JP2008540499A5 - - Google Patents
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- Publication number
- JP2008540499A5 JP2008540499A5 JP2008510642A JP2008510642A JP2008540499A5 JP 2008540499 A5 JP2008540499 A5 JP 2008540499A5 JP 2008510642 A JP2008510642 A JP 2008510642A JP 2008510642 A JP2008510642 A JP 2008510642A JP 2008540499 A5 JP2008540499 A5 JP 2008540499A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cyclodextrin
- hdac inhibitor
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 49
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 29
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 29
- 229920000858 Cyclodextrin Polymers 0.000 claims 26
- 239000004475 Arginine Substances 0.000 claims 18
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 18
- 235000009697 arginine Nutrition 0.000 claims 18
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 15
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229960003194 meglumine Drugs 0.000 claims 12
- 125000004450 alkenylene group Chemical group 0.000 claims 9
- 125000002947 alkylene group Chemical group 0.000 claims 8
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 6
- 239000001116 FEMA 4028 Substances 0.000 claims 6
- 229960004853 betadex Drugs 0.000 claims 6
- 125000005549 heteroarylene group Chemical group 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 5
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims 5
- 238000001802 infusion Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 102000003964 Histone deacetylase Human genes 0.000 claims 3
- 108090000353 Histone deacetylase Proteins 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 3
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 150000002170 ethers Chemical class 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 239000002504 physiological saline solution Substances 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 2
- 229930064664 L-arginine Natural products 0.000 claims 2
- 235000014852 L-arginine Nutrition 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000005488 carboaryl group Chemical group 0.000 claims 2
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 239000003708 ampul Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- BPKIGYQJPYCAOW-FFJTTWKXSA-I calcium;potassium;disodium;(2s)-2-hydroxypropanoate;dichloride;dihydroxide;hydrate Chemical compound O.[OH-].[OH-].[Na+].[Na+].[Cl-].[Cl-].[K+].[Ca+2].C[C@H](O)C([O-])=O BPKIGYQJPYCAOW-FFJTTWKXSA-I 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000002510 pyrogen Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1
- 239000008215 water for injection Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68123405P | 2005-05-13 | 2005-05-13 | |
| US68121505P | 2005-05-13 | 2005-05-13 | |
| US60/681,215 | 2005-05-13 | ||
| US60/681,234 | 2005-05-13 | ||
| PCT/GB2006/001737 WO2006120456A1 (en) | 2005-05-13 | 2006-05-11 | Pharmaceutical formulations of hdac inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012128900A Division JP5567068B2 (ja) | 2005-05-13 | 2012-06-06 | Ｈｄａｃ阻害剤の医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540499A JP2008540499A (ja) | 2008-11-20 |
| JP2008540499A5 true JP2008540499A5 (https=) | 2009-06-25 |
| JP5108750B2 JP5108750B2 (ja) | 2012-12-26 |
Family
ID=36617353
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510642A Active JP5108750B2 (ja) | 2005-05-13 | 2006-05-11 | Ｈｄａｃ阻害剤の医薬製剤 |
| JP2012128900A Expired - Fee Related JP5567068B2 (ja) | 2005-05-13 | 2012-06-06 | Ｈｄａｃ阻害剤の医薬製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012128900A Expired - Fee Related JP5567068B2 (ja) | 2005-05-13 | 2012-06-06 | Ｈｄａｃ阻害剤の医薬製剤 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8835501B2 (https=) |
| EP (2) | EP2494969B1 (https=) |
| JP (2) | JP5108750B2 (https=) |
| KR (2) | KR101340824B1 (https=) |
| CN (2) | CN102579417B (https=) |
| AT (1) | ATE542527T1 (https=) |
| AU (1) | AU2006245495B2 (https=) |
| BR (1) | BRPI0610128B1 (https=) |
| CA (1) | CA2606598C (https=) |
| CY (1) | CY1112498T1 (https=) |
| DK (2) | DK1901729T3 (https=) |
| EA (2) | EA018982B1 (https=) |
| EC (1) | ECSP078002A (https=) |
| ES (2) | ES2380887T3 (https=) |
| HR (1) | HRP20120341T1 (https=) |
| IL (2) | IL187231A (https=) |
| MX (1) | MX2007013938A (https=) |
| NO (1) | NO339954B1 (https=) |
| NZ (1) | NZ563236A (https=) |
| PL (1) | PL1901729T3 (https=) |
| PT (1) | PT1901729E (https=) |
| RS (1) | RS52214B (https=) |
| SI (1) | SI1901729T1 (https=) |
