JP4764518B1 - 経口毛穴改善剤 - Google Patents
経口毛穴改善剤 Download PDFInfo
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- JP4764518B1 JP4764518B1 JP2010168870A JP2010168870A JP4764518B1 JP 4764518 B1 JP4764518 B1 JP 4764518B1 JP 2010168870 A JP2010168870 A JP 2010168870A JP 2010168870 A JP2010168870 A JP 2010168870A JP 4764518 B1 JP4764518 B1 JP 4764518B1
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- pores
- extract
- oral pore
- winged bean
- skin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
【解決手段】経口毛穴改善剤をマメ科シカクマメ(Psophocarpus)属に属する植物の中から選ばれる1種または2種以上の植物またはその抽出物からなるものとする。
【選択図】なし
Description
また、特許文献2においては、不全角化抑制効果および毛穴縮小効果を有する物質としてβ−アラニル−L−ヒスチジンを挙げている。
発明者らが検討したところ、シカクマメの種子および莢の抽出物には、経口により不全角化抑制効果および毛穴縮小効果があることを見出し本発明に至った。すなわち、本発明は、毛穴周囲の皮脂中の刺激成分による不全角化を抑制し、毛穴周囲の皮膚を正常に保ち、毛穴のすり鉢状構造の目立ちを抑えることが可能な経口毛穴改善剤を提供することを目的とするものである。
前記植物またはその抽出物はマメ科シカクマメ(Psophocarpus)属に属する植物の種子または莢であることが好ましく、前記シカクマメ(Psophocarpus)属に属する植物はシカクマメ(Psophocarpus tetragonolobus)であることがより好ましい。
本発明の経口毛穴改善剤に用いられるシカクマメ(Psophocarpus)属に属する植物は、マメ科の熱帯産つる性の草本である。本発明ではシカクマメ属に属する植物であれば特に限定されるものでなく、任意に用いることができる。中でもシカクマメ(Psophocarpus tetragonolobus)が好ましく用いられる。シカクマメ(Psophocarpus tetragonolobus)は日本にも移入され、栽培されている。改良品種として「ウリズン」等が知られている。本発明ではこれら改良品種も含むことはもちろんである。市販品はサカタのタネなどで購入することができる。
以下、本発明の経口毛穴改善剤を実施例によりさらに詳細に説明する。
シカクマメ(Psophocarpus tetragonolobus)の種子部分50gを、室温で1週間90%エタノールに浸漬し、抽出液を濃縮し、90%エタノール抽出物(乾燥物)2.9gを得た。シカクマメ莢も同様にして処理し、エタノール抽出物(乾燥物)2.5gを得た。
下記表1の配合によりシカクマメ種子エキス配合試験品、莢エキス配合試験品およびプラセボ(いすれも錠剤)を製造した。
40〜49歳の女性を、シカクマメ種子エキス試験品摂取群、シカクマメ莢エキス試験品摂取群、プラセボ摂取群の3群に分け(各群n=30)、試験品を2ヶ月〜3ヶ月間、1日1回摂取してもらった。
毛穴の目立つ部位においては経皮水分蒸散量や皮脂量が高く、なかでも不飽和脂肪酸の比率が高いことが知られている。また、毛穴の目立つ部位においては敏感肌質、乾燥状態、炎症状態、脂漏性皮膚炎等の症状を起こしやすく皮膚色は赤みを呈するので、赤みの改善はこれらの症状の改善指標となる。そこで、経皮水分蒸散量、皮脂抑制、皮脂中の不飽和脂肪酸量、皮膚色の観点から以下のようにして評価を行った。
シカクマメ種子エキス試験品摂取群、シカクマメ莢エキス試験品摂取群それぞれの被験者の頬部皮膚を摂取前(0M)、摂取1ヶ月後(1M)、摂取2ヶ月後(2M)にバポメーターにて測定した。結果を表2に示す(表2の数値は各群被験者の平均値である)。測定値が低いほど水分蒸散量が低い(=良い肌状態である)ことを示しており、表2から明らかなように、本発明の経口毛穴改善剤であるシカクマメ種子エキス試験品、シカクマメ莢エキス試験品を摂取した群はいずれも経皮水分蒸散量が低下しており、肌状態が改善されていることがわかる。
シカクマメ莢エキス試験品摂取群およびプラセボ摂取群それぞれの被験者の額部皮膚を摂取前(0M)、摂取1ヶ月後(1M)、摂取2ヶ月後(2M)にセブメーターにて測定した。結果を表3に示す(表3の数値は0M時の被験者の平均値の皮脂量を100とした相対値で示している)。表3から明らかなように、プラセボ摂取群の皮脂量が増加しているのに対し、本発明の経口毛穴改善剤であるシカクマメ莢エキス試験品を摂取した群は皮脂量が抑制されていることがわかる。
シカクマメ莢エキス試験品およびプラセボ摂取3ヶ月後に、それぞれの被験者の額部皮膚に、上におもりを載せたろ紙を1分間置き、その後ろ紙をアセトンで抽出し、ガスクロマトグラフィーにて皮脂量及び不飽和脂肪酸を定量した。測定結果を表4に示す(表4の数値は被験者の平均値であり、不飽和脂肪酸量/皮脂量×100(%)で算出したものである)。表4から明らかなように、本発明の経口毛穴改善剤であるシカクマメ莢エキス試験品を摂取した群はプラセボ摂取群に比べて、皮脂中の不飽和脂肪酸量が低下していることがわかる。
