JP2005525291A5 - - Google Patents
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- JP2005525291A5 JP2005525291A5 JP2003520733A JP2003520733A JP2005525291A5 JP 2005525291 A5 JP2005525291 A5 JP 2005525291A5 JP 2003520733 A JP2003520733 A JP 2003520733A JP 2003520733 A JP2003520733 A JP 2003520733A JP 2005525291 A5 JP2005525291 A5 JP 2005525291A5
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- JP
- Japan
- Prior art keywords
- alkyl
- solvate
- salt
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 21
- 239000012453 solvate Substances 0.000 claims 21
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- -1 4,5-dihydro-5-oxo-pyrazolyl Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 125000000464 thioxo group Chemical group S=* 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- CBKDCOKSXCTDAA-UHFFFAOYSA-N 4,5,6,7-tetrahydro-1-benzothiophene Chemical group C1CCCC2=C1C=CS2 CBKDCOKSXCTDAA-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical class 0.000 claims 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims 1
- 150000003557 thiazoles Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102764A SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Compounds |
| PCT/GB2002/003745 WO2003015774A1 (en) | 2001-08-17 | 2002-08-15 | Compounds effecting glucokinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005168987A Division JP4441446B2 (ja) | 2001-08-17 | 2005-06-09 | グルコキナーゼ化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005525291A JP2005525291A (ja) | 2005-08-25 |
| JP2005525291A5 true JP2005525291A5 (OSRAM) | 2006-01-05 |
| JP3987829B2 JP3987829B2 (ja) | 2007-10-10 |
Family
ID=20285065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003520733A Expired - Fee Related JP3987829B2 (ja) | 2001-08-17 | 2002-08-15 | グルコキナーゼ化合物 |
| JP2005168987A Expired - Fee Related JP4441446B2 (ja) | 2001-08-17 | 2005-06-09 | グルコキナーゼ化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005168987A Expired - Fee Related JP4441446B2 (ja) | 2001-08-17 | 2005-06-09 | グルコキナーゼ化合物 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US7390908B2 (OSRAM) |
| EP (12) | EP1661567B1 (OSRAM) |
| JP (2) | JP3987829B2 (OSRAM) |
| KR (1) | KR100920439B1 (OSRAM) |
| CN (4) | CN101492416B (OSRAM) |
| AR (1) | AR037898A1 (OSRAM) |
| AT (11) | ATE397927T1 (OSRAM) |
| AU (1) | AU2002321462B2 (OSRAM) |
| BR (1) | BR0212008A (OSRAM) |
| CA (1) | CA2457410C (OSRAM) |
| CO (1) | CO5560563A2 (OSRAM) |
| CY (5) | CY1105746T1 (OSRAM) |
| DE (11) | DE60228897D1 (OSRAM) |
| DK (5) | DK1661563T3 (OSRAM) |
| ES (10) | ES2312051T3 (OSRAM) |
| HU (1) | HUP0401213A3 (OSRAM) |
| IL (2) | IL160219A0 (OSRAM) |
| IS (1) | IS7150A (OSRAM) |
| MX (1) | MXPA04001500A (OSRAM) |
| MY (1) | MY146279A (OSRAM) |
| NO (1) | NO20040686L (OSRAM) |
| NZ (1) | NZ531193A (OSRAM) |
| PL (1) | PL368970A1 (OSRAM) |
| PT (5) | PT1661569E (OSRAM) |
| RU (1) | RU2329043C9 (OSRAM) |
| SE (1) | SE0102764D0 (OSRAM) |
| SI (5) | SI1669068T1 (OSRAM) |
| TW (1) | TWI333855B (OSRAM) |
| UA (1) | UA83182C2 (OSRAM) |
| WO (1) | WO2003015774A1 (OSRAM) |
| ZA (1) | ZA200401015B (OSRAM) |
Families Citing this family (147)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102300D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| JP2004123732A (ja) * | 2002-09-10 | 2004-04-22 | Takeda Chem Ind Ltd | 5員複素環化合物 |
| WO2004024705A1 (ja) * | 2002-09-10 | 2004-03-25 | Takeda Pharmaceutical Company Limited | 5員複素環化合物 |
| JP2006509774A (ja) | 2002-10-03 | 2006-03-23 | ノバルティス アクチエンゲゼルシャフト | 2型糖尿病の処置において有用なグルコキナーゼアクチベーターとしての置換(チアゾール−2−イル)−アミドまたはスルホンアミド |
| GB0226930D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| PE20050194A1 (es) | 2003-02-13 | 2005-04-23 | Banyu Pharma Co Ltd | Derivados de piridina-2-carboxamida como activadores de glucoquinasa |
| MXPA05009059A (es) | 2003-02-26 | 2005-10-19 | Banyu Pharma Co Ltd | Derivados de heteroarilcarbamoilbenceno. |
| US20050032868A1 (en) * | 2003-05-02 | 2005-02-10 | Garofalo Albert W. | Selected substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists |
