JP2006347968A - 脂肪分解促進剤及びそれを含有する飲食品 - Google Patents
脂肪分解促進剤及びそれを含有する飲食品 Download PDFInfo
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- JP2006347968A JP2006347968A JP2005177058A JP2005177058A JP2006347968A JP 2006347968 A JP2006347968 A JP 2006347968A JP 2005177058 A JP2005177058 A JP 2005177058A JP 2005177058 A JP2005177058 A JP 2005177058A JP 2006347968 A JP2006347968 A JP 2006347968A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
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- Biotechnology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Hematology (AREA)
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- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
【解決手段】メース、スカンクキャベッジ、カリフォルニアンポピー、ミクリ、ブラッドルート、オレゴンマウンテングレープ、セキショウ、バナナ、エニシダ、ゴールデンシール、パイルワート、ヒューミトリー、イコジャ、クレソン、ブラッククミン、ネトル、ナズナ、ケンジンからなる群より選択される一種、又は二種以上の植物体及び/又はその抽出物を有効成分として含有する。
【選択図】なし
Description
表1に示す18種の植物を用いた。
植物を乾燥させ、その乾燥体10gに50%エタノール又は水を100mlを加え、撹拌しながら70℃で2時間抽出処理を行い、得られた抽出液をろ過後減圧濃縮し、次いで凍結乾燥し、植物抽出物を得た。
各抽出物の収率を[表1]に示す。
試験例1で調製した50%エタノール抽出物18種、水抽出物7種の凍結乾燥植物抽出物を単独又は2種類以上組み合わせて用いた。
(I)脂肪細胞の培養
マウス由来の前駆脂肪細胞であるMC3T3−G2/PA6細胞を24wellプレートに5×104個/wellになるように播き、10%牛胎児血清(FBS)添加α‐MEM培地にて5%CO2存在下、37℃で培養した。コンフルエントになる直前、デキサメタゾン、3−イソブチル−1−メチルキサンチン及びグルコースを添加した10%FBSα−MEM培地に交換し、脂肪細胞への分化を誘導した。誘導後8〜9日間培養を行い、脂肪細胞を成熟させた後に試験を行った。
培養上清を捨て、ウェルをPBS(−)で洗浄後、凍結乾燥植物抽出物と2%BSA、4.5g/Lグルコースを含むダルベッコリン酸緩衝液を加え、1時間インキュベートした。尚、凍結乾燥植物抽出物の量は単独又は2種類以上組み合わせて使用した場合の何れにおいても、この反応系における最終濃度が100μg/mlとなるように調整した。インキュベート後、上清をサンプリングし、トリグリセライドE−テストワコーを用いて脂肪の分解産物であるグリセロールの遊離量を測定した。なお、脂肪分解促進率は、以下の式で示されるコントロール(凍結乾燥植物抽出物を加えない場合)の値を100%とした場合の相対的な数値である。
A:抽出物添加時の遊離グリセロール量
B:抽出物無添加時の遊離グリセロール量
脂肪分解促進作用の判定は、脂肪分解により生成する遊離グリセロール量の測定値より求めた脂肪分解促進率により行った。[表2]、[表3]及び[表4]に示すように、供試植物抽出物を単独或いは2種類以上組み合わせて添加した場合、無添加の場合と比較して、明らかに脂肪分解が促進されていた。
ガムベース 20.0部
砂糖 55.0部
ブドウ糖 23.7部
軟化剤 1.0部
オレゴンマウンテングレープ50%エタノール抽出物 0.8部
ガムベース 20.0部
キシリトール 75.0部
還元麦芽糖 3.8部
軟化剤 1.0部
オレゴンマウンテングレープ水抽出物 0.2部
砂糖 75.0部
乳糖 20.0部
グリセリン脂肪酸エステル 0.2部
香料 0.4部
クレソン50%エタノール抽出物 0.1部
精製水 4.3部
砂糖 41.0部
カカオマス 15.0部
全脂粉乳 25.0部
ココアバター 18.0部
乳化剤 0.3部
香料 0.4部
スカンクキャベッジ50%エタノール抽出物 0.3部
果糖ブドウ糖飲料 5.00部
砂糖 4.50部
酸味料 1.28部
香料 0.20部
ケンジン50%エタノール抽出物 0.02部
精製水 89.0 部
オレンジ果汁 85.25部
砂糖 11.70部
クエン酸 2.00部
香料 1.00部
メース50%エタノール抽出物 0.05部
果糖ブドウ糖液糖 0.5部
砂糖 8.7部
酸味料 1.2部
香料 0.3部
精製水 89.0部
安定剤 0.2部
ブラッククミン水抽出物 0.1部
トウモロコシ 33.0部
小麦粉 35.0部
大豆粕 21.0部
米ぬか(脱脂) 5.5部
ミートミール 5.0部
ミネラルミックス 0.2部
イコジャ50%エタノール抽出物 0.3部
スカンクキャベッジ水抽出物 50.0部
乳糖 48.0部
ステアリン酸マグネシウム 2.0部
上記成分を均一に混合し、その混合末をハードカプセルに充填した。
ネトル50%エタノール抽出物 20.0部
直打用微粒 48.0部
(メタケイ酸アルミン酸マグネシウム20%、トウモロコシデンプン30%、乳糖50%)
結晶セルロース 30.0部
ステアリン酸マグネシウム 2.0部
上記成分を均一に混合し、その混合末を打錠して、1錠200mgの錠剤とした。
メース水抽出物 0.1部
単シロップ 30.0部
精製水 69.9部