シカクマメ種子エキス試験品摂取群、シカクマメ莢エキス試験品摂取群、およびプラセボ摂取群それぞれの被験者の頬部皮膚を摂取前(0M)、摂取1ヶ月後(1M)、摂取2ヶ月後(2M)に測色計にて測定した。結果を表5に示す(0M−1M、0M−2Mは摂取前と摂取1ヶ月後、摂取前と摂取2ヶ月後との変動値を、被験者の平均値として算出。値が正であると改善状態であり、数値は高いほどより改善していることを示している)。表5から明らかなように、本発明の経口毛穴改善剤であるシカクマメ種子エキス試験品、シカクマメ莢エキス試験品を摂取した群はいずれもプラセボ摂取群に比べて、連用により赤みが改善されていることがわかる。
以下に、本発明の経口毛穴改善剤を含むサプリメント、食品、飲料等の処方例を示す。なお、配合量は質量部または質量%で表している。
(1,500mg/日)
(配合成分) (mg)
ショ糖エステル 70
結晶セルロース 74
メチルセルロース 36
グリセリン 25
本経口毛穴改善剤:シカクマメ莢抽出物(乾燥残分) 475
N−アセチルグルコサミン 100
ヒアルロン酸 50
ビタミンE 30
ビタミンB6 20
ビタミンB2 10
α−リポ酸 20
コエンザイムQ10 40
セラミド(コンニャク抽出物) 50
L−プロリン 100
コラーゲン 400
(1,500mg/日)
(配合成分) (mg)
食用大豆油 530
トチュウエキス 50
ニンジンエキス 50
本経口毛穴改善剤:シカクマメ種子抽出物(乾燥残分) 100
ローヤルゼリー 50
マカ 30
γ−アミノ酪酸(GABA) 30
ミツロウ 60
ゼラチン 375
グリセリン 120
グリセリン脂肪酸エステル 105
(配合成分) (mg)
本経口毛穴改善剤:シカクマメ莢抽出物(乾燥残分) 400
ビタミンC 100
大豆イソフラボン 250
還元乳糖 300
大豆オリゴ糖 36
エリスリトール 36
デキストリン 30
香料 24
クエン酸 24
(配合成分) (50ml中質量%)
トチュウエキス 1.6
ニンジンエキス 1.6
本経口毛穴改善剤:シカクマメ莢抽出物(乾燥残分) 1.6
還元麦芽糖水飴 28
エリスリトール 8
クエン酸 2
香料 1.3
N−アセチルグルコサミン 1
ヒアルロン酸 0.5
ビタミンE 0.3
ビタミンB6 0.2
ビタミンB2 0.1
α−リポ酸 0.2
セラミド(コンニャク抽出物) 0.4
L−プロリン 2
コラーゲンペプチド 10
精製水 残余
(配合成分) (質量%)
薄力粉 45.0
バター 17.5
グラニュー糖 20.0
本経口毛穴改善剤:シカクマメ種子粉砕物 4.0
ニンジンエキス 適量
卵 12.5
レモンフレーバー 1.0
Claims (3)
- マメ科シカクマメ(Psophocarpus)属に属する植物の中から選ばれる1種または2種以上の植物またはその抽出物からなる不全角化を修復することによって毛穴の目立ちを抑制する経口毛穴目立ち抑制剤。
- 前記植物またはその抽出物がマメ科シカクマメ(Psophocarpus)属に属する植物の種子または莢であることを特徴とする請求項1記載の不全角化を修復することによって毛穴の目立ちを抑制する経口毛穴目立ち抑制剤。
- 前記シカクマメ(Psophocarpus)属に属する植物がシカクマメ(Psophocarpus tetragonolobus)であることを特徴とする請求項2記載の不全角化を修復することによって毛穴の目立ちを抑制する経口毛穴目立ち抑制剤。
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JP2010168870A JP4764518B1 (ja) | 2010-07-28 | 2010-07-28 | 経口毛穴改善剤 |
PCT/JP2011/004136 WO2012014417A1 (ja) | 2010-07-28 | 2011-07-22 | 毛穴改善のための植物等の使用および毛穴改善方法並びに経口毛穴改善剤 |
CN2011800368094A CN103052396A (zh) | 2010-07-28 | 2011-07-22 | 用于毛孔改善的植物等的应用和毛孔改善方法及经口毛孔改善剂 |
TW100126839A TW201210632A (en) | 2010-07-28 | 2011-07-28 | Use of plant or like for improving pores, method for improving pores and oral preparation for improving pores |
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- 2011-07-22 WO PCT/JP2011/004136 patent/WO2012014417A1/ja active Application Filing
- 2011-07-28 TW TW100126839A patent/TW201210632A/zh unknown
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CN103052396A (zh) | 2013-04-17 |
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