| UA (1) | UA99810C2 (https=) |
| WO (1) | WO2006120456A1 (https=) |
| ZA (1) | ZA200710313B (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5156392B2 (ja) | 2005-02-03 | 2013-03-06 | トポターゲット ユーケー リミテッド | Ｈｄａｃ阻害剤を用いる併用療法 |
| ATE542527T1 (de) | 2005-05-13 | 2012-02-15 | Topotarget Uk Ltd | Pharmazeutische formulierungen von hdac-hemmern |
| WO2007054719A2 (en) | 2005-11-10 | 2007-05-18 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
| ITRM20070038A1 (it) * | 2007-01-26 | 2008-07-27 | Uni Degli Studi Di Roma La Sapienza | Forme solubili di complessi di inclusione di inibitori dell istone deacetilasi e ciclodestrine loro processi di preparazione e impieghi in campo farmaceutico |
| US8946201B2 (en) * | 2007-08-27 | 2015-02-03 | Saint Louis University | Methods for inhibiting TGF-β |
| US8642809B2 (en) | 2007-09-25 | 2014-02-04 | Topotarget Uk Ltd. | Methods of synthesis of certain hydroxamic acid compounds |
| ES2536208T3 (es) * | 2008-03-07 | 2015-05-21 | Onxeo Dk, Branch Of Onxeo S.A., France | Métodos de tratamiento que emplean infusión continua prolongada de Belinostat |
| CN102159219B (zh) * | 2008-09-16 | 2015-06-24 | 圣路易斯大学 | 提高转化生长因子-β信号发送的方法 |
| JP5773877B2 (ja) | 2008-10-22 | 2015-09-02 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する化合物 |
| GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
| WO2011064663A1 (en) | 2009-11-25 | 2011-06-03 | Festuccia, Claudio | Combination treatment employing belinostat and bicalutamide |
| CA2829263C (en) | 2011-03-21 | 2020-05-12 | Valcuria Ab | A pharmaceutical composition comprising a hdac inhibitor and a steroid and the use thereof. |
| DK2758052T3 (en) * | 2011-09-18 | 2018-05-28 | Euro Celtique Sa | Pharmaceutical composition comprising an HDAC inhibitor and a cyclopolysaccharide |
| HK1200809A1 (en) * | 2011-12-29 | 2015-08-14 | 药品循环有限责任公司 | Cinnamic acid hydroxyamides as inhibitors of histone deacetylase 8 |
| TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| RU2715236C2 (ru) | 2014-03-26 | 2020-02-26 | Астекс Терапьютикс Лтд | Комбинации |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US10413517B2 (en) | 2014-06-12 | 2019-09-17 | University Of Notre Dame Du Lac | Composition and method for the treatment of neurological diseases and cerebral injury |
| TWI719960B (zh) | 2015-02-10 | 2021-03-01 | 英商阿斯迪克治療公司 | 新穎組成物 |
| US9745253B2 (en) | 2015-03-13 | 2017-08-29 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as HDAC8 inhibitors |
| WO2016205203A1 (en) | 2015-06-16 | 2016-12-22 | Spectrum Pharmaceuticals, Inc. | Combination therapy using belinostat and pralatrexate to treat lymphoma |
| CN105481736A (zh) * | 2015-12-28 | 2016-04-13 | 山东大学 | 一种含有苯甘氨酸的肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
| WO2017144548A1 (en) | 2016-02-22 | 2017-08-31 | Onxeo | Combination therapies comprising immuno-oncology agents and doxorubicin-loaded poly(cyanoacrylate) nanoparticles |
| EP3347055B1 (en) | 2016-03-31 | 2019-06-12 | Midatech Ltd. | Cyclodextrin-panobinostat adduct |
| CN109715141A (zh) * | 2016-07-08 | 2019-05-03 | 兰迪斯制药公司 | 治疗和/或预防溶酶体贮积病和其它单基因代谢性疾病的组合物和方法 |
| CN107638571B (zh) * | 2016-07-15 | 2021-07-06 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种特考韦瑞口服药物组合物及其制备方法 |
| CN107625967B (zh) * | 2016-07-15 | 2021-07-06 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种特考韦瑞注射用药物组合物及其制备方法 |
| WO2018029699A1 (en) * | 2016-08-11 | 2018-02-15 | Msn Research & Development Center | Solid state forms of (2e)-n-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide and process for preparation thereof |
| AU2016426574B2 (en) | 2016-10-11 | 2023-07-13 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
| CN106389359B (zh) * | 2016-11-30 | 2019-07-26 | 瑞阳制药有限公司 | 供注射用的贝利司他药物组合物及其制备方法 |
| CN108210501B (zh) * | 2016-12-14 | 2019-03-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种磺酰脲类药物的注射用药物组合物及其制备方法 |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| CN110996913A (zh) * | 2017-06-30 | 2020-04-10 | 欧恩科斯欧公司 | 新的贝利司他口服制剂 |
| WO2019067145A1 (en) * | 2017-08-28 | 2019-04-04 | Asdera Llc | USE OF CYCLODEXTRINS IN DISEASES AND DISORDERS INVOLVING PHOSPHOLIPID DISRUPTION |
| EP3461488A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dbait molecule and a hdac inhibitor for treating cancer |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| KR20200107927A (ko) * | 2017-09-28 | 2020-09-16 | 아스데라 엘엘씨 | 인지질 조절장애를 수반하는 질환 및 장애에서의 시클로덱스트린의 용도 |
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