上記植物抽出物を、精製水で完全に溶解し、単シロップを加えて混合し、シロップ剤とした。
カリフォルニアンポピー水抽出物 0.2部
砂糖 50.0部
水飴 35.3部
香料 0.5部
精製水 14.0部
メース50%エタノール抽出物 0.5部
小麦粉 50.6部
コーンスターチ 5.1部
砂糖 12.7部
マーガリン 6.5部
食塩 0.3部
炭酸ナトリウム 1.3部
炭酸アンモニウム 0.5部
大豆レシチン 0.3部
全卵 4.1部
香料 0.3部
精製水 17.8部
上記材料を混合してドウを形成し、延展後これを成型してオーブンで焙焼し、ビスケットを製造した。
Claims (3)
- メース(Myristica fragarance)、スカンクキャベッジ(Symplocarpus foetidus)、カリフォルニアンポピー(Escholzia california)、ミクリ(Sparganium stoloniferum)、ブラッドルート(Sanguinaria canadensis)、オレゴンマウンテングレープ(Mahonia Aquifolium)、セキショウ(Acorus gramineus)、バナナ(musa paradiciaca)の実部位、エニシダ(Cytisus scoparius)、ゴールデンシール(Hydrastis canadensis)、パイルワート(Ficaria ranunculoides)、ヒューミトリー(Fumaria officinalis)、イコジャ(unonopsis floribunda)、クレソン(Nasturtium officinale)、ブラッククミン(Nigella sativa)、ネトル(Urtica dioica)、ナズナ(Capsella bursa−pastoris)、ケンジン(Polygonum bistorta)からなる群より選択される一種、又は二種以上の植物体及び/又はその抽出物を有効成分として含有する脂肪分解促進剤。
- 抽出物が水及び/又は有機溶剤の抽出物である請求項1記載の脂肪分解促進剤。
- 請求項1又は2記載の脂肪分解促進剤を含有する飲食品。
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JP2005177058A JP5118292B2 (ja) | 2005-06-16 | 2005-06-16 | 脂肪分解促進剤 |
US11/451,399 US20060286180A1 (en) | 2005-06-16 | 2006-06-13 | Lipolysis promoter and food and drink containing the same |
KR1020060054103A KR100813175B1 (ko) | 2005-06-16 | 2006-06-15 | 지방분해 촉진제 및 이를 함유하는 비만 예방 및 개선용기능성 식품 |
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JP2009292742A (ja) * | 2008-06-03 | 2009-12-17 | Noevir Co Ltd | 保湿剤、抗老化剤、抗酸化剤及び皮膚外用剤 |
JP2011072307A (ja) * | 2009-09-01 | 2011-04-14 | Nara Women's Univ | 塩味増強剤及び塩味増強方法 |
JP2011168554A (ja) * | 2010-02-19 | 2011-09-01 | Inabata Koryo Kk | 消臭剤及びそれを用いた消臭剤組成物 |
JP2015159806A (ja) * | 2014-02-28 | 2015-09-07 | 株式会社ファーマフーズ | バナナ酵素処理物およびその利用 |
JP2016108295A (ja) * | 2014-12-09 | 2016-06-20 | コリア インスティテュート オブ オリエンタル メディシン | サンパクソウ、キョウオウ及びオンジの複合抽出物を含む、肥満の予防又は治療用薬学組成物 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008120712A1 (ja) * | 2007-03-30 | 2008-10-09 | Suntory Holdings Limited | 交感神経活動亢進作用を有する医薬組成物又は飲食物 |
JP2009292742A (ja) * | 2008-06-03 | 2009-12-17 | Noevir Co Ltd | 保湿剤、抗老化剤、抗酸化剤及び皮膚外用剤 |
JP2011072307A (ja) * | 2009-09-01 | 2011-04-14 | Nara Women's Univ | 塩味増強剤及び塩味増強方法 |
JP2011168554A (ja) * | 2010-02-19 | 2011-09-01 | Inabata Koryo Kk | 消臭剤及びそれを用いた消臭剤組成物 |
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EP3750546A4 (en) * | 2018-02-09 | 2021-10-27 | Kohaku Bio Technology Co., Ltd. | GLYCEROL RELEASE PROMOTER |
Also Published As
Publication number | Publication date |
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KR20060131684A (ko) | 2006-12-20 |
US20060286180A1 (en) | 2006-12-21 |
JP5118292B2 (ja) | 2013-01-16 |
KR100813175B1 (ko) | 2008-03-17 |
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