| CA2524269A1 (en) * | 2003-05-02 | 2004-11-18 | Elan Pharmaceuticals, Inc. | 4- bromo - 5 - (2- chloro - benzoylamino) - 1h - pyrazole - 3 - carboxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases |
| JP2007506654A (ja) * | 2003-06-20 | 2007-03-22 | エフ.ホフマン−ラ ロシュ アーゲー | Cb1受容体逆作動物質としての2−アミノベンゾチアゾール類 |
| ES2222822B1 (es) * | 2003-07-28 | 2005-12-16 | Laboratorios Farmaceuticos Rovi, S.A. | Diamidas de aminoacidos en posicion no alfa utiles como adyuvantes para la administracion de agentes biologicos activos. |
| JP4667384B2 (ja) | 2003-10-07 | 2011-04-13 | レノビス, インコーポレイテッド | イオンチャネルリガンドとしてのアミド誘導体および薬学的組成物、ならびにこれらを使用する方法 |
| GB0325402D0 (en) * | 2003-10-31 | 2003-12-03 | Astrazeneca Ab | Compounds |
| GB0328178D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Compounds |
| US20080280872A1 (en) * | 2004-02-18 | 2008-11-13 | Craig Johnstone | Benzamide Derivatives and Their Use as Glucokinase Activating Agents |
| CA2554686A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Compounds |
| ATE524479T1 (de) | 2004-04-02 | 2011-09-15 | Novartis Ag | Sulfonamidthiazolpyridinderivate als zur behandlung von typ-2-diabetes geeignete glucokinaseaktivatoren |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| JP2007530631A (ja) | 2004-04-02 | 2007-11-01 | ノバルティス アクチエンゲゼルシャフト | チアゾロピリジン誘導体、それを含む医薬組成物およびグルコキナーゼ介在性状態の処置法 |
| TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| RU2403246C2 (ru) * | 2004-06-05 | 2010-11-10 | Астразенека Аб | Гетероарилбензамидные производные для применения в качестве активаторов глюкокиназы (glk) в лечении диабета |
| KR100739367B1 (ko) * | 2004-07-14 | 2007-07-16 | 크리스탈지노믹스(주) | 설파마이드 유도체 및 이를 함유하는 지방대사 촉진용약학적 조성물 |
| GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| KR20070085371A (ko) | 2004-10-16 | 2007-08-27 | 아스트라제네카 아베 | 페녹시 벤즈아미드 화합물의 제조 방법 |
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| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| DK1951658T3 (da) | 2005-11-17 | 2012-10-15 | Lilly Co Eli | Glucagonreceptorantagonister, fremstilling og terapeutiske anvendelser |
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| US9340506B2 (en) | 2007-10-08 | 2016-05-17 | Advinus Therapeutics Limited | Acetamide derivatives as glucokinase activators, their process and medicinal applications |
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- 2002-08-15 IL IL16021902A patent/IL160219A0/xx not_active IP Right Cessation
- 2002-08-15 DE DE60210782T patent/DE60210782T2/de not_active Expired - Lifetime
- 2002-08-15 ES ES06001796T patent/ES2307237T3/es not_active Expired - Lifetime
- 2002-08-15 EP EP04028297A patent/EP1568367B3/en not_active Expired - Lifetime
- 2002-08-15 AT AT06001808T patent/ATE396720T1/de active
- 2002-08-15 EP EP06001809A patent/EP1669068B1/en not_active Expired - Lifetime
- 2002-08-16 TW TW097137990A patent/TWI333855B/zh not_active IP Right Cessation
- 2002-08-16 AR ARP020103107A patent/AR037898A1/es unknown
-
2004
- 2004-02-06 ZA ZA200401015A patent/ZA200401015B/xx unknown
- 2004-02-13 IS IS7150A patent/IS7150A/is unknown
- 2004-02-17 NO NO20040686A patent/NO20040686L/no not_active Application Discontinuation
- 2004-03-10 CO CO04022003A patent/CO5560563A2/es not_active Application Discontinuation
-
2005
- 2005-06-09 JP JP2005168987A patent/JP4441446B2/ja not_active Expired - Fee Related
-
2006
- 2006-11-01 CY CY20061101565T patent/CY1105746T1/el unknown
-
2007
- 2007-06-22 CY CY20071100836T patent/CY1107683T1/el unknown
-
2008
- 2008-02-01 US US12/024,561 patent/US7524957B2/en not_active Expired - Fee Related
- 2008-08-12 CY CY20081100851T patent/CY1108254T1/el unknown
- 2008-08-18 CY CY20081100873T patent/CY1108267T1/el unknown
- 2008-08-21 CY CY20081100889T patent/CY1108276T1/el unknown
-
2009
- 2009-02-02 US US12/363,899 patent/US7951830B2/en not_active Expired - Fee Related
-
2010
- 2010-02-11 IL IL203923A patent/IL203923A/en not_active IP Right Cessation
- 2010-11-09 MY MYPI2010005251A patent/MY146279A/en unknown
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