate
CA2389049A1 (en) 1999-09-27 2001-04-05 Georgetown University Dopamine transporter inhibitors and their use
US6444471B1 (en) 1999-10-18 2002-09-03 Research & Diagnostic Systems, Inc. Reticulocyte containing complete blood control
EP1231894B1 (en) 1999-11-23 2005-01-12 Glaxo Group Limited Pharmaceutical formulations of salmeterol
IL149622A0 (en) 1999-12-06 2002-11-10 Hoffmann La Roche 4-pyridinyl-n-acyl-l-phenylalanines
US20020160067A1 (en) 2001-04-25 2002-10-31 Oncology Science Corporation Therapeutic preparation and method for producing a therapeutic preparation using coffee beans as a substrate
DE60019167T2 (de) 1999-12-24 2006-05-11 Glaxo Group Ltd., Greenford Pharmazeutische aerosol formulierung enthaltend salmeterol und fluticason
AU2000235960A1 (en) 2000-02-14 2001-08-27 Tularik, Inc. Lxr modulators
US6378919B1 (en) 2000-04-04 2002-04-30 International Truck Intellectual Property Company, L.L.C. Cylindrical lock with slam latch and auxiliary cable release
JP2001302637A (ja) 2000-04-20 2001-10-31 Nippon Kayaku Co Ltd 感熱転写記録用色素及び感熱転写シート
AU2001262984A1 (en) 2000-05-03 2001-11-12 Tularik, Inc. Treatment of hypertriglyceridemia and other conditions using lxr modulators
AU6272301A (en) 2000-06-12 2001-12-24 Eisai Co Ltd 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
US6380256B1 (en) 2000-08-29 2002-04-30 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6369261B1 (en) * 2000-08-29 2002-04-09 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6291677B1 (en) 2000-08-29 2001-09-18 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6313107B1 (en) 2000-08-29 2001-11-06 Allergan Sales, Inc. Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI
US6369225B1 (en) * 2000-08-29 2002-04-09 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6387951B1 (en) 2000-08-29 2002-05-14 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
CA2420869A1 (en) 2000-08-29 2002-03-07 Allergan, Inc. Compounds having activity as inhibitors of cytochrome p450rai
US6303785B1 (en) 2000-08-29 2001-10-16 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6252090B1 (en) * 2000-08-29 2001-06-26 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
UY27003A1 (es) 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
MXPA03005152A (es) 2000-12-11 2004-10-14 Tularik Inc Antogonista de cxcr3.
US8176425B2 (en) 2001-02-02 2012-05-08 Ensequence, Inc. Animated screen object for annotation and selection of video sequences
WO2002089800A2 (en) 2001-05-05 2002-11-14 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
CN100448874C (zh) 2001-05-05 2009-01-07 史密斯克莱·比奇曼公司 N-芳酰基环胺
US6861424B2 (en) 2001-06-06 2005-03-01 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
GB0115862D0 (en) 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
EP1705179A1 (en) 2001-06-28 2006-09-27 Smithkline Beecham Plc N-aroyl cyclic amine derivatives as orexin receptor antagonists
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
CA2469435A1 (en) * 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
WO2004103974A1 (ja) 2003-05-23 2004-12-02 Japan Tobacco Inc. 置換2-オキソキノリン化合物およびその医薬用途
CN1289803C (zh) 2004-05-16 2006-12-13 王永钦 汽车冷却风扇驱动机构总成

Similar Documents

Publication Publication Date Title
BR122017007260A2 (ja)
BR112013013385A2 (ja)
BR112013008959A2 (ja)
BR112012031500A2 (ja)
BR112012029986A2 (ja)
BR112012028408A2 (ja)
BR112012026492A2 (ja)
BR112012019354A2 (ja)
BR112012002126A2 (ja)
BR112012026946A2 (ja)
BR112012017960A2 (ja)
BR112013006400A2 (ja)
BR112012031826A2 (ja)
BR112012016456A2 (ja)
BR112012018256A2 (ja)
BR112012027945A2 (ja)
BR112013010949A2 (ja)
BR112013012726A2 (ja)
BR112013003284A2 (ja)
BR112013002646A2 (ja)
BR112012023446A2 (ja)
BR112013006825A2 (ja)
BR112012028859A2 (ja)
BR112012016895A2 (ja)
BR112013007728A2 (ja)