JP2005060366A - 脂肪分解促進剤 - Google Patents
脂肪分解促進剤 Download PDFInfo
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- JP2005060366A JP2005060366A JP2004156535A JP2004156535A JP2005060366A JP 2005060366 A JP2005060366 A JP 2005060366A JP 2004156535 A JP2004156535 A JP 2004156535A JP 2004156535 A JP2004156535 A JP 2004156535A JP 2005060366 A JP2005060366 A JP 2005060366A
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- extract
- slimming
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- fat
- lysis
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Abstract
【解決手段】 セイヨウネズ、トゲナシ、ローズヒップ、ビンロウジ、オンジ、シャゼンソウ、コロンボ、ズイコウロウドク、キンレンカ、キダチウマノスズクサ、ヤマモモ、チガヤ、コウホン、ショウヨウカンゾウ、シラカンバ、タンジン、キクバフウロ、シロガラシ、ヒマワリ、カキドオシ、クコ、エンジュ、センネンケン、イチジク、カンカットウ、ブッソウゲ、ウスバアカザ、コロハ、セイヨウグルミ、ソウズク、コニワザクラ、クチナシ、シマカンギク、アカミノアカネ、フタバムグラ、カロオウ、ケイガイ、スベリヒユ、カラビャクシ及びニワヤナギから選ばれる植物又はその抽出物を有効成分とする脂肪分解促進剤。
【選択図】 なし
Description
また、液々分配等の技術により、上記抽出物から不活性な夾雑物を除去して用いることもでき、本発明においてはこのようなものを用いることが好ましい。これらは、必要により公知の方法で脱臭、脱色等の処理を施してから用いてもよい。
製造例1 セイヨウネズ抽出物の製造
セイヨウネズの果実より水を溶媒として抽出したセイヨウネズ抽出液W(丸善製薬製)を用い、本品1mLを105℃にて8時間加熱処理することで、抽出乾燥物21mgを得た(本発明品1)。
トゲナシの果実より50%1,3−ブチレングリコール水溶液を溶媒として抽出したトゲナシ抽出液G(丸善製薬製)を用い、本品1mLを105℃にて8時間加熱処理することで、抽出乾燥物9mgを得た(本発明品2)。
ノバラの果実より50%エタノール水溶液を溶媒として抽出したファルコレックスノバラE(一丸ファルコス製)を用い、本品1mLを105℃にて8時間加熱処理することで、抽出乾燥物25mgを得た(本発明品3)。
ビンロウの種子10gより50%エタノール水溶液を溶媒として抽出し、得られた抽出液1mLを105℃にて8時間加熱処理することで、抽出乾燥物26mgを得た(本発明品4)。
イトヒメハギの根10gより、50%エタノール水溶液を溶媒として抽出し、得られた抽出液1mLを105℃にて8時間加熱処理することで、抽出乾燥物126mgを得た(本発明品5)。
オオバコの全草5gより、50%エタノール水溶液を溶媒として抽出し、得られた抽出液1mLを105℃にて8時間加熱処理することで、抽出乾燥物34mgを得た(本発明品6)。
コロンボの根10gより、50%エタノール水溶液を溶媒として抽出し、得られた抽出液1mLを105℃にて8時間加熱処理することで、抽出乾燥物54mgを得た(本発明品7)。
ズイコウロウドクの根1gに対して50%エタノール水を10mL加え、室温にて7日間抽出した。尚、本抽出液中には、105℃にて8時間加熱処理することで得られる抽出物(本発明品8)が1.24w/v%含まれていた。
同様の処理をして表1に示す各抽出物(本発明品9〜42、比較品1〜3)を得た。尚、表中、「熱水」とは、熱水で1時間抽出することを示す。
上記の本発明品1〜42及び比較品1〜3を用い、下記の試験法により、その脂肪分解促進作用を調べた。その結果を表2(2−1、2−2)に示す。
ロッドベルの方法〔Rodbell,M.,J.Biol.Chem.,239,375(1964)〕により、ウィスター系雄性ラット(体重150〜200g)1〜3匹の腹部皮下脂肪組織からコラゲナーゼ溶液を用いて遊離脂肪細胞を調製した。被験物は乾燥抽出物又は抽出液を用い、乾燥物換算で被験物濃度が10μg/mL及びノルエピネフリンが0.3μMとなるよう調製した牛血清アルブミンを含むハンクス緩衝液中で、上記細胞を37℃にて2時間インキュベートし、遊離したグリセロールを酵素法により測定した。対照は、被験物を含まないノルエピネフリンのみでインキュベートとし、下記の式により脂肪分解促進活性を算出した。2回に分けて実験した結果を示す。
Claims (5)
- セイヨウネズ、トゲナシ、ローズヒップ、ビンロウジ、オンジ、シャゼンソウ、コロンボ、ズイコウロウドク、キンレンカ、キダチウマノスズクサ、ヤマモモ、チガヤ、コウホン、ショウヨウカンゾウ、シラカンバ、タンジン、キクバフウロ、シロガラシ、ヒマワリ、カキドオシ、クコ、エンジュ、センネンケン、イチジク、カンカットウ、ブッソウゲ、ウスバアカザ、コロハ、セイヨウグルミ、ソウズク、コニワザクラ、クチナシ、シマカンギク、アカミノアカネ、フタバムグラ、カロオウ、ケイガイ、スベリヒユ、カラビャクシ及びニワヤナギから選ばれる植物又はその抽出物を有効成分とする脂肪分解促進剤。
- セイヨウネズ、トゲナシ、ローズヒップ、ビンロウジ、オンジ、シャゼンソウ、コロンボ、ズイコウロウドク、キンレンカ、キダチウマノスズクサ、ヤマモモ、チガヤ、コウホン、ショウヨウカンゾウ、シラカンバ、タンジン、キクバフウロ、シロガラシ、ヒマワリ、カキドオシ、クコ、エンジュ、センネンケン、イチジク、カンカットウ、ブッソウゲ、ウスバアカザ、コロハ、セイヨウグルミ、ソウズク、コニワザクラ、クチナシ、シマカンギク、アカミノアカネ、フタバムグラ、カロオウ、ケイガイ、スベリヒユ、カラビャクシ及びニワヤナギから選ばれる植物又はその抽出物を有効成分とする痩身剤。
- 身体をスリムにするものである請求項1記載の脂肪分解促進剤及び請求項2記載の痩身剤。
- 請求項1記載の植物又はその抽出物を皮膚に適用する痩身方法。
- 請求項1記載の植物又はその抽出物を1〜5g/日投与する痩身方法。
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JP2004156535A JP4373280B2 (ja) | 2003-07-29 | 2004-05-26 | 脂肪分解促進剤 |
US10/900,102 US7300675B2 (en) | 2003-07-29 | 2004-07-28 | Lipolysis stimulator |
EP04018004.4A EP1502598B1 (en) | 2003-07-29 | 2004-07-29 | Lipolysis stimulator |
US11/782,160 US20080021418A1 (en) | 2003-07-29 | 2007-07-24 | Lipolysis stimulator |
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US20050064049A1 (en) | 2005-03-24 |
US7300675B2 (en) | 2007-11-27 |
EP1502598A3 (en) | 2005-03-30 |
EP1502598B1 (en) | 2016-11-02 |
EP1502598A2 (en) | 2005-02-02 |
JP4373280B2 (ja) | 2009-11-25 |
US20080021418A1 (en) | 2008-01-24 |
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